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Anthocyanins from purple corn affect gut microbiota and metabolome in inflammatory bowel disease patients under infliximab infusion: the SiCURA pilot study

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Food Science and Human Wellness 2024年第6期13卷 3536-3543页

作者： Mirco Vacca Eduardo Maria Sommella Marina Liso Giulio Verna Aurelia Scarano Annamaria Sila Margherita Curlo Mauro Mastronardi katia petroni Chiara Tonelli Bruno Di Jeso Angelo Santino Vincenzo Vestuto Fabrizio Merciai Gianluigi Giannelli Pietro Campiglia Maria De Angelis Marcello Chieppa Francesco Maria Calabrese Department of Soil Plant and Food ScienceUniversity of Bari Aldo MoroBari 70126Italy Department of Pharmacy School of PharmacyUniversity of SalernoFisciano 84084Italy Functional Gastrointestinal Disorders Research Group National Institute of Gastroenterology IRCCS“S.de Bellis”Castellana Grotte 70013Italy Department of Medicine Digestive Health Research InstituteCase Western Reserve University School of MedicineCleveland 44106USA Unit of Lecce Institute of Sciences of Food Production C.N.R.Lecce 73100Italy Department of Biosciences University of MilanMilan 20133Italy Department of Biological and Environmental Sciences and Technologies University of SalentoLecce 73100Italy Department of Biological and Environmental Sciences and Technologies(DISTEBA) University of SalentoLecce 73100Italy

Nowadays,inflammatory bowel disease(IBD)-patient therapies are mainly based on corticosteroid,thiopurine,and immunomodulator *** with active disease,that do not respond to corticosteroid and/or thiopurine treatment,can switch to the usage of the chimeric monoclonal antibody infliximab(IFX).However,to date,no treatment appeared to be conclusive in lowering the incidence of IBD *** the aim to increase the effectiveness of IFX treatment,we combined it with an adjuvant purple corn supplementation enriched in ***-patients were enrolled before they underwent to the IFX-infusion,and they were allocated in 2 different study *** in the intervention-arm followed a dietary supplementation with purple corn water-soluble extract,whereas control patients had a daily consumption of red fruit tea.16S rDNA gene-sequencing and high-resolution mass-spectrometry metabo-lipidomics analyses were conducted on stool and sera samples,*** a result,the experimental intervention mainly affected the serum metabolome of IBD-patients by decreasing the concentration of specific *** on IBD patient annotated taxa,a significant decrease in Lactobacillus and Bifi dobacterium relative abundances was *** far as it concerns the ulcerative colitis patient subset,the experimental intervention led to a decrease in Alistipes and Erysipelotrichaceae UCG-003 genus abundances and a concomitant Parabacteroides *** the contrary,after treatment,Crohn’s disease patients did not exhibit metataxonomics differences at the genus *** the end of the treatment that led to a reshaped microbiota community,the gathered data paves the way for the usage of a specifically designed probiotic supplementation as a valuable strategy for IBD-patients under IFX infusion.

关键词： Inflammatory bowel disease infliximab infusion Antioxidants Nutrigenomics Adjuvant therapy

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