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World Journal of Nephrology 2014年第1期3卷 6-15页

作者： katia lópez-revuelta Patricia Pea Galdo Ramona Stanescu leticia Parejo Carmen Guerrero Elia Pérez-Fernández Unidad de Nefrología Hospital Universitario Fundación Alcorcón 28922 Madrid Spain Unidad de AnatomíaPatológica Hospital Universitario Fundación Alcorcón 28922 Madrid Spain Unidad de Investigación Hospital Universitario Fundación Alcorcón 28922 Madrid Spain

AIM： To examine the risk of renal events in patients with biopsy-proven diabetic nephropathy （DN） and its possible associated ***： Clinical and histological data of 60 pa-tients diagnosed with diabetic nephropathy were retro-spectively collected. Patients with evidence or suspicion of other nephropathies were excluded from the study. The fnal event was defned as renal replacement ther-apy （RRT） initiation or progression of chronic kidney disease （CKD）, according to the KDIGO 2012 defnition of a decrease in CKD category and a decrease in GFR of 25% or more. RESUlTS： A total of 45 patients with a follow-up of at least 3 mo were included. Most of the patients presented type 2 DM, with a mean age of 58.3 years old. The time of evolution of DM was 9.6 ± 7.8 years, al-though in 13 patients, it was less than 5 years. A total of 62% of patients reached the fnal event in a mean period of 3.4 years （95%CI： 2.1-4.7）, with 21 of them requiring dialysis. The factors that were indepen-dently associated with renal survival were estimated glomerular fltration rate （eGFR） at the time of biopsy, cardiovascular disease （CVD） history and HbA1c less than 7%. Therefore, for each 10 ml/min per 1.73 m2 reduction in eGFR, we obtained a DN progression risk of HR = 2 （1.3-3.0）（P = 0.001）; patients with CVD were at greater risk for DN progression （HR = 2.8, 1.1-7.1, P = 0.032）, and CKD patients with HbA1c 〈 7% demonstrated greater renal risk than patients with HbA1c ≥ 7%, with an HR of 2.9 （1.0-8.4）（P = 0.054）.CONClUSION： A past history of CVD is a risk fac-tor for DN progression. levels of HbA1c less than 7% could favor an eGFR decrease in these patients.

关键词： Diabetic nephropathy Predictors of progression Histopathological diagnosis Cardiovascular disease Silent disease

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A New Member of the Thioredoxin Reductase Family from Early Oxygenic Photosynthetic Organisms

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Molecular Plant 2017年第1期10卷 212-215页

作者： Rubén M. Buey Sergio Galindo-Trigo luis lópez-Maury Adrián Velázquez-Campoy José luis revuelta F. Javier Florencio José M. de Pereda Peter Schürmann Bob B. Buchanan Monica Balsera Department of Plant and Microbial Biology University of California Berkeley CA 94720 USA

Dear Editor,Thioredoxins （Trxs） are key components of the redox system that regulates the activity of a spectrum of target proteins through dithiol-disulfide exchange reactions. Trxs are reduced by mem- bers of the Trx reductase （TR） family （Jacquot et al., 2009）. NADP-dependent thioredoxin reductases （NTRs）, the most com-mon type, belong to the family of dimeric pyridine nucleotide disul-fide oxidoreductase flavoproteins that use NADPH as the source of reducing equivalents.

关键词： Thioredoxin Early Organisms

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