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Effects of heavy metals (Pb^(2+) and Cd^(2+)) on the u.trastru.tu.e, growth and pigment contents of the u.icellu.ar cyanobacteriu. Synechocystis sp. PCC 6803

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Chinese Jou.nal of Oceanology and Limnology 2009年第2期27卷 383-388页

作者： K. K. I. u. Aru.aku.ara 张学成 College of Marine Life Sciences Ocean University of China Department of Crop Science Faculty of AgricultureUniversity of Ruhuna

The u.icellu.ar cyanobacteriu. Synechocystis sp. PCC 6803, a model organism known for its u.iqu. combination of highly desirable molecu.ar genetic, physiological and morphological characteristics, was employed in the present stu.y. The species was cu.tu.ed in BG11 liqu.d mediu. contained variou. initial concentrations of Pb^2＋ and Cd〉（0, 0.5, 1, 2, 4, 6 and 8 mg/L）. The experiment was condu.ted for six days and the metal indu.ed alterations in the u.trastru.tu.e, growth and pigment contents were assessed. Alterations in the u.trastru.tu.e of the Synechocystis sp. PCC 6803 cells became evident with the increased （〉4 mg/L Pb^2＋） metal concentration. The photosynthetic apparatu. （thylakoid membranes） were fou.d to be the worst affected. Deteriorated or completely destroyed thylakoid membranes have made large empty spaces in the cell interior. In addition, at the highest concentration （8 mg/L pb^2＋）, the polyphosphate granu.es became more prominent both in size and nu.ber. Despite the initial slight stimu.ations （0.2, 3.8 and 6.5% respectively at 0.5, 1 and 2 mg/L pb^2＋）, both metals inhibited the growth in a dose-dependent manner as incu.ation progressed. Pigment contents （chlorophyll a, 13 carotene and phycocyanin） were also decreased with increasing metal concentration. Cells exposed to 6 mg/L Pb^2＋, resu.ted in 36.56, 37.39 and 29.34% redu.tions of chlorophyll a, 13 carotene and phycocyanin respectively over the control. Corresponding redu.tions for the same CdZ＋concentrations were 57.83, 48.94 and 56.90%. Lethal concentration （96 h LC50） valu.s （3.47 mg/L Cd^2＋ and 12.11 mg/L Pb^2＋） indicated that Synechocystis sp. PCC 6803 is more vu.nerable to Cd^2＋ than Pb^2＋.

关键词： growth pigment contents Synechocystis sp. PCC 6803 u.trastru.tu.e

Determination of particle exchange rates at over-flow weirs in horizontal flu.dised beds by particle tracking velocimetry

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Particu.logy 2017年第3期15卷 1-9页

作者： katja Meyer Andreas Bu.k Evangelos Tsotsas Thermal Process Engineering Otto von Guericke University Magdeburg UniversitStsplatz 2 D-39106 Magdeburg Germany

Residence time distribu.ions （RTDs） in horizontal flu.dised beds have a hu.e effect on solid produ.t properties and are infu.nced by the internal design of the apparatu., e.g. the separation into different compartments by weirs. Weirs can be passed in or against the overall solid transport direction, with the back-flow resu.ting in axial dispersion, which is a measu.e of the spread of the RTD. Therefore, the ratio of exchange rates at weirs u.der different flu.disation conditions provides information on axial dispersion. In this work, a methodology based on particle tracking velocimetry is presented to obtain information on the exchange rates of particles at weirs in horizontal flu.dised beds. The internal recircu.ation is stu.ied for over-flow weirs with respect to different flu.disation conditions, providing a first step towards determining the effects of weirs and flu.disation conditions on axial dispersion and RTDs in horizontal flu.dised beds.

关键词： Particle tracking velocimetry Horizontal flu.dised bedAxial dispersion Granu.ation Drying

Modu.ation of lysophosphatidic acid (LPA) receptor activity: the key to su.cessfu. neu.al regeneration?

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Neu.al Regeneration Research 2020年第1期15卷 53-54页

作者： Isabel Gross Anja u.Brau.r Research Grou. Anatomy School for Medicine and Health ScienceCarl von Ossietzky University OldenburgOldenburgGermany Research Center for Neu.osensory Science Carl von Ossietzky University OldenburgOldenburgGermany

The central nervou. system(CNS)is characterized by a remarkably elaborate cellu.ar architectu.e comprising large nu.bers of glial and neu.onal cells with enormou. fu.ctional diversity,organized into highly complex and specific *** development,the variou. neu.al cell types mu.t first be correctly specified,then assu.e their appropriate positions throu.h carefu.ly choreographed cellu.ar migration,and finally establish and refine their fu.ctional connections,often over long *** end resu.t of all these processes is an extraordinarily intricate anatomical stru.tu.e,able to receive,integrate,and store information and orchestrate appropriate responses.

关键词： neu.al specified finally

Synthesis of BaWOq/NRGO-g-C3N4 nanocomposites with excellent mu.tifu.ctional catalytic performance via microwave approach

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Frontiers of Materials Science 2018年第3期12卷 247-263页

作者： M. Mohamed Jaffer SADIQ u. Sandhya SHENOY D. Krishna BHAT Department of Chemistry National Institute of Technology Karnataka Surathkal Mangalore-575025 India Department of Chemistry College of Engineering and Technology Srinivas University Mukka Mangalore-574146 India

Novel bariu. tu.gstate/nitrogen-doped redu.ed graphene oxide-graphi- tic carbon nitride （BaWO4/NRGO-g-C3N4） nanocomposite has been synthesized by a simple one-pot microwave techniqu.. The synthesized nanocomposites are well characterized by diffraction, microscopic and spectroscopic techniqu.s to stu.y its crystal stru.tu.e, elemental composition, morphological featu.es and optical properties. The material prepared is tested for its performance as an electrocatalyst, photocatalyst and redu.tion catalyst. The nanocomposite catalyzed the photodegradation of methylene blu. （MB） dye in 120 min, redu.tion of 4-nitro phenol （4-NP） to 4-amino phenol （4-AP） in 60 s, showed an impressive Tafel slope of 62 mV/dec for hydrogen evolu.ion reaction （HER）. The observed resu.ts su.gest that the nanocomposite acts as an efficient mu.tifu.ctional catalyst. The reported approach provides fu.damental insights which can be extended to other metal tu.gstate-based ternary composites for applications in the field of clean energy and environment in the fu.u.e.

关键词： BaWO4/NRGO-g-C3N4 nanocomposites microwave irradiation hydrogen evolu.ion reaction photocatalyst redu.tion

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is u.gently needed

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Infectiou. Diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebu.ders Joseph Nelson Siewe Fodjo Olivia Kamoen Lu.s-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor Ju.ia Gau.litz Achim Hoerau. Yasu.ki Sato katja Polman Maria-Gloria Basanez Dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien D.Pion Global Health Institu.e University of AntwerpAntwerpBelgium Department of Neu.ology Heilig Hart ZiekenhuisLierBelgium Department of Pu.lic Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK Department of Compu.er Science University of AntwerpAntwerpBelgium Institu.e of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(DZIF) Partner Site Bonn-CologneBonnGermany School of Global Hu.anities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectiou. Disease Analysis and London Centre for Neglected TropicalDisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institu.e for Medical Research TangaTanzania Vector Control Division Ministry of HealthKampalaUganda School of Pu.lic Health University of JubaJubaSouth Sudan Access for Hu.anity JubaSouth Sudan French National Research Institu.e for Su.tainable Development MontpellierFrance

Backgrou.d There is increasing epidemiological evidence su.porting the association between onchocerciasis and seizu.es, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an u.date on the new knowledge abou. OAE and to propose recommendations to the World Health Organization how to address this pu.lic health *** text Du.ing the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgiu., participants recognised OAE as a su.stantial yet neglected pu.lic health problem, particu.arly in areas of su.-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective popu.ation-based stu.ies su.gest that strengthening onchocerciasis elimination efforts leads to a significant redu.tion of OAE incidence. There is a need to validate an OAE case definition to estimate the bu.den of disease and identify onchocerciasis-endemic areas requ.ring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness abou. OAE will boost the popu.ation u.take of ivermectin. The implementation of a commu.ity-based epilepsy treatment programme offering free anti-seizu.e medications (ASMs) has shown high effectiveness in redu.ing the frequ.ncy of seizu.es and improving the overall qu.lity of life of people with *** To redu.e OAE bu.den, enhanced collaboration between onchocerciasis and mental health programmes at commu.ity, national, and international levels is requ.red. u.gent efforts are needed to ensu.e the u.interru.ted provision of free ASMs in onchocerciasis-endemic areas. Fu.thermore, OAE shou.d be inclu.ed in the qu.ntification of the onchocerciasis disease bu.den.

关键词： Onchocerciasis Morbidity Bu.den of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

On Ohtsu.i's Invariants of Integral Homology 3-Spheres

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Acta Mathematica Sinica,English Series 1999年第3期15卷 293-316页

作者： Xiaosong Lin Zhenghan Wang Department of Mathematics, u.iversity of California, Riverside, CA 92521, u. S. A.Department of Mathematics, Indiana u.iversity, Bloomington, IN 47405, u. S. A. Department of Mathematics, u.iversity of California, La Jolla, CA 92093, u. S. A. Department of Mathematics University of California Riverside U. S. A. Department of Mathematics Indiana University Bloomington U. S. A. Department of Mathematics University of California La Jolla U. S. A.

We provide some more explicit formu.ae to facilitate the compu.ation of Ohtsu.i’s rational invariants λn of integral homology 3-spheres extracted from Reshetikhin-Tu.aev Su.2） qu.ntu. invari- ants. Several interes... 详细信息

We provide some more explicit formu.ae to facilitate the compu.ation of Ohtsu.i’s rational invariants λu.>nu.> of integral homology 3-spheres extracted from Reshetikhin-Tu.aev Su.2） qu.ntu. invari- ants. Several interesting consequ.nces will follow from ou. compu.ation of λu.>2u.>. One of them says that λu.>2u.> is always an integer divisible by 3. It seems interesting to compare this resu.t with the fact shown by Mu.akami that λu.>1u.> is 6 times the Casson invariant. Other consequ.nces inclu.e some general criteria for distingu.shing homology 3-spheres obtained from su.gery on knots by u.ing the Jones polynomial.

关键词： Finite type invariant Fermat limit Homology sphere Su.gery formu.a

Nonlinear　Galerkin　Optimal　Tru.cated　Low－dimensionalDynamicalSystems

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Commu.ications in Nonlinear Science and Nu.erical Simu.ation 1996年第1期1卷 37-43页

作者： W. u. Chu.jie[b][a] [a] Laboratory for Nonlinear Mechanics of Continu.u. Media Institu.e of Mechanics Academia Sinica of China Beijing 100080 China [b] Air Force Institu.e of Meteorology Nanjing 211101 China

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关键词： partial differential equ.tion optimization dynamical system nonlinear Galerkin method

Hu.an leu.ocyte antigen compatibility and incidence of donorspecific antibodies in pediatric liver transplant recipients

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World Jou.nal of Gastroenterology 2024年第33期30卷 3837-3845页

作者： Melina u.Melere Flavia H Feier Jorge Neu.ann Antônio N Kalil Ju.iana de M Montagner Lu.za S Nader Carolina S da Silva Marco Au.élio F Ju.ior Gabriela P Coral Gu.lherme P Bobsin Cristina T Ferreira Department of Hepatology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil Department of Hepato-biliary-pancreatic Su.gery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil Postgradu.tion Program in Medicine:Hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Laboratory of Transplantation Immu.ology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

BACKGROu.D Antibody-mediated rejection following liver transplantation(LT)has been increasingly recognized,particu.arly with respect to the emergence of de novo donor-specific antibodies(DSAs)and their impact on graft *** su.stantial evidence for adu.t popu.ations exists,research focu.ing on pediatric LT ou.comes remains *** To investigate the prevalence of hu.an leu.ocyte antigen(HLA)mismatches and DSA and evalu.te their association with rejection episodes after pediatric *** A cohort of pediatric LT recipients u.derwent HLA testing at Santa Casa de Porto Alegre,Brazil,between December 2013 and December *** patients who su.vived for>30 days after LT with at least one DSA analysis were *** classes I and II and cross-matches were *** presence of de novo DSA(dnDSA)was evalu.ted at least 3 months after LT u.ing the Lu.inex®single antigen bead method,with a positive reaction threshold set at 1000 *** episodes were confirmed by liver *** Overall,67 transplanted children were analyzed;61 received grafts from living donors,85%of whom were related to ***-transplant DSA(class I or II)was detected in 28.3%of patients,and dnDSA was detected in 48.4%.The median time to DSA detection after LT was 19.7[interqu.rtile range(IQR):4.3-35.6]*** rejection occu.red in 13 patients at follow-u.,with C4d positivity observed in 5/13 Liver *** median time to rejection was 7.8(IQR:5.7-12.8)*** presence of dnDSA was significantly associated with rejection(36%vs 3%,Pu.vival rates at 12 and 24 months were 76%vs 100%and 58%vs 95%for patients with dnDSA anti-DQ vs those withou.,*** Ou. findings highlight the importance of incorporating DSA assessment into pre-and post-transplantation protocols for pediatric LT *** implications may inclu.e immu.osu.pression minimization strategies based on this analysis in pediatric LT recip

关键词： Hu.an leu.ocyte antigens Donor-specific antibodies Liver transplantation Pediatric Rejection

Synergy and translation of allogenic bone marrow stem cells after photodynamic treatment of rheu.atoid arthritis with tetra su.fonatophenyl porphyrin and TiO2 nanowhiskers

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Nano Research 2016年第11期9卷 3305-3321页

作者： Fawad u. Rehman Chu.qiu.Zhao Changyu.Wu.Xiaoqi Li Hu. Jiang Matthias Selke Xu.mei Wang State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China Department of Chemistry and Biochemistry California State University Los Angeles CA 90032 USA Nanjing Foreign Langu.ge School Nanjing 210096 China

Rheu.atoid arthritis （RA） etiology and amelioration remains a challenge in modern therapeu.ics. Herein, we explored the synergistic effect of allogenic bone marrow stem cell （BMSC） translation and photodynamic treatment of RA with tetra su.fonatophenyl porphyrin （TSPP） and TiO2 nanocomposites as a new strategy for RA theranostics. The translation of BMSCs with miRNAs into infected joints in long bones post-photodynamic therapy is helpfu. for treating and u.derstanding RA pathophysiology. We observed that allogenic BMSC translation combined with TSPP-TiO2 nanocomposites can significantly （p 〈 0.01） lower the concentrations of seru. biomarkers （tu.or necrosis factor-α and interleu.in-17） in a collagen indu.ed arthritis （CIA） mu.ine model, both in vitro and in vivo, as well as improve other parameters su.h as arthritis score, BMSC cou.t, complete blood cou.t, and nu.bers of platelets, red blood cells, and white blood cells. Moreover, a flu.rescent TSPP in the feet or long bones and X-ray bioimaging of RA joints revealed the clinical efficacy of BMSCs combined with TSPP-TiO2 nanocomposites. Microarray data analysis illu.trated that rnomir-375-3p and rno-mir-196b-3p were u.-regu.ated by approximately 100-fold in the BMSCs of ameliorated RA post-photodynamic therapy with TSPP-TiO2 nanocomposites. Ou. stu.y not only su.gests a new approach for RA theranostics, bu. also helps in u.derstanding RA pathophysiology.

关键词： rheu.atoid arthritis allogenic bone marrowstem cells (BMSCs) tetra su.fonatophenyl porphyrin (TSPP)-TiO2nanocomposites photodynamic treatment miRNAs