检索结果-南通市图书馆

Bioreactor for the reconstitution of a decellularized vascular matrix of biological origin

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Biomedical Science and Engineering 2011年第6期4卷 435-442页

作者： matthew G. Geeslin Gabriel J. caron Stefan m. Kren Ephraim m. Sparrow David A. Hultman Doris A. Taylor 不详

Acellular matrices derived from animal and human cadaveric donor vessels or other tubular matrices are appropriate candidates for the creation of tissue- en-gineered, small-diameter, muscular arteries. Engi-neering principles have been used to design a bio-reactor and the necessary auxiliary systems for the reconstitution of a previously decellularized vascular matrix. The bioreactor enables the attachment of cells to the luminal and/or exterior surfaces of the matrix. For the recellularization procedure, the matrix is situated within a sealed compartment in order to maintain a sterile environment. The matrix is rotated continuously to assure a spatially uniform re-constitution. The auxiliary systems that serve the bioreactor are: (a) an oxygenator, (b) peristaltic pumps, one for conveying the internal cell medium and the other for conveying the external cell medium, (c) motor and gearing to create steady and controlled rotation, (d) reservoirs for the containment of the two media, and (e) tubing to convey the respective fluids and to interconnect the bioreactor culture chamber to the various auxiliary components. A recellularized matrix produced by the bioreactor demonstrated its capabilities to reconstitute a previously decellularized scaffold.

关键词： Bioreactor Decellularize Recellularize Blood Vessel Tissue Engineering

儿童青少年体力活动与骨健康研究的10大问题

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

北京体育大学学报 2016年第1期39卷 46-52,60页

作者： kathleen F.Janz David Q.Thomas m.Allison Ford Skip m.Williams 爱荷华大学 Iowa CityIA 52242USA 伊利诺斯州立大学 NornmlIL 61790USA 密西西比大学 OxfordMS 38677USA

证据强烈支持体力活动对骨强度有积极的因果效应,并指出儿童进行体力活动对预防骨质疏松有长远益处。年轻时的健康骨骼可能对预防成年后由于骨量丢失而发生骨质疏松有重要作用。家庭、学校(特别是体育课)和社区是进行骨骼健康促进体力... 详细信息

证据强烈支持体力活动对骨强度有积极的因果效应,并指出儿童进行体力活动对预防骨质疏松有长远益处。年轻时的健康骨骼可能对预防成年后由于骨量丢失而发生骨质疏松有重要作用。家庭、学校(特别是体育课)和社区是进行骨骼健康促进体力活动的重要场所。然而,有关健康促进和体育课对骨骼健康的话题很少,因此最佳的实践方法还不清楚。基于文献资料的了解,我们提出了应该被解决的健康促进和体育课研究的10大问题,从而促进儿童青少年的体力活动。

关键词：儿童时期运动机械(冲击)载荷骨骼健康

Positioning Temperature Sensors for Frost Protection in Northern Cranberry Production

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Agricultural Sciences 2017年第9期8卷 960-971页

作者： Vincent Pelletier Silvio Jose Gumiere Steeve Pepin Jacques Gallichand Jean caron Département des Sols et de Génie Agroalimentaire Université Laval Québec Canada

Frost can cause serious economic losses in cranberry fields, particularly in northern regions. When the air temperature reaches a low critical threshold, sprinklers are operated to protect vines, to insure crop production and profitability. To avoid frost injury, proper positioning of temperature sensors is critical. A field experiment was designed and conducted to determine the optimal installation height of sensors above soil surface. Temperature data was used to investigate the spatial temperature gradient in the section of a cranberry field. A computer simulation of the temperature profile was performed to simulate the effect of wind velocity on the prediction of air temperature. For optimal use, sensors should be installed at the height of the canopy and several meters away from a dike. On nights with low wind velocities, the canopy air temperature was 2.7°C below that of 500 cm above the ground. The sensors should be put at least five m away from a dike to avoid the transfer of heat from the dike to the sensor. Also, multiple sensors should be installed because of the large variations in air temperature that were measured across the experiment. The simulated temperature indicated that wind velocity strongly influenced the temperature estimation;the effect of the wind on temperatures gradients was greater when the wind velocity was low (m/s).

关键词： Frost Protection Cranberry Production Numerical Simulation of Heat Transfer

p53 functional loss,stemness and hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatoma Research 2020年第11期6卷 67-84页

作者： Claude caron de Fromentel massimo Levrero Centre de Recherche en Cancérologie de Lyon INSERM U1052CNRS 5286UniversitéClaude Bernard Lyon 1Centre Léon BérardLyon 69008France Service d’Hépatologie et de Gastroentérologie Hôpital de la Croix-RousseHospices Civils de LyonLyon 69004France Dipartimento di Scienze Cliniche InternisticheAnestesiologiche e Cardiovascolari(SCIAC)Sapienza UniversityRome 00161Italy Center for Life Nano Science Istituto Italiano di TecnologiaSapienza UniversityRome 00161Italy

The tumor suppressor p53 is a key player in the control of genomic integrity and homeostasis in connection with p63 and p73,the two other members of the p53 *** of functional p53 leads to the proliferation and survival of mature cells and progenitor or stem cells that accumulate genetic alterations,thus favoring tumorigenesis.p53 loss of function,observed in a wide variety of human tumor types,is frequently caused by missense mutations more frequently found in the DNA binding domain,but can also be due to the expression of a plethora of viral and cellular negative *** hepatocellular carcinoma(HCC)represents a specific situation,first because the TP53 gene mutations pattern exhibits a“hot spot”rarely found in other tumor types that is linked to Aflatoxin B1 exposure and,second,because many HCCs do not exhibit any TP53 ***,we provide an overview of the current knowledge about the inhibition of p53 functions by the N-terminal(ΔN)truncated forms of the family,and their role in the emergence and maintenance of pre-malignant cells with stem cell characteristics and in HCC *** focus in particular on the Nanog-IGF1R-ΔNp73 axis that is associated with stem-like features in HCC cells and that may provide an attractive new therapeutic target and help to develop new biomarkers for HCC risk stratification,as well as preventive strategies.

关键词： p53 family p53 functional inactivation ΔNp73 hepatic progenitor cells cancer stem cells Nanog hepatocellular carcinoma

Live <i>C. elegans</i>Diffraction at a Single Point

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Biophysics 2018年第3期8卷 155-162页

作者： Jenny magnes Cheris Congo miranda Hulsey-Vincent Harold Hastings kathleen m. Raley-Susman Departments of Physics and Astronomy and Biology Vassar College Poughkeepsie NY USA Division of Science Mathematics and Computing Bard College at Simons Rock Great Barrington MA USA

Using coherent light, we analyze the temporal diffraction at a single point from real-time living C. elegans locomotion in three-dimensional space. We describe the frequency spectrum of single swimming nematodes in an optical cuvette at a single sampling point in the far-field diffraction pattern. An analytical expression of the double slit is used to model the frequency spectra of nematodes as oscillating segments. The frequency spectrum in the diffraction pattern expands discretely and linearly as a multiple of the fundamental frequency with increasing distance from the central maximum. The frequency spectrum of a worm at a single point in the frequency spectrum contains all the frequencies involved in the locomotion and is used to characterize and compare nematodes. The occurrence of resonant frequencies in the dynamic diffraction pattern increases with the distance from the central maximum. The regular spacing of the resonant frequencies is used to identify characteristic swimming frequencies.

关键词： C. elegans Nematode Temporal Diffraction Live Diffraction Locomotion

Electrical programmable multilevel nonvolatile photonic random-access memory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2023年第11期12卷 2325-2334页

作者： Jiawei meng Yaliang Gui Behrouz movahhed Nouri Xiaoxuan ma Yifei Zhang Cosmin-Constantin Popescu myungkoo Kang mario miscuglio Nicola Peserico kathleen Richardson Juejun Hu Hamed Dalir Volker J.Sorger Department of Electrical and Computer Engineering George Washington UniversityWashington DC 20052USA Florida Semiconductor Institute University of FloridaGainesvilleFL 32603USA Department of Electrical and Computer Engineering University of FloridaGainesvilleFL 32603USA Department of materials Science&Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA CREOL The College of Optics&PhotonicsUniversity of Central FloridaOrlandoFL 32816USA

Photonic Random-Access memories(P-RAm)are an essential component for the on-chip non-von Neumann photonic computing by eliminating optoelectronic conversion losses in data *** Phase-Change materials(PCms)have been showed multilevel memory capability,but demonstrations still yield relatively high optical loss and require cumbersome WRITE-ERASE approaches increasing power consumption and system package *** we demonstrate a multistate electrically programmed low-loss nonvolatile photonic memory based on a broadband transparent phase-change material(Ge2Sb2Se5,GSSe)with ultralow absorption in the amorphous state.A zero-staticpower and electrically programmed multi-bit P-RAm is demonstrated on a silicon-on-insulator platform,featuring efficient amplitude modulation up to 0.2 dB/μm and an ultralow insertion loss of total 0.12 dB for a 4-bit memory showing a 100×improved signal to loss ratio compared to other phase-change-materials based photonic *** further optimize the positioning of dual microheaters validating performance *** we demonstrate a half-a-million cyclability test showcasing the robust approach of this material and ***-loss photonic retention-of-state adds a key feature for photonic functional and programmable circuits impacting many applications including neural networks,LiDAR,and sensors for example.

关键词： retention random eliminating

Employee opinion questionnaires : 20 ready-to-use surveys that work

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

1000年

作者： Paul m. Connolly kathleen Groll Connolly.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

丹江口库区果茶场Ⅱ旧石器遗址发掘简报

人类学学报 2013年第2期32卷 144-155页

作者：李浩李超荣 kathleen KUmAN 金山大学地理、考古与环境研究学院南非约翰内斯堡WITS2050 中国科学院脊椎动物演化与人类起源重点实验室中国科学院古脊椎动物与古人类研究所北京100044 金山大学人类演化研究所南非约翰内斯堡WITS2050

丹江口库区果茶场Ⅱ旧石器遗址位于汉水上游左岸第三级阶地,海拔150-155m,2009年4-5月中国科学院古脊椎动物与古人类研究所对该遗址进行了发掘,揭露面积500m2,出土石制品132件。石制品类型有石锤、石核、石片、石器和断块,其中石器包括... 详细信息

丹江口库区果茶场Ⅱ旧石器遗址位于汉水上游左岸第三级阶地,海拔150-155m,2009年4-5月中国科学院古脊椎动物与古人类研究所对该遗址进行了发掘,揭露面积500m2,出土石制品132件。石制品类型有石锤、石核、石片、石器和断块,其中石器包括刮削器、砍砸器、手镐、手斧。剥片和加工石器的原料主要为磨圆度较高的河卵石,锤击法为主要的剥片技术,石核和石片的尺寸以中小型居多;石器中,砍砸器、手镐主要以砾石为毛坯直接加工,刮削器多采用小型石片毛坯进行加工,而手斧则以大石片为毛坯进行两面加工。遗址上部地层为强烈氧化的红色黏土层,含钙质结核和锰质薄膜;下部发育网纹红土。地层沉积物性质和地貌分析表明遗址年代大致为中更新世。

关键词：丹江口库区果茶场Ⅱ遗址石制品手斧中更新世

Evaluation of Life Quality and Dyspnea Intensity on Chronic Airway Diseases Patients in Pulmonary Rehabilitation Program

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Biosciences and medicines 2016年第1期4卷 10-15页

作者： kathleen Julia Silva Giseli Domingues Cordeiro Caroline Rossinoli maurício Longo Galhardo márcia maria Faganello Academic of Department of Physiotherapy Unisalesino Lins Brazil Department of Physiotherapy Hospital Unimed Lins Brazil Department of Pneumonology Unimed Lins Brazil Department of Physiotherapy UNESP Marilia Brazil

The chronic obstructive pulmonary disease (COPD) and asthma are chronic airway diseases that cause considerable physical, emotional and social restrictions. The life quality of patients who suffer from these diseases, is more affected by dyspnea then by other symptoms. That way is possible to correlate the impact of dyspnea on their life quality. The Pulmonary Rehabilitation Program (PRP) helps to improve the physical fitness and quality of life. This paper presents a study of the life quality and the dyspnea intensity in chronic lung disease patients. The research has participation of fourteen patients, distributed as seven suffering from COPD and the other seven suffering from asthma, for both gender and with an age average of 74.2 ± 8.9. The patients answer the following questionnaires: Baseline Dyspnea Index (BDI), medical Research Council (mRC) Dyspnea Scale, Airways Questionnaire 20 (AQ20) and the Brazilian version of the Short-Form (SF-36) life quality questionnaire. From the present study, it was concluded that asthma patients have a less impaired life quality, since the dyspnea intensity is lesser, compared to the one with COPD.

关键词： Life Quality Dyspnea Intensity Chronic Lung Disease