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Loving her into well-being one day at a time: Narratives of caring for daughters with eating disorders

Open Journal of Nursing 2012年第4期2卷 406-419页

作者： kathryn weaver Faculty of Nursing University of New Brunswick Fredericton Canada

When a child is diagnosed with an eating disorder, parents are expected to help the child recover. Yet, parents often feel under-prepared and alone, their experiences inadequately known to healthcare professionals. The research aim was to examine the meaning to parents of caring for a child with an eating disorder. Qualitative interviews with 29 parents were analyzed and the parents’ experiences were represented by a collective story of loving her into well-being one day at a time which consisted of two themes: Running on nerves and caring through transformational activism. Running on nerves included threads of feeling lost, traumatized, scarred, and disengaged that mitigated as parents engaged in transformational activism processes directed toward helping themselves, their child, and other parents and children. The findings illustrate the importance of hearing parents’ stories in order to create supportive healing environments and to build capacity within families and health care systems.

关键词： Eating Disorder Parents Narrative Analysis Transformational Activism

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Preclinical and clinical studies on cancer-associated cachexia

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Frontiers in Biology 2018年第1期13卷 11-18页

作者： D. Brooke Widner D. Clark Files kathryn E. weaver Yusuke Shiozawa Department of Cancer Biology and Comprehensive Cancer Center Wake Forest School of Medicine Winston-Salem NC 27157 USA Internal Medicine-Sections inPulmonaryand Critical Care Medicine and Geriatrics and the Critical Illness Injury and Recovery Research Center Wake Forest School of Medicine W~nston-Salem NC 27157 USA Department of Social Sciences and Health Policy and Comprehensive Cancer Center of Wake Forest University Wake Forest School of Medicine Wtnston-Salem NC 27157 USA

BACKGROUND： Cancer cachexia is the wasting condition that is often seen in advanced stage cancer patients. This wasting is largely attributable to a systemic and progressive loss of skeletal muscle mass that greatly hinders performance of normal daily activities, resulting in reduced quality of life. Moreover, it negatively influences the prognosis of cancer patients. A general consensus in the field is that the loss of muscle mass is due both to an increase in protein degradation and a decrease in protein synthesis. Recent studies using preclinical models for studying cachexia have been useful in identifying the contribution of inflammatory cytokines （e.g. tumor necrosis factor-a and Interleukin-6）, and myostatin receptors （e.g. the type IIB activin receptor） to cachexia development, and have led to several clinical trials. However, many questions remain about the molecular mechanisms thought to play a role in the development of cachexia. METHODS： We conducted a literature search using search engines, such as PubMed and Google Scholar to identify publications within the cancer cachexia field. RESULTS- We summarized our current knowledge of： 1） the driving mechanisms of cancer cachexia, 2） the preclinical models available for studying the condition, and 3） the findings of recent clinical trials. CONCLUSION： Cancer cachexia is a complex and variable condition that currently has no standard effective therapeutic treatment. Further studies are desperately needed to better understand this condition and develop effective combination treatments for patients.

关键词： cancer cachexia muscle wasting bodyweight loss metabolic changes increased protein degradation decreased protein synthesis

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Neonatal lamb mortality:major risk factors and the potential ameliorative role of melatonin

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Journal of Animal Science and Biotechnology 2021年第2期12卷 451-461页

作者： Tom Flinn David O.Kleemann Alyce M.Swinbourne Jennifer M.Kelly Alice C.weaver Simon K.Walker kathryn L.Gatford Karen L.Kind William H.E.J.van Wettere Davies Livestock Research Centre School of Animal and Veterinary SciencesThe University of AdelaideRoseworthySAAustralia Turretfield Research Centre South Australian Research and Development InstituteRosedaleSAAustralia Robinson Research Institute Adelaide Medical SchoolThe University of AdelaideAdelaideSAAustralia

High incidences of pre-weaning mortality continue to limit global sheep production,constituting a major economic and welfare *** significant advances in genetics,nutrition,and management,the proportion of lamb deaths has remained stable at 15–20%over the past four *** is mounting evidence that melatonin can improve outcomes in compromised ovine pregnancies via enhanced uterine bloodflow and neonatal *** review provides an overview of the major risk factors and underlying mechanisms involved in perinatal lamb mortality and discusses the potential of melatonin treatment as a remedial *** pregnant ewes with melatonin enhances uterine bloodflow and fetal oxygenation,and potentially birthweight and neonatal thermogenic *** freely crosses the ovine placenta and blood-brain barrier and provides neuroprotection to the fetal lamb during periods of chronic and acute hypoxia throughout gestation,with improved behavioural outcomes in hypoxic *** current literature provides strong evidence that maternal melatonin treatment improves outcomes for lambs which experience compromised in utero development or prolonged parturition,though to date this has not been investigated in livestock production *** such there is a clear basis for continued research into the effects of maternal melatonin supplementation during gestation on pre-weaning survival under extensive production conditions.

关键词： Lamb survival Melatonin Neonatal mortality Reproduction Sheep

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Review of the impact of heat stress on reproductive performance of sheep

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Journal of Animal Science and Biotechnology 2021年第3期12卷 859-876页

作者： William H.E.J.van Wettere Karen L.Kind kathryn L.Gatford Alyce M.Swinbourne Stephan T.Leu Peter T.Hayman Jennifer M.Kelly Alice C.weaver David O.Kleemann Simon K.Walker The University of Adelaide School of Animal and Veterinary SciencesDavies Livestock Research CentreRoseworthy CampusMudla Wirra RdRoseworthySouth Australia 5371Australia The University of Adelaide Robinson Research InstituteAdelaide Medical SchoolNorth TerraceAdelaideSouth Australia 5000Australia The University of Adelaide School of AgricultureFood and WineWaite Research InstituteUrrbraeSouth Australia 5064Australia South Australian Research and Development Institute Primary Industries and Regions SAGovernment of South AustraliaClimate ApplicationsWaite Research PrecinctUrrbraeSouth Australia 5064Australia South Australian Research and Development Institute Primary Industries and Regions SAReproductive BiologyLivestock SciencesTurretfield Research Centre129 Holland RdRosedaleSouth Australia 5350Australia

Heat stress significantly impairs reproduction of sheep,and under current climatic conditions is a significant risk to the efficiency of the meat and wool production,with the impact increasing as global temperatures *** from field studies and studies conducted using environmental chambers demonstrate the effects of hot temperatures(≥32℃)on components of ewe fertility(oestrus,fertilisation,embryo survival and lambing)are most destructive when experienced from 5 d before until 5 d after *** controlled studies also demonstrate that ram fertility,as measured by rates of fertilisation and embryo survival,is reduced when mating occurs during the period 14 to 50 d ***,the contribution of the ram to heat induced reductions in flock fertility is difficult to determine *** primarily on temperature controlled studies,it is clear that sustained exposure to high temperatures(≥32℃)during pregnancy reduces lamb birthweight and will,therefore,decrease lamb survival under field *** is concluded that both ewe and ram reproduction is affected by relatively modest levels of heat stress(≥32℃)and this is a concern given that a significant proportion of the global sheep population experiences heat stress of this magnitude around mating and during *** this,strategies to limit the impacts of the climate on the homeothermy,behaviour,resource use and reproduction of extensively grazed sheep are limited,and there is an urgency to improve knowledge and to develop husbandry practices to limit these impacts.

关键词： Fertility Heat stress Oogenesis Pregnancy Sheep Spermatogenesis

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