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Preoperative Feeding in Single Ventricle Neonates is Predictive of Shorter Time to Goal Feed

Congenital Heart disease 2022年第5期17卷 505-518页

作者： Alyssia Venna kathleen Reid Sarah davis Jiaxiang Gai Yves d’Udekem Sarah Clauss department of Cardiovascular Surgery Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA department of Cardiology Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA department of Biostatistics Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA

Background:Patients with single ventricle anatomy are at increased risk of growth failure and *** cardiac centers,there is little standardization of feeding practices in this complex *** hypothesized that initiation of our center’s preoperative feeding protocol would result in decreased gastrostomy tube(G-tube)use,decreased length of stay and would not result in increased Necrotizing Enterocolitis(NEC)***:A single institution review of 52 patients who had undergone stage I single ventricle palliative repair was *** diagnoses were hypoplastic left heart syndrome(39%),atrioventricular canal(15%),and other(46%).Postoperative parameters such as time to goal feed and need for gastrostomy tube(G-tube)were compared among preoperatively fed and non-preoperatively fed *** to goal feed was calculated as time from first postoperative enteral feed to goal volume of 100 mL/***:Of the 26 patients who met inclusion criteria for preoperative feeding,22 patients(85%)were fed prior to *** proportional hazard ratio revealed that age at surgery(p=0.047)and being preoperatively fed(p=0.001)were associated with reaching goal feed *** analysis revealed that being preoperatively fed made a patient twice as likely to reach goal feed sooner(p=0.047).Univariable logistic regression revealed that days on total parenteral nutrition(p=0.018),length of hospitalization(p=0.008),and time to 1st postoperative feed(p=0.020)were significantly associated with higher odds of needing a G-tube *** logistic regression did not show any predictors of postoperative G-tube ***,there was a trend towards lower G-tube usage in the preoperatively fed ***:Implementing a standardized preoperative feeding protocol in single ventricle neonates can result in significantly shorter time to goal feed in preoperatively fed *** is beneficial for institutions to begin implementi

关键词： Single ventricle feeding guidelines enteral nutrition hypoplastic left heart syndrome necrotizing enterocolitis preoperative

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Biomimetic gold nanocomplexes for gene knockdown： Will gold deliver dividends for small interfering RNA nanomedicines？

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Nano Research 2015年第10期8卷 3111-3140页

作者： Jianfeng Guo Kamil Rahme kathleen A. Fitzgerald Justin d. Holmes Caitriona M. O'driscoll PharmacodeliveryGroup SchoolofPharmacyUniversityCollegeCorkCorkIreland departmentofSciences FacultyofNaturalandAppliedScienceNotreDameUniversity(Louaize)ZoukMosbeh1200Lebanon MaterialsChemistryandAnalysisGroup DepartmentofChemistryandtheTyndallNationalInstituteUniversityCollegeCorkCorkIreland AdvancedMaterialsandBioEngineeringResearch(AMBER) CentreforResearchonAdaptiveNanostructuresandNanodevices(CRANN)TrinityCollegeDublinDublin2Ireland

RNA interference （RNAi） effectors such as small interfering RNA （siRNA） and micro RNA （miRNA） can selectively downregulate any gene implicated in the pathology of a disease. Therefore, RNAi-based therapies have immense potential for the treatment of a wide range of diseases. However, pharmacokinetic and pharmacodynamic studies have revealed that these therapeutic agents have poor bioactivity due to a number of factors, including insufficient plasma drug levels, short plasma half-lives, renal clearance, and hepatic metabolism. Non-viral delivery may facilitate the clinical application of siRNA-based therapeutics by helping to overcome these barriers. Recently, the potential of gold nanoparticles （AuNPs） as multifunctional carriers for transporting drugs, proteins, and genetic materials has been demonstrated. In this review, some of the key properties of AuNPs relevant to siRNA delivery, such as physical properties and surface chemistry have been described. In addition, the ability of AuNP-based formulation strategies to successfully overcome delivery barriers associated with siRNA, and the potential for this material to translate into safe and effective nanomedicines are critically discussed.

关键词： siRNA delivery RNA interference (RNAi)-based therapeutics,mulfifunctionalnanoparficles,nanotoxicity of goldnanoparticles

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Afterword to Sperm morphometrics today and tomorrow special issue in Asian Journal of Andrology

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Asian Journal of Andrology 2016年第6期18卷 895-897页

作者： Caries Soler Trevor G Cooper Anthony valverde Jesfis L Yanliz department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Spain department of R+d Proiser R+D Science Park University of Valencia 46980 Paterna Spain Tuen Mun New Territories Hong Kong SAR China department of Animal Production and Food Science Higher Polytechnic School of Huesca University of Zaragoza Ctra Cuarte S/N 22071 Huesca Spain

The problems associated with the subjective assessment of human sperm morphology have been well aired in another Asian Journal of Andrology Special Issue1 that marked the publication of the 5th edition of the WHO Semen analysis manual, and contrary views have subsequently been presented） However, the vagaries of the eye-brain system in assessing whether a sperm head is large or small can be eliminated by objective assessment where definitive structures are defined by their dimensions. These can then be classified automatically into as many categories as the data permit, conventionally on the basis of preset upper and lower limits, but also by more comprehensive analysis as discussed here.

关键词： STAINING TECHNIQUES MORPHOLOGY NUCLEAR

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Morphometry and subpopulation structure of Holstein bull spermatozoa： variations in ejaculates and cryopreservation straws

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Asian Journal of Andrology 2016年第6期18卷 851-857页

作者： Anthony valverde Hector Arenan Maria Sancho Jesus Contell Jesus Yaniz Alejandro Fernandez Caries Soler Technological Institute of Costa Rica San Carlos Campus S Xenetica Fontao Fontao-Esperante 27210 Lugo Spain R+d department Proiser R+D Scientific Park University of Valencia 46980 Paterna Spain department of Animal Production and Food Science Politechnical School of Huesca University of Zaragoza 22071 Huesca Spain department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Spain

Sperm quality is evaluated for the calculation of sperm dosage in artificial reproductive programs. The most common parameter used is motility, but morphology has a higher potential as a predictor of genetic quality. Morphometry calculations from CASA-Morph technology improve morphological evaluation and allow mathematical approaches to the problem. Semen from 28 Holstein bulls was collected by artificial vagina, and several ejaculates were studied. After general evaluation, samples were diluted, packaged in 0.25 ml straws, and stored in liquid nitrogen. Two straws per sample were thawed, and slides were processed and stained with diff-Quik. Samples were analyzed by a CASA-Morph system for eight morphometric parameters. In addition to the ＂classical＂ statistical approach, based on variance analysis （revealing differences between animals, ejaculates, and straws）, principal component （PC） analysis showed that the variables were grouped into PC1, related to size, and PC2 to shape. Subpopulation structure analysis showed four groups, namely, big, small, short, and narrow from their dominant characteristics, representing 31.0%, 27.3%, 24.1%, and 17.7% of the total population, respectively. The distributions varied between animals and ejaculates, but between straws, there were no differences in only four animals. This modern approach of considering an ejaculate sperm population as divided into subpopulations reflecting quantifiable parameters generated by CASA-Morph systems technology opens a new view on sperm function. This is the first study applying this approach to evaluate different ejaculates and straws from the same individual. More work must be done to improve seminal dose calculations in assisted reproductive programs.

关键词： cryopreservation Holstein bull sperm morphometry subpopulations

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Morphometric comparison by the ISAS CASA-dNAf system of two techniques for the evaluation of dNA fragmentation in human spermatozoa

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Asian Journal of Andrology 2016年第6期18卷 835-839页

作者： Sara Sadeghi Almudena Garcia-Molina Ferran Celma Anthony valverde Sogol Fereidounfar Caries Soler department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Valencia Spain R+d department Proiser R+D Scientific Park Universitat de Valencia 46980 Paterna Valencia Spain Technological Institute of Costa Rica San Carlos Campus School of Agronomy 223-21001 Alajuela Costa Rica department of Botany Kharazmi University Tehran Iran

dNA fragmentation has been shown to be one of the causes of male infertility, particularly related to repeated abortions, and different methods have been developed to analyze it. In the present study, two commercial kits based on the SCd technique （Halosperm~ and SdFA） were evaluated by the use of the dNA fragmentation module of the ISAS vl CASA system. Seven semen samples from volunteers were analyzed. To compare the results between techniques, the Kruskal-Wallis test was used. data were used for calculation of Principal Components （two PCs were obtained）, and subsequent subpopulations were identified using the Halo, Halo/Core Ratio, and PC data. Results from both kits were significantly different （P 〈 0.001）. In each case, four subpopulations were obtained, independently of the classification method used. The distribution of subpopulations differed depending on the kit used. From the PC data, a discriminant analysis matrix was obtained and a good a posterioriclassification was obtained （97.1% for Halosperm and 96.6% for SdFA）. The present results are the first approach on morphometric evaluation of dNA fragmentation from the SCd technique. This approach could be used for the future definition of a classification matrix surpassing the current subjective evaluation of this important sperm factor.

关键词： dNA fragmentation Halosperm morphometry principal component analysis SdFA subpopulation

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Current and emerging therapies for alcohol-associated hepatitis

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Liver Research 2023年第1期7卷 35-46页

作者： Francisco Idalsoaga Gustavo Ayares Luis Antonio díaz Jorge Arnold María Ayala-valverde david Hudson Marco Arrese Juan Pablo Arab department of Gastroenterology School of MedicinePontificia Universidad Catolica de ChileSantiagoChile Internal Medicine Service Hospital El PinoCritical Patient UnitClinica DavilaSantiagoChile division of Gastroenterology Department of MedicineSchulich School of MedicineWestern University&London Health Sciences CentreLondonOntarioCanada department of Epidemiology and Biostatistics Schulich School of MedicineWestern UniversityLondonOntarioCanada Alimentiv LondonOntarioCanada

Alcohol-related liver disease(ALd)encompasses a spectrum of diseases caused by excessive alcohol *** includes hepatic steatosis,steatohepatitis,variable degrees of fibrosis,cirrhosis,and alcohol-associated hepatitis(AH),the latter being the most severe acute form of the *** AH is associated with high mortality(reaching up to 30%e50%)at 90 *** cornerstone of ALd,and particularly AH,treatment continues to be abstinence,accompanied by support measures such as nutritional supplementation and management of alcohol withdrawal syndrome(AWS).In severe AH with model for end-stage liver disease(MELd)score21,corticosteroids can be used,especially MELd score between 25 and 39,where the highest benefit is *** key aspects of treatment include the early identification of infections and their associated management and the proper identification of potential candidates for liver *** development of new therapies based on the pathophysiology and mechanisms of liver injury are *** includes the modulation and management of the innate immune response,gut dysbiosis,bacterial translocation,and bacteria-derived products from the *** hold promise for the future of AH treatment.

关键词： Alcohol-associated hepatitis(AH) Alcohol-related liver disease(ALd) Alcohol use disorder(AUd) AUd treatment Nutritional therapy Steroids therapy Cirrhosis Fibrosis

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Eco-districts in France:What tools to ensure goals achievement?

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Science China Earth Sciences 2020年第6期63卷 865-874页

作者： kathleen BOQUET Charline FROITIER Jinhui LI Kaihua XU Xianlai ZENG State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China Higher Institute for Environmental Engineering and Management MINES ParisTechParis Cedex 06France GEM Company Limited Shenzhen 518101China

Globally,to build cities and communities more inclusive,safe,resilient and sustainable is one of the most important sustainable development ***-districts in cities emerged as an answer to current global environmental concerns and have been developed in France since the *** objective of this work is to gather operational feedback from sustainable neighborhood projects owners to better understand the key barriers of such projects and how to overcome them.A case study of the eco-district Les Tanneries,Lingolsheim showed that the carbon footprint of each inhabitant annually amounted to 4 tons CO2 equivalent,more than half of the French *** for improvements were clearly identified regarding transports and food carbon *** for energy consumption,social diversity and density reached the level of the eco-districts average.A governance review pointed out some superior practices such as the formalization of a specification requirements handbook,a competition between project management teams,and the use of neighborhood sustainability assessment tools to measure and track changes in *** validated tools and obtained results can be useful in building sustainable cities and even China’s ecological civilization.

关键词： Geography and environment City management Eco-district Sustainability Assessment France

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Sperm kinematic, head morphometric and kinetic- morphometric subpopulations in the blue fox （Alopex lagopus）

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Asian Journal of Andrology 2017年第2期19卷 154-159页

作者： Caries Soler Jesus Contell Lorena Bori Maria Sancho Almudena Garcia-Molina Anthony valverde Jan Segarvall department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Spain R+d department Proiser R+D Scientific Park University of Valencia 46980 Paterna Spain Technological Institute of Costa Rica San Carlos Campus School of Agronomy 223-21001 Alajuela Costa Rica Finnish Fur Breeders Association ProFur 65101 Vaasa Finland

This work provides information on the blue fox ejaculated sperm quality needed for seminal dose calculations. Twenty semen samples, obtained by masturbation, were analyzed for kinematic and morphometric parameters by using CASA-Mot and CASA-Morph system and principal component （PC） analysis. For motility, eight kinematic parameters were evaluated, which were reduced to PC1, related to linear variables, and PC2, related to oscillatory movement. The whole population was divided into three independent subpopulations： SP1, fast cells with linear movement; SP2, slow cells and nonoscillatory motility; and SP3, medium speed cells and oscillatory movement. In almost all cases, the subpopulation distribution by animal was significantly different. Head morphology analysis generated four size and four shape parameters, which were reduced to PC 1, related to size, and PC2, related to shape of the cells. Three morphometric subpopulations existed. SPI： large oval cells; SP2： medium size elongated cells; and SP3. small and short cells. The subpopulation distribution differed between animals. Combining the kinematic and morphometric datasets produced PC1, related to morphometric parameters, and PC2, related to kinematics, which generated four sperm subpopulations - SPI.. high oscillatory motility, large and short heads; SP2; medium velocity with small and short heads; SP3. slow motion small and elongated cells; and SP4. high linear speed and large elongated cells. Subpopulation distribution was different in all animals. The establishment of sperm subpopulations from kinematic, morphometric, and combined variables not only improves the well-defined fox semen characteristics and offers a good conceptual basis for fertility and sperm preservation techniques in this species, but also opens the door to use this approach in other species, included humans.

关键词： integration of motility and morphology principal component analysis sperm morphometry subpopulation

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Updating semen analysis:a subpopulation approach

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Asian Journal of Andrology 2020年第1期22卷 118-119页

作者： Almudena Garcia-Molina Anthony valverde daznia Bompart Carina Caldeira Alberto Vendrell Carles Soler Proiser R+d S.L. Scientific ParkUniversitat de ValenciaPaterna 46980ValenciaSpain department of Functional Biology and Physical Anthropology University of ValenciaBurjassot 46100ValenciaSpain Technological Institute of Costa Rica San Carlos CampusSchool of AgronomyAlajuela 223-21001Costa Rica

dear Editor,Reproductive problems affect 8%-12%of human populations worldwide;40%-50%of all infertility cases are due to the male,and up to 2%of men have suboptimal sperm quality.

关键词： dating cases infertility

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dog sperm head morphometry： its diversity and .=volution

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Asian Journal of Andrology 2017年第2期19卷 149-153页

作者： Caries Soler Ana Alambiaga Maria A Marti Almudena Garcia-Molina Anthony valverde Jesus Contell Marcos Campos department of Functional Biology and Physical Anthropology University of Valencia 46100 Burjassot Spain R+d department Proiser R+D Scientific Park University of Valencia 46980 Paterna Spain 3Technological Institute of Costa Rica San Carlos Campus School of Agronomy 223-21001 Alajuela Costa Rica department of Medicine and Animal Surgery University CardenaI-Herrera-CEU 46113 Moncada Valencia Spain Global Veterinaria (Reprovalcan) 46500 Sagunto Valencia Spain Clinica Veterinaria Sangueso 46009 Valencia Spain

dogs have been under strong artificial selection as a consequence of their relationship with man. differences between breeds are evident that could be reflected in seminal characteristics. The present study was to evaluate differences in sperm head morphometry between seven well-defined breeds of dog： the British Bulldog, Chihuahua, German Shepherd, Labrador Retriever, Spanish Mastiff, Staffordshire Terrier, and Valencian Rat Hunting dog. Semen samples were obtained by masturbation and smears stained with diff-Quik. Morphometric analysis （CASA-Morph） produced four size and four shape parameters. Length, Ellipticity, and Elongation showed higher differences between breeds. MANOVA revealed differences among all breeds. Considering the whole dataset, principal component analysis （PCA） showed that PC1 was related to head shape and PC2 to size. Procluster analysis showed the British Bulldog to be the most isolated breed, followed by the German Shepherd. The PCA breed by breed showed the Chihuahua, Labrador Retriever, Spanish Mastiff, and Staffordshire Terrier to have PC1 related to shape and PC2 to size, whereas the British Bulldog, Valencia Rat Hunting dog, and German Shepherd had PC1 related to size and PC2 to shape. The dendrogram for cluster groupings and the distance between them showed the British Bulldog to be separated from the rest of the breeds. Future work on dog semen must take into account the large differences in the breeds＇ sperm characteristics. The results provide a base for future work on phylogenetic and evolutionary studies of dogs, based on their seminal characteristics.

关键词： Canis familiaris cluster analysis diversity sperm morphometry

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