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偷偷摸摸·神神秘秘

英语学习（新锐空间） 2009年第3期 36-37页

作者： kathrin Hauger

A natural history comparison Check for updates of SOD1-mutant patients with amyotrophic lateral sclerosis between Chinese and German populations

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Translational Neurodegeneration 2021年第4期10卷 551-553页

作者： Lu Tang Johannes Dorst Lu Chen Xiaolu Liu Yan Ma Komelia Günther Sebastian Michels kathrin Müller Axel Freischmidt Jochen H.Weishaupt Dongsheng Fan Albert C.Ludolph Department of Neurology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases Peking University Third HospitalBeijing 100191China Department of Neurology Ulm University89081 UlmGermany German Center for Neurodegenerative Diseases(DZNE) Ulm Site89081 UlmGermany

Currently,there is no effective treatment for amyotrophic lateral sclerosis(ALS),despite the limited efficacy of riluzole[1]and edaravone[2].SOD1(coding for the Cu/Zn superoxide dismutase)is the second most frequent genetic cause for ALS only after C9orf72 in patients with European ancestry while being the most frequent in Asian ALS populations[3],Multiple therapeutic approaches have targeted SOD1-related ALS,including the antisense oligonucleotide tofersen with promising results in a recent phase I/II trial[4].

关键词： SOD1 patients amyotrophic

VISULISATION OF CATALYTIC ACTIVITY FOR OXYGEN REDUCTION BY MEANS OF REDOX COMPETITION MODE SCANNING ELECTROCHEMICAL MICROSCOPY(RC-SECM)

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VISULISATION OF CATALYTIC ACTIVITY FOR OXYGEN REDUCTION BY M...

Joint Multi-modal Parcellation of the Human Striatum:Functions and Clinical Relevance

第十二届北京分析测试学术报告会暨展览会(BCEIA 2007)

作者： Xingxing CHEN kathrin ECKHARD Min ZHOU Michael BRON Wolfgang SCHUHMANN Analytical Chemistry-Elektroanalytik & Sensorik RuhrUniversit?t BochumUniversit?tsstr

Efficiently designed and well-defined catalysts on structured carbon supports have potential applications in fuel cell membrane *** order to prepare Pt,Ru,Rh,or Au nanoparticles and also their binary combinations,the ...

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Neuroscience Bulletin 2020年第10期36卷 1123-1136页

作者： Xiaojin Liu Simon B.Eickhoff Felix Hoffstaedter Sarah Genon Svenja Caspers kathrin Reetz Imis Dogan Claudia R.Eickhoff Ji Chen Julian Caspers Niels Reuter Christian Mathys Andre Aleman Renaud Jardri Valentin Riedl Iris E.Sommer Kaustubh R.Patil Institute of Neuroscience and Medicine(INM-7 Brain and Behaviour)Research Centre JiilichJiilichGermany Institute of Systems Neuroscience Heinrich Heine University DusseldorfDusseldorfGermany Institute of Neuroscience and Medicine(INM-1) Research Centre Jiilich52428 JiilichGermany Institute for Anatomy I Medical FacultyHeinrich Heine University Dusseldorf40225 DusseldorfGermany Jiilich Aachen Research Alliance-BRAIN(JARA)Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum JiilichRheinisch Westfallische Technische Hochschule(RWTH)Aachen University52074 AachenGermany Department of Neurology Rheinisch Westfallische Technische Hochschule(RWTH)Aachen University52074 AachenGermany Institute of Clinical Neuroscience and Medical Psychology Medical FacultyUniversity of Dusseldorf40225 DusseldorfGermany Department of Diagnostic and Interventional Radiology Medical FacultyUniversity of Dusseldorf40225 DusseldorfGermany Institute of Radiology and Neuroradiology Evangelisches KrankenhausUniversity of Oldenburg26129 OldenburgGermany Department of Neuroscience University Medical Center GroningenUniversity of Groningen9713 AV GroningenThe Netherlands SCALab(CNRS UMR9193)&CHU de LiUe Hopital FontanPole de Psychiatrie(CURE)Universite de Lille59037 LilleFrance Departments of Neuroradiology Nuclear Medicine and Neuroimaging CenterTechnische Universitat Miinchen80333 MunichGermany

The human striatum is essential for both lowand high-level functions and has been implicated in the pathophysiology of various prevalent disorders,including Parkinson's disease(PD)and schizophrenia(SCZ).It is known to consist of structurally and functionally divergent ***,previous parcellations are based on a single neuroimaging modality,leaving the extent of the multi-modal organization of the striatum ***,we investigated the organization of the striatum across three modalities—resting-state functional connectivity,probabilistic diffusion tractography,and structural covariance—to provide a holistic convergent view of its structure and *** found convergent clusters in the dorsal,dorsolateral,rostral,ventral,and caudal *** characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions,while the caudal striatum was related to action ***,significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ,but atrophy in the dorsolateral striatum was specifically attributable to *** study revealed a cross-modal convergent organization of the striatum,representing a fundamental topographical model that can be useful for investigating structural and functional variability in aging and in clinical conditions.

关键词： Striatum Multi-modal Connectivity-based parcellation Convergent clusters Voxel-based morphometry Parkinson's disease Schizophrenia

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生物节律管理

英语学习（新锐空间） 2009年第4期 58-59页

作者： kathrin Enke 陶然(译)

最近我又读了一本时间管理方面的书，它是使我印象深刻的书中的一本。近来我订了许多这类书籍，连亚马逊都觉得我或许会对《时间管理：致花太多时间去读无价值书的人》这样的书感兴趣。不过，我还是学到了一些基本的法则。其中之一就是... 详细信息

最近我又读了一本时间管理方面的书，它是使我印象深刻的书中的一本。近来我订了许多这类书籍，连亚马逊都觉得我或许会对《时间管理：致花太多时间去读无价值书的人》这样的书感兴趣。不过，我还是学到了一些基本的法则。其中之一就是要了解自己的生物节律，不要与之对抗。

关键词：时间管理生物节律亚马逊

Algorithm-based arterial blood sampling recognition increasing safety in point-of-care diagnostics

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World Journal of Critical Care Medicine 2017年第3期6卷 172-178页

作者： Jorg Peter Wilfried Klingert kathrin Klingert Karolin Thiel Daniel Wulff Alfred Konigsrainer Wolfgang Rosenstiel Martin Schenk Department of Computer Engineering University of Tübingen Department of General Visceral and Transplant Surgery University Hospital Tübingen Department of Anesthesiology and Intensive Care Medicine University Hospital Tübingen

AIM To detect blood withdrawal for patients with arterial blood pressure monitoring to increase patient safety and provide better sample *** Blood pressure information obtained from a patient monitor was fed as a real-time data stream to an experimental medical framework. This framework was connected to an analytical application which observes changes in systolic, diastolic and mean pressure to determine anomalies in the continuous data stream. Detection was based on an increased mean blood pressure caused by the closing of the withdrawal three-way tap and an absence of systolic and diastolic measurements during this manipulation. For evaluation of the proposed algorithm, measured data from animal studies in healthy pigs were *** Using this novel approach for processing real-time measurement data of arterial pressure monitoring, the exact time of blood withdrawal could be successfully detected retrospectively and in real-time. The algorithm was able to detect 422 of 434(97%) blood withdrawals for blood gas analysis in the retrospective analysis of 7 study trials. Additionally, 64 sampling events for other procedures like laboratory and activated clotting time analyses were detected. The proposed algorithm achieved a sensitivity of 0.97, a precision of 0.96 and an F1 score of *** Arterial blood pressure monitoring data can be used toperform an accurate identification of individual blood samplings in order to reduce sample mix-ups and thereby increase patient safety.

关键词： Blood withdrawal detection Sample dating algorithm Arterial blood gas analysis Patient monitoring Point-of-care diagnostics

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在“减法”中体味奢华

缤纷 2006年第8期 44-51页

作者： kathrin Albrecht 刘轶楠范涛 AGE PHOTO

在家的营造过程中,如果只是将繁缛的元素简单地堆砌,那样的效果不能算是奢华的范本,而最真实地保留房子原有的宽敞空间以及挑高,才是对空间最奢侈的表达方式。

关键词：空间布局空间设计减法设计师业主房子营造原始结构保留设计经验

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保护生物多样性在教学、研究和实践中的体现

应用型高等教育研究 2019年第2期4卷 35-38,85页

作者： Herbert Zucchi kathrin Kiehl 陈颖(翻译) 奥斯纳布吕克应用科学大学德国奥斯纳布吕克49076 德国法院

鉴于生物多样性在全世界范围内大幅下降,必须尽一切力量来减缓、阻止物种的消失。应用科学大学应该在此承担起责任。以奥斯纳布吕克应用科学大学的景观开发专业为例,阐述高校在保护生物多样性方面通过产教学研的紧密结合作出贡献。

关键词：生物多样性自然保护教学方法应用科学大学

MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination

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Cellular & Molecular Immunology 2022年第2期19卷 234-244页

作者： Yeonsu Kim Xiaoyan Zheng kathrin Eschke M.Zeeshan Chaudhry Federico Bertoglio Adriana Tomić Astrid Krmpotić Markus Hoffmann Yotam Bar-On Julia Boehme Dunja Bruder Thomas Ebensen Linda Brunotte Stephan Ludwig Martin Messerle Carlos Guzman Ofer Mandelboim Michael Hust Stefan Pöhlmann Stipan Jonjić LukaČičin-Šain Department of Viral Immunology Helmholtz Centre for Infection Research(HZI)BraunschweigGermany Department of Biotechnology Institut für BiochemieBiotechnologie und BioinformatikTechnischen Universität BraunschweigBraunschweigGermany Oxford Vaccine Group University of OxfordOxfordUK Center for Proteomics University of RijekaFaculty of MedicineRijekaCroatia Infection Biology Unit German Primate CenterGöttingenGermany Faculty of Biology and Psychology Georg-August-University GöttingenGöttingenGermany Department of Immunology Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael Infection Immunology Institute for Medical Microbiology and Hospital HygieneHealth Campus ImmunologyInfectiology and InflammationOtto-von-Guericke-University MagdeburgMagdeburgGermanyImmune RegulationHelmholtz Centre for Infection ResearchBraunschweigGermany Department of Vaccinology and Applied Microbiology Helmholtz Centre for Infection ResearchBraunschweigGermany Institute of Virology Medical University MünsterMünsterGermany Institute of Virology Hannover Medical School(MHH)HannoverGermany German Centre for Infection Research(DZIF) Hannover-Braunschweig SiteHannoverGermany Centre for Individualized Infection medicine(CiiM) a joint venture of HZI and MHHHannoverGermany

Global pandemics caused by influenza or coronaviruses cause severe disruptions to public health and lead to high morbidity and *** remains a medical need for vaccines against these ***(cytomegalovirus)is aβ-herpesvirus that induces uniquely robust immune responses in which remarkably large populations of antigen-specific CD8+T cells are maintained for a ***,CMV has been proposed and investigated as a novel vaccine vector for expressing antigenic peptides or proteins to elicit protective cellular immune responses against numerous *** generated two recombinant murine CMV(MCMV)vaccine vectors expressing hemagglutinin(HA)of influenza A virus(MCMV^(HA))or the spike protein of severe acute respiratory syndrome coronavirus 2(MCMV^(S)).A single injection of MCMVs expressing either viral protein induced potent neutralizing antibody responses,which strengthened over ***,MCMV^(HA)-vaccinated mice were protected from illness following challenge with the influenza virus,and we excluded that this protection was due to the effects of memory T ***,we show here that MCMV vectors induce not only long-term cellular immunity but also humoral responses that provide long-term immune protection against clinically relevant respiratory pathogens.

关键词： Vaccine vector SARS-CoV-2 Influenza Cytomegalovirus humoral imunity