检索结果-南通市图书馆

In vivo measurement of NADH fluorescence lifetime in skeletal muscle via -ber-coupled time-correlated single photon counting

在线全文

学校读者我要写书评

暂无评论

j.urnal of Innovative Optical Health Sciences 2024年第1期17卷 121-134页

作者： kathryn M.Priest j.cob V.Schluns Nathania Nischal Colton L.Gattis j.ffrey C.Wolchok Timothy j.Muldoon Department of Biomedical Engineering University of Arkansas FayettevilleARUSA

Nicotinamide adenine dinucleotide(NADH)is a cofactor that serves to shuttle electrons during metabolic processes such as glycolysis,the tricarboxylic acid cycle,and oxidative phosphorylation(OXPHOS).NADH is autofluorescent,and itsfluorescence lifetime can be used to infer metabolic dynamics in living ***-coupled time-correlated single photon counting(TCSPC)equipped with an implantable needle probe can be used to measure NADH lifetime in vivo,enabling investigation of changing metabolic demand during muscle contraction or tissue *** study illustrates a proof of concept for point-based,minimally-invasive NADHfluorescence lifetime measurement in *** muscle loss(VML)inj.ries were created in the left tibialis anterior(TA)muscle of male Sprague Dawley *** lifetime measurements were collected before,during,and after a 30 s tetanic contraction in the inj.red and uninj.red TA muscles,which was subsequently-t to a biexponential decay model to yield a metric of NADH utilization(cytoplasmic vs protein-bound NADH,the A11/A22 ratio).On average,this ratio was higher during and after contraction in uninj.red muscle compared to muscle at rest,suggesting higher levels of free NADH in contracting and recovering muscle,indicating increased rates of *** inj.red muscle,this ratio was higher than uninj.red muscle overall but decreased over time,which is consistent with current knowledge of inflammatory response to inj.ry,suggesting tissue regeneration has *** data suggest that-ber-coupled TCSPC has the potential to measure changes in NADH binding in vivo in a minimally invasive manner that requires further investigation.

关键词： Glycolysis oxidative phosphorylation energy metabolism volumetric muscle loss

Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2024年第1期12卷 95-106页

作者： Tian Nie Varun S.Venkatesh Suzanne Golub kathryn S.Stok Haniyeh Hemmatian Reena Desai David j.Handelsman j.ffrey D.Zaj.c Mathis Grossmann Rachel A.Davey Department of Medicine Austin HealthUniversity of MelbourneHeidelbergVIC 3084Australia Department of Biomedical Engineering University of MelbourneParkvilleVIC 3010Australia ANZAC Research Institute University of Sydney and AndrologyConcord Repatriation General HospitalConcordNSW 2137Australia

The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent trans girls are *** address this knowledge gap,we developed a mouse model to simulate male-to-female transition in human adolescents in whom puberty is first arrested by using gonadotrophin-releasing hormone analogs with subsequent estradiol *** was suppressed by orchidectomy in male mice at 5 weeks of *** 3 weeks post-surgery,male-to-female mice were treated with a high dose of estradiol(~0.85 mg)by intraperitoneal silastic implantation for 12 *** included intact and orchidectomized males at 3 weeks post-surgery,vehicle-treated intact males,intact females and orchidectomized males at 12 weeks *** to male controls,orchidectomized males exhibited decreased peak bone mass accrual and a decreased maximal force the bone could withstand prior to *** treatment in orchidectomized male-to-female mice compared to mice in all control groups was associated with an increased cortical thickness in the mid-diaphysis,while the periosteal circumference increased to a level that was intermediate between intact male and female controls,resulting in increased maximal force and *** trabecular bone,estradiol treatment increased newly formed trabeculae arising from the growth plate as well as mineralizing surface/bone surface and bone formation rate,consistent with the anabolic action of estradiol on osteoblast *** data support the concept that skeletal integrity can be preserved and that long-term fractures may be prevented in trans girls treated with GnRHa and a sufficiently high dose of *** study is needed to identify an optimal dose of estradiol that protects the bone without adverse side effects.

关键词： treatment treatment strength

The Moser-Trudinger-Onofri Inequality

在线全文

学校读者我要写书评

暂无评论

Chinese Annals of Mathematics,Series B 2015年第5期36卷 777-802页

作者： j.an DOLBEAULT Maria j.ESTEBAN gaspard j.NKOWIAK Ceremade CNRS UMR 7534 and Université Paris-Dauphine Place de Lattre de Tassigny

This paper is devoted to results on the Moser-Trudinger-Onofri inequality, or the Onofri inequality for brevity. In dimension two this inequality plays a role similar to that of the Sobolev inequality in higher dimensions. After j.stifying this statement by recovering the Onofri inequality through various limiting procedures and after reviewing some known results, the authors state several elementary *** new results are also proved in this paper. A proof of the inequality is given by using mass transportation methods(in the radial case), consistently with similar results for Sobolev inequalities. The authors investigate how duality can be used to improve the Onofri inequality, in connection with the logarithmic Hardy-Littlewood-Sobolev *** the framework of fast diffusion equations, it is established that the inequality is an entropy-entropy production inequality, which provides an integral remainder term. Finally,a proof of the inequality based on rigidity methods is given and a related nonlinear flow is introduced.

关键词： Moser-Trudinger-Onofri inequality Duality Mass transportation Fast diffusion equation Rigidity

Characterization of colloidal arsenic at two abandoned gold mine sites in Nova Scotia, Canada, using asymmetric flow-field flow fractionation-inductively coupled plasma mass spectrometry

在线全文

学校读者我要写书评

暂无评论

j.urnal of Environmental Sciences 2016年第11期28卷 189-196页

作者： kathryn j.Tindale Pritesh j.Patel Dirk Wallschlager Environmental and Life Sciences Graduate Program School of the Environment Department of Chemistry and Water Quality Centre Trent University Peterborough ON K9L 0G2 Canada Ore Pros Inc Beamsville ON LOR 1B2 Canada

Asymmetric flow-field flow fractionation-inductively-coupled plasma-mass spectrometry was used to determine whether colloidal arsenic（As） exists in soil pore water and soil extract samples at two arsenic-contaminated abandoned gold mines（Montague and Goldenville, Nova Scotia）. Colloidal arsenic was found in 12 out of the 80 collected samples（= 15%）, and was primarily associated with iron（Fe） in the encountered colloids. The molar Fe/As ratios indicate that the colloids in some samples appeared to be discrete iron–arsenic minerals, whereas in other samples, they were more consistent with As-rich iron（oxy）hydroxides. Up to three discrete size fractions of colloidal As were encountered in the samples, with mean colloid diameters between 6 and 14 nm. The pore water samples only contained one size fraction of As-bearing colloids（around 6 nm diameter）, while larger As-bearing colloids were only encountered in soil extracts.

关键词： Arsenic Colloids Gold mine tailings ICP-MS Nova Scotia Nanoparticles

Strategies for practitioners to support patients in plant-based eating

在线全文

学校读者我要写书评

暂无评论

j.urnal of Geriatric Cardiology 2017年第5期14卷 338-341页

作者： Micaela C Karlsen kathryn j.Pollard Nutritional Epidemiology Program Tufts Friedman School of Nutrition Science and Policy Boston Massachusetts USA T. Colin Campbell Center for Nutrition Studies Ithaca NY 14851 USA

Successfully implementing a plant-based diet is attain-able for patients, but the likelihood of achieving long-term,dietary maintenance can be increased by follow-up andsupport from practitioners. Practitioners, in particular physi-cians, are seen as nutrition authorities,and are thereforewell-positioned to deliver dietary advice and nutritionalprescriptions.

关键词： Adherence Behavior change Dietary change Motivational interviewing Plant-based diet Vegetarian

A tale of motor neurons and CD4＋ T cells： moving forward by looking back

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2017年第4期12卷 562-565页

作者： Abhirami Kannan Iyer kathryn j.j.nes Department of Anatomy and Cell Biology Indiana University School of Medicine

Amyotrophic lateral sclerosis （ALS） is a fatal progressive disorder characterized by the selective degeneration of motor neurons （MN）. The impact of peripheral immune status on disease progression and MN survival is becoming increasingly recognized in the ALS research field. In this review, we briefly discuss findings from mouse models of peripheral nerve inj.ry and immunodeficiency to understand how the immune system regulates MN survival. We extend these observations to similar studies in the widely used superoxide dismutase 1 （SOD1） mouse model of ALS. Last, we present future hypotheses to identify potential causative factors that lead to immune dysregulation in ALS. The lessons from preceding work in this area offer new exciting directions to bridge the gap in our current understanding of immune mediated neuroprotection in ALS.

关键词： amyotrophic lateral sclerosis (ALS) superoxide dismutase 1 (SOD1) immune system SOD1 mice motor neuron CD4+ T cells neuroprotection

A Quantitative Phosphoproteome Analysis of cGMP-Dependent Cellular Responses in Arabidopsis thaliana

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2016年第4期9卷 621-623页

作者： Claudius Marondedze Arnoud j. Groen Ludivine Thomas kathryn S. Lilley Chris Gehring Division of Biological and Environmental Sciences and Engineering 4700 King Abdullah University of Science and Technology Thuwal 23955-6900 Kingdom of Saudi Arabia Department of Biochemistry Cambridge Centre for Proteomics Cambridge Systems Biology Centre University of Cambridge Tennis Court Road Cambridge CB2 1QR UK Bioscience Core Laboratory Division of Biological and Environmental Sciences and Engineering 4700 King Abdullah University of Science and Technology Thuwal 23955-6900 Kingdom of Saudi Arabia

Dear Editor,The second messenger cyclic nucleotide 3＇,5＇-cyclic guanosine monophosphate （cGMP） is increasingly recognized as a key signaling molecule that mediates many physiological and developmental processes in... 详细信息

关键词： cGMP 蛋白质组分磷酸化拟南芥反应细胞环磷酸鸟苷环核苷酸

Drug calculation ability of qualified paramedics:A pilot study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World j.urnal of Emergency Medicine 2018年第1期9卷 41-45页

作者： Malcolm j.Boyle kathryn Eastwood School of Medicine Griffith University School of Nursing and Midwifery Monash University

BACKGROUND: The inability of paramedics to perform accurate calculations may result in a compromise of patient safety which may result from under or over dosing of drugs, incorrect j.ules for defibrillation, or a maj.r adverse event such as death. The obj.ctive of this study was to identify the drug calculation and mathematical ability of qualified operational ***: The study used a cross-sectional design with a paper-based calculation questionnaire. Twenty paramedics enrolled in an intensive care paramedic course were eligible to participate in the study. The questionnaire consisted of demographic, drug calculation(seven questions), and mathematical(five) questions. Students were given no notice of the impending study and use of a calculator was not ***: All eligible students participated in the study. The average time employed as a paramedic was 7.25 years, SD 2.5 years, range four years to twelve years. Four(20%) students got all 12 questions correct, and five(41.6%) got 50% or less. The average score was 8.6(71.7%) correct, SD 2.8 correct, range 3 to 12 correct questions. There were eight(40%) conceptual errors, 12(60%) arithmetical errors, and five(25%) computational ***: The results from this study supports similar international studies where paramedic's ability to undertake mathematical and drug calculations without a calculator varies, with some results highlighting the paramedics mathematical skills as a potential risk to patient safety. These results highlight the need for regular continuing mathematical and drug calculation practice and education to ensure a lower error rate.

关键词： Emergency medical technician Education Medication errors Safety management