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Biomimetic gold nanocomplexes for gene knockdown： Will gold deliver dividends for small interfering RNA nanomedicines？

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Nano Research 2015年第10期8卷 3111-3140页

作者： Jianfeng Guo Kamil Rahme kathleen A. Fitzgerald Justin D. Holmes Caitriona M. O'Driscoll PharmacodeliveryGroup SchoolofPharmacyUniversityCollegeCorkCorkIreland DepartmentofSciences FacultyofNaturalandAppliedScienceNotreDameUniversity(Louaize)ZoukMosbeh1200Lebanon MaterialsChemistryandAnalysisGroup DepartmentofChemistryandtheTyndallNationalInstituteUniversityCollegeCorkCorkIreland AdvancedMaterialsandBioEngineeringResearch(AMBER) CentreforResearchonAdaptiveNanostructuresandNanodevices(CRANN)TrinityCollegeDublinDublin2Ireland

RNA interference （RNAi） effectors such as small interfering RNA （siRNA） and micro RNA （miRNA） can selectively downregulate any gene implicated in the pathology of a disease. Therefore, RNAi-based therapies have immense potential for the treatment of a wide range of diseases. However, pharmacokinetic and pharmacodynamic studies have revealed that these therapeutic agents have poor bioactivity due to a number of factors, including insufficient plasma drug levels, short plasma half-lives, renal clearance, and hepatic metabolism. Non-viral delivery may facilitate the clinical application of siRNA-based therapeutics by helping to overcome these barriers. Recently, the potential of gold nanoparticles （AuNPs） as multifunctional carriers for transporting drugs, proteins, and genetic materials has been demonstrated. In this review, some of the key properties of AuNPs relevant to siRNA delivery, such as physical properties and surface chemistry have been described. In addition, the ability of AuNP-based formulation strategies to successfully overcome delivery barriers associated with siRNA, and the potential for this material to translate into safe and effective nanomedicines are critically discussed.

关键词： siRNA delivery RNA interference (RNAi)-based therapeutics,mulfifunctionalnanoparficles,nanotoxicity of goldnanoparticles

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Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon^(TM):effect on cholesterol, hematology, and blood chemistry

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Integrative Zoology 2011年第4期6卷 409-419页

作者： Christi A.YODER Brenda A.MAYLE Carol A.FURCOLOW David P.COWAN kathleen A.FAGERSTONE National Wildlife Research Center Fort CollinsColoradoUSA Forest Research Alice Holt LodgeFarnhamSurreyUK Central Science Laboratory Sand HuttonYorkUK

Grey squirrels(Sciurus carolinensis)are an invasive species in Britain and *** have replaced native red squirrels(Sciurus vulgaris)throughout most of Britain,and cause damage to ***,lethal control is used to manage grey squirrel populations in Britain,but nonlethal methods might be more acceptable to the *** such method is contraception with 20,25-diazacholesterol dihydrochloride(DiazaCon^(TM)).DiazaCon^(TM) inhibits the conversion of desmosterol to cholesterol,resulting in increasing desmosterol concentrations and decreasing cholesterol *** cholesterol is needed for the synthesis of steroid reproductive hormones,such as progesterone and testosterone,inhibition of cholesterol synthesis indirectly inhibits *** is used as a marker of efficacy in laboratory studies with species that do not reproduce readily in *** squirrels were gavaged with a DiazaCon^(TM) solution for 2 days,and then fed DiazaCon^(TM)-coated peanuts for an additional 8 days at target doses of 50 and 100 mg DiazaCon^(TM) per kg body *** was a significant difference in cholesterol concentrations in the treatment groups compared to the control *** was reduced by≥40%for 2 months in both treatment *** were no differences among groups with respect to blood chemistry and hematology parameters,and mean values are *** mean overall dose of DiazaCon^(TM) received was 29.0±1.6 and 55.3±4.3 mg/kg in the low(50 mg/kg)and high dose(100 mg/kg)groups,***^(TM) might provide an effective,acceptable alternative to lethal control.

关键词： 20 25-diazacholesterol dihydrochloride cholesterol contraception DiazaCon^(TM) grey squirrel

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Spontaneous pneumothorax in a single lung transplant recipient-a blessing in disguise: A case report

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World Journal of Clinical Cases 2020年第14期8卷 3031-3038页

作者： Himanshu Deshwal Subha Ghosh kathleen Hogan Olufemi Akindipe Charles Randall Lane Atul C Mehta Division of Pulmonary Critical Care and Sleep MedicineNew York University Grossman School of MedicineNew YorkNY 10016United States Imaging Institute Section of Thoracic ImagingCleveland ClinicClevelandOH 44195United States Respiratory Institute Cleveland ClinicClevelandOH 44195United States

BACKGROUND End-stage chronic obstructive pulmonary disease(COPD)is one of the common lung diseases referred for lung *** to the international society of heart and lung transplantation,30%of all lung transplantations are carried out for COPD *** compared to bilateral lung transplant,singlelung transplant(SLT)has similar short-term and medium-term results for *** patients with severe upper lobe predominant emphysema,lung volume reduction surgery is an excellent alternative which results in improvement in functional status and long-term *** 2018,endobronchial valves were approved by the Food and Drug Administration for severe upper lobe predominant emphysema as they demonstrated improvement in lung function,exercise capacity,and quality of ***,the role of endobronchial valves in native lung emphysema in SLT patients has not been *** SUMMARY We describe an unusual case of severe emphysema who underwent a successful SLT 15 years ago and had gradual worsening of lung function suggestive of chronic lung allograft ***,her lung function improved significantly after a spontaneous pneumothorax of the native lung resulting in auto-deflation of large *** This case highlights the clinical significance of native lung hyperinflation in single lung transplant recipient and how spontaneous decompression due to pneumothorax led to clinical improvement in our patient.

关键词： Native lung hyperinflation Single lung transplant Pneumothorax Bronchoscopic lung volume reduction Endobronchial valve Case report

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Atm deficient zebrafish model reveals conservation of the tumour suppressor function and a role in fertility

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Genes & Diseases 2023年第2期10卷 381-384页

作者： Jeroen Vierstraete Charlotte Fieuws David Creytens Jo Van Dorpe Andy Willaert Anne Vral kathleen BM Claes Center for Medical Genetics Department of Biomolecular MedicineGhent University Hospital and Ghent University9000 GhentBelgium Department of Human Structure and Repair Ghent University9000 GhentBelgium Cancer Research Institute Ghent (CRIG) Ghent University and Ghent University Hospital9000 GhentBelgium Department of Pathology Ghent University and Ghent University Hospital9000 GhentBelgium

Biallelic loss-of-function variants in ATM (Ataxia Telangiectasia Mutated) cause Ataxia Telangiectasia (AT), a rare disorder associated with cerebellar degeneration and ataxia, cancer predisposition, infertility, growth retardation, etc. ATM is a phosphoinositide 3-kinase-related kinase (PIKK) with a role in DNA repair and maintenance of genome stability. Studying a multisystem genetic disease like AT requires animal models to ascertain its pathogenesis at the level of tissues, organs and the organism. Due to its small size, cheap maintenance, large progeny, rapid development and initial transparency, zebrafish (Danio rerio) is an increasingly popular vertebrate model organism, suitable for genetic modifications and large-scale in vivo therapeutic screens as embryos are chemically permeable to small compounds. Currently, no zebrafish model for AT exists.1 We generated atm knock-outs through CRIPSR-Cas9 mutagenesis. We show that atm conserved its function as a tumour suppressor gene and is involved in gametogenesis and fertility. Therefore, this mutant is of great value for further studies investigating the role of atm in reproduction and tumorigenesis.

关键词： ATM function transparency

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Chinese nurses’ perceived impact of international educational experiences and cultural beliefs following a 1-year study abroad program: an exploratory study

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Frontiers of Nursing 2020年第1期7卷 23-29页

作者： Debra MWolf Hui-Xin Wub kathleen Spadaro Diane FHunker Nursing and Healthcare Informatics Chatham UniversityPittsburghPennsylvania 15232USA School of Nursing Davis&Elkins CollegeElkinsWest Virginia 26241USA School of Nursing Chatham UniversityPittsburghPennsylvania 15232USA

Objectives:To examine the perceived impact of international educational experiences and cultural beliefs before and after completing a 1-year Masters of Science in Nursing ***:An exploratory study was conducted among Chinese nurses studying abroad in a private medium-sized university in the United *** 27-item electronic pre-survey was administered within 1 week of starting the program and the post-survey was administered 1 year later at the completion of the ***:Majority of participants(n=25)were female,23–36 years of *** revealed that the perceived impact of international educational experiences assessed at the start of the program was similar to the perceived impact measured at the end of the 1-year program,suggesting that the students learned and experienced what they *** was a significant impact on cultural beliefs from the start of the program compared with the end of the program suggesting that a 1-year study abroad program does influence cultural ***:Understanding what is important to provide in a study abroad program and providing the educational experiences identified by students as impactful are avenues to help host universities best develop their *** suggested that the 1-year program can influence foreign students’cultural beliefs,yet the professional and personal impact of this change warrants further study.

关键词： international Chinese nurses cultural beliefs learning needs educational impact

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An aqueous 2.1 V pseudocapacitor with MXene and V-MnO_(2) electrodes

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Nano Research 2022年第1期15卷 535-541页

作者： Jiabin Wu Qun Li Christopher E.Shuck kathleen Maleski Husam N.Alshareef Jun Zhou Yury Gogotsi Liang Huang Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China Department of Materials Science and Engineering and A./.Drexel Nanomaterials Institute Drexel UniversityPhiladelphiaPennsylvania 19104USA Materials Science and Engineering Physical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

MXenes have shown record-breaking redox capacitance in aqueous electrolytes,but in a limited voltage window due to oxidation under anodic potential and hydrogen evolution under high cathodic *** Ti3C2Tx Xene negative electrode with RuO_(2) or carbon-based positive electrodes expanded the voltage window in sulfuric acid electrolyte to about 1.5 ***,we present an asymmetric pseudocapacitor using abundant and eco-friendly vanadium doped MnO_(2) as the positive and Ti_(3)C_(2)Tx MXene as the negative electrode in a neutral 1M Li2SO4 *** all-pseudocapacitive asymmetric device not only uses a safer electrolyte and is a much less expensive counter-electrode than RuO_(2),but also can operate within a 2.1 V voltage window,leading to a maximum energy density of 46 Wh/*** study also demonstrates the possibility of using MXene electrodes to expand the working voltage window of traditional redox-capable materials.

关键词： MXene pseudocapacitors metal oxides supercapacitors manganese oxide

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Fisheries monitoring: Perspectives from the United States

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Aquaculture and Fisheries 2020年第3期5卷 131-138页

作者： Robert Boenish Daniel Willard Jacob P.Kritzer kathleen Reardon Environmental Defense Fund 18 Tremont St.Suite 850BostonMA02108USA Environmental Defense Fund 301 Congress Ave.Suite 1300AustinTX78701USA Maine Department of Marine Resources 194 McKown Point RdWest Boothbay HarborME04575USA

Fisheries monitoring in the United States exists in many forms and serves many functions due to geographically varying objectives,practices,technology,institutional structures,and *** the U.S and abroad,diverse catch methods commonly exist for the same stock,thus monitoring and reporting strategies need to be tailored to unique operational *** management challenges include funding limitation,survey design,coverage,and *** describe three innovative examples of fisheries monitoring in the United *** stories of success and failure can inform the design and implementation of new monitoring pilots and aid crafting both regional and national *** explore the innovative vessel monitoring and electronic logbook practices across multiple sectors for Gulf of Mexico red snapper(Lutjanus campechanus).Then,we examine a unique monitoring program that produces critical,near real-time genetic and population surveys for sockeye salmon(Oncorhynchus nerka)in Bristol Bay,*** final case study describes the many fishery-dependent and-independent data streams for American lobster(Homarus americanus)in New *** all monitoring cases exists an explicit focus on the most critical aspects of organism life *** find strong cross-institutional working relationships and adept agency coordination are imperatives in instances of stocks occupying multiple state or federal *** results suggest the most effective approaches address the unique data needs of a fishery,and for this,thorough understanding of both biological and socioeconomic aspects of the fishery is a ***,the monitoring program should jointly incentivize compliance while promoting continued and evolving interaction between resources users,scientists,and management.

关键词： Fisheries Fisheries monitoring Fisheries management Sustainability

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Photoreceptor-Mediated Bending towards UV-B in Arabidopsis

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Molecular Plant 2014年第6期7卷 1041-1052页

作者： Filip Vandenbussche Kimberley Tilbrook Ana Carolina Fierro kathleen Marchal Dirk Poelman Dominique Van Der Straeten Roman UIm boratory of Functional Plant Biology Department of Physiology Faculty of Sciences Ghent University B-9000 Ghent Belgium Department of Botany and Plant Biology Sciences III University of Geneva CH-1211 Geneva 4 Switzerland Department of Microbial and Molecular Systems Faculty of Bioscience Engineering KU Leuven B-3001 Heverlee Belgium Department of Plant Biotechnology and Bioinformatics Faculty of Sciences Ghent University B-9000 Ghent Belgium Department of Information Technology IMinds Faculty of Sciences Ghent University B-go00 Ghent Belgium Lumilab Department of Solid State Sciences Faculty of Sciences Ghent University B-9000 Ghent Belgium

Plants reorient their growth towards light to optimize photosynthetic light capture--a process known as phototropism. Phototropins are the photoreceptors essential for phototropic growth towards blue and ultraviolet-A （UV- A） light. Here we detail a phototropic response towards UV-B in etiolated Arabidopsis seedlings. We report that early differential growth is mediated by phototropins but clear phototropic bending to UV-B is maintained in photl phot2 double mutants. We further show that this phototropin-independent phototropic response to UV-B requires the UVoB photoreceptor UVR8. Broad UV-B-mediated repression of auxin-responsive genes suggests that UVR8 regulates directional bending by affecting auxin signaling. Kinetic analysis shows that UVR8-dependent directional bending occurs later than the phototropin response. We conclude that plants may use the full short-wavelength spectrum of sunlight to efficiently reorient photosynthetic tissue with incoming light.

关键词： phototropism UV-B auxin UVR8 Arabidopsis,

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American Holidays

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语言教育 1995年第1期 7-12页

作者： kathleen Sego

The word “holiday” originally was used to honor a sacred per-son or event,hence “Holy Days”.In time great leaders,special oc-casions that marked historical events,were *** country has special or unique days that a... 详细信息

关键词： historical honor holiday originally 耶稣受难日 Sunday religious marked hence themselves

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Locally advanced pancreatic cancer: staging, operability, and the importance of multimodality therapy

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 497-500页

作者： Rebecca Y.Kim Douglas B.Evans kathleen K.Christians Department of Surgery and the LaBahn Pancreatic Cancer Program Medical College of WisconsinMilwaukeeWIUSA

The role for surgery in the management of locally advanced pancreatic cancer(LAPC)is nicely discussed in the manuscript by Gemenetzis et *** in the Annals of Surgery(1).As the authors acknowledge,therapeutic selection... 详细信息

关键词： Surgery cancer al.

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