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Cross-sectional population based study ascertaining the characteristics of US rural adults with mental health concerns who perceived a stigma regarding mental health issues

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Health 2013年第4期5卷 695-702页

作者： kathryn j. Pederson M. Nawal Lutfiyya Laura C. Palombi David R. Simmons Darin j. Steenerson Kenzie G. Hohman Krista L. Huot Essentia Health Acute Care Pharmacy Residency Duluth USA Essentia Health System Ambulatory Care Pharmacy Services Duluth USA Essentia Institute of Rural Health Duluth USA University of Minnesota College of Pharmacy Ambulatory Care Residency Program Minneapolis USA

Introduction: Mental health is an important component of overall health. Mental illness is a leading cause of morbidity and mortality in the US and is associated with chronic diseases such as heart disease, diabetes, and arthritis. In the US, most people with mental health issues or disorders remain untreated. Epidemiological studies have identified rural residents as being at greater risk for health disparities;as a result, rural residents are a vulnerable population in terms of mental health and mental health care. Research has demonstrated that perceived stigma can be a significant barrier to rural residents seeking mental health care. This study examined the research question: What are the characteristics of US rural adults with mental health concerns who perceived stigma? Methods: 2007 Behavioral Risk Factor Surveillance System (BRFSS) data were analyzed using bivariate and multivariate techniques to answer the research question. 2007 BRFSS data were used because in that year non-institutionalized US adults in 37 states and territories were queried about their attitudes toward mental illness. BRFSS is a random digit telephone survey that uses a complex multi-stage sampling approach and subsequently a weighting factor is calculated for application to the data in order to ensure that they are representative of the US population based on the most recent census data. Only weighted data were analyzed. Results: Logistic regression analysis revealed that rural adults reporting mental health concerns who perceived stigma regarding mental health were more likely to be unemployed seeking work or not working and not seeking work, military veterans, or to have deferred medical care because of cost. They were also more likely to not have a health care provider and to rarely or never feel supported emotionally. Conclusions: Support systems may render people with mental health issues less vulnerable to perceiving stigma, thus assisting with removing stigma as a barrier to car

关键词： BRFSS Surveillance Data Rural Mental Health Perceived Stigma of Mental Health Issues

Detailed description of Division I ice hockey concussions:Findings from the NCAA and Department of Defense CARE Consortium

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journal of Sport and Health Science 2021年第2期10卷 162-171页

作者： kathryn L.Van Pelt jaclyn B.Caccese james T.Eckner Margot Putukian MAlison Brooks Kenneth L.Cameron Megan N.Houston Matthew A.Posner jonathan C.jackson Gerald T.McGinty Cameron j.Hillis Thomas W.McAllister Michael A.McCrea Steven P.Broglio Thomas A.Buckley Sanders-Brown Center on Aging University of KentuckyLexingtonKY 40536-0230USA College of Medicine School of Health and Rehabilitation Sciences The Ohio State UniversityColumbusOH 43210USA Department of Physical Medicine and Rehabilitation Michigan MedicineUniversity of MichiganAnn ArborMI 48108USA University Health Services Princeton UniversityMcCosh Health CenterPrincetonNJ 08544USA Department of Orthopedics and Rehabilitation Department of PediatricsUniversity of Wisconsin School of Medicine and Public HealthMadisonWI 53705-2281USA Keller Army Hospital United States Military AcademyWest PointNY 10996USA th Medical Group United States Air Force AcademyColorado SpringsCO 80840-4000USA Sports Medicine Athletic DepartmentUnited States Air Force AcademyU.S.Air Force AcademyCO 80840-9500USA Novant Health Charlotte Independence Soccer ClubCorneliusNC 28031USA Department of Psychiatry Indiana UniversityIndianapolisIN 46202USA Neurosurgery Medical College of WisconsinMilwaukeeWI 53226USA Michigan Concussion Center University of MichiganAnn ArborMI 48109USA Kinesiology and Applied Physiology University of DelawareNewarkDE 19713USA

Objective:Since concussion is the most common injury in ice hockey,the objective of the current study was to elucidate risk factors,specific mechanisms,and clinical presentations of concussion in men’s and women’s ice ***:Ice hockey players from 5 institutions participating in the Concussion Assessment,Research,and Education Consortium were eligible for the current *** who sustained a concussion outside of this sport were *** were 332(250 males,82 females)athletes who participated in ice hockey,and 47(36 males,11 females)who sustained a ***:Previous concussion(odds ratio(OR)=2.00;95%confidence interval(95%CI):1.02‒3.91)was associated with increased incident concussion odds,while wearing a mouthguard was protective against incident concussion(OR=0.43;95%CI:0.22‒0.85).Overall,concussion mechanisms did not significantly differ between *** were specific differences in how concussions presented clinically across male and female ice hockey players,***(9.09%)were less likely than males(41.67%)to have a delayed symptom onset(p=0.045).Additionally,females took significantly longer to reach asymptomatic(p=0.015)and return-to-play clearance(p=0.005).Within the first 2 weeks post-concussion,86.11%of males reached asymptomatic,while only 45.50%of females reached the same phase of *** males(91.67%)were cleared for return to play within 3 weeks of their concussion,compared to less than half(45.50%)of ***:The current study proposes possible risk factors,mechanisms,and clinical profiles to be validated in future concussions studies with larger female sample *** specific risk factors,concussion mechanisms,and clinical profiles of concussion in collegiate ice hockey may generate ideas for future concussion prevention or intervention studies.

关键词： Concussion risk Injury mechanism Recovery

Clinical outcome measures in dementia with Lewy bodies trials: critique and recommendations

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Translational Neurodegeneration 2022年第1期11卷 514-531页

作者： Federico Rodriguez-Porcel kathryn A.Wyman-Chick Carla Abdelnour Ruiz jon B.Toledo Daniel Ferreira Prabitha Urwyler Rimona S.Weil joseph Kane Andrea Pilotto Arvid Rongve Bradley Boeve john-Paul Taylor Ian McKeith Dag Aarsland Simon j.G.Lewis the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment(ISTAART) Department of Neurology Medical University of South Carolina208b Rutledge Av.CharlestonSC 29403USA Department of Neurology Center for Memory and AgingHealthPartnersSaint PaulMNUSA Autonomous University of Barcelona BarcelonaSpain Fixel Institute for Neurological Diseases University of FloridaGainesvilleFLUSA Division of Clinical Geriatrics Department of NeurobiologyCare Sciencesand SocietyCenter for Alzheimer’s ResearchKarolinska InstitutetStockholmSweden Department of Radiology Mayo ClinicRochesterMNUSA ARTORG Center for Biomedical Engineering Research University of BernBernSwitzerland Dementia Research Centre University College LondonLondonUK Centre for Public Health Queen’s UniversityBelfastUK Neurology Unit Department of Clinical and Experimental SciencesUniversity of BresciaBresciaItaly Department of Research and Innovation Helse FonnaHaugesund HospitalHaugesundNorway Institute of Clinical Medicine(K1) The University of Ber-genBergenNorway Department of Neurology Center for Sleep MedicineMayo ClinicRochesterMNUSA Translational and Clinical Research Institute Newcastle UniversityNewcastle upon TyneUK Department of Old Age Psychiatry Institute of Psychiatry Psychology and Neuroscience King’s College LondonLondonUK ForeFront Parkinson’s Disease Research Clinic Brain and Mind CentreSchool of Medical SciencesUniversity of Sydney100 Mallett StreetCamperdownNSW 2050Australia. 不详

The selection of appropriate outcome measures is fundamental to the design of any successful clinical trial. Although dementia with Lewy bodies (DLB) is one of the most common neurodegenerative conditions, assessment of therapeutic benefit in clinical trials often relies on tools developed for other conditions, such as Alzheimer’s or Parkinson’s disease. These may not be sufficiently valid or sensitive to treatment changes in DLB, decreasing their utility. In this review, we discuss the limitations and strengths of selected available tools used to measure DLB-associated outcomes in clinical trials and highlight the potential roles for more specific objective measures. We emphasize that the existing outcome measures require validation in the DLB population and that DLB-specific outcomes need to be developed. Finally, we highlight how the selection of outcome measures may vary between symptomatic and disease-modifying therapy trials.

关键词： Dementia with Lewy bodies Clinical trials Outcomes Measurement properties

亚洲古近纪早期的年代学和哺乳动物群更替(英文)

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古脊椎动物学报 2011年第1期49卷 1-28页

作者：丁素因童永生 William C.CLYDE Paul L.KOCH 孟津王元青 Gabriel j.BOWEN 李茜 kathryn E.SNELL 美国路易斯安那州立大学自然科学博物馆巴吞鲁日LA70803 中国科学院古脊椎动物与古人类研究所北京100044 美国新罕布什尔大学达拉莫NH03824 美国加州大学圣克鲁斯分校圣克鲁斯CA95064 美国自然历史博物馆纽约NY10024 美国普渡大学西拉斐特IN47907

对广东南雄盆地、江西池江盆地、安徽潜山盆地、湖南衡阳盆地和内蒙古二连盆地古新世和早始新世沉积物进行的生物地层学、化学地层学和磁性地层学研究,第一次给亚洲早古近纪地层框架提供了严格的年代限定。亚洲古新世和早始新世地层划分... 详细信息

对广东南雄盆地、江西池江盆地、安徽潜山盆地、湖南衡阳盆地和内蒙古二连盆地古新世和早始新世沉积物进行的生物地层学、化学地层学和磁性地层学研究,第一次给亚洲早古近纪地层框架提供了严格的年代限定。亚洲古新世和早始新世地层划分为4个生物年代单位(陆生哺乳动物期),从老到新为上湖期、浓山期、格沙头期和伯姆巴期4个亚洲陆生哺乳动物期。南雄盆地古地磁数据显示上湖期的底界约位于C29r的上2/3位置。南雄盆地的古地磁资料及池江盆地最新的古地磁和同位素结果显示上湖-浓山期界线在C27n的上部和C26r的下部之间,接近C27n-C26r转换界面。这一记录支持将上湖-浓山期的界线与北美陆生哺乳动物期中的Torrejonian-Tiffanian期以及海相记录中丹尼-塞兰特期(Danian-Selandi-an)的界线相对比。二连盆地古地磁和同位素研究表明典型的格沙头动物群延续至C24r,并且可能向下延伸至C25r和C26n。南雄盆地的记录指示浓山组和古城村组可能相当于C26r的上部。这些结果表明亚洲哺乳动物分期中的浓山-格沙头期的界线可能在北美哺乳动物分期的Tiffanian期中。衡阳盆地的古地磁和同位素证据指示,以短暂的碳同位素漂移为标志的古新世-始新世界线出现在栗木坪组和岭茶组之间,位于C24r中,与海相记录中的坦尼特-伊普里斯期(Thanetian-Ypresian)界线一致。伯姆巴期岭茶动物群的时代似乎与北美Wa-satchian-0带的动物群可以比较。上湖期和浓山期动物群主要由亚洲特有的动物组成。发生在上湖期和浓山期界线处的动物群更替,与北美Torrejonian-Tiffanian期界线以及丹尼-塞兰特期界线一致。在相隔很远的生态系统上的这种巧合,可能反映出各自独立的对气候变化的生态和/或进化上的响应。格沙头动物群的地方性色彩更弱,有与北美Clarkforkian期动物群共有的属一级分类单元。伯姆巴动物群是全球性的。现生哺乳动物各目在格沙头-伯姆巴期界线处突然出现,与北美和欧洲的记录一致,显示动物群的更替与古新世-始新世界线处短暂出现的全球变暖事件(又称古新世-始新世高温事件)有关。

关键词：亚洲古新世早始新世年代学

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马铃薯收获后干燥对其贮后发病率的影响

园艺与种苗 1993年第4期 45-47页

作者： G.A.Hide kathryn j.Boorer 丁双阳

1980～1984年,以节卵孢Polyscytalum pustulans接种或使其自然侵染马铃薯块茎的试验表明,收获后在干燥条件下保持8周,能够大大地减轻贮藏中马铃薯皮斑病。1986～1988年,以自然侵染的薯块为试材,进一步试验贮前干燥对4种有损于块茎外观... 详细信息

1980～1984年,以节卵孢Polyscytalum pustulans接种或使其自然侵染马铃薯块茎的试验表明,收获后在干燥条件下保持8周,能够大大地减轻贮藏中马铃薯皮斑病。1986～1988年,以自然侵染的薯块为试材,进一步试验贮前干燥对4种有损于块茎外观品质病害的影响。

关键词：皮斑病块茎侵染地下茎土豆茄属马铃薯干燥处理病害指数粗皮病菌核病丝核菌病发病率

Structural and functional analysis of two new positive allosteric modulators of GluR2 desensitization and deactivation

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Structural and functional analysis of two new positive allos...

The 4th ISGO International Conference on Structural Genomics

作者： Autumn M.Weeks David E.Timm Morris j.Benveniste Eric S.Nisenbaum kathryn M.Partin Colorado State University Fort Collins CO80523U.S.A. Lilly Research Labs Lilly Corporate Center IndianapolisIN46285USA Colorado State University Fort Collins CO80523U.S.A. Lilly Research Labs Lilly Corporate Center Indianapolis IN46285 USA Colorado State University Fort Collins CO 80523 U.S.A.

＜正＞Recent crystallographic and functional analyses of AMPA receptors have identified a common binding pocket for two classes of positive allosteric AMPA receptor modulators. From those studies, a working model of channel desensitization and deactivation has been established. Here we present structural and functional data on two new positive allosteric modulators of AMPA receptors. These compounds

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马铃薯收获后干燥对其贮后发病率的影响

国外农学（杂粮作物） 1993年第4期 45-47页

作者： G.A.Hide kathryn j.Boorer 丁双阳

关键词：马铃薯干燥贮藏发病率

Secreted frizzled related-protein 2(Sfrp2)deficiency decreases adult skeletal stem cell function in mice

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Bone Research 2021年第4期9卷 606-617页

作者： Luis Fernandez de Castro Brian丄Sworder Byron Mui kathryn Futrega Agnes Berendsen Matthew D.Phillips Nathan j.Burbach Natasha Cherman Sergei Kuznetsov Yankel Gabet Kenn Holmbeck Pamela G.Robey Skeletal Biology Section National Institute of Dental and Craniofacial ResearchNational Institutes of HealthDepartment of Health and Human ServicesNational Institutes of HealthBethesdaMDUSA Department of Molecular Medicine Boston UniversityBostonMAUSA School of Dentistry University of Minnesota-Twin CitiesMinneapolisMNUSA Department of Anatomy and Anthropology Sackler Faculty of MedicineTel Aviv UniversityTel Aviv-YafoIsrael

In a previous transcriptomic study of human bone marrow stromal cells(BMSCs,also known as bone marrow-derived^mesenchymal stem cells#,)/SFRP2 was highly over-represented in a subset of multipotent BMSCs(skeletal stem cells,SSCs),which recreate a bone/marrow organ in an in vivo ectopic bone formation *** modulate WNT signaling,which is essential to maintain skeletal homeostasis,but the specific role of SFRP2 in BMSCs/SSCs is ***,we evaluated Sfrp2 deficiency on BMSC/SSC function in models of skeletal organogenesis and *** skeleton of Sfrp2-def\c\ent(KO)mice is overtly normal;but their BMSCs/SSCs exhibit reduced colony-forming efficiency,reflecting low SSC self-renewal/***2 KO BMSCs/SSCs formed less trabecular bone than those from WT littermates in the ectopic bone formation ***,regeneration of a cortical drilled hole defect was dramatically impaired in Sfrp2 KO ***2-deficient BMSCs/SSCs exhibited poor in vitro osteogenic differentiation as measured by Runx2 and Osterix expression and calcium ***,activation of the Wnt co-receptor;Lrp6,and expression of Wnt target genes,Axin2,C-myc and Cyclin Dl,were reduced in Sfrp2-deficient BMSCs/*** of recombinant Sfrp2 restored most of these activities,suggesting that Sfrp2 acts as a Wnt *** demonstrate that Sfrp2 plays a role in self-renewal of SSCs and in the recruitment and differentiation of adult SSCs during bone ***2 is also a useful marker of BMSC/SSC multipotency,and a factor to potentially improve the quality of ex vivo expanded BMSC/SSC products.

关键词： skeletal impaired healing

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澳大利亚绵羊罩衣的研制及利用

中国养羊 1995年第3期15卷 42-43页

作者： kathryn L.Ford D. j. Cottle 钱春元新南维尔士大学羊毛和动物科学系

羊毛纤维损伤与污染程度直接决定毛纺织产品质量的高低。绵羊罩衣的应用可减少原毛中植物杂质及灰尘的含量。澳大利亚自1930年起开始研制与应用羊罩衣生产优质羊毛。羊罩衣可保护羊毛避免热辐射引起羊毛顶端分化,因寒冷而形成的羊毛纤... 详细信息

羊毛纤维损伤与污染程度直接决定毛纺织产品质量的高低。绵羊罩衣的应用可减少原毛中植物杂质及灰尘的含量。澳大利亚自1930年起开始研制与应用羊罩衣生产优质羊毛。羊罩衣可保护羊毛避免热辐射引起羊毛顶端分化,因寒冷而形成的羊毛纤维结冰后引起的羊毛纤维断裂,同时可防止蚊蝇在潮湿的被毛中繁殖而引起绵羊被毛腐烂,对于增加净毛量,减少被毛中植物杂质及灰尘含量具有直接效果。改进后的羊罩衣可随羊毛生长调节其大小型号。

关键词：羊罩衣羊毛品质植物杂质绵羊澳大利亚