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Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma:A case report

World Journal of Clinical Cases 2021年第4期9卷 854-863页

作者： katsuhiro hayashi Norio Yamamoto Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Yoshihiro Araki Hirotaka Yonezawa Sei Morinaga Yohei Asano Hiroyuki Tsuchiya Department of Orthopaedic Surgery Kanazawa UniversityKanazawa 9208641Japan

BACKGROUND Hutchinson-Gilford progeria syndrome(HGPS)is an extremely rare disease characterized by the rapid appearance of aging with an onset in *** cardiovascular complications can be life-threatening events for affected patients and the cause of early *** we report a HGPS patient with osteosarcoma hat was successfully managed and is alive 13 years after the *** is the first report describing the detailed surgical procedure and long-term follow-up of osteosarcoma in a patient with *** SUMMARY The patient was diagnosed with HGPS at 5 years of age with typical features and was referred to our department with a suspected bone tumor of the left proximal tibia at the age of *** biopsy of the tibial bone tumor revealed a conventional fibroblastic *** have developed and performed a freezing technique using liquid nitrogen for tumor *** technique overcame the small size of the tibia for megaprosthesis and avoided amputation and limb salvage was achieved 13 years *** the patient had a number of surgical site complications,such as wound dehiscence,and superficial and deep infections due to vulnerable skin in HGPS,no recurrence or metastases were detected for 13 years,and she walks assisted by *** general health was good at the latest follow-up at 31 years of *** A HGPS patient with osteosarcoma was successfully managed and she was alive 13 years after the diagnosis.

关键词： Hutchinson-Gilford progeria syndrome Osteosarcoma Frozen autograft Biological reconstruction Case report Thyroid cancer

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Dedifferentiated chondrosarcoma of the middle finger arising from a solitary enchondroma:A case report

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World Journal of Clinical Cases 2022年第10期10卷 3297-3305页

作者： Hirotaka Yonezawa Norio Yamamoto katsuhiro hayashi Akihiko Takeuchi Shinji Miwa Kentaro Igarashi Sei Morinaga Yohei Asano Shiro Saito Yasunori Tome Hiroko Ikeda Takayuki Nojima Hiroyuki Tsuchiya Department of Orthopaedic Surgery Graduate School of Medical SciencesKanazawa UniversityKanazawa 920-8641IshikawaJapan Department of Orthopedic Surgery Graduate School of MedicineUniversity of the RyukyusNishihara 903-0215OkinawaJapan Department of Diagnostic Pathology Kanazawa University HospitalKanazawa 920-8641IshikawaJapan

BACKGROUND Dedifferentiated chondrosarcoma(DDCS)accounts for 10%of all chondrosarcomas and has the poorest outcome,with a 5-year survival rate of 7%-25%.DDCS commonly occurs in the femur and pelvis,whereas DDCS of the finger is extremely ***,the histological findings of preexisting solitary enchondroma samples are important and valuable for diagnosing malignant *** SUMMARY We report our experience with DDCS in the proximal phalanx of the left middle finger of an 87-year-old *** had undergone surgery for enchondroma,with curettage and artificial bone grafting,11 years ago,in the same *** years after the primary surgery,the left middle finger gradually started to enlarge,and the growth speed increased in the past *** radiographs showed an expansive osteolytic lesion with calcifications and residual grafting *** to the suspicion of malignancy,we performed ray *** findings revealed an abrupt transition between the low-grade chondrosarcoma and dedifferentiated sarcoma *** dedifferentiated components showed the features of a high-grade undifferentiated pleomorphic *** patient was diagnosed with DDCS arising from a preexisting *** had no local recurrence or distant metastasis and died of pneumonia 6 years and 10 months after the second *** The histological findings of a precursor lesion showed a typical enchondroma,suggesting that DDCS can arise from enchondroma.

关键词： Dedifferentiated chondrosarcoma Enchondroma Finger Phalanx Ray amputation Case report

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Reconstruction Using a Free Vascularized Fibular Graft after Frozen Autograft Reconstruction for Osteosarcoma of the Distal Tibia: A Case Report

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Modern Plastic Surgery 2013年第1期3卷 47-50页

作者： Seigo Suganuma Kaoru Tada Norio Yamamoto Toshiharu Shirai katsuhiro hayashi Akihiko Takeuchi Hiroyuki Tsuchiya Department of Orthopaedic Surgery Graduate School of Medical Science Kanazawa University Kanazawa Japan

Recently we have been performing biological reconstruction for malignant bone tumors of the extremities using frozen autografts. Here we present a case treated with free vascularized fibular graft (FVFG) after this method. A 23-year-old man developed osteosarcoma in his left distal tibia. There was nonunion after frozen autograft reconstruction, which we treated with FVFG. Twenty-four months later, bridging between the host bone and the frozen autograft was achieved. Our department has achieved bone union in almost all cases, but we sometimes encounter cases of nonunion after this method because of delayed blood supply. In these instances, reconstruction using FVFG may represent an attractive choice for salvage treatment.

关键词： Free Vascularized Fibular Graft Frozen Autograft Reconstruction Malignant Bone Tumor

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