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Angle Effect to Dropping of Dew in Closed Suction Catheters

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Health 2018年第6期10卷 719-729页

作者： Kazuto Doi Mayumi Doi Yukoh Yaegashi katsuhisa imoto Masaru Ando Junichi Kadota Department of Pathophysiology Faculty of Medicine Oita University Oita Japan Department of Clinical Pharmacology & Therapeutics Faculty of Medicine Oita University Oita Japan Department of Medical Engineering Faculty of Health Sciences Junshin Gakuen University Fukuoka Japan Department of Respiratory Medicine & Infectious diseases Faculty of Medicine Oita University Oita Japan

Intratracheal aspiration in a patient on ventilation is generally performed using a catheter. Of late, closed suction systems have been used more frequently than open systems. To remove tracheal secretions through the intratracheal tube, catheter suction is used, and the suction catheter may be of the closed- or open-type. The catheters are cleaned by flushing with sterile 0.9% saline, resulting in dropping of dew. This phenomenon is caused by some factors: influence of flow, clogging of the suction tube, problem of manipulation of flushing and angle between the intubation tube and the connection port. But this dropping has not yet been investigated. In this study, we focused at this angle and we used the test lung which is simulated machine on behalf of patient. We consider two situations adult and child, also two types of catheters Eco-Cath and Ty-care. In child case we consider elbow-type suction catheters and Y-connector type. The angle was set at 0°, 20°, 40°, 60°, and 90°, and we observed the difference between Eco-Cath and Ty-care. In adults difference is significant (p 0.001), In 90°between Tracheal intubation and Tracheotomy (p ≈ 0.26). In child difference is significant (p 0.001), In 90°between Tracheal intubation and Tracheotomy (p ≈ 0.15). In child case we observed dependency of angle on various conditions too. The relation of the angle and dew was clarified.

关键词： Catheters Intratracheal Intubation Respiration Suction Tracheostomy Ventilators

Development and Evaluation of 3D Delivery Animation Software Designed to Improve the Mother’s and Spouse’s Satisfaction with Delivery

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Health 2024年第5期16卷 439-458页

作者： Ayako Sasaki Sachi Chikazawa Nojima Kumiko Tomita Takako Hatakeyama Keiko imoto Yasufumi imoto Nobutane Faculty of Nursing Osaka Medical and Pharmaceutical University Takatsuki Japan imoto Ladies Clinic Echizen Japan

Purpose: To clarify the effectiveness of 3-D delivery animation software for the mother’s and husband’s satisfaction with delivery. Subjects and Method: We independently developed a software application used to display the pelvic region and explain the labor process. The study involved a collaboration with hospital staff who recruited 18 primiparous and 18 multiparous mothers who were hospitalized for delivery at Facility A. The midwife explained the process of delivery using the “Delivery Animation Software”. A self-administered, anonymous questionnaire was distributed and analyzed separately for primiparous and multiparous mothers and their husbands. Results: 1) For both primiparous and multiparous couples, both mothers and their husbands gained a significantly higher level of understanding after delivery than during pregnancy. 2) The Self-Evaluation Scale for Experience of Delivery results were as follows: “I did my best for the baby even if it was painful” was selected more often for “birth coping skills”;“reliable medical staff” was selected more often for “physiological birth process”;“the birth progressed as I expected” was selected frequently by primiparous mothers;and “the birth progressed smoothly” was selected often by multiparous mothers. 3) In terms of husbands’ satisfaction with the delivery, “I was satisfied with the delivery”, “I was given an easy-to-understand explanation”, and “They explained the process to me” was selected of primiparous and multiparous fathers. 4) All primiparous and multiparous mothers positively evaluated whether the delivery animation was helpful in understanding the process of delivery. Conclusion: The delivery animation was effective in improving the understanding and satisfaction of both the mothers and their husbands.

关键词： Mother Spouse Satisfaction 3D Delivery Animation Software

Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening

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Journal of Biomedical Research 2024年第3期38卷 195-205页

作者： katsuhisa Horimoto Yuki Suyama Tadamasa Sasaki Kazuhiko Fukui Lili Feng Meiling Sun Yamin Tang Yixuan Zhang Dongyin Chen Feng Han SOCIUM Inc. Tokyo 1350064Japan International Medical Center Saitama Medical UniversitySaitama 350-1298Japan Artificial Intelligence Research Center National Institute of Advanced Industrial Science and TechnologyTokyo 1350064Japan Department of Informatics and Data Science Sanyo-Onoda City UniversityYamaguchi 7560884Japan International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversitySuzhouJiangsu 215001China National Vaccine Innovation Platform Nanjing Medical UniversityNanjingJiangsu 211166China

We have developed a protein array system,named"Phospho-Totum",which reproduces the phosphorylation state of a sample on the *** protein array contains 1471 proteins from 273 known signaling *** to the activation degrees of tyrosine kinases in the sample,the corresponding groups of substrate proteins on the array are phosphorylated under the same *** addition to measuring the phosphorylation levels of the 1471 substrates,we have developed and performed the artificial intelligence-assisted tools to further characterize the phosphorylation state and estimate pathway activation,tyrosine kinase activation,and a list of kinase inhibitors that produce phosphorylation states similar to that of the *** Phospho-Totum system,which seamlessly links and interrogates the measurements and analyses,has the potential to not only elucidate pathophysiological mechanisms in diseases by reproducing the phosphorylation state of samples,but also be useful for drug discovery,particularly for screening targeted kinases for potential drug kinase inhibitors.

关键词： Phospho-Totum protein array signal transduction pathways artificial intelligence tools drug screening

日本社会保障面临的挑战——基于人口减少社会的视角

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社会保障评论 2024年第2期8卷 39-55页

作者： [日]小岛克久万琳静日本国立社会保障·人口问题研究所信息调查部西安交通大学公共政策与管理学院

日本已成功建立了全面的社会保障体系,实现了全民医疗和全民年金等目标。该制度的演变跨越了漫长的历史,适应了每个时代的挑战。第二次世界大战结束后,日本采取政策措施为生活贫困者、儿童和残疾人建立了相应的社会救助和社会福利制度。... 详细信息

日本已成功建立了全面的社会保障体系,实现了全民医疗和全民年金等目标。该制度的演变跨越了漫长的历史,适应了每个时代的挑战。第二次世界大战结束后,日本采取政策措施为生活贫困者、儿童和残疾人建立了相应的社会救助和社会福利制度。从20世纪50年代末到70年代初,日本完善了全民医疗和全民年金等社会保障制度。自20世纪90年代起,日本开始应对出生率下降和人口老龄化问题,并对社会保障制度进行改革,以确保其可持续性。至此,日本建成了包括医疗、年金、长期护理、育儿支持和公共援助在内的全面社会保障体系以保障民生。然而,在未来老龄化社会的背景下,出生率下降、人口减少以及地区差异的存在,都给政策带来了挑战,包括财政的可持续性、基于社区的医疗和社会服务供给的发展以及应对相对贫困等政策。当前人口减少不仅在日本,在中国和韩国也已成为普遍现象。对中日韩的研究人员来说,探讨人口减少背景下的社会保障等政策选择具有重要意义。

关键词：日本社会保障制度地区差异人口减少东亚

Carbon Nanobelts:Brief History and Perspective

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Precision Chemistry 2023年第9期1卷 516-523页

作者： Daiki imoto Akiko Yagi Kenichiro Itami Department of Chemistry Graduate School of ScienceNagoya UniversityNagoya 464-8602Japan Institute of Transformative Bio-Molecules(WPI-ITbM) Nagoya UniversityNagoya 464-8602Japan

Carbon nanotubes(CNTs)are an emerging nanomaterial because of their outstanding performance in various *** recent years,the segment molecules of CNTs,referred to as carbon nanorings(CNRs)or carbon nanobelts(CNBs),have gained attention for their unique structures and properties,as well as their potential as seed molecules for the precise synthesis of *** are rigid and thick segments of CNTs whose synthesis has been addressed by scientists fascinated by the uniqueness of CNBs long before the discovery of *** 60 years of efforts by synthetic chemists all over the world,the synthesis of the first CNB,(6,6)CNB,was achieved by our group in *** this milestone,diverse types of nanobelts have been synthesized through various synthetic routes,thereby demonstrating their photophysical,magnetic,and redox properties derived from rigid belt *** applications of CNBs have also been introduced *** formation of the host−guest complex,transformation to three-dimensional molecules,and measurement of conductivity have been reported for *** paper summarizes the brief history and perspective of *** synthetic campaigns and aggressive application of CNBs would create novel and groundbreaking scenes in materials science.

关键词： carbon nanobelt carbon nanoring carbon nanotube cycloparaphenylene aromatic compounds organic synthesis

Network-Based Predictions and Simulations by Biological State Space Models: Search for Drug Mode of Action

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Journal of Computer Science & Technology 2010年第1期25卷 131-153页

作者： Rui Yamaguchi Seiya imoto Satoru Miyano Human Genome Center Institute of Medical Science University of Tokyo

Since time-course microarrav data are short but contain a large number of genes, most of statistical models should be extended so that they can handle such statistically irregular situations. We introduce biological state space models that are established as suitable computational models for constructing gene networks from microarray gene expression data. This chapter elucidates theory and methodology of our biological state space models together with some representative analyses including discovery of drug mode of action. Through the applications we show the whole strategy of biological state space model analysis involving experimental design of time-course data, model building and analysis of the estimated networks.

关键词： gene networks state space models time-course gene expression data

ON OPTIMAL LOCAL BUFFER ALLOCATION IN FLEXIBLE MANUFACTURING SYSTEMS

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Chinese Journal of Mechanical Engineering 1998年第4期11卷 65-71页

作者： Zhao, Xiaobo Ohno, katsuhisa Qinghua Univ Beijing China

An optimal design problem of local buffer allocation in the FMS is discussed in order to maximize a reward earned from processed jobs at all workstations. Structural properties of the optimal design problem are analyzed for the model with two job routing policies. Based on these properties, approaches to optimal solutions are given.

关键词： Queueing network FMS Blocking mechanism Job routing policy Buffer allocation

Inhibitory effect and mechanism of acarbose combined with gymnemic acid on maltose absorption in rat intestine

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World Journal of Gastroenterology 2001年第1期7卷 9-15页

作者： Toshiaki imoto Yasutake Hiji Departments of Physiology Faculty of Medicine Tottori University Yonago 683-0826 Japan

AIM To compare the combinative andindividual effect of acarbose and gymnemic acid(GA) on maltose absorption and hydrolysis insmall intestine to determine whether nutrientcontrol in diabetic care can be improved bycombination of *** The absorption and hydrolysis ofmaltose were studied by cyclic perfusion ofintestinal loops in situ and motility of theintestine was recorded with the intestinal ring invitro using Wistar *** The total inhibitory rate of maltoseabsorption was improved by the combination ofGA (0.1 g/L 1.0 g/L) and acarbose(0.1 mmol/L 2.0 mmol/L) throughout theireffective duration (P＜0.05, U test of Mann-Whitney), although the improvement only couldbe seen at a Iow dosage during the first *** the combination, inhibitory duration of acarbose on maltose absorption was prolonged to 3 h and the inhibitory effect onset of GA was fastened to 15min. GA suppressed the intestinal mobility with a good correlation (r-0.98) to the inhibitory effect of GA on maltose absorption and the inhibitory effect of 2mmol/L (high dose) acarbose on maltose hydrolysis was dual modulated by 1 g/L GA in vivo indicating that the combined effects involved the functional alteration of intestinal *** There are augmented effects of acarbose and GA, which involve pre-cellular and paracellular barriers. Diabetic care can be improved by employing the combination.

关键词： diabetes mellitus maltose gymnemic acid alpha-glucosidases intestinal mucosa rats nutrition

Enzyme inhibition assay for pyruvate dehydrogenase complex: Clinical utility for the diagnosis of primary biliary cirrhosis

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World Journal of Gastroenterology 2005年第43期11卷 6735-6739页

作者： katsuhisa Omagari Hiroaki Hazama Shigeru Kohno Second Department of Internal Medicine

Primary biliary cirrhosis (PBC) is usually diagnosed by the presence of characteristic histopathological features of the liver and/or antimitochondrial antibodies (AMA) in the serum traditionally detected by immunofluorescence. Recently, new and more accurate serological assays for the detection of AMA, such as enzyme-linked immunosorbent assay (ELISA), immunoblotting, and enzyme inhibition assay, have been developed. Of these, the enzyme inhibition assay for the detection of anti-pyruvate dehydrogenase complex (PDC) antibodies offers certain advantages such as objectivity, rapidity, simplicity, and low cost. Since this assay has almost 100% specificity, it may have particular applicability in screening the at-risk segment of the population in developing countries. Moreover, this assay could be also used for monitoring the disease course in PBC. Almost all sera of PBC-suspected patients can be confirmed for PBC or non-PBC by the combination results of immunoblotting and enzyme inhibition assay without histopathological examination. For the development of a "complete" or "gold standard" diagnostic assay for PBC, similar assays of the enzyme inhibition for anti-2-oxoglutarate dehydrogenase complex (OGDC) and anti-branched chain oxo-acid dehydrogenase complex (BCOADC) antibodies will be needed in future.

关键词：酶抑制复合物临床应用胆汁疾病诊断方法