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室内设计 2013年第1期28卷 52-60,70页

作者：小野田泰明北野央菅野实坂口大洋刘智(译) 谷光灿(译) 东北大学大学院东京电机大学信息环境学部重庆大学建筑城规学院山地城镇建设与新技术教育部重点实验室

通过将LA空间模式下的社区式公寓楼与常规公寓楼在居住者的空间环境以及隐私意识这两方面的对比,本文研究评估了前者的相关效应,并发现前者比后者容纳了更多的社区行为。社区式公寓楼的居民们通过控制自己住房的边界状况来把握和解决自... 详细信息

通过将LA空间模式下的社区式公寓楼与常规公寓楼在居住者的空间环境以及隐私意识这两方面的对比,本文研究评估了前者的相关效应,并发现前者比后者容纳了更多的社区行为。社区式公寓楼的居民们通过控制自己住房的边界状况来把握和解决自身隐私需求,其方法可被分为五类。本论文研究者发现,居民们并不会简单地否定或肯定来自外部的视线影响,而是在一种复杂的社会交往与空间调整中控制着他们之间那条互相作用着的界线。

关键词：社区隐私 LA 空间调整公寓楼

新型显微垂直剪用于手术切除视网膜微血管瘤性增殖病变

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世界核心医学期刊文摘（眼科学分册） 2005年第7期1卷 20-20页

作者： sakaguchi H. Ohji M. Gomi F. 潘佳鸿 Department of Ophthalmology Osaka University Medical School 2- 2 Yamadaoka E- 7 Suita Osaka565- 0871 Japan

Purpose: To develop new micro vertical scissors for the ablation of retinal angiomatous proliferation (RAP) to minimize possible retinal damage. Design: Interventional case report. Methods: New micro vertical scissors were developed and used for the ablation of RAP vessels. Results: The length of the inner side of the tip is 180 μ m, which is approximately one seventh that of regular vertical scissors. The scissors handled easily and the RAP vessels were ablated with less retinal damage compared with that associated with use of standard vertical scissors. Postoperatively, intraretinal hemorrhage was reduced and hyperfluorescence seen on indocyanine green angiography resolved. Conclusions: The new micro vertical scissors developed for the ablation of RAP vessels can be used safely and effectively during this surgical procedure.

关键词：垂直剪微血管瘤吲哚青绿高荧光干预性最小限度血管造影损伤比内侧面

TGF-βⅡ型受体基因在子宫内膜癌中的异常表达和突变

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世界核心医学期刊文摘（妇产科学分册） 2006年第1期2卷 45-45页

作者： sakaguchi J. Kyo S. Kanaya T. 张丽娟(译) S. Kyo. Department of Obstetrics and Gynecology Kanazawa University Graduate School of Medical Science 13-1 Takaramachi Kanazawa Ishikawa 920-8641 Japan 不详

. Transforming growth factor β (TGF- β ) is a multifunctional cytokine that strongly inhibits epithelial cell growth. Disabling of TGF- β signaling is thought to be involved in development of a variety of tumors in which abnormal expression or function of TGF- β receptor plays critical roles. In the present study, we examined aberrant expression and mutation of the gene TGF- β receptor type II (Tβ RII) in endometrial cancers of endometrioid subtype. Methods and results. Real-time PCR analysis using surgical tissue specimens of 27 endometrial cancers and 24 normal endometria revealed that endometrial cancers had significantly decreased levels of Tβ RII mRNA expression (mean level 2.44 ± 2.65), compared to normal endometria (mean level 7.23 ± 6.07) (P < 0.001). Methylation status of Tβ RII promoter containing 30 CpGs was examined by bisulfite sequencing analysis, and 98% (51/52) of the patients were found to have unmethylated Tβ RII promoter, indicating that promoter hypermethylation is not the major cause of decreased expression of Tβ RII in endometrial cancers. Mutational analysis revealed that 15.1% (8/53) of endometrial cancers had frameshift mutations at polyadenine repeats in exon 3 of the Tβ RII gene. Notably, these mutations were preferentially accumulated in patients with MSI- H phenotype (7/19:37% ) (P < 0.001) or with those with methylated MLH1 promoters (6/16:38% ) (P < 0.01). Thus, it appears that the Tβ RII gene is a target of mismatch repair deficiency. Conclusion. Taken together, we found that the decreased expression of Tβ RII as well as frameshift mutation of Tβ RII via mismatch repair deficiency frequently occurs in this tumor type, possibly causing loss of receptor function and unresponsiveness of TGF- β signaling that may lead to endometrial carcinogenesis.

关键词： TGF-βⅡ型受体 TGF-β受体子宫内膜癌移码突变异常表达受体基因转化生长因子β 正常子宫内膜多功能细胞因子 TβRⅡ

增生性糖尿病视网膜病变患者玻璃体内注射贝伐单抗后虹膜新生血管退行

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世界核心医学期刊文摘(眼科学分册) 2006年第11期 17-17页

作者： Oshima Y. sakaguchi H. Gomi F. Tano Y. 曹绪胜 Department of Ophthalmology Osaka University Medical SchoolSuitaOsakaJapan Dr.

Purpose:To assess the short-term safety and efficacy of intravitreal injection of bevacizumab for iris neovascularization(INV) .Design:Noncomparative,interventional case ***:Intravitreal bevacizumab was injected in seven eyes of five patients with INV that was associated with proliferative diabetic retinopathy(PDR) .The main outcome measurements were visual acuity,intraocular pressure(IOP) ,and regression of INV by fluorescein angiography before and one week,one month,and two months after ***:Regression of INV was confirmed in all eyes(100%) from one week after *** injections stabilized the recurrence(two eyes;29%) that was observed two months after the initial *** visual acuity remained stable or improved,and the intraocular pressure was controlled in six eyes(86%) throughout the follow-up *** inflammation or complications were ***:Intravitreal injection of bevacizumab may be an effective and safe alternative for patients with INV that is refractory to conventional treatments.

关键词：贝伐单抗体内注射糖尿病视网膜病变新生血管虹膜葡萄膜增生性患者

对于高度近视引起的黄斑裂孔和视网膜脱离采用曲安西龙和吲哚青绿检测视网膜上组织的多种成分

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世界核心医学期刊文摘（眼科学分册） 2005年第5期1卷 34-34页

作者： sakaguchi H. Ikuno Y. Choi J.-S. 秦雪娇

To examine three layers of membranes detected by triamcinolone acetonide (TA) and indocyanine green (ICG) during surgery for macular hole and retinal detachme nt (MHRD) as a result of high myopia. Histologic study. We excised three layers of membranes visualized with TA and ICG that were tightly adhering to the retina l surface during vitrectomy and examined them by transmission electron microscop y. The first membrane was made of acellular collagen fibers, suggestive of vitre ous, and the second was comprised of parts of fibro-blast-like cells and colla gen fibrils, suggesting a proliferative epiretinal membrane. The third membrane was an internal limiting membrane. Multiple components of epiretinal tissue coul d be delaminated with the assistance of TA and ICG during surgery for myopic MHR D.

关键词：视网膜脱离黄斑裂孔高度近视吲哚青绿曲安西龙玻璃体切割手术内界膜胶原微纤维胶原纤维成纤维样细胞

血管造影显示冠状动脉全闭塞病人的T1WMRI上高信号与冠状动脉闭塞持续时间的关系

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国际医学放射学杂志 2017年第6期 737-737页

作者： K.Matsumoto S.Ehara T.Hasegawa M.sakaguchi K.Shimada 张毓婧 Department of Cardiovascular Medicine Osaka City University Graduate School of Medicine

摘要目的评估血管造影显示冠状动脉全闭塞（CTO）的病人冠状动脉闭塞持续时间与1.5 T T1W MRI上高信号（HIS）的关系。方法测量冠状动脉目标区的信号强度与邻近

关键词：冠状动脉 CTO T1WMRI 血管造影慢性完全闭塞持续时间