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A Short-Term Intervention to Reduce Stress Levels in Workplace for Office Worker at UEFA—The Union of European Football Associations in Nyon/Switzerland

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Open j.urnal of Preventive Medicine 2021年第5期11卷 211-228页

作者： katia A. Henry Karl j. Neeser Claus Muss Health Management Collegium Humanum Warsaw Management University Warsaw Poland College Public Health Sciences Chulalongkorn University Bangkok Thailand School Public Health and Social Work St Elizabeth University Bratislava Slovakia

Background: Today, according to the WHO, workplace stress is particularly common. Several medical and scientific studies have shown that workplace stress can have a serious impact on overall health, a triggering or aggravating factor for many diseases and pathological conditions. This study was conducted to investigate the effects of a stress-reducing eight-week workshop and online messages campaign on office workers. Methods: To collect data of this quasi-experimental study with pre- and post-test, DASS-21 (Depression Anxiety Stress Scale) was used (only part stress;14 items). For eligible samples, stress-reducing workshops and online messages were held for 8 weeks by a specialist. Data were analyzed using SPSS version 20. Results: Of the 68 participants at the beginning, 43 participants were able to follow up on the 8-week campaign. The drop of participants must be explained by the sudden Covid-19 situation and the postponement of the UEFA EURO 2020 football activities. Overall, 13 of 14 items of stress perception had a decreased score number from pre-test to the post-test results in participants. The test results revealed that there was a significant difference mean of stress score before and after the participants got the campaign with the p-value less than 0.001. The mean difference was 4.18. It meant that after the campaign the mean of the stress score decrease was 4.18. Conclusion: The intervention at the workplace of office employees at UEFA, the United European Football Association, has shown that simple specific lifestyle behaviors, wrapped up in weekly workshops and online messages over a period of eight weeks, significantly reduced stress and stress-related conditions in office employees and improved positive dimensions of mental health and stress-related behavior. This campaign can be applicable to office workers of any type of organization or company.

关键词： Stress Stress Management Office Workers Workplace Lifestyle Behaviors

Corrigendum to ‘Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes’ [Gene Dis (10) (2023),1187–1189]

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Genes & Diseases 2024年第2期11卷 1084-1084页

作者： Giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi katia De Marco Valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo Nicoletta Resta Vittoria Disciglio Cristiano Simone Medical Genetics National Institute of Gastroenterology “S. de Bellis” Research Hospital Castellana Grotte Bari 70013 Italy Medical Genetics Department of Precision and Regenerative Medicine and Jonic Area (DiMePRe-J) University of Bari Aldo Moro Bari 70124 Italy

What a few hairs can tell us about the resource use of giant armadillos

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Integrative Zoology 2023年第1期18卷 129-142页

作者： Marcelo MAGIOLI Nina ATTIAS Gabriel MASSOCATO Danilo KLUYBER Marcelo Zacharias MOREIRA katia Maria Paschoaletto Micchi de Barros FERRAZ Adriano Garcia CHIARELLO Arnaud L.j.DESBIEZ Instituto Pró-Carnívoros AtibaiaSão PauloBrazil Centro Nacional de Pesquisa e Conservação de Mamíferos Carnívoros(CENAP) Instituto Chico Mendes de Conservação da Biodiversidade(ICMBio)AtibaiaSão PauloBrazil Instituto de Conservação de Animais Silvestres(ICAS) Campo GrandeMato Grosso do SulBrazil Instituto de Pesquisas Ecológicas Organização Não GovernamentalNazaréPaulistaSão PauloBrazil Houston Zoo HoustonTexasUSA Naples Zoo at Caribbean Gardens NaplesFloridaUSA Laboratório de Ecologia Isotópica Centro de Energia Nuclear na AgriculturaUniversidade de São PauloPiracicabaSão PauloBrazil Laboratório de Ecologia Manejo e Conservação de Fauna Silvestre(LEMaC)Departamento de Ciências FlorestaisEscola Superior de Agricultura“Luiz de Queiroz”(ESALQ)Universidade de São Paulo(USP)PiracicabaSão PauloBrazil Departamento de Biologia Faculdade de FilosofiaCiências e LetrasUniversidade de São Paulo(USP)Ribeirão PretoSão PauloBrazil RZSS-Royal Zoological Society of Scotland(RZSS) MurrayfieldEdinburghUK

Understanding of resource requirements of vulnerable species is key for conservation ***,we used sta-ble carbon(δ13C)and nitrogen isotopes(δ15N)of hair from giant armadillos(Priodontes maximus)to understand individual resource *** collected hair from 19 giant armadillos analyzing 34 samples from the Brazilian Pan-tanal and compared the resource use between sexes and age *** also assessed the relationship of isotopic values with individuals’body mass and the habitat type *** observed a wide variation in resource use by giant armadillos,showing that individuals consume prey that feeds on distinct resources and occupies different habitat types,indicating that there is individual variation in foraging *** giant armadillos presented a mixed diet(C3/C4 resources,forests/open areas),but a quarter of individuals had strictly C4 diets(open areas).Males are more prone to forage on C4 resources,presenting an isotopic niche 2.6-times larger than that of *** presented diets more associated with habitats with high arboreal cover(C3 resources,forests),while adults foraged more in open areas(C4 resources).This result is mirrored by the positive relationship betweenδ13C values and body mass,suggesting that larger giant armadillos tend to feed more in open *** observed thatδ13C values decreased as individuals increased the use of habitats with high arboreal *** stress the importance of con-serving the natural mosaic in the Pantanal landscape for the species persistence,given that giant armadillos require all habitat types to fulﬁll their dietary,spatial,and developmental needs.

关键词： diet ontogenetic changes resource partitioning stable isotopes telemetry

Oral administration of S-nitroso-N-acetylcysteine prevents the onset of non alcoholic fatty liver disease in rats

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World j.urnal of Gastroenterology 2006年第12期12卷 1905-1911页

作者： Claudia PMS de Oliveira Fernanda I Simplicio Vicencia MR de Lima katia Yuahasi Fabio P Lopasso Venancio AF Alves Dulcinéia SP Abdalla Flair j.Carrilho Francisco RM Laurindo Marcelo G de Oliveira University of Sāo Paulo School of Medicine Department of Gastroenterology Saoo Paulo SP Brazil School of Medicine Department of Pathology Sāo Paulo SP Brazil University of So Paulo Medical School Heart Institute InCor Sāo Paulo SP Brazil University of Sāo Paulo School of Pharmaceutical Sciences Department of Clinical and Toxicological Analysis Sao Paulo SP Brazil State University of CamDinas. Chemistry Department. Campinas. SE Brazil

AIM： To evaluate the potential of S-nitroso-N-acetylcysteine （SNAC） in inhibition of lipid peroxidation and the effect of oral SNAC administration in the prevention of nonalcoholic fatty liver disease （NAFLD） in an animal model.METHODS： NAFLD was induced in Wistar male rats by choline-deficient diet for 4 wk. SNAC-treated animals （n=6）（1.4 mg/kg/day of SNAC, orally） were compared to 2 control groups： one （n=6） received PBS solution and the other （n=6） received NAC solution （7 mg/kg/d）. Histological variables were semiquantitated with respect to macro and microvacuolar fat changes, its zonal distribution, foci of necrosis, portal and perivenular fibrosis, and inflammatory infiltrate with zonal distribution. LOOHs from samples of liver homogenates were quantified by HPLC. Nitrate levels in plasma of portal vein were assessed by chemiluminescence. Aqueous low-density lipoprotein （LDL） suspensions （200 pg protein/mL） were incubated with CuCl2 （300 μmol/L） in the absence and presence of SNAC （300 μmol/L） for 15 h at 37 ℃ Extent of LDL oxidation was assessed by fluorimetry. Linoleic acid （LA）（18.8 μmol/L） oxidation was induced by soybean lipoxygenase （SLO）（0.056 μmol/L） at 37 ℃ in the presence and absence of N-acetylcysteine （NAC） and SNAC （56 and 560 pmol/L） and monitored at 234 nm. RESULTS： Animals in the control group developed moderate macro and microvesicular fatty changes in periportal area. SNAC-treated animals displayed only discrete histological alterations with absence of fatty changes and did not develop liver steatosis. The absence of NAFLD in the SNAC-treated group was positively correlated with a decrease in the concentration of LOOH in liver homogenate, compared to the control group （0.7±0.2 nmol/mg vs 3.2±0.4 nmol/mg protein, respectively, P〈0.05）, while serum levels of aminotransferases were unaltered. The ability of SNAC in preventing lipid peroxidation was confirmed in in vitro experiments using LA and LDL as model substrates. CONCLUSION： Oral

关键词： Nitric oxide S-nitroso-N-acetylcysteine Oxidative stress Nonalcoholic fatty liver disease

Coinheritance of germline mutations in APC and MUTYH genes defines the clinical outcome of adenomatous polyposis syndromes

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Genes & Diseases 2023年第4期10卷 1187-1189页

作者： Giovanna Forte Filomena Cariola Antonia Lucia Buonadonna Anna Filomena Guglielmi Andrea Manghisi katia De Marco Valentina Grossi Candida Fasano Martina Lepore Signorile Paola Sanese Rosanna Bagnulo Nicoletta Resta b Vittoria Disciglio Cristiano Simone Medical Genetics National Institute of Gastroenterology“S.de Bellis”Research HospitalCastellana GrotteBari 70013Italy Medical Genetics Department of Precision and Regenerative Medicine and Jonic Area(DiMePRe-J)University of Bari Aldo MoroBari 70124Italy

Familial adenomatous polyposis(FAP)and MUTYH-associ-ated polyposis(MAP)are colon cancer predisposition *** is an autosomal dominant inherited condition caused by germline mutations in the adenomatous polyposis coli(AP... 详细信息

关键词： polyposis adenomatous colon

A novel supplement with yeast b-glucan, prebiotic, minerals and Silybum marianum synergistically modulates metabolic and inflammatory pathways and improves steatosis in obese mice

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j.urnal of Integrative Medicine 2021年第5期19卷 439-450页

作者： Victor Abou Nehmi Gilson Masahiro Murata Ruan Carlos Macêdo de Moraes Gabriely Cristina AlvesLima Danielle Arauj. De Miranda Katrin Radloff Raquel Galvao Figuerêdo Costa j.yce de Cassia Rosade j.sus j.ssica Alves De Freitas Nayara Izabel Viana Ruan Pimenta katia Ramos Moreira Leite j.séPinhata Otoch Ana Flávia Marcal Pessoa Laboratory of Medical Investigation(LIM-26) Department of SurgeryUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Laboratory of Medical Investigation(LIM-29) Clinic Medical DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil Department of Physiology Escola Paulista de Medicina/Universidade Federal de Sao PauloSP 04023062Brazil Max Rubner-Institut Federal Research Institute of Nutrition and FoodKarlsruheBW 76131Germany Cancer and Inflammation Program Center for Cancer ResearchNational Cancer InstituteNational Institutes of HealthBethesdaMD 20892United States Laboratory of Medical Investigation(LIM-55) Urology DepartmentUniversity of Sao Paulo Medical SchoolSao PauloSP 01246903Brazil D'Or Institute for Research and Education RJ 22281-100Brazil Program in Anesthesiology Surgical Sciencesand Perioperative MedicineUniversity of Sao PauloSao PauloSP 01246903Brazil Brazilian Academic Consortium for Integrative Health(CABSIN) Natural Products CommitteeSao PauloSP 05449-070Brazil

Obj.ctive: To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics,yeast b-glucans, minerals and silymarin(Silybum marianum), on lipid and glycidic metabolism, inflammatory and mitochondrial proteins of the liver, in control and high-fat diet-induced obese ***: After an acclimation period, 32 male C57 BL/6 mice were divided into the following groups:nonfat diet(NFD) vehicle, NFD supplemented, high-fat diet(HFD) vehicle and HFD supplemented. The vehicle and experimental formulation were administered orally by gavage once a day during the last four weeks of the diet(28 consecutive days). We then evaluated energy homeostasis, inflammation, and mitochondrial protein expression in these groups of ***: After four weeks of supplementation, study groups experienced reduced glycemia, dyslipidemia,fat, and hepatic fibrosis levels. Additionally, proliferator-activated receptor-α, AMP-activated protein kinase-1α, peroxisome proliferator-activated receptor γ co-activator-1α, and mitochondrial transcription factor A expression levels were augmented;however, levels of inhibitor of nuclear factor-κB kinase subunit a and p65 nuclear factor-κB expression, and oxidative markers were reduced. Notably, the cortisol/C-reactive protein ratio, a well-characterized marker of the hypothalamic–pituitary–adrenal axis immune interface status, was found to be modulated by the ***: We discovered that the novel supplement was able to modify different antioxidant, metabolic and inflammatory pathways, improving the energy homeostasis and inflammatory status, and consequently alleviated hepatic steatosis.

关键词： Supplement Silymarin Prebiotic Obese Mice Steatosis Inflammation Mitochondrial biogenesis

Hypertension and chronic ethanol consumption: What do we know after a century of study?

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World j.urnal of Cardiology 2014年第5期6卷 283-294页

作者： katia Colombo Marchi j.queline j.ice Muniz Carlos Renato Tirapelli Programa de pósgraduacao em Farmacologia Faculdade de Medicina de Ribeirao PretoUniversidade de Sao PauloSao PauloCEP 14040-900Brazil Departamento de Enfermagem Psiquiátrica e Ciências Humanas Laboratório de FarmacologiaEscola de Enfermagem de Ribeirao PretoUniversidade de Sao PauloS?o PauloCEP 14040-902Brazil

The influences of life habits on the cardiovascularsystem may have important implications for publichealth, as cardiovascular diseases are among the lead-ing causes of shorter life expectancy worldwide. A linkbetween excessive ethyl alcohol(ethanol) consumptionand arterial hypertension was first suggested early lastcentury. Since then, this proposition has received con-siderable attention. Support for the concept of ethanolas a cause of hypertension derives from several epi-demiologic studies demonstrating that in the generalpopulation, increased blood pressure is significantlycorrelated with ethanol consumption. Although thelink between ethanol consumption and hypertension iswell established, the mechanism through which etha-nol increases blood pressure remains elusive. Possiblemechanisms underlying ethanol-induced hypertensionwere proposed based on clinical and experimental ob-servations. These mechanisms include an increase insympathetic nervous system activity, stimulation of therenin-angiotensin-aldosterone system, an increase of intracellular Ca2+ in vascular smooth muscle, increased oxidative stress and endothelial dysfunction. The pres-ent report reviews the relationship between ethanol intake and hypertension and highlights some mecha-nisms underlying this response. These issues are of interest for the public health, as ethanol consumption contributes to blood pressure elevation in the population.

关键词： Ethanol Hypertension Calcium Nitric oxide Oxidative stress

Using the Spectral Similarity Ratio and Morphological Operators for the Detection of Building Locations in Very High Spatial Resolution Images

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通讯和计算机（中英文版） 2013年第3期10卷 309-324页

作者： katia Stankov Dong-Chen He Center for Research and Applications in Remote Sensing (CARTEL) University of Sherbrooke Quebec J1K 2R1 Canada Departement of Applied Geomatics University of Sherbrooke Quebec J I K 2RI Canada

Recently there is a growing interest toward elaboration of automatic or semi-automatic building detection in VHSR (very high spatial resolution) images. The complex spectral appearance of buildings in VHSR images has led to studies that exploit mostly the spatial information in these images. Spectral information in addition to spatial and contextual information improves the accuracy of the detection. In this paper, they present a method for the detection of building locations in VHSR multispectral images. Buildings are detected using spectral, spatial and contextual information. First, potential building locations are enhanced on the basis of the spectral similarity between their roofs using the spectral similarity ratio. Next, the HMT (hit-or-miss transform) from mathematical morphology is used to assign pixels to buildings and to define potential building locations. The differential morphological profile is used to identify shadowed areas. Then, building locations are verified based on the proximity of shadows. The method is tested on large WorldView-2 and pan-sharpened Ikonos image subsets. Both subsets included heterogeneous urban types: residential, commercial and industrial areas. The accuracy achieved was high for both subsets, despite the heterogeneous urban types and the different sensors used.

关键词：高空间分辨率数学形态学图像检测多光谱地点遥感影像相似比 IKONOS影像

The Sustainable Expansion of the Cocoa Crop in the State of Paráand Its Contribution to Altered Areas Recovery and Fire Reduction

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j.urnal of Geographic Information System 2022年第3期14卷 294-313页

作者： Adriano Venturieri Rodrigo Rafael Souza de Oliveira Tassio Koiti Igawa katia De Avila Fernandes Marcos Adami Moisés Cordeiro Mourão de Oliveira j.nior Cláudio Aparecido Almeida Luiz Guilherme Teixeira Silva Ana I. R. Cabral j.ão Felipe Kneipp Cerqueira Pinto Antônio j.sé Amorim Menezes Sandra Maria Neiva Sampaio Embrapa Eastern Amazonia Belém Brazil University of Para State Belém Brazil Coordination for the Improvement of Higher Education Personnel Belém Brazil University of Arkansas Fayetteville USA International Research Institute for Climate and Society Columbia University New York USA National Institute for Space Research S&#227 o j.sé dos Campos S&#227 o Paulo Forest Research Centre School of Agriculture University of Lisbon Lisbon Portugal Research Development Foundation S&#227 o j.sé dos Campos Brazil

The state of Pará, located in the Amazon region of Brazil, has observed in recent years an increase in cocoa (Theobroma cacao) cultivation and has become the largest producer in Brazil. Due to its physiological characteristics, cacao is cultivated in native forests understory or under the shade produced by fast-growing native tree species, serving as an important species for restoration of degraded areas. However, mapping and monitoring cocoa plantation using optical sensor images is a challenge given its botanical and arboreal characteristics that can be confused with other native species at various stages of secondary regrowth. Agroforestry systems are important components of sustainable production in the Amazon and our work sought to better describe the evolution of cocoa plantations in terms of their historical expansion, farming properties practices, land use transitions and fire regimes. Our findings to analyze the relationships between cocoa plantations and hotspots, data from the INPE’s reference satellite between the years 2004 to 2020 were used in this study, polygons classified as cocoa areas, generated by the MapCacau research proj.ct, were used, in a total of 69,904 hectares distributed throughout the state of Pará. Finally, we used the protected areas’ official limits in the State of Pará to analyze the plantations’ occurrence in regions in discordance with environmental legislation. The data show that cocoa-producing properties are statistically fewer than non-producing properties, as well as having lower deforestation rates. In our study, we observed that 52,778 hectares (88.87%) of the cocoa area planted had already been deforested by the year 2008—the threshold of deforestation defined by Brazil’s Forest Code. It was also possible to verify that approximately 20,900 hectares continue to be mapped as forest by PRODES, despite our field data identifying cocoa plantations shaded by explored forest in these areas. Regarding the crop’s formation, the da

关键词： Amazon Machine Learning Participative Mapping Pará Cocoa Amazon MapCacau