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Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVID-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jacobs Steven D Morley Kay Samuel katie morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield Peter C Hayes John N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** injury(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVID-19),while preexisting MASLD increases the risk of LI and the development of COVID-19-associated *** of injury at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVID-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic ACE2 levels are altered during progression of MASLD and in patients who died with severe *** ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVID-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLD *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVID-19 COVID-19-associated cholangiopathy

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Exploring the associations between skeletal muscle echogenicity and physical function in aging adults:A systematic review with meta-analyses

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Journal of Sport and Health Science 2024年第6期13卷 820-840页

作者： Dustin J.Oranchuk Stephan G.Bodkin katie L.Boncella Michael O.Harris-Love Muscle Morphology Mechanicsand Performance LaboratoryDepartment of Physical Medicine and RehabilitationUniversity of Colorado Anschutz Medical CampusAuroraCO 80045USA Department of Physical Therapy

Background:Assessment and quantification of skeletal muscle within the aging population is vital for diagnosis,treatment,and injury/disease *** clinical availability of assessing muscle quality through diagnostic ultrasound presents an opportunity to be utilized as a screening tool for function-limiting ***,relationships between muscle echogenicity and clinical functional assessments require authoritative ***,we aimed to(a) synthesize the literature to assess the relationships between skeletal muscle echogenicity and physical function in older adults(≥60 years),(b) perform pooled analyses of relationships between skeletal muscle echogenicity and physical function,and(c) perform sub-analyses to determine between-muscle ***:CINAHL,Embase,MEDLINE,PubMed,and Web of Science databases were systematically searched to identify articles relating skeletal muscle echogenicity to physical function in older ***-of-bias assessments were conducted along with funnel plot ***-analyses with and without sub-analyses for individual muscles were performed utilizing Fisher's Z transformation for the most common measures of physical ***'s Z was back-transformed to Pearson's r for ***:Fifty-one articles(n=5095,female=~2759,male=~2301,72.5± 5.8 years,mean±SD(1 study did not provide sex descriptors))were extracted for review,with previously unpublished data obtained from the authors of 13 *** rectus femoris(n=34) and isometric knee extension strength(n=22) were the most accessed muscle and physical qualities,*** relationship between quadriceps echogenicity and knee extensor strength was moderate(n=2924,r=-0.36(95% confidence interval:-0.38 to-0.32),p <0.001),with all other meta-analyses(grip strength,walking speed,sit-to-stand,timed up-and-go) resulting in slightly weaker correlations(r:-0.34 to-0.23,all p <0.001).Sub-analyses determined minimal differences in predicti

关键词： Correlations Echo intensity Elderly Intramuscular fat Strength

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Impact of Social Determinants of Health on Self-Perceived Resilience: An Exploratory Study of Two Cohorts of Adults with Congenital Heart Disease

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Congenital Heart Disease 2024年第1期19卷 33-48页

作者： Albert Osom Krysta S.Barton katie Sexton Lyndia Brumback Joyce P.Yi-Frazier Abby R.Rosenberg Ruth Engelberg Jill M.Steiner Department of Biostatistics University of WashingtonSeattleWA98195USA Biostatistics Epidemiology and Analytics for Research(BEAR)Core Seattle Children’s Research InstituteSeattleWA98101USA College of Medicine University of WashingtonSeattleWA98195USA Center for Clinical and Translational Research Seattle Children’s Research InstituteSeattleWA98101USA Department of Psychosocial Oncology and Palliative Care Dana-Farber Cancer InstituteDepartment of MedicineBoston Children’s HospitalBostonMA02215USA Department of Pediatrics Harvard Medical SchoolBostonMA02215USA Division of Pulmonary Critical Care and Sleep MedicineDepartment of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonHarborview Medical CenterSeattleWA98104USA Division of Cardiology Department of Medicine&Cambia Palliative Care Center of ExcellenceUniversity of WashingtonSeattleWA98195USA

Social determinants of health(SDOH)affect quality of *** investigated SDOH impacts on self-perceived resilience among people with adult congenital heart disease(ACHD).Secondary analysis of data from two com-plementary studies:a survey study conducted May 2021–June 2022 and a qualitative study conducted June 2020–August *** was assessed through CD-RISC10 score(range 0–40,higher scores reﬂect greater self-perceived resilience)and interview *** and SDOH(education,employment,living situa-tion,monetary stability,ﬁnancial dependency,area deprivation index)data were collected by healthcare record review and *** used linear regression with robust standard errors to analyze survey data and performed a thematic analysis of interview *** participants(N=127)mean age was 42±14 years;51%were female,87%*** was moderate(75%)or complex(25%);41%functional class C or ***(mean 30±7)varied by monetary stability:compared to people with difﬁculty paying bills,resilience was 15.0 points higher(95%CI:6.9–23.1,p<0.001)for people reporting having enough money and 14.2 points higher(95%CI:5.9–22.4,p=0.001)for those reporting just enough *** participants’(N=25)mean age was 32 years(range 22–44);52%were female,72%*** was moderate(56%)or complex(44%);76%functional class C or *** discussed factors affecting resilience aligned with each of the major SDOH,prominently,economic stability and healthcare access and *** stability may be important for supporting self-perceived resi-lience in *** knowledge can inform the development of resilience interventions for this population.

关键词： Social determinants of health adult congenital heart disease resilience ﬁnancial stability

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Biomass gasification,catalytic technologies and energy integration for production of circular methanol:New horizons for industry decarbonisation

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Journal of Environmental Sciences 2024年第6期140卷 306-318页

作者： Luis F.Bobadilla Lola Azancot Miriam González-Castañ Estela Ruíz-López Laura Pastor-Pérez Francisco J.Durán-Olivencia Runping Ye katie Chong Paula HBlanco-Sánchez Zenthao Wu Tomás R.Reina JoséA.Odriozola Departamento de Química Inorgánica e Instituto de Ciencia de Materiales de Sevilla Centro Mixto CSIC-Universidad de SevillaAvda.Américo Vespucio 49Sevilla 41092Spain Departamento de Ingeniería Universidad Loyola AndalucíaAvda.de Las Universidades s/nSevilla 41704Spain Key Laboratory of Jiangxi Province for Environment and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirminghamB47ETUnited Kingdom Department of Chemical and Process Engineering University of SurreyGuildfordGU27XHUnited Kingdom

The Intergovernmental Panel on Climate Change(IPCC)recognises the pivotal role of renewable energies in the future energy system and the achievement of the zero-emission *** implementation of renewables should provide major opportunities and enable a more secure and decentralised energy supply *** fuels provide long-term solutions for the transport sector,particularly for applications where fuels with high energy density are *** addition,it helps reducing the carbon footprint of these sectors in the *** on biomass characteristics feedstock is essential for scaling-up gasification from the laboratory to *** review deals with the transformation biogenic residues into a valuable bioenergy carrier like biomethanol as the liquid sunshine based on the combination of modified mature technologies such as gasification with other innovative solutions such as membranes and microchannel *** abatement is a critical process in product gas upgrading since tars compromise downstream processes and equipment,for this,membrane technology for upgrading syngas quality is discussed in this *** reactor technology with the design of state-of-the-art multifunctional catalysts provides a path to develop decentralised biomethanol synthesis from biogenic ***,the development of a process chain for the production of(i)methanol as an intermediate energy carrier,(ii)electricity and(iii)heat for decentralised applications based on biomass feedstock flexible gasification,gas upgrading and methanol synthesis is analysed.

关键词： Biogenic residues Gasification Biomethanol Circular Economy Microreactors

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格雷森的周末课程项目

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英语画刊(高中版) 2024年第2期 19-21页

作者： katie Clark

星期五放学前星期五放学前，史密斯先生给全班布置了一个周末课程项目。大家都很兴奋，唯独格雷森似乎闷闷不乐——参考译文：格雷森独自坐在放学回家的公交车上，他不想和朋友或任何人说话。他们都在讨论周末的课程项目。他们很兴奋，...

星期五放学前星期五放学前，史密斯先生给全班布置了一个周末课程项目。大家都很兴奋，唯独格雷森似乎闷闷不乐——参考译文：格雷森独自坐在放学回家的公交车上，他不想和朋友或任何人说话。他们都在讨论周末的课程项目。他们很兴奋，他们不明白格雷森为什么不兴奋。他也不打算解释。格雷森一想到自己毫无兴奋之情，就窘迫得脸颊发热。他们的父母都愿意帮他们，他们怎么能理解他的感受呢？格雷森找不到人帮忙，他妈妈一直在工作，他爸爸从来不想和他一起做任何事。

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证书并非一切

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科学新闻 2024年第1期 59-60页

作者： katie Suleta 倪伟波乔治华盛顿大学 HCA医疗保健公司

“你真聪明！你为什么没有博士学位？”这个问题是作为赞美而提出的，但总感觉像是一记耳光打在我脸上。我在这家公司工作了两个星期，每个人似乎都喜欢我所做的工作——我的观点以及为团队设想的方向。但只有一个小问题——我还没有完...

“你真聪明！你为什么没有博士学位？”这个问题是作为赞美而提出的，但总感觉像是一记耳光打在我脸上。我在这家公司工作了两个星期，每个人似乎都喜欢我所做的工作——我的观点以及为团队设想的方向。但只有一个小问题——我还没有完成博士学位。所有和我一起工作的受过高等教育的人似乎都知道这一点——而且他们不会让我忘记。我知道没有博士学位并不会降低我的能力，这不意味着我不够聪明或是不适合待在这个房间里。事实上，我很自豪的是，

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专注于前进——马克·塞洛

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中国花卉园艺 2024年第8期 15-18页

作者：李艳梅(译) katie Mcdaniel 不详

在富有远见的领导者马克·塞洛(Mark Sellew)的带领下,美国的骄傲角农场(Prides Corner Farms)始终关注未来,并不断寻求改善业务的方法,使公司在不断变化的行业中一直保持着市场地位和竞争力。

关键词：竞争力马克远见

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From filaments to function: The role of the plant actin cytoskeleton in pathogen perception,signaling and immunity

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Journal of Integrative Plant Biology 2016年第4期58卷 299-311页

作者： katie Porter Brad Day Graduate Program in Cell and Molecular Biology Michigan State University Department of Plant Soil and Microbial Sciences Michigan State University Graduate Program in Genetics Michigan State University

The eukaryotic actin cytoskeleton is required for numerous cellular processes, including cell shape, development and movement, gene expression and signal transduction, and response to biotic and abiotic stress. In recent years,research in both plants and animal systems have described a function for actin as the ideal surveillance platform, linking the function and activity of primary physiological processes to the immune system. In this review, we will highlight recent advances that have defined the regulation and breadth of function of the actin cytoskeleton as a network required for defense signaling following pathogen infection. Coupled with an overview of recent work demonstrating specific targeting of the plant actin cytoskeleton by a diversity of pathogens,including bacteria, fungi and viruses, we will highlight the importance of actin as a key signaling hub in plants, one that mediates surveillance of cellular homeostasis and the activation of specific signaling responses following pathogen perception. B4 ased on the studies highlighted herein, we propose a working model that posits changes in actin filament organization is in and of itself a highly specific signal, which induces, regulates and physically directs stimulus-specific signaling processes, most importantly, those associated with response to pathogens.

关键词： Actin cytoskeleton immunity pathogen plant Pseudomonas syringae surveillance

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追踪北美日全食

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环球科学 2024年第7期 92-93页

作者：凯蒂·皮克红猪(译) 不详

今年四月,遮天蔽日的阴影将以一种独特的方式扫过北美洲。太阳的体积比月球大400倍,但它和我们的距离也比月球大400倍——这是一个宇宙级别的壮丽巧合,造成了两者排成一线的时候,月球会正好将太阳的面目遮挡起来。遮挡的结果就是日全食... 详细信息

今年四月,遮天蔽日的阴影将以一种独特的方式扫过北美洲。太阳的体积比月球大400倍,但它和我们的距离也比月球大400倍——这是一个宇宙级别的壮丽巧合,造成了两者排成一线的时候,月球会正好将太阳的面目遮挡起来。遮挡的结果就是日全食。这种连线效果只能在一条狭长地带上看见,那就是“全食带”(path of totality),它将在今年4月8日沿弧线扫过北美大陆。

关键词：日全食全食带北美大陆狭长地带扫过遮挡北美洲

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The“Dragging Foot”of Jose Garcia Villa’s Performative“Comma Poems”

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Journal of Foreign Languages and Cultures 2022年第2期6卷 121-131页

作者： katie Bradshaw University of Southern California

Jose Garcia Villa’s "comma poem,"in which he introduces“a new,special and poetic use”for the comma,is arguably the poet's most contentious *** from an appropriation of Leonard Caspar’s description of the comma poems as "demonstrably malfunctional as a dragging foot,"this essay argues that the comma poem was a visual performance whereby Villa dis-oriented and de-naturalized poetic“flows”through a quccr/crip aesthetic of hesitation and *** as footsteps and/or footnotes,the comma’s minor mark interrupts and dis-ablcs normative flow,forcing the reader to adopt a nonnormative“gait.”Utilizing Sara Ahmed’s phenomenological theory of "queer orientation,"I examine how the comma poems’specific incongruity extends beyond modem grammars:anticipating readings of his“foreignness”and"insensitivity"to the English *** performs the essentiality of the“minor mark”through linguistic *** doing so,he queers not only the“direction”of modem poetry and its canonicity,but also a contemporary politics of recuperation.

关键词： JoséGarcia Villa modernist poetry commas Sara Ahmed queer/erip theory

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