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怎样预示孔隙压力

国外地质勘探技术 1984年第8期 39-43页

作者： Dr.Preston l.moore 宋希雄

钻孔孔内情况主要通过监测设备来掌握,这些监测设备包括:(1)泵压表,(2)扭矩表,(3)泥浆池液面指示器,(4)泥浆性能测试仪器,(5)钻速记录器,(6)钻压指示器。只有当钻头下的岩屑能立即排走,才能清楚地了解孔内情况。孔底清洁的重要意义

关键词：孔隙压力增加值岩石钻速泥浆比重钻井液密度

Recent developments in topoisomerase-targeted cancer chemotherapy

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Acta Pharmaceutica Sinica B 2018年第6期8卷 844-861页

作者： Kirk E.Hevener Tatsiana A.Verstak katie E.lutat Daniel l.Riggsbee Jeremiah W.Mooney Department of Pharmaceutical Sciences University of Tennessee Health Science Center

The DNA topoisomerase enzymes are essential to cell function and are found ubiquitously in all domains of life. The various topoisomerase enzymes perform a wide range of functions related to the maintenance of DNA topology during DNA replication, and transcription are the targets of a wide range of antimicrobial and cancer chemotherapeutic agents. Natural product-derived agents, such as the camptothecin, anthracycline, and podophyllotoxin drugs, have seen broad use in the treatment of many types of cancer. Selective targeting of the topoisomerase enzymes for cancer treatment continues to be a highly active area of basic and clinical research. The focus of this review will be to summarize the current state of the art with respect to clinically used topoisomerase inhibitors for targeted cancer treatment and to discuss the pharmacology and chemistry of promising new topoisomerase inhibitors in clinical and preclinical development.

关键词： Topoisomerase Inhibition Cancer Oncology Clinical Pre-clinical

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Geographic segregation and evidence of density-dependent changes in sex ratios in an abundant colonial waterbird

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Integrative Zoology 2014年第5期9卷 570-582页

作者： Brian S.DORR katie C.HANSON-DORR Travis l.DeVAUlT Alban GUIllAUMET Scott C.BARRAS United States Department of Agriculture Wildlife Services(USDA-WS)National Wildlife Research CenterMississippi Field StationMississippi StateMississippiUSA USDA-WS National Wildlife Research CenterOhio Field StationSanduskyOhioUSA Department of Wildlife Fisheries and AquacultureMississippi State UniversityMississippi StateMississippiUSA USDA-WS MoseleyVirginiaUSA University of Hawaii Office of Research/PIPESHiloHIUSA.

Demographic information,such as geographic segregation of sexes and sex ratio data,is needed to develop,model and evaluate conservation and management strategies for wildlife.A variety of physiological,behavioral and environmental factors can influence segregation of sexes and sex ratios,many of which originate with density-dependent *** from 50:50 sex ratios of double-crested cormorants(Phalacrocorax auritus)collected during control efforts in breeding and wintering areas across their eastern range of the USA were evaluated using using a Z-test as well as Stouffer’s weighted *** addition,a specifically-designed randomization test was used to evaluate density-dependent effects on primary sex ratios in cormorants from egg collections and colony nest count data over a 21-year *** collected from breeding colonies were strongly male-biased,whereas cormorants collected from feeding flocks were slightly biased toward *** were partly segregated by sex on the wintering grounds,with significantly more males found in areas with intensive channel catfish *** null hypothesis that females produced a balanced sex ratio independent of number of nesting cormorants was rejected:more male embryos were produced during rapid population growth,whereas at maximum nesting number more female embryos were *** populations stabilized,the sex ratio was more *** examination of sex ratios indicates that different management methods and locations result in sex-biased culling of ***-biased culling in cormorants could make population reduction efforts more efficient and reduce overall *** suggest further research to examine density-dependent effects on primary sex ratios documented here.

关键词： Ashmole’s halo management Phalacrocorax auritus population growth sex ratio theory

Time-lapse videography reveals different morphokinetic profiles of human embryos displaying direct or reverse cleavage at different stages of development: A retrospective sibling embryo study

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Asian pacific Journal of Reproduction 2020年第6期9卷 261-266页

作者： Chloé Brits katie Feenan Vince Chapple Phillip l.Matson Yan-he liu School of Medical and Health Science Edith Cowan UniversityJoondalupWestern AustraliaAustralia Fertility Specialists of Western Australia ClaremontWestern AustraliaAustralia Fertility North Joondalup Private HospitalJoondalupWestern AustraliaAustralia School of Human Sciences University of Western AustraliaCrawleyWestern AustraliaAustralia Monash IVF Group SouthportQueenslandAustralia

Objective:To investigate morphokinetic characteristics of embryos displaying either reverse cleavage or direct cleavage during the first,second or third cleavage ***:A total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(35.0±4.6)years]were included for reverse cleavage analysis,and a total of 167 in vitro fertilization and/or intracytoplasmic sperm injection treatment cycles undertaken by 167 women[aged(33.8±4.3)years]were included for direct cleavage analysis in this *** a sibling-embryo design,morphokinetic profiles(both before and after the onset of abnormal event)of embryos displaying reverse cleavage(n=241)or direct cleavage(n=244)were compared with their unaffected siblings(the controls)in the first,second and third cell cycles(n=32,n=142,n=562;n=195,n=412,n=205,respectively),at different developmental stages up to day ***:Direct cleavage embryos demonstrated significantly delayed cleavage rates prior to the event regardless of developmental stage of the occurrence,while reverse cleavage embryos showed similar cleavage rates to their unaffected *** event,direct cleavage embryos sped up cleavage rates while reverse cleavage embryos slowed ***:Altered morphokinetic profiles are displayed by direct cleavage embryos both before and after their occurrence and reverse cleavage embryos after the occurrence,which could potentially confound morphokinetic comparisons if not separated from their unaffected sibling *** study is warranted in order to fully understand the biological mechanisms of such events.

关键词： Time-lapse Direct cleavage Reverse cleavage Morphokinetics Cleavage abnormality

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全光纤相位和偏振调制器评述

应用光学 1988年第3期 48-53页

作者： Ramon P.De Paula Emery l.moore 高学武

一、前言光纤工作者致力于光纤光信号调制技术的研究到现在至少已经有十年了。这种技术是变化的相位、偏振和频率技术。可是,尽管相位和偏振调制技术可以用名为“全光纤”法(即无破损或无接头的光纤)的非常有效的方式来完成,但全光纤技... 详细信息

一、前言光纤工作者致力于光纤光信号调制技术的研究到现在至少已经有十年了。这种技术是变化的相位、偏振和频率技术。可是,尽管相位和偏振调制技术可以用名为“全光纤”法(即无破损或无接头的光纤)的非常有效的方式来完成,但全光纤技术用于调频系统却不是很有效的(在2％以下)。到目前为止,由于实用的调频技术只局限于用光纤外面的大块布喇格盒介质,现在讨论光纤内的频率调制时机尚未成熟。所以,本文将评述在原位显示的光纤调制技术上用的光信号调制技术,即全光纤相位和偏振的调制。

关键词：调制器相移偏振调制护套激光调制全光纤压电换能器相位

Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease

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World Journal of Gastroenterology 2016年第8期22卷 2611-2620页

作者： Alice l Bennett David moore Peter A Bampton Robert V Bryant Jane M Andrews Department of Gastroenterology Royal Adelaide Hospital North Terrace Adelaide SA 5000 Australia Department of Gastroenterology Flinders Medical Centre Flinders Drive Bedford Park SA 5042 Australia School of Medicine University of Adelaide Adelaide SA 5000 Australia Department of Gastroenterology Women's and Children's Hospital Adelaide SA 5006 Australia School of Medicine Flinders University Adelaide SA 5001 Australia

AIM: To describe the disease and psychosocial outcomes of an inflammatory bowel disease (IBD) transition cohort and their ***: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition ***: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance (35%), there was a very low usage (5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority (54%) felt they were not strongly prepared. A high rate (78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex (8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices (of the options offered) was a shared clinic appointment with all key ***: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans.

关键词： Transition care Crohn’ s disease Ulcerative colitis Chronic illness Inflammatory bowel disease Patient perspectives Disease outcomes

Comparison of phase unwrapping algorithms for living cell's interference pattern

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Journal of Beijing Institute of Technology 2013年第4期22卷 530-535页

作者：王霞佟洁王萌 SCHMIDT Greg moore Duncan T. MCGRATH James l. School of Optoelectronics Beijing Institute of Technology Institute of Optics University of Rochester Biomedical Engineering University of Rochester

A multiphase microscopic interference system is designed to measure the height of cell which is important to the research of collective cell migration in physiology and medicine. This sys- tem can quantitatively measure cell height across a living monolayer without knowing the refractive index of cells. For the interference pattern, because the phases are all wrapped between - π to π, it is necessary to get the real phase through phase unwrapping,a method to restore the wrapped phase data of the object by using numerical calculations. Three representative algorithms are selected to unwrap the interference pattern of ceils： branch-cut method, quality-guided method and network method. Although each of them can restore the phase, their performances are obviously different. We compare these methods and find that branch-cut method needs the smallest execution time and can obtain good unwrapped patterns when noises are not serious.

关键词： unwrapping algorithms interference pattern cell height branch-cut quality-guided

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防治潜叶蝇的新的昆虫生长调节剂cyromazine

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世界农药 1987年第5期 61-64页

作者： T.Schlapfer T.Cotti l.moore 杜英娟瑞士汽巴-嘉基公司瑞士汽巴-嘉基公司瑞士汽巴-嘉基公司

1976年在华盛顿召开的第15届国际昆虫学会上,瑞士汽巴-嘉基公司提出了一种新的昆虫生长调节剂,其对双翅目幼虫和蛹的发育有强抑制作用,代号为CGA-t9255(2-叠氮基4-环丙氨基-6-乙氨基均三嗪)。进一步研究表明,它的主要代谢物eyromazine... 详细信息

1976年在华盛顿召开的第15届国际昆虫学会上,瑞士汽巴-嘉基公司提出了一种新的昆虫生长调节剂,其对双翅目幼虫和蛹的发育有强抑制作用,代号为CGA-t9255(2-叠氮基4-环丙氨基-6-乙氨基均三嗪)。进一步研究表明,它的主要代谢物eyromazine与母体化合物同样有效,并且无药害。

关键词：有效成份幼虫昆虫生长调节剂防治效果 cyromazine 剂量用药量

Evolutionary lineages and Functional Diversification of Plant Hexokinases

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Molecular Plant 2010年第2期3卷 334-346页

作者： Rucha Karve Michael lauria Annie Virnig Xiaoxia Xia Bradley l. Rauh Brandon d. moore Department of Genetics and Biochemistry Clemson University Clemson SC 29634 USA

Sequencing data from 10 species show that a plant hexokinase （HXK） family contains 5-11 genes. Functionally, a given family can include metabolic catalysts, glucose signaling proteins, and non-catalytic, apparent regulatory enzyme homologs. This study has two goals. The first aim is to develop a predictive method to determine which HXK proteins within a species have which type of function. The second aim is to determine whether HXK-dependent glucose signaling proteins occur among more primitive plants, as well as among angiosperms. Using a molecular phylogeny ap- proach, combined with selective experimental testing, we found that non-catalytic HXK homologs might occur in all plants, including the relatively primitive Selaginella moellendorffi. We also found that different lineages of angiosperm HXKs have apparent conserved features for catalytic activity and for sub-cellular targeting. Most higher-plant HXKs are expressed predominantly at mitochondria, with HXKs of one lineage occurring in the plastid, and HXKs of one monocot lineage occurring in the cytosol. Using protoplast transient expression assays, we found that HXK glucose signaling pro- teins occur likely in all higher plants and in S. moellendorffi as well. Thus, the use of glucose by plant HXK isoforms in metabolism and/or as a regulatory metabolite occurs as widespread, conserved processes.

关键词： Hexokinase molecular phylogeny moonlighting proteins plant glucose signaling Selaginella.