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Treatment and disease management patterns for bacillus Calmette-Guérin unresponsive nonmuscle invasive bladder cancer in North America,Europe and Asia:A real-world data analysis

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Current Urology 2022年第3期16卷 147-153页

作者： Edward I.Broughton Danielle S.Chun Kyna M.Gooden katie l.mycock Ivana Rajkovic Gavin Taylor-Stokes WW Health Economics and Outcomes Research Bristol Myers SquibbPrincetonNJUSA The University of North Carolina Chapel HillNCUSA Observational Research Department Adelphi Real WorldBollingtonUK

Background:This study examined real-world treatment and management of bacillus Calmette-Guérin(BCG)-unresponsive patients across 3 continents,including patients unable or unwilling to undergo *** and methods:Physicians actively involved in managing patients with nonmuscle invasive bladder cancer completed online case report forms for their 5 consecutive patients from the broad BCG-unresponsive population and a further 5 consecutive BCG-unresponsive patients who did not undergo cystectomy(in Japan,physicians provided a total of 5 patients across both cohorts).Results:Most patients had received 1(37%)or 2(24%)maintenance courses of *** or more maintenance BCG courses were received by patients in Japan(59%)and China(31%),while in Germany 76%of patients received only 1 *** patients became BCG-unresponsive during their first(44%)or second(22%)treatment course;in Germany,77%became BCG-unresponsive during their first treatment *** countries did not provide another course of BCG after a patient first became unresponsive,whereas unresponsive patients in Japan and China were most likely to be retreated with BCG."Untreated-on watch and wait"was the main treatment/management approach received post-BCG treatment for 42%or more of patients in most countries except China(39%)and the United States(36%)."Following treatment guidelines"was consistently the top reason for post-BCG treatment selection across all treatment ***:This study confirmed the global unmet need for patients with nonmuscle invasive bladder cancer,and found that many patients experienced periods of no treatment after not responding to BCG therapy.

关键词： Bacillus Calmette-Guérin Bladder cancer Cystectomy Treatment failure Urinary tract

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Exploring the associations between skeletal muscle echogenicity and physical function in aging adults:A systematic review with meta-analyses

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Journal of Sport and Health Science 2024年第6期13卷 820-840页

作者： Dustin J.Oranchuk Stephan G.Bodkin katie l.Boncella Michael O.Harris-love Muscle Morphology Mechanicsand Performance LaboratoryDepartment of Physical Medicine and RehabilitationUniversity of Colorado Anschutz Medical CampusAuroraCO 80045USA Department of Physical Therapy

Background:Assessment and quantification of skeletal muscle within the aging population is vital for diagnosis,treatment,and injury/disease *** clinical availability of assessing muscle quality through diagnostic ultrasound presents an opportunity to be utilized as a screening tool for function-limiting ***,relationships between muscle echogenicity and clinical functional assessments require authoritative ***,we aimed to(a) synthesize the literature to assess the relationships between skeletal muscle echogenicity and physical function in older adults(≥60 years),(b) perform pooled analyses of relationships between skeletal muscle echogenicity and physical function,and(c) perform sub-analyses to determine between-muscle ***:CINAHl,Embase,MEDlINE,PubMed,and Web of Science databases were systematically searched to identify articles relating skeletal muscle echogenicity to physical function in older ***-of-bias assessments were conducted along with funnel plot ***-analyses with and without sub-analyses for individual muscles were performed utilizing Fisher's Z transformation for the most common measures of physical ***'s Z was back-transformed to Pearson's r for ***:Fifty-one articles(n=5095,female=~2759,male=~2301,72.5± 5.8 years,mean±SD(1 study did not provide sex descriptors))were extracted for review,with previously unpublished data obtained from the authors of 13 *** rectus femoris(n=34) and isometric knee extension strength(n=22) were the most accessed muscle and physical qualities,*** relationship between quadriceps echogenicity and knee extensor strength was moderate(n=2924,r=-0.36(95% confidence interval:-0.38 to-0.32),p ll other meta-analyses(grip strength,walking speed,sit-to-stand,timed up-and-go) resulting in slightly weaker correlations(r:-0.34 to-0.23,all p lyses determined minimal differences in predicti

关键词： Correlations Echo intensity Elderly Intramuscular fat Strength

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Biomass gasification,catalytic technologies and energy integration for production of circular methanol:New horizons for industry decarbonisation

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Journal of Environmental Sciences 2024年第6期140卷 306-318页

作者： luis F.Bobadilla lola Azancot Miriam González-Castañ Estela Ruíz-lópez laura Pastor-Pérez Francisco J.Durán-Olivencia Runping Ye katie Chong Paula HBlanco-Sánchez Zenthao Wu Tomás R.Reina JoséA.Odriozola Departamento de Química Inorgánica e Instituto de Ciencia de Materiales de Sevilla Centro Mixto CSIC-Universidad de SevillaAvda.Américo Vespucio 49Sevilla 41092Spain Departamento de Ingeniería Universidad Loyola AndalucíaAvda.de Las Universidades s/nSevilla 41704Spain Key laboratory of Jiangxi Province for Environment and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirminghamB47ETUnited Kingdom Department of Chemical and Process Engineering University of SurreyGuildfordGU27XHUnited Kingdom

The Intergovernmental Panel on Climate Change(IPCC)recognises the pivotal role of renewable energies in the future energy system and the achievement of the zero-emission *** implementation of renewables should provide major opportunities and enable a more secure and decentralised energy supply *** fuels provide long-term solutions for the transport sector,particularly for applications where fuels with high energy density are *** addition,it helps reducing the carbon footprint of these sectors in the *** on biomass characteristics feedstock is essential for scaling-up gasification from the laboratory to *** review deals with the transformation biogenic residues into a valuable bioenergy carrier like biomethanol as the liquid sunshine based on the combination of modified mature technologies such as gasification with other innovative solutions such as membranes and microchannel *** abatement is a critical process in product gas upgrading since tars compromise downstream processes and equipment,for this,membrane technology for upgrading syngas quality is discussed in this *** reactor technology with the design of state-of-the-art multifunctional catalysts provides a path to develop decentralised biomethanol synthesis from biogenic ***,the development of a process chain for the production of(i)methanol as an intermediate energy carrier,(ii)electricity and(iii)heat for decentralised applications based on biomass feedstock flexible gasification,gas upgrading and methanol synthesis is analysed.

关键词： Biogenic residues Gasification Biomethanol Circular Economy Microreactors

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Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors

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Eye and Vision 2016年第1期3卷 263-282页

作者： katie l.Pennington Margaret M.DeAngelis Department of Ophthalmology John A.Moran Eye CenterUniversity of UtahSalt Lake CityUTUSA

Age-related macular degeneration(AMD)is the leading cause of irreversible blindness in adults over 50 years ***,epidemiological,and molecular studies are beginning to unravel the intricate mechanisms underlying this complex disease,which implicate the lipid-cholesterol pathway in the pathophysiology of disease development and *** of the genetic and environmental risk factors associated with AMD are also associated with other complex degenerative diseases of advanced age,including cardiovascular disease(CVD).In this review,we present epidemiological findings associating AMD with a variety of lipid pathway genes,cardiovascular phenotypes,and relevant environmental *** a number of studies showing significant associations between AMD and these lipid/cardiovascular factors,results have been mixed and as such the relationships among these factors and AMD remain *** is imperative that researchers not only tease out the various contributions of such factors to AMD development but also the connections between AMD and CVD to develop optimal precision medical care for aging adults.

关键词： Atherosclerosis Hypertension Retina Statins Stroke Cholesterol Obesity BMI Antioxidants Genetic association

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Recent developments in topoisomerase-targeted cancer chemotherapy

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Acta Pharmaceutica Sinica B 2018年第6期8卷 844-861页

作者： Kirk E.Hevener Tatsiana A.Verstak katie E.lutat Daniel l.Riggsbee Jeremiah W.Mooney Department of Pharmaceutical Sciences University of Tennessee Health Science Center

The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously in all domains of life. The various topoisomerase enzymes perform a wide range of functions related to the maintenance of DNA topology during DNA replication, and transcription are the targets of a wide range of antimicrobial and cancer chemotherapeutic agents. Natural product-derived agents, such as the camptothecin, anthracycline, and podophyllotoxin drugs, have seen broad use in the treatment of many types of cancer. Selective targeting of the topoisomerase enzymes for cancer treatment continues to be a highly active area of basic and clinical research. The focus of this review will be to summarize the current state of the art with respect to clinically used topoisomerase inhibitors for targeted cancer treatment and to discuss the pharmacology and chemistry of promising new topoisomerase inhibitors in clinical and preclinical development.

关键词： Topoisomerase Inhibition Cancer Oncology Clinical Pre-clinical

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Geographic segregation and evidence of density-dependent changes in sex ratios in an abundant colonial waterbird

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Integrative Zoology 2014年第5期9卷 570-582页

作者： Brian S.DORR katie C.HANSON-DORR Travis l.DeVAUlT Alban GUIllAUMET Scott C.BARRAS United States Department of Agriculture Wildlife Services(USDA-WS)National Wildlife Research CenterMississippi Field StationMississippi StateMississippiUSA USDA-WS National Wildlife Research CenterOhio Field StationSanduskyOhioUSA Department of Wildlife Fisheries and AquacultureMississippi State UniversityMississippi StateMississippiUSA USDA-WS MoseleyVirginiaUSA University of Hawaii Office of Research/PIPESHiloHIUSA.

Demographic information,such as geographic segregation of sexes and sex ratio data,is needed to develop,model and evaluate conservation and management strategies for wildlife.A variety of physiological,behavioral and environmental factors can influence segregation of sexes and sex ratios,many of which originate with density-dependent *** from 50:50 sex ratios of double-crested cormorants(Phalacrocorax auritus)collected during control efforts in breeding and wintering areas across their eastern range of the USA were evaluated using using a Z-test as well as Stouffer’s weighted *** addition,a specifically-designed randomization test was used to evaluate density-dependent effects on primary sex ratios in cormorants from egg collections and colony nest count data over a 21-year *** collected from breeding colonies were strongly male-biased,whereas cormorants collected from feeding flocks were slightly biased toward *** were partly segregated by sex on the wintering grounds,with significantly more males found in areas with intensive channel catfish *** null hypothesis that females produced a balanced sex ratio independent of number of nesting cormorants was rejected:more male embryos were produced during rapid population growth,whereas at maximum nesting number more female embryos were *** populations stabilized,the sex ratio was more *** examination of sex ratios indicates that different management methods and locations result in sex-biased culling of ***-biased culling in cormorants could make population reduction efforts more efficient and reduce overall *** suggest further research to examine density-dependent effects on primary sex ratios documented here.

关键词： Ashmole’s halo management Phalacrocorax auritus population growth sex ratio theory

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Time-lapse videography reveals different morphokinetic profiles of human embryos displaying direct or reverse cleavage at different stages of development: A retrospective sibling embryo study

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Asian pacific Journal of Reproduction 2020年第6期9卷 261-266页

作者： Chloé Brits katie Feenan Vince Chapple Phillip l.Matson Yan-he liu School of Medical and Health Science Edith Cowan UniversityJoondalupWestern AustraliaAustralia Fertility Specialists of Western Australia ClaremontWestern AustraliaAustralia Fertility North Joondalup Private HospitalJoondalupWestern AustraliaAustralia School of Human Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia Monash IVF Group SouthportQueenslandAustralia

Objective:To investigate morphokinetic characteristics of embryos displaying either reverse cleavage or direct cleavage during the first,second or third cleavage ***:A total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(35.0±4.6)years]were included for reverse cleavage analysis,and a total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(33.8±4.3)years]were included for direct cleavage analysis in this *** a sibling-embryo design,morphokinetic profiles(both before and after the onset of abnormal event)of embryos displaying reverse cleavage(n=241)or direct cleavage(n=244)were compared with their unaffected siblings(the controls)in the first,second and third cell cycles(n=32,n=142,n=562;n=195,n=412,n=205,respectively),at different developmental stages up to day ***:Direct cleavage embryos demonstrated significantly delayed cleavage rates prior to the event regardless of developmental stage of the occurrence,while reverse cleavage embryos showed similar cleavage rates to their unaffected *** event,direct cleavage embryos sped up cleavage rates while reverse cleavage embryos slowed ***:Altered morphokinetic profiles are displayed by direct cleavage embryos both before and after their occurrence and reverse cleavage embryos after the occurrence,which could potentially confound morphokinetic comparisons if not separated from their unaffected sibling *** study is warranted in order to fully understand the biological mechanisms of such events.

关键词： Time-lapse Direct cleavage Reverse cleavage Morphokinetics Cleavage abnormality

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Targeting multiple signaling pathways:the new approach to acute myeloid leukemia therapy

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Signal Transduction and Targeted Therapy 2021年第1期6卷 41-69页

作者： Jenna lCarter katie Hege Jay Yang Hasini AKalpage Yongwei Su Holly Edwards Maik Hüttemann Jeffrey WTaub Yubin Ge Cancer Biology Graduate Program Wayne State University School of MedicineDetroitMIUSA MD/PhD Program Wayne State University School of MedicineDetroitMIUSA Department of Oncology Wayne State University School of MedicineDetroitMIUSA Molecular Therapeutics Program Barbara Ann Karmanos Cancer InstituteWayne State University School of MedicineDetroitMIUSA Center for Molecular Medicine and Genetics Wayne State University School of MedicineDetroitMIUSA National Engineering laboratory for AIDS Vaccine Key Laboratory for Molecular Enzymology and EngineeringThe Ministry of EducationSchool of Life SciencesJilin UniversityChangchunChina Division of Pediatric Hematology/Oncology Children’s Hospital of MichiganDetroitMIUSA Department of Pediatrics Wayne State University School of MedicineDetroitMIUSA

Acute myeloid leukemia(AMl)is the most common form of acute leukemia in adults and the second most common form of acute leukemia in *** this,very little improvement in survival rates has been achieved over the past few *** is partially due to the heterogeneity of AMl and the need for more targeted therapeutics than the traditional cytotoxic chemotherapies that have been a mainstay in therapy for the past 50 *** the past 20 years,research has been diversifying the approach to treating AMl by investigating molecular pathways uniquely relevant to AMl cell proliferation and *** we review the development of novel therapeutics in targeting apoptosis,receptor tyrosine kinase(RTK)signaling,hedgehog(HH)pathway,mitochondrial function,DNA repair,and c-Myc *** has been an impressive effort into better understanding the diversity of AMl cell characteristics and here we highlight important preclinical studies that have supported therapeutic development and continue to promote new ways to target AMl *** addition,we describe clinical investigations that have led to FDA approval of new targeted AMl therapies and ongoing clinical trials of novel therapies targeting AMl survival *** also describe the complexity of targeting leukemia stem cells(lSCs)as an approach to addressing relapse and remission in AMl and targetable pathways that are unique to lSC *** comprehensive review details what we currently understand about the signaling pathways that support AMl cell survival and the exceptional ways in which we disrupt them.

关键词： myeloid approach approval

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Impaired glymphatic function in the early stages of disease in a TDP-43 mouse model of amyotrophic lateral sclerosis

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Translational Neurodegeneration 2022年第1期11卷 707-717页

作者： Akram Zamani Adam K.Walker Ben Rollo katie l.Ayers Raysha Farah Terence J.O’Brien David K.Wright Department of Neuroscience Central Clinical SchoolMonash UniversityMelbourneVIC 3004Australia Queensland Brain Institute The University of QueenslandSt LuciaQLD 4072Australia The Murdoch Children’s Research Institute The Royal Children’s HospitalParkvilleVIC 3052Australia Department of Pediatrics The University of MelbourneParkvilleVIC 3052Australia Department of Medicine The Royal Melbourne HospitalThe University of MelbourneParkvilleVIC 3052Australia

Background: Multiple lines of evidence suggest possible impairment of the glymphatic system in amyotrophic lateral sclerosis (AlS). To investigate this, we used in vivo magnetic resonance imaging (MRI) to assess glymphatic func-tion early in the course of disease in a transgenic mouse with doxycycline (Dox)-controlled expression of cytoplasmic human TDP-43 (hTDP-43ΔNlS), mimicking the key pathology implicated in AlS. Methods: Adult TDP-43 transgenic and littermate monogenic control mice underwent longitudinal multimodal MRI one and three weeks after the cessation of Dox feed, together with weekly rotarod assessments of motor per-formance. Glymphatic function was assessed using dynamic contrast-enhanced MRI to track the clearance of an MR contrast agent injected into the cisterna magna. Results: Compared to their littermate controls, TDP-43 mice exhibited progressive neurodegeneration including that within the primary motor cortex, primary somatosensory cortex and corticospinal tract, significant weight loss includ-ing gastrocnemius atrophy, and shortened telomere length. Furthermore, in the presence of this AlS-like phenotype, these mice have significantly disrupted glymphatic function. Conclusions: Although the relationship between glymphatic clearance and AlS disease progression remains to be elucidated, these changes occurred very early in the disease course. This provides initial evidence to suggest that the glymphatic system might be a potential therapeutic target in the treatment of AlS.

关键词： Magnetic resonance imaging Diffusion-weighted imaging Neurodegeneration Cerebrospinal fluid Telomere

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Clinical lesson learned from genetic analysis in patients prior to surgical repair of hypospadias

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Asian Journal of Urology 2022年第2期9卷 186-189页

作者： Nurin A.listyasari Gorjana Robevska katie l.Ayers Tiong Yang Tan Andrew H.Sinclair Sultana M.H.Faradz Division of Human Genetics Center for Biomedical ResearchFaculty of Medicine Diponegoro UniversitySemarangIndonesia Murdoch Children’s Research Institute MelbourneAustralia Department of Paediatrics University of MelbourneMelbourneAustralia Victorian Clinical Genetics Services Murdoch Children’s Research InstituteMelbourneAustralia Diponegoro National Hospital SemarangIndonesia

In Indonesia,undervirilisation in 46,XY males is the most common form of difference of sex development(DSD).This can include hypospadias(misplacement of the urethra),micropenis,bifid scrotum,and undescended testis[1].Undervirilisation or 46,XY DSD can be associated with a number of congenital syndromes,including Smith-lemli-Opitz Syndrome(OMIM 602858),caused by an inborn error of cholesterol synthesis,and characterised by growth delay,intellectual disability,microcephaly,distinctive facial features,cleft palate,limb anomalies,and hypospadias[2]or Opitz syndrome(also known as Opitz G/BBB syndrome).Opitz syndrome can be caused by variants in the X-linked midline 1(MID1)gene(Type I)or in an autosomal dominant manner by monoallelic variants in sperm antigen with calponin homology and coiled-coil domains 1-like(SPECC1l)on chromosome 22q11.2(Type II)[3].Opitz syndrome is characterised by hypospadias,hypertelorism,cleft lip/palate,and heart defects[4].The prevalence of X-linked Opitz syndrome is estimated to be from 1 in 50000 to 1 in 100000 males[5].Recognition of a syndrome informs appropriate clinical management and patient ***,although these syndromes are rare,hypospadias may be diagnosed before the emergence of other comorbidities meaning that it is crucial for clinicians to perform a thorough clinical evaluation with syndromic causes in mind.

关键词： cholesterol analysis prior

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