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A cadaveric model for transesophageal echocardiography transducer placement training: A pilot study

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World Journal of Emergency Medicine 2022年第1期13卷 18-22页

作者： Ryan W.Horton Kian R.Niknam Viveta Lobo kathryn H.Pade Drew Jones Kenton L.Anderson Department of Emergency Medicine Stanford University School of MedicinePalo Alto 94304USA Emergency Medicine Residency Program University of Texas at Austin Dell Medical SchoolAustin 78756USA University of California San Francisco School of Medicine San Francisco 94143USA Department of Emergency Medicine Rady Children’s HospitalSan Diego 92123USA Department of Emergency Medicine University of Central Florida/HCA Ocala RegionalOcala 34471USA

BACKGROUND: Transesophageal echocardiography(TEE) is used in the emergency department to guide resuscitation during cardiac arrest. Insertion of a TEE transducer requires manual skill and experience, yet in some residency programs cardiac arrest is uncommon, so some physicians may lack the means to acquire the manual skills to perform TEE in clinical practice. For other infrequently performed procedural skills, simulation models are used. However, there is currently no model that adequately simulates TEE transducer insertion. The aim of this study is to evaluate the feasibility and efficacy of using a cadaveric model to teach TEE transducer placement among novice ***: A convenience sample of emergency medicine residents was enrolled during a procedure education session using cadavers as tissue models. A pre-session assessment was used to determine prior knowledge and confidence regarding TEE manipulation. Participants subsequently attended a didactic and hands-on education session on TEE placement. All participants practised placing the TEE transducer until they were able to pass a standardized assessment of technical skill(SATS). After the educational session, participants completed a post-session assessment. RESULTS: Twenty-five residents participated in the training session. Mean assessment of knowledge improved from 6.2/10 to 8.7/10(95% confidence interval [CI] of knowledge difference 1.6–3.2, P<0.001) and confidence improved from 1.6/5 to 3.1/5(95% CI of confidence difference 1.1–2.0, P<0.001). There was no relationship between training level and the delta in knowledge or ***: In this pilot study, the use of a cadaveric model to teach TEE transducer placement methods among novice users is feasible and improves both TEE manipulation knowledge and confidence levels.

关键词： Cardiopulmonary resuscitation Echocardiography Education Simulation

High-brightness polarized light-emitting diodes

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Light(Science & Applications) 2012年第1期1卷 72-78页

作者： Elison Matioli Stuart Brinkley kathryn M Kelchner Yan-Ling Hu Shuji Nakamura Steven DenBaars James Speck Claude Weisbuch Department of Electrical Engineering and Computer Science Massachusetts Institute of TechnologyCambridgeMAUSA Department of Electrical and Computer Engineering University of CaliforniaSanta BarbaraCAUSA Materials Department University of CaliforniaSanta BarbaraCAUSA Laboratoire de Physique de la Matie`re Condense´e CNRSEcole PolytechniquePalaiseauFrance

Light-emitting diodes are becoming the alternative for future general lighting applications,with huge energy savings compared to conventional light sources owing to their high efficiency and *** light sources would largely enhance the efficiency in a number of applications,such as in liquid-crystal displays,and also greatly improve contrast in general illumination due to the reduction in indirect ***,we demonstrate light-emitting diodes presenting high-brightness polarized light emission by combining the polarization-preserving and directional extraction properties of embedded photonic-crystals applied to non-polar gallium nitride.A directional enhancement of up to 1.8-fold was observed in the total polarized light emission together with a high polarization degree of 88.7%at 465 *** discuss the mechanisms of polarized light emission in non-polar gallium nitride and the photonic-crystal design rules to further increase the light-emitting diode *** work could open the way to polarized white-light emitters through their association with polarization-preserving down-converting phosphors.

关键词： GaN LEDs m-plane polarized light

Ad Hoc File Systems for High-Performance Computing

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Journal of Computer Science & Technology 2020年第1期35卷 4-26页

作者： AndréBrinkmann kathryn Mohror Weikuan Yu Philip Carns Toni Cortes Scott A.Klasky Alberto Miranda Franz-Josef Pfreundt Robert B.Ross Marc-AndréVef Zentrum für Datenverarbeitung Johannes Gutenberg University MainzMainz 55128Germany Center for Applied Scientific Computing Lawrence Livermore National LaboratoryLivermoreCA 94550U.S.A Department of Computer Science Florida State UniversityTallahasseeFL 32306U.S.A Mathematics and Computer Science Division Argonne National LaboratoryLemontIL 60439U.S.A Department of Computer Architecture Universitat Politecnica de CatalunyaBarcelona 08034Spain Computer Science and Mathematics Division Oak Ridge National LaboratoryOak RidgeTN 37831U.S.A Computer Science Department Barcelona Supercomputing CenterBarcelona 08034Spain Fraunhofer Institute for Industrial Mathematics ITWM Fraunhofer-Platz 1Kaiserslautern 67663Germany

Storage backends of parallel compute clusters are still based mostly on magnetic disks,while newer and faster storage technologies such as flash-based SSDs or non-volatile random access memory(NVRAM)are deployed within compute *** these new storage technologies into scientific workflows is unfortunately today a mostly manual task,and most scientists therefore do not take advantage of the faster storage *** approach to systematically include nodelocal SSDs or NVRAMs into scientific workflows is to deploy ad hoc file systems over a set of compute nodes,which serve as temporary storage systems for single applications or longer-running *** paper presents results from the Dagstuhl Seminar 17202"Challenges and Opportunities of User-Level File Systems for HPC"and discusses application scenarios as well as design strategies for ad hoc file systems using node-local storage *** discussion includes open research questions,such as how to couple ad hoc file systems with the batch scheduling environment and how to schedule stage-in and stage-out processes of data between the storage backend and the ad hoc file *** presented are strategies to build ad hoc file systems by using reusable components for networking and how to improve storage device *** interfaces and semantics are presented,for example those used by the three ad hoc file systems BeeOND,GekkoFS,and *** presentation covers a range from file systems running in production to cutting-edge research focusing on reaching the performance limits of the underlying devices.

关键词： parallel architectures distributed file system high-performance computing burst buffer POSIX(portable operating system interface)

Linking tree growth rate, damage repair, and susceptibility to a genus-specific pest infestation

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Journal of Forestry Research 2019年第5期30卷 1935-1941页

作者： Kayla N.Boyes kathryn G.Hietala-Henschell Alexander P.Barton Andrew J.Storer Jordan M.Marshall Department of Biology Purdue University Fort WayneFort WayneIN 46805USA School of Forest Resources and Environmental Science Michigan Technological UniversityHoughtonMI 49931USA

Pest preference and subsequent susceptibility of a host individual is likely related to previous growth patterns in that *** ash borer(Agrilus planipennis Fairmaire)is a pestiferous beetle introduced to North America from *** all species of ash are susceptible to attack,some individual trees appear to survive *** selected ash trees in southeastern Michigan,collected cores and categorized trees as high tolerance to emerald ash borer attack(high overall health,low crown dieback),low tolerance(low overall health,high crown dieback)and intermediate tolerance(in-between the other categories).We artificially wounded trees and measured wound closure after 3 *** width indices were not correlated between high and low tolerance *** slopes comparing growth and years were significantly different between the three tolerance categories,with high tolerance trees having the steepest *** closure was greatest in high tolerance *** tolerance trees demonstrating more rapid(steeper regression slope),consistent(lower variance),and effective(greater wound closure)*** vigorously growing trees likely had more capacity to repair damage caused by emerald ash borer,leading to healthier trees in our *** previous host growth patterns to health may have implications related to identifying individual trees potentially tolerant to attack.

关键词： Agrilus Ash Dendrochronology Emerald ash borer Fraxinus Invasive species

Locomotor analysis identifies early compensatory changes during disease progression and subgroup classification in a mouse model of amyotrophic lateral sclerosis

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Neural Regeneration Research 2017年第10期12卷 1664-1679页

作者： Melissa M.Haulcomb Rena M.Meadows Whitney M.Miller kathryn P.Mc Millan Me Kenzie J.Hilsmeyer Xuefu Wang Wesley T.Beaulieu Stephanie L.Dickinson Todd J.Brown Virginia M.Sanders kathryn J.Jones Department of Anatomy and Cell Biology Indiana University School of MedicineIndianapolisINUSA Research and Development Service Roudebush Veterans Administration Medical CenterIndianapolisINUSA Program in Medical Neurosciences Indiana University School of MedicineIndianapolisINUSA Department of Statistics Indiana UniversityBloomingtonINUSA Department of Epidemiology and Biostatistics Indiana UniversityBloomingtonINUSA Department of Cancer Biology and Genetics The Ohio State University Wexner Medical CenterColumbusOHUSA

Amyotrophic lateral sclerosis is a motoneuron degenerative disease that is challenging to diagnose and presents with considerable variability in *** identification and enhanced understanding of symptomatic patterns could aid in diagnosis and provide an avenue for monitoring disease *** of the m SOD1 G93 A mouse model provides control of the confounding environmental factors and genetic heterogeneity seen in amyotrophic lateral sclerosis patients,while investigating underlying disease-induced *** the present study,we performed a longitudinal behavioral assessment paradigm and identified an early hindlimb symptom,resembling the common gait abnormality foot drop,along with an accompanying forelimb compensatory mechanism in the m SOD1 G93 A *** these initial changes,m SOD1 mice displayed a temporary hindlimb compensatory mechanism resembling an exaggerated steppage *** the disease progressed,these compensatory mechanisms were not sufficient to sustain fundamental locomotor parameters and more severe deficits *** next applied these initial findings to investigate the inherent variability in B6 SJL m SOD1 G93 A *** identified four behavioral variables that,when combined in a cluster analysis,identified two subpopulations with different disease progression rates：a fast progression group and a slow progression *** behavioral assessment paradigm,with its analytical approaches,provides a method for monitoring disease progression and detecting m SOD1 subgroups with different disease *** affords researchers an opportunity to search for genetic modifiers or other factors that likely enhance or slow disease *** factors are possible therapeutic targets with the potential to slow disease progression and provide insight into the underlying pathology and disease mechanisms.

关键词： nerve regeneration amyotrophic lateral sclerosis motoneuron degenerative disease locomotor disease progression disease variability SOD1 mouse neural regeneration

Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis

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Frontiers of Medicine 2012年第4期6卷 395-405页

作者： Riffat Meraj kathryn A.Wikenheiser-Brokamp Lisa R.Young Sue Byrnes Francis X.McCormack Division of Pulmonary Critical Care and Sleep MedicineDepartment of Internal MedicineUniversity of Cincinnati School of MedicineCincinnatiOH 45529USA Pathology and Laboratory Medicine Cincinnati Children’s Hospital Medical Center and University of Cincinnati School of MedicineCincinnatiOH 45529USA Division of Pediatric Pulmonary Medicine Department of PediatricsVanderbilt UniversityNashvilleTN 37232USA The LAM Foundation Executive DriveCincinnatiOH 45241USA

Pulmonary lymphangioleiomyomatosis(LAM)is a rare cystic lung disease that targets women during their reproductive years.A confident diagnosis can often be based on clinical grounds,but diagnostic certainty requires pathological *** surgical lung biopsy is considered the gold standard for obtaining tissue in patients with diffuse lung disease,it is also associated with higher morbidity and mortality than alternative,less invasive *** objective of our study was to examine the utility of transbronchial biopsy in the diagnosis of *** conducted two online surveys of over 1000 LAM patients registered with the LAM Foundation who were accessible by *** biopsy specimens were subsequently collected and reviewed by an expert pathologist to validate the *** found that transbronchial biopsy has a yield of approximately 60% in patients with *** conclude that transbronchial biopsy may be a safe and effective method for establishing the diagnosis of LAM,obviating the need for surgical lung biopsy in more than half of LAM patients.

关键词： lymphangioleiomyomatosis lymphangiomyomatosis multicystic lung disease diffuse cystic lung disease transbronchial biopsy perivascular epithelioid cell tumor(PEComa) HMB-45

Reproductive ecology of the black rat (Rattus rattus) in Madagascar: the influence of density-dependent and -independent effects

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Integrative Zoology 2024年第1期19卷 66-86页

作者： kathryn SCOBIE Soanandrasana RAHELINIRINA Voahangy SOARIMALALA Fehivola Mandanirina ANDRIAMIARIMANANA Corinne RAHAINGOSOAMAMITIANA Toky RANDRIAMORIA Soloandry RAHAJANDRAIBE Xavier LAMBIN Minoarisoa RAJERISON Sandra TELFER School of Biological Sciences University of AberdeenAberdeenUK Plague Unit Institut Pasteur de MadagascarAntananarivoMadagascar Association Vahatra AntananarivoMadagascar

The black rat(Rattus rattus)poses a severe threat to food security and public health in Madagascar,where it is a major cause of pre-and post-harvest crop losses and an important reservoir for many zoonotic diseases,including ***,ecologically based rodent management(EBRM)strategies have been developed using ecologi-cal information to inform decisions on where and when to target *** could deliver improved health and well-being outcomes in Madagascar if adapted to the local ecological *** data collected from removal studies,we explored spatio-temporal patterns in the breeding activity of the black rat(***)in domestic and agricultural habitats across Madagascar and investigated to what extent these trends are influenced by rainfall and rat *** identified clear spatio-temporal variation in the seasonality of *** *** was highly seasonal both inside and outside of houses,but seasonal trends varied between these two ***-sonal trends were explained,in part,by variation in rainfall;however,the effect of rainfall on reproductive rates did itself vary by season and habitat type.A decline in breeding intensity with increasing rat density was recorded outside of *** has important implications for control,as populations may compensate for removal through increased *** recommend that sustained control initiated before the main breeding season,combined with improved hygiene and adequate rodent-proofing in homes and grain stores,could curtail population growth and reduce pre-and post-harvest losses provided that these measures overcome the compensatory response of rodent populations.

关键词： Madagascar Rattus rattus reproductive ecology rodent control

Pathophysiology : The Biologic Basis for Disease in Adults and Children / kathryn L. McCance, Sue E. Huether.

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Pathophysiology : The Biologic Basis for Disease in Adults a...

Animal Welfare in Biomedical Research and the Role of AAALAC International

2006年

作者： kathryn L. McCance Sue E. Huether.

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Animal Welfare in Biomedical Research and the Role of AAALAC...