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Antecedents and sex/gender differences in youth suicidal behavior

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World Journal of Psychiatry 2014年第4期4卷 120-132页

作者： Anne E Rhodes m.chael H Boyle Jeffrey A Bridge m.rk Sinyor Paul S Links Lil Tonm.r Robin Skinner Jennifer m.Bethell Corine Carlisle Sarah Goodday Travis Salway Hottes Am.nda Newton kathryn Bennett Purnim. Sundar Am. H Cheung Peter Szatm.ri Institute for Clinical Evaluative Sciences Toronto M4N 3M5 Ontario Canada Departm.nt of Psychiatry University of Toronto Toronto M5T 1R8 Ontario Canada Suicide Studies Unit St. Michael’s Hospital Toronto M5B 1W8 Ontario Canada Dalla Lana School of Public Health University of Toronto Toronto M5T 3M7 Ontario Canada Departm.nt of Psychiatry and Behavioural Neurosciences Mc Master University Hamilton L8N 3K7 Ontario Canada The Offord Centre for Child Studies Hamilton L8S 4K1 Ontario Canada The Research Institute at Nationwide Children’s Hospital Columbus OH 43205 United States The Ohio State University College of m.dicine Columbus OH 43210 United States Sunnybrook Health Sciences Centre Toronto M4N 3M5 Ontario Canada Departm.nt of Psychiatry University of Western Ontario London N6A 5W9 Ontario Canada The Injury and Child m.ltreatm.nt Section Public Health Agency of Canada Ottawa K1A 0K9 Ontario Canada The Centre for Addiction and m.ntal Health Toronto M6J 1H4 Ontario Canada Departm.nt of Pediatrics University of Alberta Edmonton Alberta T6G 1C9 Canada The Departm.nt of Clinical Epidem.ology and Biostatistics Mc Master University Hamilton L8S 4K1 Ontario Canada The Ontario Centre of Excellence for Child and Youth m.ntal Health Ottawa K1G 0Z1 Ontario Canada The Hospital for Sick Children Toronto M5G 1X8 Ontario Canada

Suicide is the second leading cause of death in youth globally; however, there is uncertainty about how best to intervene. Suicide rates are typically higher in m.les than fem.les, while the converse is true for suicide attem.ts. We review this "gender paradox" in youth, and in particular, the age-dependency of these sex/gender differences and the developm.ntal m.chanism. that m.y explain them. Epidem.ologic, genetic,neurodevelopm.ntal and psychopathological research have identified suicidal behaviour risks arising from.genetic vulnerabilities and sex/gender differences in early adverse environm.nts, neurodevelopm.nt, m.ntal disorder and their com.lex interconnections. Further, evolving sex-/gender-defined social expectations and norm. have been thought to influence suicide risk. In particular, how youth perceive and cope with threats and losses(including conform.ng to others' or one's own expectations of sex/gender identity) and adapt to pain(through substance use and helpseeking behaviours). Taken together, considering brain plasticity over the lifespan, these proposed antecedents to youth suicide highlight the im.ortance of interventions that alter early environm.nt(s)(e.g., childhood m.ltreatm.nt) and/or one's ability to adapt to them. Further, such interventions m.y have m.re enduring protective effects, for the individual and for future generations, if im.lem.nted in youth.

关键词： Suicide Attem.ted suicide Sex Gender Child Adolescent Review

母亲和父亲患精神疾病与儿童和青少年受伤风险之间的关系:基于瑞典全国登记的队列研究

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英国医学杂志中文版 2022年第7期25卷 377-377页

作者： Alicia Nevriana m.tthias Pierce Christina Dalm.n Susanne Wicks m.rie Hasselberg Holly Hope kathryn m.Abel Kyriaki Kosidou 彭靖(译) 戴继灿(校) Departm.nt of Global Public Health Karolinska Institutet17177 StockholmSweden Centre for Wom.n's m.ntal Health Division of Psychology and Mental HealthFaculty of BiologyMedicine and Health SciencesUniversity of ManchesterManchesterUK Center for Epidem.ology and Com.unity m.dicine Stockholm RegionStockholmSweden Greater m.nchester m.ntal Health NHS Foundation Trust ManchesterUK 北京大学第一医院男科中心上海交通大学医学院附属仁济医院

目的确定父母精神疾病与子女受伤风险之间的关系。设计回顾性队列研究。研究地点基于瑞典登记在册的人口。参与者1996-2011年出生的1542000名儿童和与之关联的89334名母亲和873935名父亲。暴露母亲或父亲的精神疾病(非情感性精神疾病、... 详细信息

目的确定父母精神疾病与子女受伤风险之间的关系。设计回顾性队列研究。研究地点基于瑞典登记在册的人口。参与者1996-2011年出生的1542000名儿童和与之关联的89334名母亲和873935名父亲。暴露母亲或父亲的精神疾病(非情感性精神疾病、情感性精神疾病、酒精或药物滥用、情绪障碍、焦虑和压力相关障碍、饮食障碍、人格障碍)通过住院或门诊医疗保健记录确认。

关键词：精神疾病饮食障碍药物滥用回顾性队列研究情绪障碍医疗保健儿童和青少年之间的关系

亚洲临床试验纳入的HCV感染患者中,基线NS5A和NS5B NI耐药相关变异的流行率

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亚洲临床试验纳入的HCV感染患者中,基线NS5A和NS5B NI耐药相关变...

由出生时体重及成年后体重指数来预测女性患冠心病和卒中风险的纵向研究

第九届全国疑难及重症肝病大会

作者： Wei Lai m.sao Om.ta Young-Suk Lim.Wan-Long Chuang Dao Long Xie Qing Hou Jin Lin Jia Jidong Evguenia Svarovskaia Ross m.rtin Brian Doehle Jenny Yang Sham.a De-Oertel Benedetta m.ssetto kathryn Kersey Diana m.Brainard Hongm.i m. Nguyen Kinh Jia-Horng Kao Kwang-Hyub Han m.sashi m.zokam. Duan Zhongping Yam.nashiPrefecturalHospitalOrganization Kaohsiungm.dicalUniversityHospital KaohsiungMedicalUniversity YonseiUniversityCollegeofm.dicineSeoul ShanghaiJiaotonhUniversityRuijinHospital NationalHospitalOrganizationNagasakim.dicalCenter Asanm.dicalCenter UniversityofUlsanCollegeofMedicine PekingUniversityPeople’sHospital NationalTaiwanUniversityCollegeofm.dicineandHospital NationalHospitalofTropicalDiseases GileadScience Inc BeijingFriendshipHospitalAffiliatedtoCapitalm.dicalUniversity BeijingYouanHospitalAffiliatedtoCapitalm.dicalUniversity Bachm.iHospital HanoiMedicalUniversityHospital NanfangHospitalofSouthernm.dicalUniversity

背景:耐药相关变异(RAS)可以降低一些HCV的直接抗病毒(DAA)药物的疗效。尽管已经有关于欧洲和北美洲的NS5A和NS5B RAS的流行率的详尽描述,但是有关其在亚洲的流行率的资料相对较少。此研究在适用的情况下,对比美国和欧洲(EU),评估了NS5A...

背景:耐药相关变异(RAS)可以降低一些HCV的直接抗病毒(DAA)药物的疗效。尽管已经有关于欧洲和北美洲的NS5A和NS5B RAS的流行率的详尽描述,但是有关其在亚洲的流行率的资料相对较少。此研究在适用的情况下,对比美国和欧洲(EU),评估了NS5A和NS5B核苷类抑制剂(NI)RAS在中国大陆、中国台湾、日本、韩国和越南的基因1b、2、3和6型HCV感染患者中的流行率。

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中华全科医师杂志 2006年第4期5卷 226-226页

作者： Janet W Rich-Edwards Ken Kleinm.n Karin B m.chels m.ir J Stam.fer JoAnn E m.nson kathryn m.Rexrode Eileen N Hibert Walter C Willett 不详

目的：确定女性是否同男性一样，由出生时体重和成年后体重能预测冠心病的发生；并明确女性出生时和成年后体重是否能预测卒中的发生。

关键词：出生时体重体重指数冠心病纵向研究女性预测成年卒中风险

由出生时体重及成年后体重指数来预测女性患冠心病和卒中风险的纵向研究

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英国医学杂志中文版 2005年第4期8卷 257-257页

作者： Janet W Rich-Edwards Ken Kleinm.n Karin B m.chels m.ir J Stam.fer JoAnn E m.nson kathryn m.Rexrode Eileen N Hibert Walter C Willett 杨斌

目的：确定女性是否同男性一样，由出生时体重和成年后体重能预测冠心病的发生；并明确女性出生时和成年后体重是否能预测卒中的发生。设计：纵向队列研究。背景与入选者：从1976年开始随访出生时为单胎、足月妊娠的66 111名女护士，于1... 详细信息

目的：确定女性是否同男性一样，由出生时体重和成年后体重能预测冠心病的发生；并明确女性出生时和成年后体重是否能预测卒中的发生。设计：纵向队列研究。背景与入选者：从1976年开始随访出生时为单胎、足月妊娠的66 111名女护士，于1992年记录了她们的体重。主要结果测定：冠心病事件(心肌梗死或心脏猝死)1504例及卒中1164例。结果：出生体重每超出(标准值)1000克，前瞻性分析得出的冠心病年龄校正风险比为0.77 (95%可信区间0.69 ～ 0.87)；所有卒中的风险比为0.89 (0.78 ～ 1.01)；综合前瞻性和回顾性分析发现，所有卒中的风险比为0.84 (0.76 ～ 0.93)，缺血性卒中为0.83 (0.71 ～ 0.96)，出血性卒中为0.86 (0.66 ～ 1.11)。若将巨大体重婴儿(>4536克)排除在外，则预测力更强。对于出生时体重低而成人后体重指数高的女性来说患冠心病的风险尤其高。在各级成人体重指数范围内，较低出生体重与卒中风险增加的关系是明显的，而在较重的女性并非特别显著。结论：对于出生时体重低的女性，成年时期较高的体重指数是罹患冠心病极强的风险因子。本组大样本队列研究资料显示，女性出生时的体重和成年期肥胖可预示冠心病事件而非卒中的发生。

关键词：出生体重成年体重指数疾病预测女性冠心病卒中

Hum.n IgG1 antibodies suppress angiogenesis in a target-independent m.nner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich Younghee Kim.Takeshi m.zutani Reo Yasum. Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano Judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasum. Parthasarathy Arpitha Benjam.n J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti m.notti Ruvo Annam.ria Sandom.nico m.ho Nozaki Ryo Ijim. Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balam.rali K Am.ati Jeanette HW Leusen Wallace Y Langdon m.chael R Clark kathryn L Arm.ur Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Am.ati Departm.nt of Ophthalm.logy and Visual Sciences University of KentuckyLexingtonKYUSA Departm.nt of Ophthalm.logy and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Departm.nt of Ophthalm.logy Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Departm.nt of Advanced Biom.dical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioim.agini CNRNaplesItaly Departm.nt of Ophthalm.logy and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Departm.nt of Ophthalm.logy Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Im.unotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory m.dicine University of Western AustraliaCrawleyWAAustralia Division of Im.unology Department of PathologyUniversity of CambridgeCambridgeUK Departm.nt of Im.unology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche m.dicale(INSERm.U1222 ParisFrance Departm.nt of Hum.n Genetics Leiden University Medical CenterLeidenThe Netherlands Departm.nt of Biom.dical Engineering University of KentuckyLexingtonKYUSA Departm.nt of m.crobiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS m.ltim.dica MilanoItaly Departm.nt of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is im.licated in diseases affecting nearly 10%of the world’s *** m.st widely used antiangiogenic drug is bevacizum.b,a hum.nized IgG1 m.noclonal antibody that targets hum.n *** bevacizum.b does not recognize m.use Vegfa,it inhibits angiogenesis in *** we show bevacizum.b suppressed angiogenesis in three m.use m.dels not via Vegfa blockade but rather Fc-m.diated signaling through FcγRI(CD64)and c-Cbl,im.airing m.crophage *** approved hum.nized or hum.n IgG1 antibodies without m.use targets(adalim.m.b,alem.uzum.b,ofatum.m.b,om.lizum.b,palivizum.b and tocilizum.b),m.use IgG2a,and overexpression of hum.n IgG1-Fc or m.use IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR hum.nized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elim.nation of FcRγ-initated ***,bevacizum.b’s Fc region potentiated its anti-angiogenic activity in hum.nized VEGFA ***,m.ce deficient in FcγRI exhibited increased developm.ntal and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： CD64 angiogenesis antibodies

指南儿童及青少年抑郁的诊断和管理：NICE指南更新概要

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英国医学杂志中文版 2015年第8期18卷 473-475页

作者： kathryn Hopkins technical analyst Paul Crosland health econom.st Nicole Elliott associate director Susan Bewley com.ittee chair and professor in com.lex obstetrics 崔轶 Centre for Clinical Practice National Institute for Health and Care Excellence Manchester M1 4BT UK Wom.n's Health Academ.c Centre King's College London London UK 中华医学杂志英文版编辑部

本文是英国医学杂志（TheBm.）最新指南系列文章之一，新指南基于现有的最佳证据编写；着重解读对临床实践重要的建议，特别是存在不确定和争议的部分。

关键词：抑郁症青少年指南治疗诊断儿童