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World Journal of Gastroenterology 2007年第29期13卷 3981-3984页

作者： Shoji Hirasaki Hiromitsu Kanzaki Minoru Matsubara Kohei Fujita Fusao ikeda Hideaki Taniguchi Eiichiro Yumoto Seiyuu Suzuki From Second Department of Internal Medicine Sumitomo Besshi Hospital 3-1 Ohji-cho Niihama 792-8543 Japan

AIM： To evaluate the effectiveness of endoscopic submucosal dissection using an insulation-tipped diathermic knife （IT-ESD） for the treatment of patients with over 20 mm early gastric cancer （EGC）. METHODS： A total of 112 patients with over 10 mm EGC were treated with IT-ESD at Sumitomo Besshi Hospital and Shikoku Cancer Center in the 5 year period from January 2002 to December 2006, including 40 patients with over 20 mm EGC. We compared patient backgrounds, the one-piece resection rate, complete resection （CR） rate, operation time, bleeding rate, perforation rate between patients with over 20 mm EGC [over 20 mm group （21-40 ram）] and the remaining patients （under 20 mm group）. RESULTS： We found no significant difference in the rate of underlying cardiopulmonary disease （over 20 mm group vs under 20 mm group, 5.0% vs 5.6%）, one- piece resection rate （95% vs 96%）, CR rate （85% vs 89%）, operation time （72.3 rain vs 66.5 rain）, bleeding rate （50 vs 4.2%）, and perforation rate （0% vs 1.4%） between the 2 groups. Three patients in each group had submucosal invasion and two in each groups underwent additional surgery. CONCLUSION： There was no significant difference in the outcome resulting from IT-ESD between the 2 groups. Our study proves that IT-ESD is a feasible treatment for patients with over 20 mm mucosal gastric cancer although the long-term outcome should be evaluated in the future.

关键词： Gastric cancer Endoscopic mucosal resection Insulation-tipped diathermic knife Complication

Trophic factors are essential for the survival of grafted oligodendrocyte progenitors and for neuroprotection after perinatal excitotoxicity

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Neural Regeneration Research 2020年第3期15卷 557-568页

作者： Megumi Hirose-ikeda Brian Chu Paul Zhao Omar Akil Elida Escalante Laurent Vergnes Carlos Cepeda Araceli Espinosa-Jeffrey Intellectual and Developmental Disabilities Research Center Jane and Terry Semel Institute for Neuroscience and Human BehaviorDepartments of NeurobiologyPsychiatry&Biobehavioral SciencesUniversity of CaliforniaLos AngelesCAUSA Department of Human Genetics David Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA

The consequences of neonatal white matter injury are devastating and represent a major societal problem as currently there is no ***,low weight birth and maternal pre-natal infection are the most frequent causes of acquired myelin deficiency in the human neonate leading to cerebral palsy and cognitive *** the developing brain,oligodendrocyte(OL)maturation occurs perinatally,and immature OLs are particularly *** replacement therapy is often considered a viable option to replace progenitors that die due to glutamate *** previously reported directed specification and mobilization of endogenous committed and uncommitted neural progenitors by the combination of transferrin and insulin growth factor 1(TSC1).Here,considering cell replacement and integration as therapeutic goals,we examined if OL progenitors(OLPs)grafted into the brain parenchyma of mice that were subjected to an excitotoxic insult could rescue white matter *** that purpose,we used a well-established model of glutamate excitotoxic ***-day-old mice received a single intraparenchymal injection of the glutamate receptor agonist N-methyl-D-aspartate alone or in conjunction with TSC1 in the presence or absence of OLPs grafted into the brain *** and expression of stress proteins and OL developmental specific markers were examined.A comparison of the proteomic profile per treatment was also *** found that OLPs did not survive in the excitotoxic environment when grafted *** contrast,when combined with TSC1,survival and integration of grafted OLPs was ***,energy metabolism in OLPs was significantly increased by N-methyl-D-aspartate and modulated by *** proteomic profile after the various treatments showed elevated ubiquitination and stress/heat shock protein 90 in response to *** changes were reversed in the presence of TSC1 and ubiquitination was *** results obtained i

关键词： myelin regeneration myelination oligodendrocytes periventricular leukomalacia premature birth proteomics trophic factors white matter injury

An Algebraic-Numeric Algorithm for the Model Selection in Network Motifs in Escherichia coli

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An Algebraic-Numeric Algorithm for the Model Selection in Ne...

Massive low-grade myxoid liposarcoma of the floor of the mouth:A case report and review of literature

第二届最优化与系统生物学国际研讨会

作者： Masahiko Nakatsui Hiroshi Yoshida katsuhisa Horimoto Computational Biology Research Center (CBRC) National Institute of Advanced Industrial Science and Technology (AIST) Faculty of Mathematics Organization for the Promotion of Advanced Research Kyushu University

Recently, we have proposed a novel algorithm to select a model that is the most consistent with the time series of observed data. In the algorithm, first, a system of differential equations that express the kinetics for a biological phenomenon and a sum of exponentials that are fitted to the observed data are transformed into the corresponding system of algebraic equations, by the Laplace transformation. Then, the two systems of algebraic equations are compared by an algebraic-numeric approach. One of the merits of our algorithm estimates the model’s consistency with the observed data and the determined kinetic constants. Furthermore, our algorithm allows a kinetic model with cyclic relationships between variables that cannot be handled by the usual approaches. In this paper, we examined the performance of our proposed algorithm by using three kinds of highly significant network motifs in Escherichia coli;feed-forward loop, single input module, dense overlapping regulons, which are found by Shen-Orr, et al[14].

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World Journal of Clinical Cases 2022年第34期10卷 12742-12749页

作者： Takuma Kugimoto Yuko Yamagata Toshimitsu Ohsako Hideaki Hirai Naoto Nishii Kou Kayamori Tohru ikeda Hiroyuki Harada Department of Oral and Maxillofacial Surgical Oncology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan Department of Oral Pathology Division of Oral Health ScienceGraduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityBunkyo-ku 113-8549TokyoJapan

BACKGROUND Oral liposarcoma is an extremely rare lesion that is often clinically misdiagnosed as a benign tumor due to its asymptomatic and indolent clinical ***,we report a case of massive low-grade myxoid liposarcoma(MLS)of the floor of the *** SUMMARY A 71-year-old man presented with a huge mass in the left floor of the mouth.A biopsy was performed,and a diagnosis of a myxoid tumor suspicious for lowgrade MLS or myxoma was ***-enhanced T1-weighted magnetic resonance imaging showed an intensely enhanced tumor lesion that occupies the left sublingual space and extends to the submandibular *** dissection,tumor resection,and reconstruction with a radial forearm flap were *** surgical specimen exhibited histologically low-grade *** in sarcoma(FUS,also known as TLS)and DNA damage-inducible transcript 3(DDIT3,also known as CHOP)break-apart was not detected in the fluorescence in situ hybridization *** tumor was completely encapsulated and did not require additional ***,no recurrence was reported 40 mo after *** We experienced an extremely rare,massive,low-grade MLS emerging from the floor of the ***,an MLS of the floor of the mouth lacks significant clinical findings and is often *** no FUS-DDIT3 fusion gene was detected,a low-grade MLS was ultimately diagnosed based on the histological findings.

关键词： Myxoid liposarcoma Floor of mouth Surgery Fluorescence in situ hybridization Sublingual space Case report

“Abnormal transient creep” in fine-grained Al-5356 alloy observed at low strain rates by high-resolution strain measurement

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Transactions of Nonferrous Metals Society of China 2013年第5期23卷 1209-1214页

作者：申俊杰 Kenichi ikeda Satoshi HATA Hideharu NAKASHIMA 天津理工大学机械工程学院天津300191 Department of Electrical and Materials Science Faculty of Engineering SciencesKyushu University

Transient creep at very low strain rates （less than 10-10 s-1） is still unclear. The traditional uniaxial creep testing is less useful due to unsatisfied resolution strain （~10-6）. To study transient creep behavior at such low strain rates, a high-resolution strain measurement using the helicoid spring specimen technique was employed in a fine-grained Al-5356 alloy at temperatures ranging from 0.47Tm to 0.74Tm （Tm： melting point）. To clarify transient creep mechanism at such low strain rates, transmission electron microscopy （TEM） was used in microstructure observation of crept specimens. The abnormal transient creep, high temperature strengthening at T〉Tp （Tp： the phase transformation temperature, 0.58Tm） or intermediate temperature softening at 0.4Tm〈T￡Tp and double-normal type （creep curves including double work-hardening stages） at T=Tp, were firstly observed. The substructure observation in a crept specimen at T=0.58Tm and e=1×10-4 shows pile-up dislocations including many small jogs with equal interval, and dislocations emitted from grain boundaries. The b-Al3Mg2 phase dissolves under the condition of testing temperatures higher than 523 K, which causes solid-solution quantity of Mg atoms to increase. Therefore, the “abnormal transient creep” may be related to the difference of solid solution strengthening caused by phase change during the creep tests.

关键词： Al-5356 alloy transient creep phase change low strain rate

Investigation of Experimental Con6guration for Electron Bernstein Wave Heating on LHD

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Plasma Science and Technology 2009年第4期11卷 430-438页

作者： Hiroe IGAMI Ryosuke ikeda Hiromi TAKAHASHI Yasuo YOSHIMURA Takashi SHIMOZUMA Shin KUBO Hitoshi TANAKA Kazunobu NAGASAKI Takashi MUTOH the LHD Experiment Group National Institute for Fusion Science 509-5292 Toki Japan Graduate School of Energy Science Kyoto University 606-8502 Kyoto Japan Institute of Advanced Energy Kyoto University 611-0011 Uji Japan

Investigation of experimental configuration for the electron Bernstein wave （EBW） heating by using the existing electron cyclotron heating （ECH） antennas on LHD was performed. By using an antenna installed in the lower port, direct oblique launching of the extraordinary （X-） mode from the high magnetic field side （HFS） is available. Since the parallel component of the refractive index （NIF） varies during propagation because of the inhomogeneity of the magnetic field, NH can be zero when the launched X-mode crosses the fundamental electron cyclotron resonance （ECR） layer even NⅡ is noonzero initially. In such a condition, if the electron density is above a certain level the obliquely launched X-mode can pass the fundamental ECR layer without being damped out and can be mode-converted to EBW that is absorbed at the Doppler shifted ECR layer. By using an antenna installed in the horizontal port, oblique launching from the lower magnetic field side （LFS） toward the over-dense plasma is available. Excitation of EBW via the mode conversion process of ordinary mode（O）-extraordinary mode（X）-electron Bernstein wave （B） is expected with the O-mode launching toward an appropriate direction. The O-X-B mode conversion rate and the region of power deposition were surveyed by varying the magnetic field strength and the launching direction. The results of the survey suggest that efficient heating in the core region is difficult by using the existing antenna. Rearrangement of the final mirror of the launching antenna may be needed.

关键词： LHD electron cyclotron heating (ECH) electron Bernstein wave (EBW),high density plasma

Lithium Ion Transport Environment by Molecular Vibrations in Ion-Conducting Glasses

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Energy & Environmental Materials 2024年第3期7卷 133-142页

作者： Hiroki Yamada Koji Ohara Satoshi Hiroi Atsushi Sakuda Kazutaka lkeda Takahiro Ohkubo Kengo Nakada Hirofumi Tsukasaki Hiroshi Nakajimai Laszlo Temleitner Laszlo Pusztai Shunsuke Ariga Aoto Matsuo Jiong Ding Takumi Nakano Takuya Kimura Ryo Kobayashi Takeshi Usuki Shuta Tahara Koji Amezawa Yoshitaka Tateyama Shigeo Mori Akitoshi Hayashi Diffraction and Scattering Division Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 KoutoSayo-choSayo-gun Hyogo 679-5198Japan Faculty of Materials for Energy Shimane University1060Nishi-Kawatsu-ChoMatsue Shimane 690-8504Japan Department of Applied Chemistry Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Institute of Materials Structure Science High Energy Accelerator Research Organization(KEK)203-1 ShirakataTokai-muraNaka-gunlbaraki 319-1106Japan Graduate School of Engineering Chiba University 1-33 Yayoi-cho Inage-kuChiba 263-8522Japan Department of Materials Science Graduate School of EngineeringOsaka Metropolitan University1-1 Gakuen-choSakaiOsaka 599-8531Japan Wigner Research Centre for Physics Konkoly Thegeút 29-33 H-1121Budapest Hungary International Research Organisation of Advanced Science and Technology(IROAST) Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan Department of Applied Physics Nagoya Institute of TechnologyGokisoShowaNagoya 466-8555Japan Faculty of Science Yamagata University1-4-12 KojirakawaYamagata-shiYamagata 990-5860Japan Faculty of Science University of the Ryukyus1 SenbaruNishihara-choOkinawa 903-0213Japan Institute of Multidisciplinary Research for Advanced Materials Tohoku University2-1-1 KatahiraAoba-kuSendai 980-8577Japan Center for Green Research on Energy and Environmental Materials(GREEN)and International Center for Materials Nanoarchitectonics(MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan

Controlling Li ion transport in glasses at atomic and molecular levels is key to realizing all-solid-state batteries,a promising technology for electric *** this context,Li_(3)PS_(4)glass,a promising solid electrolyte candidate,exhibits dynamic coupling between the Li^(+)cation mobility and the PS_(4)^(3-)anion libration,which is commonly referred to as the paddlewheel *** addition,it exhibits a concerted cation diffusion effect(i.e.,a cation-cation interaction),which is regarded as the essence of high Li ion ***,the correlation between the Li^(+)ions within the glass structure can only be vaguely determined,due to the limited experimental information that can be ***,this study reports that the Li ions present in glasses can be classified by evaluating their valence oscillations via Bader analysis to topologically analyze the chemical *** is found that three types of Li ions are present in Li_(3)PS_(4)glass,and that the more mobile Li ions(i.e.,the Li3-type ions)exhibit a characteristic correlation at relatively long distances of ***,reverse Monte Carlo simulations combined with deep learning potentials that reproduce X-ray,neutron,and electron diffraction pair distribution functions showed an increase in the number of Li3-type ions for partially crystallized glass structures with improved Li ion transport *** results show order within the disorder of the Li ion distribution in the glass by a topological analysis of their ***,considering the molecular vibrations in the glass during the evaluation of the Li ion valences is expected to lead to the development of new solid electrolytes.

关键词： electrolytes ionic conductors modeling molecular dynamics

Preparation and Characterization of Phenolated Wood Using Sulfuric Acid as a Catalyst I: Liquefaction Behavior of Plantation Wood

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Chinese Forestry Science and Technology 2002年第4期1卷 67-70页

作者： Atsushi ikeda Research Institute of Wood Industry Chinese Academy of Forestry Beiiins 100091. China

Chinese fir (Cunninghamia lanceolata) and poplar (Populus spp.) wood meal were phenolated in the presence of sulfuric acid used as a catalyst. The effects of reaction time and reaction temperature on the wood liquefaction were investigated. The results showed that the reaction temperature had the greater influence on the residue content than reaction time. Additionally, the liquefaction curve for the Chinese fir and Poplar were similar in general.

关键词： wood phenolation sulfuric acid reaction time reaction temperature.

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Ni-Mo基催化剂上卟啉加氢脱氮(英文)

催化学报 2013年第1期34卷 152-158页

作者： Eika W.QIAN Satoshi ABE Yusaku KAGAWA Hiroyuki ikeda Department of Chemical Engineering Tokyo University of Agriculture and Technology Nippon Ketjen Co.Ltd

The hydrodenitrogenation(HDN) of porphyrins was carried out over a series of phosphorus containing NiMo/Al 2 O 3 catalysts using a fixed‐bed flow reaction system.A method of quantitative analysis of the porphyrin and its derivatives produced by HDN was *** HDN of porphyrin,four types of hydrocarbons:C8 alkanes,C 8 alkenes,C9 alkanes,and C10 alkanes,and two groups of nitrogen‐containing compounds:alkyl substituted bipyrrolidines(alkylbipyrrolidines) and alkyl substituted tripyrrolidines(alkyltripyrrolidines) were *** hydrogenolysis of porphyrins occurred rapidly at lower temperature but higher temperatures were required for the HDN of *** NiMoP3 catalyst showed the highest catalytic activity for the HDN of *** on the characterization of the supports and catalysts,it is suggested that the dispersion of Mo is improved and the number of weak acidic sites on the NiMoP catalysts increases with the addition of phosphorus.

关键词： Mo基催化剂脱氮性能加氢脱氮卟啉 Ni HDN 反应体系定量分析

Atomically precise thiolate-protected gold nanoclusters:Current status of designability of the structure and physicochemical properties

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聚集体(英文)

聚集体(英文) 2023年第2期4卷 1-41页

作者： Sakiat Hossain Daisuke Hirayama Ayaka ikeda Mai Ishimi Sota Funaki Arpan Samanta Tokuhisa Kawawaki Yuichi Negishi Research Institute for Science and Technology Tokyo University of ScienceShinjuku-kuJapan Department of Applied Chemistry Faculty of ScienceTokyo University of ScienceShinjuku-kuJapan

Thiolate(SR)-protected gold nanoclusters(Aun(SR)m NCs)are a rare type of material capable of simultaneously exhibiting multiple physicochemical properties well-suited to specific applications,including photoluminescence,thermocatalysis,electrocatalysis,photocatalysis,magnetism,and optical *** the past several decades,there has been tremendous progress in our understanding of the structure and physicochemical properties of Aun(SR)m NCs,resulting in the ability to fine-tune the characteristics of these *** is therefore helpful to examine the extent to which the properties of Aun(SR)m and related metal NCs can now be adjusted based on *** review presents representative examples of previous studies concerning the geometry,electronic structure,luminescence properties,catalysis,magnetism and optical activity of Aun(SR)m and related metal NCs and discusses the current status of the designability of these NCs to impart specific structural and physicochemical *** information is expected to accelerate the fabrication of highly functional materials based on Aun(SR)m and related metal NCs.

关键词： atomically precise metal nanoclusters gold nanoclusters physicochemical properties structures thiolate