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Journal of Genetics and Genomics 2016年第5期43卷 307-318页

作者： Jason Ear Jessica Hsueh melinda Nguyen QingHua Zhang Victoria Sung Rajesh Chopra kathleen m.sakamoto Shuo Lin Department of molecular Cell and Developmental Biology University of California Los Angeles Los Angeles CA 90095 USA Celgene Corporation San Francisco 94158 USA Celgene Corporation Summit NJ 07901 USA Division of Hematology/Oncology Department of Pediatrics Stanford University School of Medicine Stanford CA 94304 USA

5q-syndrome is a distinct form of myelodysplastic syndrome（mDS） where a deletion on chromosome 5 is the underlying *** is characterized by bone marrow failures,including macrocytic *** mapping and studies using various models support the notion that ribosomal protein S14（RPS14） is the candidate gene for the erythroid *** disruption of RPS14 causes an increase in p53 activity and p53-mediated apoptosis,similar to what is observed with other ribosomal ***,due to the higher risk for cancer development in patients with ribosome deficiency,targeting the p53 pathway is not a viable treatment *** better understand the pathology of RPS14 deficiency in 5q-deletion,we generated a zebrafish model harboring a mutation in the RPS14 *** model mirrors the anemic phenotype seen in ***,the anemia is due to a late-stage erythropoietic defect,where the erythropoietic defect is initially p53-independent and then becomes ***,we demonstrate the versatility of this model to test various pharmacological agents,such as RAP-011,L-leucine,and dexamethasone in order to identify molecules that can reverse the anemic phenotype.

关键词： 5q-syndrome RPS14 Ribosomopathy myelodysplastic syndrome

magnetic Sensorless Control of Plasma Position and Shape in a Tokamak

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Plasma Science and Technology 2006年第1期8卷 80-83页

作者： K.NAKAmURA 罗家融王华忠季振山王华王枫齐娜 K.N.SATO K.HANADA m.sakamoto H.IDEI m.HASEGAWA S.KAWASAKI H.NAKASHImA A.HIGASHIJImA Research Institute for Applied mechanics Kyushu UniversityFukuoka816-8580Japan Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China Interdisciplinary Graduate School of Engineering Sciences Kyushu UniversityFukuoka816-8580Japan

magnetic sensorless sensing and control experiments with the plasma horizontal position have been carried out in the superconducting tokamak HT-7. The sensing is made to focus on the ripple frequency component of the power supply with thyristor and directly from them without time integration. There is no drift problem with the integrator of wagnetic sensors. Two kinds of control experiments have been carried out： to keep the position constant and swing the position in a triangular waveform, And magnetic sensorless sensing of plasma shape is discussed.

关键词： sensorless control drift problem HT-7 shape control EAST

magnetic Sensorless Sensing of Plasma Position in the Superconducting Tokamak HT-7

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Plasma Science and Technology 2004年第5期6卷 2459-2462页

作者： K.Nakamura Z.S.Ji B.Shen P.J.Qin S.Itoh K.Hanada m.sakamoto E.Jotaki m.Hasegawa A.Iyomasa S.Kawasaki H.Nakashima Research Institute for Applied mechanics Kyushu University 6-1 Kasuga-koen Kasuga City Fukuoka 816-8580 JapanInstitute of Plasma Physics Chinese Academy of Sciences Hefei 230031 ChinaInstitute of Plasma Physics Chinese Academy of Sciences Hefei 230031 ChinaInstitute of Plasma Physics Chinese Academy of Sciences Hefei 230031 ChinaResearch Institute for Applied Mechanics Kyushu University 6-1 Kasuga-koen Kasuga City Fukuoka 816-8580 JapanResearch Institute for Applied Mechanics Kyushu University 6-1 Kasuga-koen Kasuga City Fukuoka 816-8580 JapanResearch Institute for Applied Mechanics Kyushu University 6-1 Kasuga-koen Kasuga City Fukuoka 816-8580 JapanInstitute of Plasma Physics Chinese Academy of Sciences Hefei 230031 ChinaResearch Institute for Applied Mechanics Kyushu University 6-1 Kasuga-koen Kasuga City Fukuoka 816-8580 JapanResearch Institute for Applied Mechanics Kyushu University 6-1 Kasuga-koen Kasuga City Fukuoka 816-8580 JapanResearch Institute for Applied Mechanics Kyushu University 6-1 Kasuga-koen Kasuga City Fukuoka 816-8580 JapanResearch Institute for Applied Mechanics Kyushu University 6-1 Kasuga-koen Kasuga City Fukuoka 816-8580 Japan

magnetic sensorless sensing experiments of the plasma horizontal positionhave been carried out in the superconducting tokamak HT-7. The horizontal position is calculatedfrom the vertical field coil current and voltage without using signals of magnetic probes placednearby a plasma. The calculations are focused on the ripple frequency component of the power *** is no drift problem with the time integration of magnetic probe signals. The error of thederived plasma position is lower than 2% of the plasma minor radius.

关键词： sensorless sensing plasma position HT-7

Evolution of IPv6 Internet topology with unusual sudden changes

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Chinese Physics B 2013年第7期22卷 602-609页

作者：艾均赵海 kathleen m. Carley 苏湛李辉 College of Information Science and Engineering Northeastern University Institute for Software Research Carnegie Mellon University

The evolution of Internet topology is not always smooth but sometimes with unusual sudden changes. Consequently, identifying patterns of unusual topology evolution is critical for Internet topology modeling and simulation. We analyze IPv6 Internet topology evolution in IP-level graph to demonstrate how it changes in uncommon ways to restructure the Internet. After evaluating the changes of average degree, average path length, and some other metrics over time, we find that in the case of a large-scale growing the Internet becomes more robust; whereas in a top–bottom connection enhancement the Internet maintains its efficiency with links largely decreased.

关键词： scale-free network Internet topology evolution unusual evolution of Internet topology complex network analysis

Saline Drinking Water and Salt in Diet:An Approximate Picture of the Situation in a Coastal Area of Southeastern Bangladesh

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International Journal of Disaster Risk Science 2017年第2期8卷 109-120页

作者： maiko sakamoto Department of International Studies Graduate School of Frontier SciencesThe University of Tokyo

Coastal areas of Bangladesh have been facing increasing salinity of surface water and *** study provides the approximate scope of the problem in a coastal area of southeastern Bangladesh by using less-accurate,but lower-cost salinity measuring devices that enable local people to assess the *** local women were employed to monitor 10 tube wells each on a weekly basis,from mid-February to mid-may,during the2016 dry *** Information System and time series clustering were used to visualize the spatial distribution and seasonal change of the salinity *** addition,the tube well users were asked about the salt consumption in their daily ***-third of the monitored tube wells were found to contain more sodium than the tolerable level in terms of taste suggested by the World Health ***,the mean salinity level across all monitored tube wells was much *** salinity level varied depending on the depth of the tube wells rather than their locations or altitudes,and those deeper than 200 m were likely to be salt *** results of the diet survey showed that wealthier households tended to use more salt in their daily diets,but at the same time they tended to have deeper tube wells that are less likely to contain high levels of sodium.

关键词： Bangladesh Climate change Drinking water salinity Participatory water monitoring

Predicting phosphorus sorption isotherm parameters in soil using data of routine laboratory tests

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Pedosphere 2021年第5期31卷 694-704页

作者： kathleen S.DUNNE Nicholas m.HOLDEN Karen DALY Teagasc Johnstown CastleEnvironmental Research CentreCo.Wexford Y35TC97(Ireland) UCD School of Biosystems and Food Engineering University College DublinBelfieldDublin 4 D04VIW8(Ireland)

Knowledge of phosphorus(P)sorption dynamics across different soil types could direct agronomic and environmental management of *** objective of this study was to predict P isotherm parameters for a national soil population using data of routine laboratory *** and Freundlich sorption parameters were calculated from two different ranges(0-25 and 0-50 mg P L^(-1))using an archive of representative agricultural soil types from *** linear regression(mLR)identified labile forms of aluminium(Al)and iron(Fe),organic matter(Om),cation exchange capacity(CEC),and clay as significant *** and Freundlich sorption capacities,Freundlich affinity constant,and Langmuir buffer capacity were predicted reliably,with R^(2) of independent validation>*** isotherm parameters were predicted from P sorbed at a single concentration of 50 mg P L^(-1)(S_(50)).An mLR prediction of P sorption maximum in the 0-50 mg P L-1 range was achieved,to an accurate standard,using S_(50),Om,and mehlich-3 Fe(R^(2) of independent calibration and validation being 0.91 and 0.95,respectively).Using Giles’four shapes of isotherms(C,L,H,and S),L non-strict-and C-shaped isotherm curves accounted for 64% and 27% of the soils,*** clustering identified a separation of isotherm curves influenced by two ranges of mehlich-3 *** with a low range of mehlich-3 Al(2.5-698 mg kg^(-1))had no incidence of rapid sorption(C shape).Single point indices,Al,or available soil data make the regression approach a feasible way of predicting Langmuir parameters that could be included with standard agronomic soil P testing.

关键词： available phosphorus binding fertilizer soil test sorption maximum

PREPARATION OF IODINE-INCLUDED CARBON USING RF PLASmA CVD

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Acta metallurgica Sinica(English Letters) 2005年第3期18卷 423-426页

作者： Y. sakamoto m. Takaya T. Uchiyama Department of Precision Engineering Faculty of Engineering Chiba Institute of Technology Tsudanuma Narashino Chiba 275-0016 JapanDepartment of Precision Engineering Faculty of Engineering Chiba Institute of Technology Tsudanuma Narashino Chiba 275-0016 JapanGraduate School Department of Precision Engineering Faculty of Engineering Ch iba Institute of Technology Tsudanuma Narashino Chiba 275-0016 Japan

For the aim of synthesis of the carbon-iodine compound, the preparation of iodin e-included carbon using RF plasma CVD was studied. Iodine-included carbon was sy nthesized on Si substrate using ICP type RF plasma CVD apparatus. C2H5OH and I2 dissolved C2H5OH was used as reactant gases. As a result, surface morphologies o f Iodine included carbon films showed flat surfaces for each samples. On the str ucture of films estimated by Raman spectroscopy, amorphous carbon was recognized . And I2 peaks were observed in XPS spectra. As a result of friction test, frict ion coefficient of the sample growth with C2H5OH showed about 0.45. On the other hand, that of the sample with I2-C2H5OH showed about 0.3 and decrease of fricti on coefficient was recognized. Iodine inclusion for carbon materials can be achi eved by RF plasma CVD using an I2-C2H5OH reactant. The coefficient of iodine-inc luded carbon showed lower than of without iodine

关键词： carbon iodine plasma CVD tribological property

Genetic variability of the stable fly assessed on a global scale using amplified fragment length polymorphism

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Insect Science 2016年第5期23卷 695-703页

作者： kathleen m Kneeland Steven R. Skoda John E. Foster Department of Entomology 103 Entomology Haft University of Nebraska-Lincoln Lincoln NE 68583 USDA-ARS-KBUSLIRL Screwworm Research Unit 2700 Fredericksburg Road Kern/ille TX 78028 USA

The stable fly, Stomoxys calcitrans （L.）（Diptera： muscidae）, is a blood-feeding, economically important pest of animals and humans worldwide. Improved management strategies are essential and their development would benefit from studies on genetic di- versity of stable flies. Especially if done on a global scale, such research could generate information necessary for the development and application of more efficient control meth- ods. Herein we report on a genetic study of stable flies using amplified fragment length polymorphism, with samples of 10-40 individuals acquired from a total of 25 locations in the Nearctic, Neotropic, Palearctic, Afrotropic and Australasian biogeographical regions. We hypothesized that genetic differentiation would exist across geographical barriers. Although Fsx （0.33） was moderately high, the Gsx （0.05; representing genetic diversity between individuals） was very low; Nm values （representing gene flow） were high （9.36）. The mismatch distribution and tests of neutrality suggested population expansion, with no genetic differentiation between locations. The analysis of molecular variance （AmOVA） results showed the majority of genetic diversity was within groups. The mantel test showed no correlation between geographic and genetic distance; this strongly supports the AmOVA results. These results suggest that stable flies did not show genetic differentiation but are panmictic, with no evidence of isolation by distance or across geographical barriers.

关键词： AFLP biting flies external parasites genetic diversity livestock pests Stomoxys calcitrans

Evolving roles of magnifying endoscopy and endoscopic resection for neoplasia in inflammatory bowel diseases

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World Journal of Gastrointestinal Oncology 2022年第3期14卷 646-653页

作者： Shintaro Akiyama Taku sakamoto Joshua m Steinberg Yutaka Saito Kiichiro Tsuchiya Department of Gastroenterology University of TsukubaIbaraki 305-8575Japan Endoscopy Division National Cancer Center HospitalTokyo 104-0045Japan Department of Inflammatory Bowel Disease Gastroenterology of the RockiesDenverCO 80218United States

magnifying endoscopy is a useful technique to differentiate neoplasia from non-neoplastic lesions. Data regarding the clinical utility of magnifying endoscopy for neoplasia in patients with inflammatory bowel disease(IBD) has been *** Kudo’s pit pattern types Ⅲ-Ⅴ are findings suggestive of neoplasia in non-IBD patients, these pit patterns are predictive of IBD-associated neoplasia as ***, active chronic inflammatory processes, particularly regenerative changes, can mimic neoplastic pit patterns and may affect a meticulous evaluation of pit pattern diagnosis in patients with IBD. The clinical evidence regarding the utility of magnifying endoscopy with narrow band imaging or endocytoscopy has also been evolving in regard to the diagnosis of IBD-associated neoplasia. These advanced endoscopic techniques are promising for multiple reasons;not only for making an accurate diagnosis of neoplasia, but also in determining if endoscopic resection is appropriate for such lesions in patients with IBD. In this review, we discuss the diagnostic accuracy and limitations of magnifying endoscopy in assessing IBD-associated neoplasia and examine the feasibility and outcomes of endoscopic resection for these lesions.

关键词： magnifying endoscopy Neoplasia Ulcerative colitis Inflammatory bowel disease Endoscopic resection

Experimental and modeling Study of Forest Fire Effect on Soil Thermal Conductivity

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Pedosphere 2016年第4期26卷 462-473页

作者： kathleen m.SmITS Elizabeth KIRBY William J.mASSmAN Larry Scott BAGGETT Center for the Experimental Study of Subsurface Environmental Processes Department of Civil and Environmental EngineeringColorado School of Mines USDA Forest Service Rocky Mountain Research Station

An understanding of soil thermal conductivity after a wildfire or controlled burn is important to land management and post-fire recovery efforts. Although soil thermal conductivity has been well studied for non-fire heated soils, comprehensive data that evaluate the long-term effect of extreme heating from a fire on the soil thermal conductivity are limited. The purpose of this study was to evaluate the long-term impact of fire on the effective thermal conductivity of soils by directly comparing fire-heated and no-fire control soils through a series of laboratory studies. The thermal conductivity was measured for ten soil samples from two sites within the manitou Experimental Forest, Colorado, USA, for a range of water contents from saturation to the residual degree of saturation. The thermal conductivity measured was compared with independent estimates made using three empirical models from literature, including the Campbell et al. （1994）, CSt~ and Konrad （2005）, and massman et al. （2008） models. Results demonstrate that for the test soils studied, the thermal conductivity of the fire-heated soils was slightly lower than that of the control soils for all observed water contents. modeling results show that the Campbell et al. （1994） model gave the best agreement over the full range of water contents when proper fitting parameters were employed. Further studies are needed to evaluate the significance of including the influence of fire burn on the thermal properties of soils in modeling studies.

关键词： controlled burn degree of saturation empirical model water content wildfire