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SARS-CoV-2-specific T cell responses wane profoundly in convalescent individuals 10 months after primary infection

Virologica Sinica 2023年第4期38卷 606-619页

作者： Ziwei Li Tiandan Xiang Boyun Liang Jing Liu Hui Deng Xuecheng Yang Hua Wang Xuemei Feng Gennadiy Zelinskyy Mirko Trilling kathrin sutter Mengji Lu Ulf Dittmer Baoju Wang Dongliang Yang Xin Zheng Jia Liu Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Institute for Virology University Hospital of EssenUniversity of Duisburg-EssenEssen45147Germany Joint International Laboratory of Infection and Immunity Huazhong University of Science and TechnologyWuhan430022China

A key question in the coronavirus disease 2019(COVID-19)pandemic is the duration of specific T cell responses against the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)post primary infection,which is difficult to address due to the large-scale COVID-19 vaccination and re-exposure to the virus.Here,we conducted an analysis of the long-term SARS-CoV-2-specific T cell responses in a unique cohort of convalescent individuals(CIs)that were among the first to be infected worldwide and without any possible antigen re-exposure since then.The magnitude and breadth of SARS-CoV-2-specific T cell responses correlated inversely with the time that had elapsed from disease onset and the age of those CIs.The mean magnitude of SARS-CoV-2-specific CD4 and CD8 T cell responses decreased about 82%and 76%,respectively,over the time period of ten months after infection.Accordingly,the longitudinal analysis also demonstrated that SARS-CoV-2-specific T cell responses waned significantly in 75%of CIs during the follow-up.Collectively,we provide a comprehensive characterization of the long-term memory T cell response in CIs,suggesting that robust SARS-CoV-2-specific T cell immunity post primary infection may be less durable than previously expected.

关键词： COVID-19 SARS-CoV-2 T cell response Convalescence

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A Crowned Killer’s Ré sumeé: Genome, Structure, Receptors, and Origin of SARS-CoV-2

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Virologica Sinica 2020年第6期35卷 673-684页

作者： Shichuan Wang Mirko Trilling kathrin sutter Ulf Dittmer Mengji Lu Xin Zheng Dongliang Yang Jia Liu Department of Infectious Diseases Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Institute for Virology University Hospital of EssenUniversity of Duisburg-EssenEssen 45147Germany Joint International Laboratory of Infection and Immunity Huazhong University of Science and TechnologyWuhan 430022China

The recent emergence and rapid global spread of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) pose an unprecedented medical and socioeconomic crisis, and the disease caused by it, Coronavirus disease 2019(COVID-19),was declared a pandemic by the World Health Organization(WHO) on March 11, 2020. Chinese scientists and physicians rapidly identified the causative pathogen, which turned out to be a novel betacoronavirus with high sequence similarities to bat and pangolin coronaviruses. The scientific community has ignited tremendous efforts to unravel the biological underpinning of SARS-CoV-2, which constitutes the foundation for therapy and vaccine development strategies. Here, we summarize the current state of knowledge on the genome, structure, receptor, and origin of SARS-CoV-2.

关键词： Coronavirus Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Coronavirus disease 2019(COVID-19) Genome Structure Receptor Origin

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Ca^(2+) binding to the C_(2)E domain of otoferlin is required for hair cell exocytosis and hearing

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Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin Slitin Jakob Neef Shashank S.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Benseler Nils Brose kathrin Kusch Carolin Wichmann Nicola Strenzke Barbara Vona Julia Preobraschenski Tobias Moser Institute for Auditory Neuroscience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Research Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuroscience and Synaptic Nanophysiology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neurosciences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemistry of Membrane Dynamics Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of Synapses Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Biostructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory Systems Physiology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multiscale Bioimaging Cluster of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Institute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent synapses of cochlear inner hair cells(IHCs)employ a unique molecular machinery(see extended background in Supplementary Materials).Otoferlin is a key player in this machinery and its defects cause human auditory synaptopathy(Moser and Starr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)specific to hair cells(Roux et al.,2006),is a member of the ferlin protein family involved in membrane trafficking and repair that are of major disease relevance(Pangršičet al.,2012),also see Supplementary Materials.Otoferlin is distributed broadly within IHCs(Fig.2Ai-Aiii;Pangrsic et al.,2010;Roux et al.,2006).

关键词： auditory hair

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Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide prevalence.Understanding the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy balance.They,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from adipocytes.Mutations in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset obesity.Here,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy balance.Deficiency of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose homeostasis.Consistently,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from obesity.Therefore,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

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Thermal desorption of mercury from lignite in a high-temperature furnace and in power plant mills

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International Journal of Coal Science & Technology 2022年第5期9卷 150-159页

作者： Anne-Christin Kropp kathrin Gebauer Michael Beckmann Institute of Process Engineering and Environmental Technology Faculty of Mechanical Science and EngineeringTU Dresden01062 DresdenGermany

In this article,the binding forms of two lignite samples are determined by thermal desorption using a high-temperature furnace.Each mercury compound,such as HgCl2,has a specifc binding strength whose decomposition requires a certain thermal energy.Hence,the release of mercury from pure substances and lignite samples was analyzed in a high-temperature furnace.The released mercury is determined with a Mercury Vapor Monitor.The obtained characteristic temperature range and peak of the mercury release were compared between lignite samples and mercury pure substances.For the lignite samples investigated,the binding form of mercury was then identifed as Humic Acid.These organic compounds vaporize at lower temperatures.About half of the mercury bound in the lignite was already released at 350℃.Furthermore,the question arises whether mercury is already released during the grinding-drying process in the coal mill of a power plant.At two power plants,lignite samples were taken simultaneously at the feeder before entering the coal mill and at the dust line afterwards.The samples were analyzed for mercury concentration.The results show that up to one third of the mercury was already released in the coal mill.The vaporized mercury enters the combustion chamber detached from the lignite.The stated analysis methods and the results presented in this article contribute to the understanding of the mercury binding forms in lignite.It also shows the potential of thermal coal pretreatment as a favorable alternative mercury separation technology to others such as activated carbon dosing.

关键词： Mercury binding forms Thermal desorption Mercury release Coal mill Coal pretreatment

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The C:N:P stoichiometry in bryophytes: relationships with habitat,climate and growth form

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National Science Review 2023年第4期10卷 16-18页

作者： Xin Liu Zhe Wang Xiaoming Li Weikai Bao kathrin Rousk China-Croatia ‘Belt and Road' Joint Laboratory on Biodiversity and Ecosystem Services CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization and Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province Chengdu Institute of BiologyChinese Academy of Sciences Shanghai Normal University Department of Biology Terrestrial Ecology Section University of Copenhagen

The elemental composition and stoichiometry of organisms provide a useful lens for explaining and predicting ecological paterns and processes. However, few studies have focused on stoichiometry in bryophytes, even though they are abundant in many pristine ecosystems. Several case studies found variable paterns in bryophyte stoichiometry(e.g. [1,2]).

关键词： TEMPERATURE NITROGEN

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维生素D代谢物有助于母猪分娩过程

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国外畜牧学（猪与禽） 2024年第1期44卷 12-13页

作者： Katia Pedrosa kathrin Buehler Jan Dirk Van der Klis 张相鑫(译) 王晶晶(校) 孟祥光(制图) 不详

维生素D是一种重要的营养物质,母猪在妊娠后期和哺乳期对其需要量非常高。本文概述了维生素D对母猪分娩的影响,提出可以在常规添加维生素D之外补充1,25-二羟基维生素D3糖苷,以缩短分娩时间,减少分娩过程中的人为干预,减少死胎数。

关键词：维生素D 1 25-二羟基维生素D3糖苷分娩

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Seasonal changes in the parasite prevalence of a small Malagasy lemur species (Lepilemur edwardsi)

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Integrative Zoology 2023年第3期18卷 427-439页

作者： Janina BETHGE Jean Claude RAZAFIMAMPIANDRA Arne WULFF kathrin H.DAUSMANN Institute of Zoology Functional EcologyUniversität HamburgHamburgGermany Mention Zoologie et BiodiversitéAnimale Facultédes SciencesUniversitéd’AntananarivoAntananarivoMadagascar

Parasitic infections can impact theﬁtness of individuals and can have inﬂuence on animals’population dynamics.An individuals’parasite prevalence often changes depending on external or seasonal changes,for example,rainfall and ambient temperatures,but also on internal changes,for example,changes in body condition.In this study we aimed to identify the environmental factors that may inﬂuence the intestinal parasite and ectoparasite prevalence of the folivorous Malagasy primate species,Lepilemur edwardsi,living in a seasonal dry deciduous forest.Species living in this habitat have to adapt to seasonal changes of ambient temperature,with almost no precipitation during the dry season and hence strongﬂuctuations of resource availability throughout the year.We sampled the feces and ectoparasites of L.edwardsi throughout the year.Intestinal parasite prevalence increased from the wet to the dry season and was highest in the late dry season,which might be due to the accompanying decrease in diet quality.Conversely,ectoparasite prevalence decreased in the dry season,presumably due to the prevailing unfavorable environmental conditions for the development of ectoparasites(i.e.,mites and ticks).Paired with the higher resting metabolism and stress level of L.edwardsi during the late dry season,it seems that this species may struggle when dry seasons intensify in its habitat.

关键词： ectoparasites intestinal parasites Madagascar primates seasonality

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Prodromal Parkinson’s disease: hype or hope for disease-modification trials?

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Translational Neurodegeneration 2022年第1期11卷 777-789页

作者： Philipp Mahlknecht kathrin Marini Mario Werkmann Werner Poewe Klaus Seppi Department of Neurology Innsbruck Medical University6020 InnsbruckAustria

The ultimate goal in Parkinson’s disease (PD) research remains the identification of treatments that are capable of slowing or even halting the progression of the disease. The failure of numerous past disease-modification trials in PD has been attributed to a variety of factors related not only to choosing wrong interventions, but also to using inadequate trial designs and target populations. In patients with clinically established PD, neuronal pathology may already have advanced too far to be modified by any intervention. Based on such reasoning, individuals in yet prediagnostic or prodromal disease stages, may provide a window of opportunity to test disease-modifying strategies. There is now sufficient evidence from prospective studies to define diagnostic criteria for prodromal PD and several approaches have been studied in observational cohorts. These include the use of PD-risk algorithms derived from multiple established risk factors for disease as well as follow-up of cohorts with single defined prodromal markers like hyposmia, rapid eye movement sleep behavior disorders, or PD gene carriers. In this review, we discuss recruitment strategies for disease-modification trials in various prodromal PD cohorts, as well as potential trial designs, required trial durations, and estimated sample sizes. We offer a concluding outlook on how the goal of implementing disease-modification trials in prodromal cohorts might be achieved in the future.

关键词： Neuroprotection Preclinical Prevention Epidemiology Probability Randomized controlled trial Preventive Neuroprotective

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A small number of male-biased candidate pheromone receptors are expressed in large subsets of the olfactory sensory neurons in the antennae of drones from the European honey bee Apis mellifera

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Insect Science 2022年第3期29卷 749-766页

作者： Joerg Fleischer Alexander Rausch kathrin Dietze Silvio Erler Sina Cassau Jurgen Krieger Martin Luther University Halle-Wittenberg Institute of Biologyl ZoologyDepartment of Animal PhysiologyHalle(Saale) Institute for Bee Protection Julius Kuhn Institute(JKI)-Federal Research Centre for Cultivated PlantsBraunschweigGermany

In the European honey bee(Apis mellifera),the olfactory system is essential for foraging and intraspecific communication via pheromones.Honey bees are equipped with a large repertoire of olfactory receptors belonging to the insect odorant receptor(OR)family.Previous studies have indicated that the transcription level of a few OR types including OR11,a receptor activated by the queen-released pheromone compound(2£)-9-oxodecenoic acid(9-ODA),is significantly higher in the antenna of males(drones)than in female workers.However,the number and distribution of antennal cells expressing male-biased ORs is elusive.Here,we analyzed antennal sections from bees by in situ hybridization for the expression of the male-biased receptors OR11,OR18,and OR170.Our results demonstrate that these receptors are expressed in only moderate numbers of cells in the antennae of females(workers and queens),whereas substantially higher cell numbers express these ORs in drones.Thus,the reported male-biased transcript levels are due to sex-specific differences in the number of antennal cells expressing these receptors.Detailed analyses for OR11 and OR18 in drone antennae revealed expression in two distinct subsets of olfactory sensory neurons(OSNs)that in total account for approximately 69%of the OR-positive cells.Such high percentages of OSNs expressing given receptors are reminiscent of male-biased ORs in moths that mediate the detection of female-released sex pheromone components.Collectively,our findings indicate remarkable similarities between male antennae of bees and moths and support the concept that male-biased ORs in bee drones serve the detection of female-emitted sex pheromones.

关键词： chemosensory odorant receptor olfaction pheromone detection sensilla placodea

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