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Framework to Design Type-based Transfer Processes Between Technology and Product Development

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Management Studies 2014年第6期2卷 357-372页

作者： guenther Schuh Katharina Apfel Fraunhofer Institute for Production Technology Aachen Germany

To stay globally competitive, manufacturing companies are increasingly under pressure to bring new products and applications to market, improve existing products, and discover new technologies to produce them at a lower price. New technological findings can enable companies to overcome these challenges. In practice, technology development associated with a long time horizon is often given a lower priority compared with short-term focused product development thus being stronger restricted by everyday business. More and more companies separate their technology development department from product development to promote technological innovations. Due to this additional interface in the R＆D organization new problems arise, resulting in technologies not being implemented in products. The reasons for these problems amongst others concern wrong timing for the transfer or inadequate definition of responsibilities. In this paper of ongoing research, authors introduce a framework to design the transfer processes between technology development and product development. Although there are a number of options for designing the operative transfer, there is no regulatory framework specifying which configuration options are at this particular interface. The approach is to develop a model, which is able to design different company-specific transfer processes taking into account the object being transferred at this interface. Thus, for different objects to be transferred, different transfer processes are designed. The model＇s aim is to enable responsibility of the R＆D management to design their company-specific transfer processes to enable more technologies being implemented into products, thus giving the whole company the possibility to act more innovatively.

关键词： technology development product development interface management R&D management

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长白山温带森林单萜烯排放模拟

环境科学学报 2012年第9期32卷 2236-2244页

作者：白建辉 guenther Alex Turnipseed Andrew 中国科学院大气物理研究所中层大气与全球环境探测重点实验室北京100029 美国国家大气研究中心 boulderco80307

于2010年夏季,采用松弛涡度积累(Relaxed Eddy Accumulation)技术在长白山温带森林铁塔上测量了挥发性有机物(VOC)冠层尺度的排放通量,同步测量了气象参数、光合有效辐射(PAR)等,初步获得长白山阔叶林单萜烯的排放通量.同时,利用PAR能... 详细信息

于2010年夏季,采用松弛涡度积累(Relaxed Eddy Accumulation)技术在长白山温带森林铁塔上测量了挥发性有机物(VOC)冠层尺度的排放通量,同步测量了气象参数、光合有效辐射(PAR)等,初步获得长白山阔叶林单萜烯的排放通量.同时,利用PAR能量守恒原理,建立了冠层尺度上单萜烯排放的经验模式.结果发现,模拟结果与测量结果比较一致,平均而言,模拟值高出测量值约20%～40%.采用不同方法对经验模式进行了检验,结果表明,采用比较各个采样时段平均值的方法可行,而且经验模式对于2010年夏季不同采样时段的平均值也给出了较好的模拟结果,其模拟值高出测量值约20%～24%.

关键词：挥发性有机物单萜烯排放通量光合有效辐射经验模式

Rethinking quasispecies theory: From fittest type to cooperative consortia

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World Journal of Biological Chemistry 2013年第4期4卷 79-90页

作者： Luis P Villarreal guenther Witzany Department of Molecular Biology and Biochemistry University of California Telos-Philosophische Praxis

Recent investigations surprisingly indicate that single RNA "stem-loops" operate solely by chemical laws that act without selective forces, and in contrast, self-ligated consortia of RNA stem-loops operate by biological selection. To understand consortial RNA selection, the concept of single quasi-species and its mutant spectra as drivers of RNA variation and evolution is rethought here. Instead, we evaluate the current RNA world scenario in which consortia of cooperating RNA stem-loops(not individuals) are the basic players. We thus redefine quasispecies as RNA quasispecies consortia(qs-c) and argue that it has essential behavioral motifs that are relevant to the inherent variation, evolution and diversity in biology. We propose that qs-c is an especially innovative force. We apply qs-c thinking to RNA stem-loops and evaluate how it yields altered bulges and loops in the stem-loop regions, not as errors, but as a natural capability to generate diversity. This basic competencenot error-opens a variety of combinatorial possibilities which may alter and create new biological interactions, identities and newly emerged self identity(immunity) functions. Thus RNA stem-loops typically operate as cooperative modules, like members of social groups. Fromsuch qs-c of stem-loop groups we can trace a variety of RNA secondary structures such as ribozymes, viroids, viruses, mobile genetic elements as abundant infection derived agents that provide the stem-loop societies of small and long non-coding RNAs.

关键词： Quasispecies RNA stem-loops Infectious agents Cooperative interactions Evolution

Does Coronary Microvascular Spasm Exist?Objective Evidence from Intracoronary Doppler Flow Measurements During Acetylcholine Testing

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Cardiovascular Innovations and Applications 2020年第1期4卷 205-209页

作者： Fabian guenther Andreas Seitz Valeria Martinez Pereyra Raffi Bekeredjian Udo Sechtem Peter Ong Department of Cardiology Robert-Bosch-KrankenhausAuerbachstr.11070376 StuttgartGermany

A 43-year-old woman with recurrent atypical angina underwent invasive coronary angiography including intracoronary Doppler blood flow assessment and coronary spasm provocation *** obstructive epicardial disease could be ruled-out angiographically,the patient experienced reproduction of her angina symptoms after intracoronary administration of acetylcholine(100μg)during spasm provocation ***,the ECG showed new-onset ST-segment depression in the absence of epicardial *** addition,coronary fl ow velocity was signifi cantly reduced after acetylcholine compared to the baseline *** intracoronary administration of nitroglycerine(200μg),the patient’s symptoms as well as the ECG changes and coronary flow reduction were *** the ongoing challenges in appropriate evaluation of the pathophysiological mechanisms of coronary microvascular dysfunction,simultaneous intracoronary Doppler flow measurement during spasm testing–as shown in this case–may provide objective evidence for microvascular spasm in addition to the standardized diagnostic criteria,especially if they are ambiguous.

关键词： acetylcholine coronary microcirculation coronary flow reserve coronary spasm

Protein-losing pseudomembranous colitis with cap polyposis-like features

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World Journal of Gastroenterology 2017年第16期23卷 3003-3010页

作者： Wolfgang Kreisel guenther Ruf Richard Salm Adhara Lazaro Bertram Bengsch Anna-Maria Globig Paul Fisch Silke Lassmann Annette Schmitt-Graeff Department of Medicine II GastroenterologyHepatologyEndocrinology and Infectious DiseasesMedical CenterUniversity of FreiburgFaculty of MedicineUniversity of Freiburg79106 FreiburgGermany Department of General and Visceral Surgery Center for SurgeryUniversity of FreiburgFaculty of MedicineUniversity of Freiburg79106 FreiburgGermany Department of Surgery RKK Bruder-Klaus-Krankenhaus79183 WaldkirchGermany Institute for Exercise and Occupational Medicine Center for MedicineMedical Center-University of FreiburgFaculty of MedicineUniversity of Freiburg79106 FreiburgGermany Silke Lassmann Annette Schmitt-GraeffInstitute of Surgical PathologyMedical Center and Faculty of MedicineUniversity of Freiburg79106 FreiburgGermany

Protein-losing enteropathy(PLE) is characterized by loss of serum proteins into the gastrointestinal tract. It may lead to hypoproteinemia and clinically present as protein deficiency edema, ascites, pleural or pericardial effusion and/or malnutrition. In most cases the site of protein loss is the small intestine. Here we present an unusual case of severe PLE in a 55-year old female with a one-year history of recurrent diarrhea, crampy abdominal pain, and peripheral edema. Endoscopy and MRI showed a diffuse inflammatory thickening of the sigmoid colon and the rectum. Surgical resection of the involved colon was performed and the symptoms were significantly resolved. The final histologic evaluation confirmed a diagnosis of a pseudomembranous colitis with cap polyposis-like features. Such a cause of PLE has never been described before.

关键词： Protein-losing enteropathy Cap polyposis Ulcerative colitis Goblet cells Pseudomembranes

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气候变化对中国农业生产的影响

地理学报 2000年第2期55卷 129-138页

作者：唐国平李秀彬 guenther Fischer Sylvia Prieler 中国科学院地理研究所北京100101 国际应用系统分析研究所

根据 1 958～ 1 997年中国 31 0个气象站的月平均最高、最低气温 ,月平均降水量 ,日照时数等气象参数分析了中国气候的背景特征。用 3个大气环流模型 ,即 Had CM2、 CGCM1、ECHAM4来模拟未来中国气候变化的情景。同时 ,建立未来气候变化... 详细信息

根据 1 958～ 1 997年中国 31 0个气象站的月平均最高、最低气温 ,月平均降水量 ,日照时数等气象参数分析了中国气候的背景特征。用 3个大气环流模型 ,即 Had CM2、 CGCM1、ECHAM4来模拟未来中国气候变化的情景。同时 ,建立未来气候变化的 6种方案。最后 ,根据3个 GCMs模拟的结果 ,利用国际应用系统分析研究所 (IIASA)发展并改进的农业生态地带模型 (AEZ)评估气候变化对中国农业生产的影响。评估主要集中于气候变化对不同区域复种指数、可耕种土地面积、潜在粮食产量及其土地生产潜力的影响。

关键词：气候变化大气环流模型农业生产气温降水

An Improved Treed Gaussian Process

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Applied Mathematics 2020年第7期11卷 613-638页

作者： John guenther Herbert K. H Lee Department of Statistics and Biostatistics California State University Hayward CA USA Department of Statistics University of California Santa Cruz CA USA

Many black box functions and datasets have regions of different variability. Models such as the Gaussian process may fall short in giving the best representation of these complex functions. One successful approach for modeling this type of nonstationarity is the Treed Gaussian process [1], which extended the Gaussian process by dividing the input space into different regions using a binary tree algorithm. Each region became its own Gaussian process. This iterative inference process formed many different trees and thus, many different Gaussian processes. In the end these were combined to get a posterior predictive distribution at each point. The idea was that when the iterations were combined, smoothing would take place for the surface of the predicted points near tree boundaries. We introduce the Improved Treed Gaussian process, which divides the input space into a single main binary tree where the different tree regions have different variability. The parameters for the Gaussian process for each tree region are then determined. These parameters are then smoothed at the region boundaries. This smoothing leads to a set of parameters for each point in the input space that specify the covariance matrix used to predict the point. The advantage is that the prediction and actual errors are estimated better since the standard deviation and range parameters of each point are related to the variation of the region it is in. Further, smoothing between regions is better since each point prediction uses its parameters over the whole input space. Examples are given in this paper which show these advantages for lower-dimensional problems.

关键词： Bayesian Statistics Treed Gaussian Process Gaussian Process Emulator Binary Tree

Cluster Search Algorithm for Finding Multiple Optima

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Applied Mathematics 2016年第7期7卷 736-752页

作者： John guenther Herbert K. H. Lee Department of Applied Mathematics and Statistics University of California Santa Cruz CA USA

The black box functions found in computer experiments often result in multimodal optimization programs. Optimization that focuses on a single best optimum may not achieve the goal of getting the best answer for the purposes of the experiment. This paper builds upon an algorithm introduced in [1] that is successful for finding multiple optima within the input space of the objective function. Here we introduce an alternative cluster search algorithm for finding these optima, making use of clustering. The cluster search algorithm has several advantages over the earlier algorithm. It gives a forward view of the optima that are present in the input space so the user has a preview of what to expect as the optimization process continues. It employs pattern search, in many instances, closer to the minimum’s location in input space, saving on simulator point computations. At termination, this algorithm does not need additional verification that a minimum is a duplicate of a previously found minimum, which also saves on simulator point computations. Finally, it finds minima that can be “hidden” by close larger minima.

关键词： Bayesian Statistics Treed Gaussian Process Emulator DBSCAN Optimization

At the dawn of a new revolution in life sciences

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World Journal of Biological Chemistry 2013年第2期4卷 13-15页

作者： Frantiek Baluka guenther Witzany IZMB University of Bonn Telos-Philosophische Praxis

In a recently published article Sydney Brenner argued that the most relevant scientific revolution in biology at his time was the breakthrough of the role of "information" in *** fundamental concept that integrates this new biological "information" with matter and energy is the universal Turing machine and von Neumann's self-reproducing *** this article we demonstrate that in contrast to Turing/von Neumann machines living cells can really reproduce *** current knowledge on the roles of noncoding RNAs indicates a radical violation of the central dogma of molecular biology and opens the way to a new revolution in life sciences.

关键词： History of science Paradigm shift Information Non-coding RNAs