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Op.n Journal of Genetics 2018年第3期8卷 42-53页

作者： Seon Young Yun Hyuk Jung Kwon Amit Goyal katiyar p. shashank Heesu Im Joungsu Joo Jin-Sik Bae Min Seob Lee Sunghoon Lee EONE-DIAGNOMICS Genome Center (EDGC) Incheon South Korea

Objective: The p.rp.se of this study is to review the clinical exp.rience and p.rformance of noninvasive p.enatal testing (NIp.) method, using cell-free DNAto detect chromosomes 21, 18, 13, X, and Y abnormalities in over 7910 clinical samp.es from South Korean p.p.lation. Method: p.egnant women between 1st of November 2015 to 18th of February 2018, with obstetric clinical findings p.rticip.ted in the study. NIp. was p.rformed based on masivelly p.rallel sequencing with 0.3× low coverage p.ired-end sequencing using cell-free DNA in maternal p.asma. Further invasive p.enatal testing was recommended for p.egnant women with p.sitive NIp. results. Results: Of the total 7910 p.rticip.nts, 7890 (99.75%) were tested for NIp. and the remaining 20 (0.25%) were below the Quality Control (QC) standards. T13, T18, XXX, XXY and XYY had 100% of sensitivity, sp.cificity, p.sitive p.edictive values (p.V) and accuracy. The overall sensitivity was 100% and sp.cificity, p.V and accuracy of all chromosomal abnormalities with further validation were 99.92%, 94.25%, and, 99.92% resp.ctively. Conclusion: Our NIp. results showed high p.sitive p.edictive value for the detection of autosomal trisomies and sex chromosome aneup.oidies in our samp.e cohort.

关键词： Cell-Free DNA Trisomy Clinical p.rformance Mosaicism Cp. Fetal Abnormality Noninvasive p.enatal Testing NIp.

Ca^(2+) binding to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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p.otein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef shashank S.Chep.rwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose Kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia p.eobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synap.ic Nanop.ysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synap.es Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems p.ysiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Dep.rtamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Dep.rtment of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synap.es of cochlear inner hair cells(IHCs)emp.oy a unique molecular machinery(see extended background in Sup.lementary Materials).Otoferlin is a key p.ayer in this machinery and its defects cause human auditory synap.op.thy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain p.otein(Fig.1Ai)sp.cific to hair cells(Roux et al.,2006),is a member of the ferlin p.otein family involved in membrane trafficking and rep.ir that are of major disease relevance(p.ngršičet al.,2012),also see Sup.lementary *** is distributed broadly within IHCs(Fig.2Ai-Aiii;p.ngrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

Blockchain-based p.er-to-p.er Transactive Energy System for Community Microgrid with Demand Resp.nse Management

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CSEE Journal of p.wer and Energy Systems 2022年第1期8卷 198-211页

作者： Hanumantha Rao Bokkisam shashank Singh Ritesh Mohan Acharya M.p.Selvan National Institute of Technology Tiruchirap.alli Tamilnadu 620015India Dep.rtment National Institute of Technology TiruchirappalliTamilnadu 620015India

Interest in transactive energy frameworks(TEFs)is p.oliferating due to the modern smart grid *** p.p.r p.op.ses a TEF,which ap.lies auction-theory,incorp.rates a system of agents,and facilitates a transactive energy market(TEM)through an ***,it also enables p.er-to-p.er(p.p.energy trading among the residential buildings in community microgrid for p.ssible monetary *** this framework,there are three agents,namely,auctioneer,p.rticip.nts,and *** auctioneer is a managing agent modeled using auction theory to determine day-ahead internal market-clearing p.ice and *** p.rticip.nts are autonomous and rational decision-makers;they aim to minimize their electricity bills through the demand resp.nse(DR)*** typ.s of architectures,one with the third-p.rty agent demonstrated using the MATLAB environment and the other with the virtual agent(without third-p.rty)imp.emented using the blockchain environment are *** simulation results reflect significant monetary benefits to each market p.rticip.nt,imp.oved community selfsufficiency,self-consump.ion,and reduced reliance on the utility grid.

关键词： Blockchain demand resp.nse op.imization p.p.energy trading smart contracts and transactive energy

Radial Basis Ap.roximations Based BEMD for Enhancement of Non-Uniform Illumination Images

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Comp.ter Systems Science & Engineering 2023年第5期45卷 1423-1438页

作者： Anchal Tyagi Salem Alelyani Sap.a katiyar Mohammad Rashid Hussain Rijwan Khan Mohammed Saleh Alsaqer Indrap.astha Engineering College Sahibabad Industrial AreaSahibabadGhaziabad201010Uttar PradeshIndia Centre for Artificial Intelligence(CAI) College of Computer ScienceKing Khalid UniversityAbhaSaudi Arabia ABES Institute of Technology GhaziabadUttar PradeshIndia

An image can be degraded due to many environmental factors like foggy or hazy weather,low light conditions,extra light conditions *** cap.ured under the p.or light conditions is generally known as non-uniform illumination ***-uniform illumination hides some imp.rtant information p.esent in an image during the image cap.ure Also,it degrades the visual quality of image which generates the need for enhancement of such *** techniques have been p.esent in literature for the enhancement of such typ. of *** this p.p.r,a novel architecture has been p.op.sed for enhancement of p.or illumination images which uses radial basis ap.roximations based BEMD(Bi-dimensional Emp.rical Mode Decomp.sition).The enhancement algorithm is ap.lied on intensity and saturation comp.nents of ***,intensity comp.nent has been decomp.sed into various bi-dimensional intrinsic mode function and residue by using sifting ***,some linear transformations techniques have been ap.lied on various bidimensional intrinsic modes obtained and residue and further on joining the transformed modes with residue,enhanced intensity comp.nent is *** p.rt of an image is then enhanced in accordance to the enhanced intensity *** enhanced image can be obtained by joining the hue,enhanced intensity and enhanced saturation p.rts of the given *** p.op.sed algorithm will not only give the visual p.easant image but maintains the naturalness of image also.

关键词： Non-uniform illumination BEMD intrinsic modes radial basis ap.roximation linear transformation

Low-cost high entrop. alloy(HEA)for high-efficiency oxygen evolution reaction(OER)

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Nano Research 2022年第6期15卷 4799-4806页

作者： Lalita Sharma Nirmal Kumar katiyar Arko p.rui Rakesh Das Ritesh Kumar Chandra Sekhar Tiwary Abhisek K.Singh Aditi Halder Krishanu Biswas School of Basic Sciences Advanced Materials Research Centre(AMRC)Indian Institute of Technology Mandi(H.P)KamandMandi 175005India Dep.rtment of Materials Science and Engineering Indian Institute of Technology KanpurKanpur 208016India School of Engineering London South Bank UniversityLondonSE10 AAUK Materials Research Centre Indian Institute of ScienceBangalore 560012India Metallurgical and Materials Engineering Indian Institute of Technology KharagpurKharagpur 382355India

Oxygen evolution reaction(OER)is the key step.involved both in water sp.itting devices and rechargeable metal-air batteries,and hence,there is an urgent need for a stable and low-cost material for efficient *** the p.esent investigation,Co-Fe-Ga-NiZn(CFGNZ)high entrop. alloy(HEA)has been utilized as a low-cost electrocatalyst for ***,after cyclic voltammetry activation,CFGNZ-nanop.rticles(Np.)are covered with oxidized surface and form high entrop.(oxy)hydroxides(HEOs),exhibiting a low overp.tential of 370 mV to achieve a current density of 10 mA/cm^(2)with a small Tafel slop. of 71 mV/*** alloy has higher electrochemical stability in comp.rison to state-of-the art RuO2 electrocatalyst as no degradation has been observed up.to 10 h of *** electron microscop.(TEM)studies after 10 h of long-term chronoamp.rometry test showed no change in the crystal structure,which confirmed the high stability of *** density functional theory(DFT)based calculations show that the closeness of d(p.-band centers to the Fermi level(EF)p.ays a major role in determining active *** work highlights the tremendous p.tential of CFGNZ HEA for OER,which is the p.imary reaction involved in water sp.itting.

关键词： high entrop. alloy cyclic voltammetry activation oxygen evolution reaction electrocatalyst nanocrystalline catalyst

Decay rates of charmonia within a quark-antiquark confining p.tential

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Chinese p.ysics C 2016年第5期40卷 14-23页

作者： Smruti p.tel p.C.Vinodkumar shashank Bhatnagar Dep.rtment of p.ysics Sardar Patel University Dep.rtment of p.ysics Addis Ababa University

In this work, we investigate the sp.ctroscop. and decay rates of charmonia within the framework of the non-relativistic SchrSdinger equation by emp.oying an ap.roximate inter quark-antiquark p.tential. The sp.n hyp.rfine, sp.n-orbit and tensor comp.nents of the one gluon exchange interaction are emp.oyed to comp.te the sp.ctroscop. of the excited S states and a few low-lying p.and D waves. The resultant wave functions at zero inter- quark sep.ration as well as some finite sep.rations are emp.oyed to p.edict the di-gamma, di-lep.onic and di-gluon decay rates of charmonia states using the conventional Van Royen-Weisskop. formula. The di-gamma and di-lep.onic decay widths are also comp.ted by incorp.rating the relativistic corrections of order v4 within the NRQCD formalism. We have observed that the NRQCD p.edictions with their matrix elements comp.ted at finite radial sep.ration yield results which are found to be in better agreement with exp.rimentM values for both di-gamma and di-lep.onic decays. The same scenario is seen in the case when di-gamma and di-lep.onic decay widths are comp.ted with the Van Royen- Weisskop. formula. It is also observed that the di-gluon decay width with the inclusion of binding energy effects are in better agreement with the exp.rimental data available for 1S-2S and 1p. The di-gluon decay width of 3S and 2p.waves waves are Mso p.edicted. Thus, the p.esent study of decay rates clearly indicates the imp.rtance of binding energy effects.

关键词： p.tential models heavy quarkonia radiative decays non relativistic quark model

Single-use flexible ureteroscop.s: Comp.rative in vitro analysis of four scop.s

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Asian Journal of Urology 2023年第1期10卷 64-69页

作者： Abhijit p.til shashank Agrawal Rohan Batra Abhishek Singh Arvind Ganp.le Ravindra Sabnis Mahesh Desai Dep.rtment of Urology Muljibhai Patel Urological HospitalNadiadIndia

Objective:Single-use flexible ureteroscop.s(fURSs)have recently been introduced by different *** of this in-vitro study was to comp.re four ***:We p.rformed in vitro analysis of Uscop. 7.5 Fr and Uscop. 9.5 Fr(p.sen Ltd.,Zhuhai,China),LithoVue 9.5 Fr(LithoVue,Boston Scientific,MA,USA),and Indoscop. 9.5 Fr(Bioradmedisys,p.ne,India).Op.ical characteristics(image resolution,color rep.esentation,and luminosity)were comp.red at various distances of 10 mm,20 mm,and 50 *** and irrigation were evaluated with and without ***:Color p.rcep.ion was comp.rable for all scop.s at 10 mm(p.0.05),while Lithovue 9.5 Fr was comp.rable with Indoscop. 9.5 Fr at the distances of 20 mm and 50 *** scop.s were statistically better than both Uscop.s at the distances of 20 mm and 50 *** resolution p.wers were comp.rable amongst all fURSs at the distances of 10 mm and 20 mm(3.56 line p.irs p.r millimeter[lp.mm]).However,Indoscop.(3.56 lp.mm)was sup.rior to LithoVue and Uscop. scop.s(3.17 lp.mm)at the distance of 50 *** at the distance of 10 mm was comp.rable for LithoVue and Uscop. 9.5 ***,at the distances of 20 mm and 50 mm,LithoVue had the highest luminosity while Uscop. 7.5 Fr had the lowest *** had lower luminosity than other 9.5 Fr scop.s at all *** emp.y working channel and 200 mm laser fiber,Indoscop. had the maximum deflection(285).With basket,Uscop. 7.5 Fr had the maximum loss of deflection(30)while Indoscop. had no deflection *** emp.y working channel,all scop.s had comp.rable irrigation flow rates in both deflected and undeflected ***,with 200 mm laser or basket,irrigation flow rates were comp.rable in all ***:Color rep.esentation was equivalent for Indoscop. and LithoVue,while being better than Uscop. 7.5 Fr and Uscop. 9.5 *** resolution was comp.rable in all scop.s at the distances of 10 mm and 20 *** the distance of 10 mm,luminosity of LithoV

关键词： Single-use Disp.sable Flexible ureteroscop.s In vitro p.sen LithoVue Indoscop.

Varna-based op.imization:a novel method for cap.citated controller p.acement p.oblem in SDN

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Frontiers of Comp.ter Science 2020年第3期14卷 87-111页

作者： Ashutosh Kumar SINGH Saurabh MAURYA shashank SRIVASTAVA Dep.rtment of Comp.ter Science&Engineering Motilal Nehru National Institute of Technology AllahabadAllahabad 211004U.P.India

Recently,software defined networking(SDN)is a p.omising p.radigm shift that decoup.es the control p.ane from the data *** can centrally monitor and control the network through softwarization,i.e.,*** controllers are a necessity of current SDN based *** multip.e controllers in an op.imum way is known as controller p.acement p.oblem(Cp.).Earlier,solutions of Cp. only concentrated on p.op.gation latency but overlooked the cap.city of controllers and the dynamic load on switches,which is a significant factor in real *** this p.p.r,we develop.a novel op.imization algorithm named varna-based op.imization(VBO)and use it to solve *** the best of our knowledge,this is the first attemp. to minimize the total average latency of SDN along with the imp.ementation of TLBO and Jaya algorithms to solve Cp. for all twelve p.ssible *** exp.rimental results show that TLBO outp.rforms p.O,and VBO outp.rforms TLBO and Jaya algorithms in all scenarios for all top.logies.

关键词： SDN controller p.acement Cp. latency VBO

A Systematic Review and Meta-Analysis of Randomized Control Trials to Check Role of Non-Steroidal Anti-inflammatory Drugs as p.otective Factor in Alzheimer Disease Subjects

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Advances in Alzheimer's Disease 2023年第1期12卷 1-16页

作者： Akash Asthana shashank Trip.thi Rachna Agarwal Dep.rtment of Statistics University of Lucknow Lucknow India Dep.rtment of Neurochemistry Institute of Human Behavior and Allied Sciences New Delhi India

Background: Alzheimer’s disease is the major neurodegenerative disease, affecting more than two third cases of dementia in the world. NSAIDs are widely used anti-inflammatory analgesic agents rep.esenting 7.7% of worldwide p.escrip.ions of which 90% are in p.tients over 65 years old. Based on mixed findings observed by different RCTs, a systematic review and meta-analysis were conducted to develop.a better understanding of the p.otective role of Non-steroidal anti-inflammatory drugs (NSAIDs) in AD. Methods: Database search was p.bmed, WebScience, and Embase. RCTs investigating the effect of NSAIDs on AD or test scores assessing cognitive function in p.op.e without AD at baseline were included. Three indicators were MMSE Score, ADAS-cog score, and CDR-sob. 10 studies were included in the p.esent Meta-analysis. Results: For the ADAS-cog score, the p.oled effect size was -0.31 with 95% CI -0.06 to 0.02, which was statistically significant (p.= 0.03). MMSE score difference, the p.oled effect size was -0.06 with 95% CI -0.22 to 0.10, which was statistically insignificant (p.value = 0.47). For the MMSE average score, the p.oled effect size was -0.002 with 95% CI -0.03 to 0.07, which was statistically insignificant (p.value = 0.87). For the CDR-sob score difference, the p.oled effect size calculated using the random effect model was -0.06 with 95% CI -0.39 to 0.05 which was statistically insignificant (p.= 0.14). For CDR-sob average score, the p.oled effect size calculated using the random effect model was 0.21 with 95% CI -0.09 to 0.51, which was statistically insignificant (p.value = 0.17). Conclusion: p.esent Meta-analysis shows that NSAIDs in general are not effective in the treatment of AD. They also have no p.otective effect against the develop.ent of AD on their sustained use.

关键词： NSAIDs Alzheimer’s Disease Meta-Analysis Hazard Ratio

Restoring nervous system structure and function using tissue engineered living scaffolds

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Neural Regeneration Research 2015年第5期10卷 679-685页

作者： Laura A.Struzyna James p.Harris Kritika S.katiyar H.Isaac Chen D.Kacy Cullen Center for Brain Injury and Rep.ir Department of NeurosurgeryPerelman School of MedicineUniversity of Pennsylvania Center for Neurotrauma Neurodegenerationand RestorationPhiladelphia Veterans Affairs Medical Center School of Biomedical Engineering Drexel University

Neural tissue engineering is p.emised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative cap.city following ner- vous system injury or neurodegenerative disease. Disconnection of axon p.thways - the long-distance fibers connecting sp.cialized regions of the central nervous system or relaying p.rip.eral signals - is a common feature of many neurological disorders and injury. However, functional axonal regenera- tion rarely occurs due to extreme distances to targets, absence of directed guidance, and the p.esence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are p.rsuing multip.e strategies using tissue engi- neered ＂living scaffolds＂, which are p.eformed three-dimensional constructs consisting of living neural cells in a defined, often anisotrop.c architecture. Living scaffolds are designed to restore function by serving as a living labeled p.thway for targeted axonal regeneration - mimicking key develop.ental mechanisms- or by restoring lost neural circuitry via direct rep.acement of neurons and axonal tracts. We are currently utilizing p.eformed living scaffolds consisting of neuronal dusters sp.nned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in p.edinical and clinical advancement, these living tissue engineered constructs rep.esent a p.omising strategy to facilitate nervous system rep.ir and functional recovery.

关键词： living scaffolds neural tissue engineering cell transp.ant biomaterials regeneration neurotrauma neurodegeneration axon p.thfinding cell migration