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Acute h.patitis B of genotype h.resulting in persistent infection

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World Journal of Gastroenterology 2014年第11期20卷 3044-3049页

作者： Norie Yamada Ryuta Sh.gefuku Ryuich. Sugiyama Minoru Kobayash. h.roki Ikeda h.deaki Takah.sh. Ch.aki Okuse Mich.h.ro Suzuki Fumio Itoh.h.rosh. Yotsuyanagi Kiyomi Yasuda Kyoji Moriya Kazuh.ko Koike Takaji Wakita Takanobu kato Department of Virology Ⅱ National Institute of Infectious DiseasesShinjyuku-KuTokyo 162-8640Japan Department of Internal Medicine Center for Liver DiseasesKiyokawa HospitalSuginamiTokyo 166-0004Japan Division of Gastroenterology and h.patology Department of Internal MedicineSt. Marianna University School of MedicineKanagawa 216-8511Japan Department of Infectious Diseases Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Infection Control and Prevention Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Gastroenterology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan

A 47-year-old man presented with.general fatigue and dark *** laboratory data sh.wed increased levels of h.patic *** patient was positive for h.patitis B virus(h.V)markers and negative for antih.man immunodeficiency *** h.V-DNA titer was set to 7.7 log copies/*** patient was diagnosed with.acute h.patitis *** h.V infection route was *** serum levels of h.patic transaminases decreased to normal ranges with.ut any treatment,but th. h.VDNA status was maintained for at least 26 mo,indicating th. presence of persistent *** isolated h.V from th. acute-ph.se serum and determined th. genome sequence.A ph.logenetic analysis revealed th.t th. isolated h.V was genotype *** th.s patient,th. elevated peak level of h.V-DNA and th. risk alleles at h.man genome single nucleotide polymorph.sms s3077and rs9277535 in th. h.man leukocyte antigen-DP locus were considered to be risk factors for ch.onic *** case suggests th.t th.re is a risk of persistent infection by h.V genotype h.following acute h.patitis;furth.r cases of h.V genotype h.infection must be identified and ***,th. complete determination of th. h.V genotype may be essential during routine clinical care of acute h.patitis B outpatients.

关键词： Acute h.patitis Ch.onic h.patitis Genotyping h.patitis B virus Single nucleotide polymorph.sms

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凸柱面透镜列阵线聚焦系统

光学学报 1999年第5期19卷 713-717页

作者：黄关龙王世绩林尊琪顾援唐华泾张国平中国科学院上海光学精密机械研究所高功率激光物理国家实验室上海激光等离子体研究所应用物理与计算数学研究所

主要描述了柱面透镜列阵聚焦系统的原理及结构，分析了凹柱面透镜列阵线聚焦系统中非球面透镜损坏的原因，介绍了凸柱面透镜列阵线聚焦系统的设计原则。

关键词：柱面透镜列阵组合焦线 X射线激光聚焦系统

Anti-inflammatory activity of probiotic Bifidobacterium: Enh.ncement of IL-10 production in periph.ral blood mononuclear cells from ulcerative colitis patients and inh.bition of IL-8 secretion in h.-29 cells

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World Journal of Gastroenterology 2008年第16期14卷 2511-2516页

作者： Akemi Imaoka Tatsuich.ro Sh.ma Kimitosh. kato Sh.geaki Mizuno Tosh.ki Ueh.ra Satosh. Matsumoto h.romi Setoyama Taeko h.ra Yosh.nori Umesaki Yakult Central Institute for Microbiological Research Yaho Kunitachi Department of Gastroenterology and h.patology Nihon University School of Medicine

AIM: To determine th. anti-inflammatory activity of probiotic Bifidobacteria in Bifidobacteria-fermented milk (BFM) wh.ch.is effective against active ulcerative colitis (UC) and exacerbations of UC, and to explore th. immunoregulatory mech.nisms. METh.DS: Periph.ral blood mononuclear cells (PBMNC) from UC patients or h.-29 cells were co-cultured with.h.at-killed probiotic bacteria or culture supernatant of Bifidobacterium breve strain Yakult (BbrY) or Bifidobacterium bifidum strain Yakult (BbiY) to estimate th. amount of IL-10 or IL-8 secreted. RESULTS: Both.strains of probiotic Bifidobacteria contained in th. BFM induced IL-10 production in PBMNC from UC patients, th.ugh.BbrY was more effective th.n BbiY. Conditioned medium (CM) and DNA of both.strains inh.bited IL-8 secretion in h.-29 cells stimulated with.TNF-α, wh.reas no such.effect was observed with.h.at- killed bacteria. Th. inh.bitory effect of CM derived from BbiY was greater th.n th.t of CM derived from BbrY. DNAs of th. two strains h.d a comparable inh.bitory activity against th. secretion of IL-8. CM of BbiY induced a repression of IL-8 gene expression with.a h.gh.r expression of IκB-ζ mRNA 4 h.after culture of h.-29 cells compared to th.t in th. absence of ***: Probiotic Bifidobacterium strains in BFM enh.nce IL-10 production in PBMNC and inh.bit IL-8 secretion in intestinal epith.lial cells, suggesting th.t BFM h.s anti-inflammatory effects against ulcerative colitis.

关键词： Bifidobacterium Ulcerative colitis Anti-inflammatory Intedeukin-10 Interleukin-8

考虑系统柔度影响的水压致裂法测量深部岩石应力

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国际地震动态 2011年第1期32卷 25-32页

作者： Ito T Satoh.T kato h.甄宏伟（译）田家勇（校） Institute of Fluid Science Tohoku University Japan National Institute of Advance Industrial Science and Tech.ology （AIST） Japan Akema Boring Co. Ltd. Japan 中国地震局地壳应力研究所

为了有效测量水压致裂方法中的重张压力,必须使用具有足够小柔度的试验设备,否则无法从重张压力估计垂直钻孔平面的最大水平应力。仅通过替换水压致裂系统中的某一部件来大幅度降低系统柔度是很难的。但如果流量计尽可能安装在靠近跨接... 详细信息

为了有效测量水压致裂方法中的重张压力,必须使用具有足够小柔度的试验设备,否则无法从重张压力估计垂直钻孔平面的最大水平应力。仅通过替换水压致裂系统中的某一部件来大幅度降低系统柔度是很难的。但如果流量计尽可能安装在靠近跨接式封隔器隔离出的钻孔测试区,那么系统柔度就会大大降低。为此,我们研制出配有井下流量计的试验系统,并在野外试验中成功验证。此外,我们还介绍了能开展几千米深应力测量的一种新方法。

关键词：水压致裂法试验系统应力测量柔度岩石应力井下流量计深部最大水平应力

First-line eradication for h.licobacter pylori-positive gastritis by esomeprazole-based triple th.rapy is influenced by CYP2C19 genotype

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World Journal of Gastroenterology 2015年第48期21卷 13548-13554页

作者： Yosh.masa Saito h.rosh. Serizawa Yukako kato Masaru Nakano Masah.ko Nakamura h.detsugu Saito h.dekazu Suzuki Takanori Kanai Division of Gastroenterology Kitasato Institute Hospital Division of Ph.rmacoth.rapeutics Keio University Faculty of Pharmacy Division of Gastroenterology Department of Internal MedicineKeio University School of Medicine Sch.ol of Ph.rmaceutical Sciences Kitasato University

AIM: To evaluate th. effect of first line esomeprazole(EPZ)-based triple th.rapy on h.licobacter pylori(h. pylori) ***: A total of 80 Japanese patients with.gastritis wh. were diagnosed as positive for h. pylori infection by endoscopic biopsy-based or ^(13)C-urea breath.tests were included in th.s study. Th. average age of th. patients was 57.2 years(male/female, 42/38). Th.se patients were treated by first-line eradication th.rapy with.EPZ 40 mg/d, amoxicillin 1500 mg/d, and clarith.omycin 400 mg/d for 7 d. All drugs were given twice per day. Correlations between h. pylori eradication, CYP2C19 genotype, and serum pepsinogen(PG) level were analyzed. Th.s study was registered with.th. UMIN Clinical Trials Registry(UMIN000009642).RESULTS: Th. h. pylori eradication rates by EPZbased triple th.rapy evaluated by intention-to-treat and per protocol were 67.5% and 68.4%, respectively, wh.ch.were similar to triple th.rapies with.oth.r first-generation proton pump inh.bitors(PPIs). Th. eradication rates in th.ee different CYP2C19 genotypes, described as extensive metabolizer(EM), intermediate metabolizer, and poor metabolizer, were 52.2%, 72.1%, and 84.6%, respectively. Th. h. pylori eradication rate was significantly lower in EM th.n non-EM(P h. serum PG?Ⅰ?level and PG?Ⅰ/Ⅱ ratio were significantly increased after eradication of h. pylori(P h.t gastric atroph. was improved by h. pylori eradication. Th.s, first-line eradication by EPZbased triple th.rapy for patients with.h. pylori-positive gastritis was influenced by CYP2C19 genotype, and th. eradication rate was on th. same level with.oth.r firstgeneration PPIs in th. Japanese ***: Th. results from th.s study suggest th.t th.re is no advantage to EPZ-based triple th.rapy on h. pylori eradication compared to oth.r firstgeneration PPIs.

关键词： CYP2C19 esomeprazole h.licobacterpylori pepsinogen proton pump inh.bitor

h.rbal cardiotonic pills prevent gut isch.mia/reperfusion-induced h.patic microvascular dysfunction in rats fed eth.nol ch.onically

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World Journal of Gastroenterology 2005年第4期11卷 511-515页

作者： Yosh.nori h.rie Sh.ka Mori Masah.ro Konish. Mikio Kajih.ra Takeh.ko Kaneko Yosh.yuki Yamagish. Sh.nzo kato h.romasa Ish.i Tosh.fumi h.bi Department of Internal Medicine Sch.ol of Medicine Keio University Tokyo Japan

AIM: Cardiotonic Pill (CP), an oral h.rbal medicine th.t includes Dansh.n (Salviae Miltiorrh.zae), Panax notoginseny and Dyroblanops aromatica gaettn, h.s been clinically used for vascular diseases such.as occlusive vasculitis, coronary diseases, ath.rosclerosis, and cerebral infarction. Th. main component, Salviae Miltiorrh.zae, h.s been reported to prevent cerebral and intestinal reperfusion injury. h.wever, little is known about th. effect of CP on h.patic microcirculation. Th.s, th.s study aimed to determine wh.th.r CP could affect h.patic microvascular dysfunction elicited by gut isch.mia/ reperfusion (I/R) in rats fed eth.nol ch.onically. METh.DS: Male Wistar rats were pair-fed with.a liquid diet containing eth.nol or isocaloric control diet for 6 wk. After laparotomy, one lobe of th. liver was examined th.ough.an inverted intravital microscope. Th. rats were exposed to 30 min of gut isch.mia followed by 60 min of reperfusion. Rh.damine-6G-labeled leukocytes in th. sinusoids were observed 90 min after th. onset of superior mesenteric artery occlusion. Plasma tumor necrosis factor (TNF)-α and endotoxin levels were measured 1 h.after th. onset of reperfusion. Plasma alanine aminotransferase (ALT) activities were measured 6 h.after th. onset of reperfusion. In anoth.r set of experiments, CP (0.8 g/kg, intragastrically) was administered 1 and 24 h.before th. onset of isch.mia. RESULTS: In control rats, gut I/R elicited increases in th. number of stationary leukocytes, and plasma TNF-α and endotoxin levels and plasma ALT activities. Th.se ch.nges were mitigated by pretreatment with.CP. In eth.nol-fed rats, th. gut I/R-induced increases in th. number of stationary leukocytes, plasma endotoxin levels and ALT activities were enh.nced. Pretreatment with.CP attenuated th. enh.ncement of gut I/R-induced responses by ch.onic eth.nol consumption. CONCLUSION: Th.se results suggest th.t CP prevents th. gut I/R-induced h.patic microvascular dysfunction and h.patocellular inju

关键词： Intestinal reperfusion injury h.patic microvascular dysfunction Cardiotonic Pill Eth.nol

Paradoxical reduction of cerebral blood flow after acetazolamide loading:a h.modynamic and metabolic study with.^(15)O PET

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Neuroscience Bulletin 2014年第5期30卷 845-856页

作者： Tadash. Watabe Eku Sh.mosegawa h.roki kato Kayako Isoh.sh. Mana Ish.bash. Mitsuaki Tatsumi Kazuo Kitagawa Tosh.yuki Fujinaka Tosh.ki Yosh.mine Jun h.tazawa Department of Molecular Imaging in Medicine Department of Nuclear Medicine Department of Nuclear Medicine and Tracer Kinetics Stroke Center Osaka University Hospital Department of Radiology Department of Neurology Department of Neurosurgery Osaka University Graduate School of Medicine

Paradoxical reduction of cerebral blood flow （CBF） after administration of th. vasodilator acetazolamide is th. most severe stage of cerebrovascular reactivity failure and is often associated with.an increased oxygen extraction fraction （OEF）. In th.s study, we aimed to reveal th. mech.nism underlying th.s ph.nomenon by focusing on th. ratio of CBF to cerebral blood volume （CBV） as a marker of regional cerebral perfusion pressure （CPP）. In 37 patients with.unilateral internal carotid or middle cerebral arterial （MCA） steno-occlusive disease and 8 normal controls, th. baseline CBF （CBFb）, CBV, OEF, cerebral oxygen metabolic rate （CMRO2）, and CBF after acetazolamide loading in th. anterior and posterior MCA territories were measured by （15）~O positron emission tomograph.. Paradoxical CBF reduction was found in 28 of 74 regions （18 of 37 patients） in th. ipsilateral h.misph.re. h.gh.CBFb （〉47.6 mL/100 mL/min, n = 7） was associated with.normal CBFb/CBV, increased CBV, decreased OEF, and normal CMRO2. Low CBFb （〈31.8 mL/100 mL/min, n = 9） was associated with.decreased CBFb/CBV, increased CBV, increased OEF, and decreased CMRO2. Th.se findings demonstrated th.t paradoxical CBF reduction is not always associated with.reduction of CPP, but partly includes h.gh. CBFb regions with.normal CPP, wh.ch.h.s not been described in previous studies.

关键词： acetazolamide cerebral blood flowparadoxical reduction positron emission tomograph.vasodilatation

Vascular endoth.lial growth.factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial h.patectomy in rats

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World Journal of Gastroenterology 2005年第46期11卷 7254-7260页

作者： h.roaki Sh.mizu Noboru Mitsuh.sh. Masayuki Oh.suka h.rosh. Ito Fumio Kimura Satosh. Ambiru Akira Togawa h.royuki Yosh.dome Atsush. kato Masaru Miyazaki Department of General Surgery Graduate Sch.ol of Medicine Chiba University Chiba 260-0856 Japan

AIM： To study th. regulatory mech.nisms of sinusoida regeneration after partial h.patectomy. METh.DS： We invesldgated th. expression of angiopoietin （Ang）-1, Ang-2, Tie-2, and vascular endoth.lial growth.factor （VEGF） in regenerating liver tissue by quantitative reverse-transcription polymerase ch.in reaction （RT- PCR） using a Ligh.Cycler （Roch. Diagnostics） and also immunoh.stoch.mical staining after 70% h.patectomy in rats. In th. next step, we isolated liver cells （h.patocytes, sinusoidal endoth.lial cell （SEC）, Kupffer cell, and h.patic stellate cells （h.C）） from regenerating liver tissue by in situ collagenase perfusion and counterflow elutriation, to determine potential cellular sources of th.se angiogenic factors after h.patectomy. Proliferation and apoptosis of SECs were also evaluated by proliferating cell nuclear antigen （PCNA） staining and th. terminal deoxynucleotidyl transferase d-uridine triph.sph.te nick end labeling （TUNEL） assay, respectively. RESULTS： VEGF mRNA expression increased with.a peak at 72 h.after h.patectomy, decreasing th.reafter. Th. expression of Ang-1 mRNA was present at detectable levels before h.patectomy and increased slowly with.a peak at 96 h. Meanwh.le, Ang-2 mRNA was h.rdly detected before h.patectomy, but was remarkably induced at 120 and 144 h. In isolated cells, VEGF mRNA expression was found mainly in th. h.patocyte fraction. Meanwh.le, mRNA for Ang-1 and Ang-2 was found in th. SEC and h.C fractions, but was more prominent in th. latter. Th. PCNA labeling index of SECs increased slowly, reach.ng a peak at 72 h. wh.reas apoptotic SECs were detected between 120 h.and 144 h. CONCLUSION： Ang-Tie system, togeth.r with.VEGF, plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after h.patectomy. h.wever, th. VEGF system plays a more important role in th. early ph.se of sinusoidal regeneration th.n angiopoietin/Tie system.

关键词： Vascular endoth.lial cell growth.factor Angiopoietin Sinusoidal endoth.lial cell h.patectomy Liver regeneration

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掺硅类金刚石膜的摩擦学性能研究

真空科学与技术学报 2011年第1期31卷 61-66页

作者：兰惠清崔俊豪加藤孝久北京交通大学机械与电子控制工程学院北京100044 东京大学机械系

以甲苯(C7h.)和四甲基硅烷(Si(Ch.)4)的混合气体为反应气源,使用离子气相沉积技术制备了不同Si含量(原子比)(不超过20%)的掺硅类金刚石(Si-DLC)薄膜,用X射线光电子谱和拉曼光谱测出薄膜和对磨钢球上转移膜的微观结构,纳米压痕仪、摩擦... 详细信息

以甲苯(C7h.)和四甲基硅烷(Si(Ch.)4)的混合气体为反应气源,使用离子气相沉积技术制备了不同Si含量(原子比)(不超过20%)的掺硅类金刚石(Si-DLC)薄膜,用X射线光电子谱和拉曼光谱测出薄膜和对磨钢球上转移膜的微观结构,纳米压痕仪、摩擦试验机和电子探针微分析仪分别得到薄膜的硬度、摩擦系数、磨痕和转移膜的元素变化结果。结果表明,添加少量Si能提高Si-DLC薄膜的硬度,但是Si含量的进一步增加则使薄膜的硬度降低。而薄膜的摩擦系数始终随着Si含量的增加而减少。从摩擦实验后钢球表面转移膜的进一步分析,我们认为该薄膜的低摩擦特性是由于转移膜的增加和石墨化两者共同造成的结果。

关键词：掺硅类金刚石膜结构摩擦硬度