检索结果-南通市图书馆

Assessment of molecular markers and marker-assisted selection for drought tolerance in barley(Hordeum vulgare L.)

Journal of Integrative Agriculture 2024年第1期23卷 20-38页

作者： Akmaral Baidyussen Gulmira Khassanova Maral Utebayev Satyvaldy Jatayev Rystay Kushanova Sholpan Khalbayeva Aigul Amangeldiyeva Raushan Yerzhebayeva KulpashBulatova Carly Schramm Peter Anderson Colin L.d.Jenkins kathleen LSoole Yuri Shavrukov Faculty of Agronomy S.Seifullin Kazakh AgroTechnical Research UniversityAstana 010000Kazakhstan A.I.Barayev Research and Production Centre of Grain Farming Shortandy 021601Kazakhstan Kazakh Research Institute of Agriculture and Plant Growing AlmalybakAlmaty District 040909Kazakhstan College of Science and Engineering Biological SciencesFlinders UniversityAdelaideSA 5042Australia

This review updates the present status of the field of molecular markers and marker-assisted selection(MAS),using the example of drought tolerance in *** accuracy of selected quantitative trait loci(QTLs),candidate genes and suggested markers was assessed in the barley genome *** common strategies are described for molecular marker development,candidate gene identification and verification,and their possible applications in MAS to improve the grain yield and yield components in barley under drought *** strategies are based on the following five principles:(1)Molecular markers are designated as genomic‘tags’,and their‘prediction’is strongly dependent on their distance from a candidate gene on genetic or physical maps;(2)plants react differently under favourable and stressful conditions or depending on their stage of development;(3)each candidate gene must be verified by confirming its expression in the relevant conditions,e.g.,drought;(4)the molecular marker identified must be validated for MAS for tolerance to drought stress and improved grain yield;and(5)the small number of molecular markers realized for MAS in breeding,from among the many studies targeting candidate genes,can be explained by the complex nature of drought stress,and multiple stress-responsive genes in each barley genotype that are expressed differentially depending on many other factors.

关键词： barley candidate genes drought tolerance gene verification via expression grain yield marker-assisted selection(MAS) molecular markers quantitative trait loci(QTLs) strategy for MAS

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Uptake and outcomes of small intestinal and urinary tract cancer surveillance in Lynch syndrome

引用

World Journal of Clinical Oncology 2021年第11期12卷 1023-1036页

作者： Jeshua deJesse Ravy K Vajravelu Christina dudzik Gillain Constantino Jessica M Long Kirk J Wangensteen kathleen d valverde Bryson W Katona department of Genetics University of PennsylvaniaPhiladelphiaPA 19104United States division of Gastroenterology and Hepatology University of Pennsylvania Perelman School of MedicinePhiladelphiaPA 19104United States division of Hematology and Oncology University of PennsylvaniaPhiladelphiaPA 19104United States

BACKGROUNd Lynch syndrome(LS)is a hereditary cancer predisposition syndrome associated with increased risk of multiple *** colorectal cancer surveillance decreases mortality in LS and is recommended by guidelines,there is lack of evidence for the efficacy of surveillance for extra-colonic cancers associated with LS,including small intestinal cancer(SIC)and urinary tract cancer(UTC).Given the limited evidence,guidelines do not consistently recommend surveillance for SIC and UTC,and it remains unclear how often individuals will choose to undergo and follow through with extra-colonic surveillance *** To study factors associated with SIC and UTC surveillance uptake and outcomes in *** This is an IRB-approved retrospective analysis of individuals with LS seen at a tertiary care referral *** individuals had a pathogenic or likely pathogenic variant in MLH1,MSH2,MSH6,PMS2,or EPCAM,or were a confirmed obligate carrier,and had at least one documented visit to our *** regarding SIC and UTC surveillance was captured for each individual,and detailed personal and family history was obtained for individuals who had an initial LS management visit in our center’s dedicated high-risk LS clinic between January 1,2017 and October 29,*** these initial management visits,all patients had in-depth discussions of SIC and UTC surveillance with 1 of 3 providers experienced in LS management to promote informed decision-making about whether to pursue SIC and/or UTC *** analysis using Pearson’s chi-squared test and Wilcoxon rank-sum test was completed to understand the factors associated with pursuit and completion of SIC and UTC surveillance,and a P value below 0.05 was deemed statistically *** Of 317 individuals with LS,86(27%)underwent a total of 105 SIC surveillance examinations,with 5 leading to additional work-up and no SICs ***,99(31%)patients underwent a total of 3

关键词： Lynch syndrome Urinary tract cancer Intestinal neoplasms Early diagnosis of cancer Patient preference Gastrointestinal surgical procedure

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

湖泊沉积植物dNA宏条形码技术在青藏高原植被调查中的应用

引用

中国科学:地球科学 2024年

作者：吴铠李凯贾伟瀚 kathleen R.STOOF-LEICHSENRING Ulrike HERZSCHUH 倪健廖梦娜田芳浙江师范大学生命科学学院 Polar Terrestrial Environmental Systems Research Group Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Institute of Environmental Science and Geography University of Potsdam Institute of Biochemistry and Biology University of Potsdam 首都师范大学资源环境与旅游学院

得益于环境dNA技术的快速发展,沉积dNA(seddNA)正在成为偏远地区植被监测和调查的便捷方法,并具有较大的发展潜力.青藏高原气候环境条件恶劣,同时小型湖泊众多,利用seddNA进行植被调查不仅有助于了解高原现代植被状况,也是进行高原古植... 详细信息

得益于环境dNA技术的快速发展,沉积dNA(seddNA)正在成为偏远地区植被监测和调查的便捷方法,并具有较大的发展潜力.青藏高原气候环境条件恶劣,同时小型湖泊众多,利用seddNA进行植被调查不仅有助于了解高原现代植被状况,也是进行高原古植被重建的潜在需求.本研究以中国青藏高原西南部59个泡子/湖泊表层沉积物为研究对象,使用通用植物引物g-h扩增叶绿体trn L(UAA)内含子P6环区,获取了seddNA中的植物组成信息,并将其与野外植被调查记录和沉积物花粉数据进行对比分析,探讨了基于沉积物的植物dNA宏条形码技术在青藏高原地区现代植被监测和古植被重建中的适用性和局限性.研究结果表明,植物dNA宏条形码信号共记录了186个陆生植物类群,其中30.1%的序列可以鉴定到种水平.植物seddNA方法可以揭示调查地点周围的主要植物类群(包括菊科、莎草科和禾本科)以及重要植被组合.植物seddNA的类群数量和分类学分辨率均超过花粉分析(75个类群,其中5.3%的类群可以鉴定到种水平).与花粉保留大量的区域植物信号(包括松属和蒿属)不同,植物seddNA反映了高度局地的植物信号,凸显了植物seddNA在局地植被监测和重建中的重要性.综上所述,(小型)湖泊植物seddNA宏条形码研究在未来的青藏高原区域植被监测和重建中值得更多的关注.

关键词：沉积dNA 宏条形码花粉植被组成青藏高原

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Application of plant dNA metabarcoding of lake sediments for monitoring vegetation compositions on the Tibetan Plateau

引用

Science China Earth Sciences 2024年

作者： Kai WU Kai LI Weihan JIA kathleen R.STOOF-LEICHSENRING Ulrike HERZSCHUH Jian NI Mengna LIAO Fang TIAN College of Life Sciences Zhejiang Normal University Polar Terrestrial Environmental Systems Research Group Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Institute of Environmental Science and Geography University of Potsdam Institute of Biochemistry and Biology University of Potsdam College of Resource Environment and Tourism Capital Normal University

Benefiting from the rapid development of environmental dNA (edNA) technologies,sedimentary dNA (seddNA)emerges as a promising tool for monitoring plant compositions in remote *** Tibetan Plateau (TP),renowned for its harsh environment and numerous ponds and lakes,presents a potentially demanding region for the application of seddNA on vegetation ***,we used the g and h universal primers for the P6 loop region of the chloroplast trn L (UAA)intron to amplify plant dNA in surface sediments from 59 ponds and small lakes on the southwestern *** applicability and limitations of using plant dNA metabarcoding for modern vegetation monitoring and palaeo-vegetation reconstructions have been assessed by comparing seddNA,pollen,and vegetation survey *** results showed that plant dNA metabarcoding recorded 186 terrestrial taxa,of which 30.1%can be identified at the species *** plant seddNA approach can effectively disclose the dominant plant taxa (including Asteraceae,Cyperaceae and Poaceae) and significant vegetation assemblages in the vicinity of the investigated *** number of taxa and taxonomic resolution of plant seddNA exceeded that of pollen analysis(75 taxa detected,5.3%can be identified at species level).Unlike pollen that retains a broad spectrum of regional plant signals(including Pinus and Artemisia),plant seddNA mirrors very local plants,underscoring its utility in local vegetation monitoring and *** conclude,plant dNA metabarcoding of (small) lake sediments warrant increased attention in the future for local vegetation monitoring and reconstructions on the TP.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Elucidating regulatory processes of intense physical activity by multi-omics analysis

引用

Military Medical Research 2024年第4期 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie d.Nicora Nathalie Munoz kathleen M. Navarro daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L. Paurus Kent J. Bloodsworth Kelsey A. Allen Lisa M. Bramer Fernando Montes kathleen A. Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences division Pacific Northwest National Laboratory Environmental and Molecular Sciences division Pacific Northwest National Laboratory Centers for disease Control and Prevention National Institute for Occupational Safety and Health Western States Division Computational Analytics division Pacific Northwest National Laboratory National Security directorate Pacific Northwest National Laboratory Los Angeles County Fire department Centers for disease Control and Prevention National Institute for Occupational Safety and Health Respiratory Health Division Environmental and Molecular Toxicology Oregon State University

Background: Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations, such as firefighting, law enforcement, military, and sports. A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***: To study regulatory processes in intense physical activity simulating real-life conditions, we performed a multi-omics analysis of 3 biofluids(blood plasma, urine, and saliva) collected from 11 wildland firefighters before and after a 45 min, intense exercise regimen. Omics profiles post-vs. pre-exercise were compared by Student's t-test followed by pathway analysis and comparison between the different omics ***: Our multi-omics analysis identified and quantified 3835 proteins, 730 lipids and 182 metabolites combining the 3 different types of samples. The blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy demands. The urine analysis showed a strong, concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites, reabsorption of nutrients and maintenance of fluid balance. In saliva, we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides. A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***: This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility, suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Aminopeptidase A and dipeptidyl peptidase 4:a pathogenic duo in Alzheimer’s disease?

引用

Neural Regeneration Research 2022年第10期17卷 2215-2217页

作者： Frédéric Checler Audrey valverde UniversitéCôte d’Azur INSERMCNRSIPMCteam labelled“Laboratory of Excellence(LABEX)DistAlz”ValbonneFrance

The etiology of Alzheimer’s disease is far from being completely *** approaches have helped in this matter and have greatly supported the view that theβ-amyloid precursor protein(βAPP)could be at the center of gravity of the ***,mutations responsible for autosomal dominant aggressive forms of Alzheimer’s disease(Ad)are all harbored by eitherβAPP itself or by its cleaving enzyme presenilins 1/2 referred to asγ-*** was therefore convincing to note that fully independent gene products harboring Ad-linked mutations,all concur to modulateβAPP proteolytic *** genetic clues combined with a bulk of anatomical observations and cellular manipulations pointed to the role of amyloid-β(Aβ),the main biochemical component of senile plaques that accumulate at late stages of ***,a series of clinical trials designed to either abolish Aβproduction or neutralize it once produced have consistently failed(Checler et al.,2021).

关键词： Alzheimer Aβ senile

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preoperative Feeding in Single Ventricle Neonates is Predictive of Shorter Time to Goal Feed

引用

Congenital Heart disease 2022年第5期17卷 505-518页

作者： Alyssia Venna kathleen Reid Sarah davis Jiaxiang Gai Yves d’Udekem Sarah Clauss department of Cardiovascular Surgery Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA department of Cardiology Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA department of Biostatistics Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA

Background:Patients with single ventricle anatomy are at increased risk of growth failure and *** cardiac centers,there is little standardization of feeding practices in this complex *** hypothesized that initiation of our center’s preoperative feeding protocol would result in decreased gastrostomy tube(G-tube)use,decreased length of stay and would not result in increased Necrotizing Enterocolitis(NEC)***:A single institution review of 52 patients who had undergone stage I single ventricle palliative repair was *** diagnoses were hypoplastic left heart syndrome(39%),atrioventricular canal(15%),and other(46%).Postoperative parameters such as time to goal feed and need for gastrostomy tube(G-tube)were compared among preoperatively fed and non-preoperatively fed *** to goal feed was calculated as time from first postoperative enteral feed to goal volume of 100 mL/***:Of the 26 patients who met inclusion criteria for preoperative feeding,22 patients(85%)were fed prior to *** proportional hazard ratio revealed that age at surgery(p=0.047)and being preoperatively fed(p=0.001)were associated with reaching goal feed *** analysis revealed that being preoperatively fed made a patient twice as likely to reach goal feed sooner(p=0.047).Univariable logistic regression revealed that days on total parenteral nutrition(p=0.018),length of hospitalization(p=0.008),and time to 1st postoperative feed(p=0.020)were significantly associated with higher odds of needing a G-tube *** logistic regression did not show any predictors of postoperative G-tube ***,there was a trend towards lower G-tube usage in the preoperatively fed ***:Implementing a standardized preoperative feeding protocol in single ventricle neonates can result in significantly shorter time to goal feed in preoperatively fed *** is beneficial for institutions to begin implementi

关键词： Single ventricle feeding guidelines enteral nutrition hypoplastic left heart syndrome necrotizing enterocolitis preoperative

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current and emerging therapies for alcohol-associated hepatitis

引用

Liver Research 2023年第1期7卷 35-46页

作者： Francisco Idalsoaga Gustavo Ayares Luis Antonio díaz Jorge Arnold María Ayala-valverde david Hudson Marco Arrese Juan Pablo Arab department of Gastroenterology School of MedicinePontificia Universidad Catolica de ChileSantiagoChile Internal Medicine Service Hospital El PinoCritical Patient UnitClinica DavilaSantiagoChile division of Gastroenterology Department of MedicineSchulich School of MedicineWestern University&London Health Sciences CentreLondonOntarioCanada department of Epidemiology and Biostatistics Schulich School of MedicineWestern UniversityLondonOntarioCanada Alimentiv LondonOntarioCanada

Alcohol-related liver disease(ALd)encompasses a spectrum of diseases caused by excessive alcohol *** includes hepatic steatosis,steatohepatitis,variable degrees of fibrosis,cirrhosis,and alcohol-associated hepatitis(AH),the latter being the most severe acute form of the *** AH is associated with high mortality(reaching up to 30%e50%)at 90 *** cornerstone of ALd,and particularly AH,treatment continues to be abstinence,accompanied by support measures such as nutritional supplementation and management of alcohol withdrawal syndrome(AWS).In severe AH with model for end-stage liver disease(MELd)score21,corticosteroids can be used,especially MELd score between 25 and 39,where the highest benefit is *** key aspects of treatment include the early identification of infections and their associated management and the proper identification of potential candidates for liver *** development of new therapies based on the pathophysiology and mechanisms of liver injury are *** includes the modulation and management of the innate immune response,gut dysbiosis,bacterial translocation,and bacteria-derived products from the *** hold promise for the future of AH treatment.

关键词： Alcohol-associated hepatitis(AH) Alcohol-related liver disease(ALd) Alcohol use disorder(AUd) AUd treatment Nutritional therapy Steroids therapy Cirrhosis Fibrosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Optimization of enhanced weathering networks with alternative transportation modes

引用

Carbon Resources Conversion 2022年第2期5卷 167-176页

作者： Raymond R.Tan Beatriz A.Belmonte Michael Francis d.Benjamin Viknesh Andiappan kathleen B.Aviso department of Chemical Engineering De La Salle University2401 Taft Avenue0922 ManilaPhilippines Research Center for the Natural and Applied Sciences/department of Chemical Engineering University of Santo TomasEspana Blvd.1015 ManilaPhilippines School of Engineering and Physical Sciences Heriot-Watt University Malaysia62200PutrajayaWilayah Persekutuan PutrajayaMalaysia Faculty of Engineering Computing and ScienceSwinburne University of TechnologyJalan Simpang Tiga93350KuchingSarawakMalaysia

Enhanced weathering of alkaline rocks and minerals is a negative emissions technology (NET) that is potentiallyscalable to deliver gigaton-level carbon dioxide removal (CdR) for climate change mitigation. This techniquerelies on the acceleration of naturally occurring weathering reactions with water and carbon dioxide by reducingthese substances into a fine powder with high specific surface area. The ex situ enhanced weathering processchain consists of the acquisition of suitable natural or synthetic materials, grinding to a fine particle size,transportation, and application on suitable sites. Future enhanced weathering systems can be envisioned assupply chain-like networks which have to be optimized to deliver maximum CdR given physical *** is a notable research gap in the literature on decision support for such systems. To address this gap, amixed integer linear programming (MILP) model is developed in this work to optimize enhanced weatheringnetworks for CdR. The model also incorporates the availability of multiple transportation options and constraintson network topology. Two test cases are used to demonstrate the model capability to determine optimal andnear-optimal networks. The top ten solutions in these two scenarios yield total CdR levels of 3.4316–3.4363 Mtand 15.27017–15.27960 Mt.

关键词： Process integration Optimization Mathematical programming Carbon drawdown Carbon management network decarbonization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

EEG/ERP evidence of possible hyperexcitability in older adults with elevated beta-amyloid

引用

Translational Neurodegeneration 2022年第1期11卷 835-844页

作者： Hannes devos kathleen Gustafson Ke Liao Pedram Ahmadnezhad Bradley Estes Laura E.Martin Jonathan d.Mahnken William M.Brooks Jeffrey M.Burns department of Physical Therapy Rehabilitation Scienceand Athletic TrainingUniversity of Kansas Medical CenterKansas CityKS 66160USA department of Neurology University of Kansas Medical CenterKansas CityKS 66160USA Hoglund Biomedical Imaging Center University of Kansas Medical CenterKansas CityKS 66160USA department of Population Health University of Kansas Medical CenterKansas CityKS 66160USA department of Biostatistics and data Science University of Kansas Medical CenterKansas CityKS 66160USA University of Kansas Alzheimer’s disease Center University of Kansas Medical CenterKansas CityKS 66160USA.

Background: Although growing evidence links beta-amyloid (Aβ) and neuronal hyperexcitability in preclinical mouse models of Alzheimer’s disease (Ad), a similar association in humans is yet to be established. The first aim of the study was to determine the association between elevated Aβ (Aβ+) and cognitive processes measured by the P3 event-related potential (ERP) in cognitively normal (CN) older adults. The second aim was to compare the event- related power between CNAβ+ and CNAβ−. Methods: Seventeen CNAβ+ participants (age: 73 ± 5, 11 females, Montreal Cognitive Assessment [MoCA] score 26 ± 2) and 17 CNAβ- participants group-matched for age, sex, and MOCA completed a working memory task (n-back with n = 0, 1, 2) test while wearing a 256-channel electro-encephalography net. P3 peak amplitude and latency of the target, nontarget and task difference effect (nontarget−target), and event-related power in the delta, theta, alpha, and beta bands, extracted from Fz, Cz, and Pz, were compared between groups using linear mixed models. P3 ampli-tude of the task difference effect at Fz and event-related power in the delta band were considered main outcomes. Correlations of mean Aβ standard uptake value ratios (SUVR) using positron emission tomography with P3 amplitude and latency of the task difference effect were analyzed using Pearson Correlation Coefficient r. Results: The P3 peak amplitude of the task difference effect at Fz was lower in the CNAβ+ group (P = 0.048). Simi-larly, power was lower in the delta band for nontargets at Fz in the CNAβ+ participants (P = 0.04). The CNAβ+ partici-pants also demonstrated higher theta and alpha power in channels at Cz and Pz, but no changes in P3 ERP. Strong correlations were found between the mean Aβ SUVR and the latency of the 1-back (r = − 0.69;P = 0.003) and 2-back (r = − 0.69;P = 0.004) of the task difference effect at channel Fz in the CNAβ+ group. Conclusions: Our data suggest that the elevated amyloid in cognitively normal ol

关键词： Event-related potentials Electro-encephalography Working memory Older adults Preclinical Beta-amyloid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：