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Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment

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Bone Research 2022年第1期10卷 107-121页

作者： Anke Baranowsky Denise Jahn Shan Jiang Timur Yorgan Peter Ludewig Jessika Appelt Kai K.Albrecht Ellen Otto Paul Knapstein Antonia Donat Jack Winneberger Lana Rosenthal Paul Köhli Cordula erdmann Melanie Fuchs Karl-Heinz Frosch Serafeim Tsitsilonis Michael Amling Thorsten Schinke Johannes Keller Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-EppendorfHamburg 20246Germany Department of Osteology and Biomechanics University Medical Center Hamburg-EppendorfHamburg 20246Germany Center for Musculoskeletal Surgery Charité-Universitätsmedizin BerlinBerlin 13353Germany Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration Charité-Universitätsmedizin BerlinBerlin 13353Germany Department of Neurology University Medical Center Hamburg-EppendorfHamburg 20251Germany Berlin Institute of Health Berlin 10178Germany

Intermittent injections of parathyroid hormone(iPTH) are applied clinically to stimulate bone formation by osteoblasts, although continuous elevation of parathyroid hormone(PTH) primarily results in increased bone resorption. Here, we identified Calca,encoding the sepsis biomarker procalcitonin(ProCT), as a novel target gene of PTH in murine osteoblasts that inhibits osteoclast formation. During iPTH treatment, mice lacking ProCT develop increased bone resorption with excessive osteoclast formation in both the long bones and axial skeleton. Mechanistically, ProCT inhibits the expression of key mediators involved in the recruitment of macrophages, representing osteoclast precursors. Accordingly, ProCT arrests macrophage migration and causes inhibition of early but not late osteoclastogenesis. In conclusion, our results reveal a potential role of osteoblast-derived ProCT in the bone microenvironment that is required to limit bone resorption during iPTH.

关键词： treatment representing skeleton

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临床心脏病学研究的教益

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德国医学 2000年第5期17卷 252-253页

作者： E.erdmann 王琳 Medizinische Klinik der Medizinischen Einrichtungen der Universitt zu Kln Joseph-Stelzmann-Straβe 9D-50924 KlnGermany 同济医科大学附属同济医院

10年来心血管领域的发展速度是最快的。通过超声可以使以前很难诊断的某些疾病如心包积液、瓣膜病、心房粘液瘤、复杂的先天性心脏病、肺动脉栓塞、主动脉夹层等在数分钟内得以明确。MRI应用于心血管疾病中,提供了心脏和大血管的精确影... 详细信息

10年来心血管领域的发展速度是最快的。通过超声可以使以前很难诊断的某些疾病如心包积液、瓣膜病、心房粘液瘤、复杂的先天性心脏病、肺动脉栓塞、主动脉夹层等在数分钟内得以明确。MRI应用于心血管疾病中,提供了心脏和大血管的精确影像。仅去年就有53万余人接受了冠状动脉造影,而且病例数还会增加。肌钙蛋白T的测定有助于心肌梗死的快速诊断。这一系列有价值的检查方法得到了广泛的应用。治疗方面的进展:介入性心脏病学获得很大成功(每年15万以上的病人从中受益！),冠状动脉再通术,房间隔缺损封闭术。

关键词：心脏病治疗高血压预后

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Comparison of Protein Expression Profiles of Novel Halomonas smyrnensisAAD6Tand Halomonas salinaDSMZ 5928T

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Natural Science 2014年第9期6卷 628-640页

作者： Aydan Salman Dilgimen Kazim Yalcin Arga Volker A. erdmann Brigitte Wittmann-Liebold Aziz Akin Denizci Dilek Kazan Bioengineering Department Faculty of Engineering Marmara University (Goztepe Campus) Istanbul Turkey Bioengineering Department Faculty of Engineering Marmara University (Goztepe Campus) Istanbul Turkey Institute for Chemistry/Biochemistry Freie University Berlin Germany Present Address: Department of Biochemistry & Molecular Biology University of Calgary Calgary Canada Institute for Chemistry/Biochemistry Freie University Berlin Germany The Scientific and Technological Research Council of Turkey (TUBITAK) Marmara Research Center (MAM) Genetic Engineering and Biotechnology Institute Gebze Turkey Wita GmbH Berlin Germany

In this work, the protein pattern of novel Halomonas smyrnensis AAD6T was compared to that of Halomonas salina DSMZ5928T, which is the closest species on the basis of 16S rRNA sequence, to understand how AAD6T differs from type strains. Using high resolution NEPHEGE technique, the whole cell protein composition patterns of both Halomonas salina DSMZ5928T and H. smyrnensis AAD6T were mapped. The expressed proteins of the two microorganisms were mostly located at the acidic side of the gels, at molecular weight values of 60 to 17 kDa, and at isoelectric points 3.8 to 6.0, where they share a significant number of common protein spots. Identification and characterization of protein spots via whole genome sequencing data indicated that these two microorganisms used similar pathways, especially TCA cycle, for their survival;in other words, for their energy requirements. On the other hand, the protein expression differences in AAD6T and H. salina DSMZ 5928T showed that they prefer different metabolic pathways for lipid biosynthesis and in adaptation to extreme environments. Thus, we suggested that phylogenetic dissimilarities between these microorganisms could be related to the protein expression differences;in other words, metabolic flux differences in AAD6T and H. salina DSMZ 5928T. This is the first study to explain the dissimilarities of phenotypic characters and DNA-DNA hybridization between type strain and novel strain AAD6T by using protein expression differences.

关键词： Proteomics Halomonas salina DSMZ 5928T Halomonas smyrnensis AAD6T NEPHGE Technique Genome

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Functional assessment of liver regeneration after major hepatectomy

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Hepatobiliary Surgery and Nutrition 2022年第4期11卷 530-538页

作者： Fadi Rassam Pim B.Olthof Bart Takkenberg Marc G.Besselink Olivier R.Busch Joris I.erdmann Rutger-Jan Swijnenburg Krijn Pvan Lienden Ulrich H.Beuers Roelof J.Bennink Thomas Mvan Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamThe Netherlands Department of Gastroenterology&Hepatology Amsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands Departments of Radiology and Nuclear Medicine Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdamThe Netherlands

Background: Liver regeneration is crucial to restore the functional liver mass after liver resection. The aim of this study was to evaluate the early postoperative changes in remnant liver function, volume and liver stiffness after major liver resection and their correlation with postoperative outcomes. Methods: Patients undergoing major liver resection (≥3 segments) between February and November 2018 underwent both functional assessment using technetium-99m mebrofenin hepatobiliary scintigraphy (HBS) and CT-volumetry of the (future) remnant liver on preoperative day 1, the 5th postoperative day, and 4-6 weeks after resection. At the same time points, patients underwent transient elastography (TE) for the assessment of liver stiffness. Severe postoperative complications (Clavien-Dindo ≥ 3A) and mortality were correlated with the functional and volumetric increases of the remnant liver. Liver failure was graded according to the International Study Group of Liver Surgery (ISGLS) criteria. Results: A total of 18 patients were included of whom 10 (56%) had severe complications and one patient (5%) developed liver failure. Function and volume of the remnant liver had increased by the 5th postoperative day from 6.9 (5.4-10.9) to 9.6 (6.7-13.8) %/min/m2, P=0.004 and from 795.5 (538.3-1,037.5) to 1,080.0 (854.0-1,283.3) mL, P<0.001, respectively. After 4-6 weeks, remnant liver volume had further increased [from 1,080.0 (854.0-1,283.3) to 1,222.0 (1,016.0-1,380.5) mL, P=0.035], however, liver function did not show any significant, further increase [from 9.6 (6.7-13.8) to 10.9 (8.8-13.6) %/min/m2, P=0.177]. Liver elasticity of the future remnant liver (FRL) increased [from 10.8 (5.7-18.7) to 17.5 (12.4-22.6) kPa, P=0.018] and gradually recovered after 4-6 weeks to a median of 10.9 (5.7-18.8) kPa (T3 vs. T4, P=0.079). Patients who had severe postoperative complications did not show a significant increase in liver function on the 5th postoperative day (P=0.203), despite increas

关键词： Hepatobiliary scintigraphy(HBS) liver resection liver regeneration posthepatectomy liver failure liver function test

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Occurrence of seeding metastases in resectable perihilar cholangiocarcinoma and the role of low-dose radiotherapy to prevent this

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World Journal of Hepatology 2020年第11期12卷 1089-1097页

作者： Lotte C Franken Eva Roos Job Saris Jeanin E van Hooft Otto M van Delden Joanne Verheij Joris I erdmann Marc G Besselink Olivier R Busch Geertjan van Tienhoven Thomas M van Gulik Department of Surgery Cancer Center AmsterdamAmsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Pathology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Gastroenterology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Interventional Radiology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands Department of Radiation Oncology Amsterdam UMCUniversity of AmsterdamAmsterdam 1105 AZNetherlands

BACKGROUND Preoperative biliary drainage in patients with presumed resectable perihilar cholangiocarcinoma(PHC)is hypothesized to promote the occurrence of seeding *** metastases can occur at the surgical scars or at the site of postoperative drains,and in case of percutaneous biliary drainage,at the catheter *** prevent seeding metastases after resection,we routinely treated PHC patients with preoperative radiotherapy(RT)for over 25 years until January *** To investigate the incidence of seeding metastases following resection of *** All patients who underwent resection for pathology proven PHC between January 2000 and March 2019 were included in this retrospective *** 2000-January 2018,patients received preoperative RT(3×3.5 Gray).RT was omitted in patients treated after January *** A total of 171 patients underwent resection for PHC between January 2000 and March *** 171 patients undergoing resection,111 patients(65%)were treated with preoperative *** bile cytology showed no difference in the presence of viable tumor cells in bile of patients undergoing preoperative RT or ***,two patients(1.2%)with seeding metastases were identified,both in the laparotomy scar and both after preoperative RT(one patient with endoscopic and the other with percutaneous and endoscopic biliary drainage).CONCLUSION The incidence of seeding metastases in patients with resected PHC in our series was low(1.2%).This low incidence and the inability of providing evidence that preoperative low-dose RT prevents seeding metastases,has led us to discontinue preoperative RT in patients with resectable PHC in our center.

关键词： Perihilar cholangiocarcinoma Seeding metastases Preventive radiotherapy

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Experimental constraints on crystallization parameters and fractionation in A-type granites:a case study on the Qitianling Pluton,South China

Experimental constraints on crystallization parameters and f...

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2019年中国地球科学联合学术年会

作者： Fangfang HUANG Bruno SCAILLET Rucheng WANG Saskia erdmann Yan CHEN Michel FAURE Hongsheng LIU School of Earth Sciences and Engineering Nanjing University Institut des Sciences de la Terre d'Orléans(ISTO) Université d'Orléans-CNRS-BRGM Orléans Guangzhou Institute of Geochemistry Chinese Academy of Sciences

Phase equilibrium experiments are essential for robustly and accurately constraining the intensive parameters of magma systems and their fractionation history, which is particularly true for A-type granites crystallized from H2 O-rich melts and at reducing conditions. In this study, we constrain the crystallization conditions of the ferroan(A-

关键词： Experimental constraints on crystallization parameters and fractionation in A-type granites:a case study on the Qitianling Pluton,South China

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在“欧洲”与“民族”之间经营——面对《基本法》与《里斯本条约》的德国新执政联盟

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德国研究 2009年第4期24卷 4-14+85页

作者：艾德曼-辛蔷

"欧洲"因《整合责任法》而被列入了德国联邦议院的辩论议程。《里斯本条约》对自下而上、有限支持和适度原则进行了具体化,"民族"通过由成员国议员作为代表而全面介入欧盟事务之中。德国新执政联盟在其《联合执政协议》中确定,"欧洲"成... 详细信息

"欧洲"因《整合责任法》而被列入了德国联邦议院的辩论议程。《里斯本条约》对自下而上、有限支持和适度原则进行了具体化,"民族"通过由成员国议员作为代表而全面介入欧盟事务之中。德国新执政联盟在其《联合执政协议》中确定,"欧洲"成为新联邦政府的政治方向,而"民族"是政府政策的目标。在这种情况下,新联邦政府就成了"欧洲"与"民族"的经营者。新联邦政府在欧盟事务上的行动能力取决于其与联邦议院之间的沟通。而新联邦政府的欧洲政策施政空间——联邦政府在欧盟事务上可能的立法权限——则受政策取向影响,即联邦政府与州政府的政策取向是趋同,还是相悖。这又取决于联邦的执政党或执政联盟与州的执政党或执政联盟有一致还是相悖的政策偏好。

关键词：德国与欧盟《联合执政协议》《里斯本条约》《基本法》联邦宪法法院裁决

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医疗照护的改进：患者和照护者“点赞”才是真的好他们的观点对于所有成功的医疗改进都至关重要

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英国医学杂志中文版 2018年第8期21卷 425-426页

作者： Anya de Iongh Sibylle erdmann 李俊(译) The BMJ London UK London Neonatal Network London UK 北京大学医学人文研究院

提高医疗照护质量需要团队的努力，当团队中包括服务使用者及其照护者、家人和倡导者时，效果最佳。团队中的这些人员可根据个人应对疾病的经验，提供有利于健康的一手建议，或是提供医疗照护系统以外的相关生活技巧。提高医疗照护质量... 详细信息

提高医疗照护质量需要团队的努力，当团队中包括服务使用者及其照护者、家人和倡导者时，效果最佳。团队中的这些人员可根据个人应对疾病的经验，提供有利于健康的一手建议，或是提供医疗照护系统以外的相关生活技巧。提高医疗照护质量需要团队的努力，当团队中包括服务使用者及其照护者、家人和倡导者时，效果最佳。团队中的这些人员可根据个人应对疾病的经验，提供有利于健康的一手建议，或是提供医疗照护系统以外的相关生活技巧。

关键词：医疗照护医疗卫生行业患者发展现状

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