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Cell-Based Microfluidic Device Utilizing Cell Sheet Technology

Cyborg and Bionic Systems 2022年第1期2022卷 35-42页

作者： katsuhisa sakaguchi Kei Akimoto Masanori Takaira Ryu-ichiro Tanaka Tatsuya Shimizu Shinjiro Umezu Department of Integrative Bioscience and Biomedical Engineering Graduate School of Advaneed Science and Enginring TWInsWaseda University2-2 Wakamatsu-ChoShinju-KuTokyo 162-8480Japan Department of Modern Mechanical Engineering Graduate School of Creative Science and Engineering Waseda University 1-104 Totsuka-ChoShinju-KuTokyo 169-8555Japan Insttute of Advanced BiomedicalEngineering and Seience TWIns Tokyo Women's Medical University8-1 Kawada-ChoShinju-KuTokyo 162-8666Japan

The developmentof microelectromechanical systems hasresulted in the rapid development of polydimethylpolysiloxane(PDMS)microfluidic devices for drug screening *** cell functions,such as the response of endothelial cells to fluids,have beenelucdated using microuidic ***,organon-achip systems that includeorgans that are importantfor biologicalcirculation,such as the heart,liver,pancreas,kidneys,and brain,have been *** organs realize the biologicalcirculation system in a manner that cannot be reproduced by artificial organs;however,the flow channels between the organsare often artifically created by *** this study,we developeda microfluidic device consisting only of cels,by combiningcell sheet technology with microtitanium *** were placed between stacked fibroblast cellsheets,and the celisheets adhered to each other,afer which the microwires were removed leaving a luminal structure with a size approximatelyequal to the arteriolar *** lumen structure was constructed using wires with diameters of 50,100,150,and 200μm,which were approximations of the arteriole *** using a perfusion device,we successfully perfused theluminal structure created inside the *** results revealed that a aulture solution can be supplied toa cellsheet witha very high cell *** biofabrication technology proposed in this study can contribute to the development of organ-on-a-chip systems.

关键词： organs fluid diameters

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Titanium Culture Vessel Presenting Temperature Gradation for the Thermotolerance Estimation of Cells

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Cyborg and Bionic Systems 2023年第1期4卷 166-177页

作者： Chikahiro Imashiro Yangyan Jin Motoaki Hayama Takahiro GYamada Akira Funahashi katsuhisa sakaguchi Shinjiro Umezu Jun Komotori Graduate School of Engineering The University of TokyoTokyo 113-0033Japan Department of Mechanical Engineering Keio UniversityYokohamaKanagawa 223-0061Japan School of Integrated Design Engineering Graduate School of Science and TechnologyKeio UniversityYokohamaKanagawa 223-0061Japan Department of Biosciences and Informatics Keio UniversityYokohamaKanagawa 223-0061Japan Department of Integrative Bioscience and Biomedical Engineering Graduate School of Advanced Science and EngineeringWaseda UniversityTWInsTokyo 162-8480Japan Department of Modern Mechanical Engineering Waseda UniversityTokyo 169-8555Japan

Hyperthermia can be induced to exploit the thermal intolerance of cancer cells,which is worse than that of normal cells,as a potential noninvasive cancer *** develop an effective hyperthermia treatment,thermal cytotoxicity of cells should be comprehensively ***,to conduct such investigations,the culture temperature must be accurately *** previously reported a culture system in which the culture temperature could be accurately regulated by employing metallic culture ***,appropriate temperature conditions for hyperthermia depend on the cell ***,several experiments need to be conducted,which is a bottleneck of inducing ***,we developed a cell culture system with temperature gradation on a metallic culture *** Cancer Foundation-7 cells and normal human dermal fibroblasts were used as cancer and normal cell models,*** cells showed stronger thermal tolerance;this was because the novel system immediately exhibited a temperature ***,the developed culture system can be used to investigate the optimum thermal conditions for effective hyperthermia ***,as the reactions of cultured cells can be effectively assessed with the present results,further research involving the thermal stimulation of cells is possible.

关键词： stimulation culture Titanium

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Best mix of primary energy resources by renewable energy and fossil fuel with CCS in view of security,stability and sustainability——A vision on hydrogen supply chain by organic chemical hydride method

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Science China(Technological Sciences) 2010年第1期53卷 62-68页

作者： Junichi sakaguchi Research Institute of Technology Innovation & Strategy of Chiyoda Corporation 2-12-1TsurumichuoTsurumi-kuYokohama230-8601Japan

The best mix scenario by renewable energy and fossil fuel with or without CCS(Carbon Dioxide Capture and Storage) would be a solution to compromise Greenhouse Gases emission issue caused by carbon dioxide(CO2),and depletion of crude oil and natural gas *** fossil fuel with pre-combustion CCS means hydrogen manufacturing and also hydrogen can be produced via electrolysis with renewable energy,it is desirable to establish transportation and storage systems of hydrogen as a clean *** this paper a vision on Hydrogen Supply Chain by Organic Chemical Hydride(OCH) Method as well as comparison of CCS configuration are discussed.

关键词： pre-combustion CCS compressors and pumps for CCS Hydrogen Supply Chain Organic Chemical Hydride Method

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New models for multi-dimensional stable vortex solitons

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Frontiers of physics 2019年第1期14卷 91-92页

作者： Hidetsugu sakaguchi Nonlinear Physics Laboratory Department of Advanced Energy Science and Engineering Kyushu University Japan

Solitons are stable solitary *** 1834,Scott Russel first observed such a solitary water wave in a narrow channel near *** 1895,*** and *** Vries had derived the Korteweg-de Vries (KdV)equations for waves on shallow water *** 1965,*** and *** had demonstrated the stability of the solitary waves in the Korteweg-de Vries equation using numerical simulations,and coined the term "soliton".In 1967,Gardner, Greene,Kruskal,and Miura had discovered the mathematical technique of the inverse scattering transform to find analytical solutions to the KdV equation in a systematic manner,and the KdV equation was thus recognized as a paradigmatic integrable partial differential equation.

关键词： multi-dimensional stable vortex solitons D.Korteweg G.de Vries

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Multi-point Optimization of Recirculation Flow Type Casing Treatment in Centrifugal Compressors

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Journal of Thermal Science 2016年第3期25卷 231-241页

作者： Min Thaw Tun Daisaku sakaguchi Nagasaki University 1-14 Bunkyo-machi 852-8521 Nagasaki Japan

High-pressure ratio and wide operating range are highly required for a turbocharger in diesel engines. A recirculation flow type casing treatment is effective for flow range enhancement of centrifugal compressors. Two ring grooves on a suction pipe and a shroud casing wall are connected by means of an annular passage and stable recirculation flow is formed at small flow rates from the downstream groove toward the upstream groove through the annular bypass. The shape of baseline recirculation flow type casing is modified and optimized by using a multi-point optimization code with a metamodel assisted evolutionary algorithm embedding a commercial CFD code CFX from ANSYS. The numerical optimization results give the optimized design of casing with improving adiabatic efficiency in wide operating flow rate range. Sensitivity analysis of design parameters as a function of efficiency has been performed. R is found that the optimized casing design provides optimized recirculation flow rate, in which an increment of entropy rise is minimized at grooves and passages of the rotating impeller.

关键词： Centrifugal Compressor Casing Treatment Multi-point Optimization Turbocharger

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Markov decision processes associated with two threshold probability criteria

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控制理论与应用（英文版） 2013年第4期11卷 548-557页

作者： Masahiko sakaguchi Yoshio OHTSUBO Department of Mathematics Faculty of ScienceKochi University

This paper deals with Markov decision processes with a target set for nonpositive rewards. Two types of threshold probability criteria are discussed. The first criterion is a probability that a total reward is not greater than a given initial threshold value, and the second is a probability that the total reward is less than it. Our first （resp. second） optimizing problem is to minimize the first （resp. second） threshold probability. These problems suggest that the threshold value is a permissible level of the total reward to reach a goal （the target set）, that is, we would reach this set over the level, if possible. For the both problems, we show that 1） the optimal threshold probability is a unique solution to an optimality equation, 2） there exists an optimal deterministic stationary policy, and 3） a value iteration and a policy space iteration are given. In addition, we prove that the first （resp. second） optimal threshold probability is a monotone increasing and right （resp. left） continuous function of the initial threshold value and propose a method to obtain an optimal policy and the optimal threshold probability in the first problem by using them in the second problem.

关键词： Markov decision process Minimizing risk model Threshold probability Policy space iteration

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Velocity and Size of Droplets in Dense Region of Diesel Fuel Spray on Transient Needle Opening Condition

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Journal of Thermal Science 2005年第2期14卷 181-186页

作者： Hironobu UEKI Masahiro ISHIDA Daisaku sakaguchi Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521JapanNagasaki University 1-14 Bunkyo-machiNagasaki 852-8521JapanNagasaki University 1-14 Bunkyo-machiNagasaki 852-8521Japan

In order to investigate the effect of transient needle opening on early stage of spray behavior, simultaneous measurements of velocity and size of droplet were conducted by a newly developed laser 2-focus velocimeter (L2F). The micro-scale probe of the L2F was consisted of two foci with a distance of 36μm. The tested nozzle had a single hole with a diameter of 0.2 mm. The measurements of injection pressure, needle lift, and crank angle were synchronized with the spray measurement by the L2F at the position 10 mm downstream from the nozzle exit. It has been clearly shown that the velocity and size of droplet increase with needle valve opening and that the probability density distribution of droplet size can be fitted to the Nukiyama-Tanasawa distribution under the transient needle opening condition.

关键词： droplet disintegration optical characterization laser 2-focus velocimeter.

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Contribution of adult-born neurons to memory consolidation during rapid eye movement sleep

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Neural Regeneration Research 2022年第2期17卷 307-308页

作者： Akinobu Ohba Masanori sakaguchi International Institute for Integrative Sleep Medicine(WPI-IIIS) University of TsukubaTsukubaIbarakiJapan

Introduction: Memory consolidation stabilizes newly acquired memories by integrating them into pre-existing memory networks, which is thought to occurvia changes in synaptic strength. Sleep may influence memory consol... 详细信息

关键词： strength. sleep integrating

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Sorbitol-based osmotic diarrhea:Possible causes and mechanism of prevention investigated in rats

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World Journal of Gastroenterology 2006年第47期12卷 7635-7641页

作者： Md Shahidul Islam Ei sakaguchi Laboratory of Animal Nutri-tion Faculty of Agriculture Okayama University 1-1-1 Tsushima-naka Okayama City 700-8530 Japan

AIM: To study the possible causes of sorbitol (S)-based diarrhea and its mechanism of reduction by rice gruel (RG) in cecectomized rats. METHODS: S was dissolved either in distilled water or in RG (50 g/L) and ingested as a single oral dose (1.2 g/kg body mass, containing 0.5 g/L phenol red as a re-covery marker) by S (control) and S + RG groups (n = 7), respectively. This dose is over the laxative dose for hu-mans. Animals were sacrificed exactly 1 h after dose in-gestion, without any access to drinking water. The whole gastro-intestinal tract was divided into seven segments and sampled to analyze the S and marker remaining in its ***: Gastric-emptying and intestinal transit were comparatively slower in the S + RG group. Also, the S absorption index in the 3rd and last quarter of the small intestine (24.85 ± 18.88% vs 0.0 ± 0.0% and 39.09 ± 32.75% vs 0.0 ± 0.0%, respectively, P < 0.05) was sig-nificantly higher in the S + RG group than in the control group. The S absorption index and the intestinal fluid volume are inversely related to each other. CONCLUSION: The intestinal mal-absorption of S is the main reason for S-based osmotic diarrhea. Where RG en-hanced the absorption of S through passive diffusion, the degree of diarrhea was reduced in cecectomized rats.

关键词： Cecectomized rat Sorbitol Diarrhea Rice gruel Phenol red

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Global Search of a Three-dimensional Low Solidity Circular Cascade Diffuser for Centrifugal Blowers by Meta-model Assisted Optimization

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Journal of Thermal Science 2018年第2期27卷 111-116页

作者： Daisaku sakaguchi Daiki Sakue Min Thaw Tun Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521 Japan Yangon Technological University Insein Road East Gyogone Insein Township Yangon

A three-dimensional blade of a low solidity circular cascade diffuser in centrifugal blowers is designed by means of a multi-point optimization technique. The optimization aims at improving static pressure coefficient at a design point and at a small flow rate condition. Moreover, a clear definition of secondary flow expressed by positive radial velocity at hub side is taken into consideration in constraints. The number of design parameters for three-dimensional blade reaches to 10 in this study, such as a radial gap, a radial chord length and mean camber angle distribution of the LSD blade with five control points, control point between hub and shroud with two design freedom. Optimization results show clear Pareto front and selected optimum design shows good improvement of pressure rise in diffuser at small flow rate conditions. It is found that three-dimensional blade has advantage to stabilize the secondary flow effect with improving pressure recovery of the low solidity circular cascade diffuser.

关键词： Multi-point optimization Low solidity cascade diffuser Flow range enhancement

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