检索结果-南通市图书馆

Integrative Zoology 2010年第1期5卷 15-30页

作者： kathleen a.fagerstone Lowell A.MILLER Gary KILLIAN Christi A.YODER Department of Agriculture/Animal and Plant Health Inspection Service/Wildlife Services National Wildlife Research CenterFort Collins Almquist Research Center Pennsylvania State UniversityUniversity ParkUSA

This manuscript provides an overview of past wildlife contraception efforts and discusses the current state of *** fertility control agents,an avian reproductive inhibitor containing the active ingredient nicarbazin and an immunocontraceptive vaccine,have received regulatory approval with the Environmental Protection Agency and are commercially available in the *** G Contraceptive Bait for Canada Geese and Ovo Control for pigeons are delivered as oral *** injectable immunocontraceptive vaccine(GonaCon Immunocontraceptive Vaccine)was registered with the Environmental Protection Agency for use in female white-tailed deer in September *** injectable product(GonaCon Immunocontraceptive Vaccine)is registered for use in female white-tailed *** products are labeled for use in urban/suburban areas where these species are *** other compounds are currently being tested for use in wildlife in the USA,Europe,Australia and New Zealand that could have promise in the *** development and use of reproductive inhibitors for resolving human-wildlife conflicts will depend on a number of factors,including meeting the requirements of regulatory agencies for use in the environment and on the biological and economical feasibility of their *** will also be dependent on health and safety issues and on public acceptance of the techniques.

关键词： contraceptives fertility control registration reproductive inhibitors wildlife

Feeding of grey squirrels (Sciurus carolinensis) with the contraceptive agent DiazaCon^(TM):effect on cholesterol, hematology, and blood chemistry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrative Zoology 2011年第4期6卷 409-419页

作者： Christi A.YODER Brenda A.MAYLE Carol A.FURCOLOW David P.COWAN kathleen a.fagerstone National Wildlife Research Center Fort CollinsColoradoUSA Forest Research Alice Holt LodgeFarnhamSurreyUK Central Science Laboratory Sand HuttonYorkUK

Grey squirrels(Sciurus carolinensis)are an invasive species in Britain and *** have replaced native red squirrels(Sciurus vulgaris)throughout most of Britain,and cause damage to ***,lethal control is used to manage grey squirrel populations in Britain,but nonlethal methods might be more acceptable to the *** such method is contraception with 20,25-diazacholesterol dihydrochloride(DiazaCon^(TM)).DiazaCon^(TM) inhibits the conversion of desmosterol to cholesterol,resulting in increasing desmosterol concentrations and decreasing cholesterol *** cholesterol is needed for the synthesis of steroid reproductive hormones,such as progesterone and testosterone,inhibition of cholesterol synthesis indirectly inhibits *** is used as a marker of efficacy in laboratory studies with species that do not reproduce readily in *** squirrels were gavaged with a DiazaCon^(TM) solution for 2 days,and then fed DiazaCon^(TM)-coated peanuts for an additional 8 days at target doses of 50 and 100 mg DiazaCon^(TM) per kg body *** was a significant difference in cholesterol concentrations in the treatment groups compared to the control *** was reduced by≥40%for 2 months in both treatment *** were no differences among groups with respect to blood chemistry and hematology parameters,and mean values are *** mean overall dose of DiazaCon^(TM) received was 29.0±1.6 and 55.3±4.3 mg/kg in the low(50 mg/kg)and high dose(100 mg/kg)groups,***^(TM) might provide an effective,acceptable alternative to lethal control.

关键词： 20 25-diazacholesterol dihydrochloride cholesterol contraception DiazaCon^(TM) grey squirrel

Go to the back before going forward:Addressing psychological responses in anterior cruciate ligament reconstruction rehabilitation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第5期13卷 666-669页

作者： Terese L.Chmielewski Adam Meierbachtol Rick Aberman Travis Gunderson Jonathon Sikorski kathleen Cummer TRIA Orthopedic Center BloomingtonMN 55431USA Rehabilitation Science Graduate Program Department of Family Medicine and Community HealthMedical SchoolUniversity of MinnesotaMinneapolisMN 55455USA Optum Inc. Clinical OperationsPhysical Health DivisionEden PrairieMN 55344USA Dr.Rick Aberman Consulting MinnetonkaMN 55305USA Department of Rehabilitation Medicine Division of Physical TherapyUniversity of WashingtonSeattleWA 98195USA

Helping athletes return to sports participation is a primary goal of anterior cruciate ligament(ACL)reconstruction *** facilitate the achievement of this goal,decades of research studies have sought to identify knee impairments that reduce knee function as well as interventions to resolve them.1Yet,over the past 10 years,research pertaining to psychological responses(i.e.,cognitions and emotions)after ACL reconstruction has grown exponentially—a phenomenon that can be visualized by entering the search terms"psychological"and"anterior cruciate ligament reconstruction"into the PubMed search engine.

关键词： ligament return psychological

Maintenance of stem cell self-renewal by sex chromosomal zincfinger transcription factors

在线全文

学校读者我要写书评

暂无评论

World Journal of Methodology 2024年第4期14卷 23-29页

作者： Katsuhiro Kita Celine Morkos kathleen Nolan Department of Biology St.Francis CollegeBrooklynNY 11201United States

In this Editorial review,we would like to focus on a very recent discovery showing the global autosomal gene regulation by Y-and inactivated X-chromosomal transcription factors,zinc finger gene on the Y chromosome(ZFY)and zinc finger protein X-linked(ZFX).ZFX and ZFY are both zinc-finger proteins that encode general transcription factors abundant in hematopoietic and embryonic stem *** both proteins are homologs,interestingly,the regulation of self-renewal by these transcriptional factors is almost exclusive to *** fact implies that there are some differential roles between ZFX and ZFY in regulating the maintenance of self-renewal activity in stem *** the maintenance of stemness,ZFX overexpression or mutations may be linked to certain *** cancers and stem cells are double-edged swords,there is no study showing the link between ZFX activity and the ***,stemness or cancers with ZFX may be linked to other molecules,such as Oct4,Sox2,Klf4,and *** on very recent studies and a few lines of evidence in the past decade,it appears that the ZFX is linked to the canonical Wnt signaling,which is one possible mechanism to explain the role of ZFX in the self-renewal of stem cells.

关键词： ZFX ZFY Self-renewal Stem cell Sex chromosome regulators

Assessment of molecular markers and marker-assisted selection for drought tolerance in barley(Hordeum vulgare L.)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第1期23卷 20-38页

作者： Akmaral Baidyussen Gulmira Khassanova Maral Utebayev Satyvaldy Jatayev Rystay Kushanova Sholpan Khalbayeva Aigul Amangeldiyeva Raushan Yerzhebayeva KulpashBulatova Carly Schramm Peter Anderson Colin L.D.Jenkins kathleen LSoole Yuri Shavrukov Faculty of Agronomy S.Seifullin Kazakh AgroTechnical Research UniversityAstana 010000Kazakhstan A.I.Barayev Research and Production Centre of Grain Farming Shortandy 021601Kazakhstan Kazakh Research Institute of Agriculture and Plant Growing AlmalybakAlmaty District 040909Kazakhstan College of Science and Engineering Biological SciencesFlinders UniversityAdelaideSA 5042Australia

This review updates the present status of the field of molecular markers and marker-assisted selection(MAS),using the example of drought tolerance in *** accuracy of selected quantitative trait loci(QTLs),candidate genes and suggested markers was assessed in the barley genome *** common strategies are described for molecular marker development,candidate gene identification and verification,and their possible applications in MAS to improve the grain yield and yield components in barley under drought *** strategies are based on the following five principles:(1)Molecular markers are designated as genomic‘tags’,and their‘prediction’is strongly dependent on their distance from a candidate gene on genetic or physical maps;(2)plants react differently under favourable and stressful conditions or depending on their stage of development;(3)each candidate gene must be verified by confirming its expression in the relevant conditions,e.g.,drought;(4)the molecular marker identified must be validated for MAS for tolerance to drought stress and improved grain yield;and(5)the small number of molecular markers realized for MAS in breeding,from among the many studies targeting candidate genes,can be explained by the complex nature of drought stress,and multiple stress-responsive genes in each barley genotype that are expressed differentially depending on many other factors.

关键词： barley candidate genes drought tolerance gene verification via expression grain yield marker-assisted selection(MAS) molecular markers quantitative trait loci(QTLs) strategy for MAS

Elucidating regulatory processes of intense physical activity by multi-omics analysis

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

Application of plant DNA metabarcoding of lake sediments for monitoring vegetation compositions on the Tibetan Plateau

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2024年

作者： Kai WU Kai LI Weihan JIA kathleen R.STOOF-LEICHSENRING Ulrike HERZSCHUH Jian NI Mengna LIAO Fang TIAN College of Life Sciences Zhejiang Normal University Polar Terrestrial Environmental Systems Research Group Alfred Wegener Institute Helmholtz Centre for Polar and Marine Research Institute of Environmental Science and Geography University of Potsdam Institute of Biochemistry and Biology University of Potsdam College of Resource Environment and Tourism Capital Normal University

Benefiting from the rapid development of environmental DNA (eDNA) technologies,sedimentary DNA (sedDNA)emerges as a promising tool for monitoring plant compositions in remote *** Tibetan Plateau (TP),renowned for its harsh environment and numerous ponds and lakes,presents a potentially demanding region for the application of sedDNA on vegetation ***,we used the g and h universal primers for the P6 loop region of the chloroplast trn L (UAA)intron to amplify plant DNA in surface sediments from 59 ponds and small lakes on the southwestern *** applicability and limitations of using plant DNA metabarcoding for modern vegetation monitoring and palaeo-vegetation reconstructions have been assessed by comparing sedDNA,pollen,and vegetation survey *** results showed that plant DNA metabarcoding recorded 186 terrestrial taxa,of which 30.1%can be identified at the species *** plant sedDNA approach can effectively disclose the dominant plant taxa (including Asteraceae,Cyperaceae and Poaceae) and significant vegetation assemblages in the vicinity of the investigated *** number of taxa and taxonomic resolution of plant sedDNA exceeded that of pollen analysis(75 taxa detected,5.3%can be identified at species level).Unlike pollen that retains a broad spectrum of regional plant signals(including Pinus and Artemisia),plant sedDNA mirrors very local plants,underscoring its utility in local vegetation monitoring and *** conclude,plant DNA metabarcoding of (small) lake sediments warrant increased attention in the future for local vegetation monitoring and reconstructions on the TP.

关键词：

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国手斧技术演化:新进展和未来展望

Science Bulletin 2024年第14期69卷 2161-2165页

作者：李浩王社江 Matt G.Lotter Robin Dennell kathleen Kuman 陈发虎 State Key Laboratory of Tibetan Plateau Earth System Resources and Environment(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Palaeo-Research Institute University of JohannesburgAuckland Park 2006South Africa Department of Archaeology University of ExeterExeter EX44QEUK School of Geography Archaeology and Environmental StudiesUniversity of the WitwatersrandJohannesburg WITS 2050South Africa

Handaxes are often regarded as the"tool-type-specimenoof the Acheulean techno-complex,not only because they are a very common artefact but because they contain rich technological,behavioral,and cognitive data that have been used to highlight trends in human evolution and lithic production *** this end,the handaxe is the earliest tool possessing consistent morphological features,in particular,the appearance of a symmetrical concept in handaxe shape when compared with other Acheulean large shaping tools(e.g.,cleavers),and their manufacture is widely regarded as a significant milestone in the evolution of lithic technology,indicating improvements in tool-making hominins’abilities for complex thought and cognition.

关键词：技术演化未来展望 earliest

Psychiatric Sequelae of Chronic Pruritic Dermatoses

在线全文

学校读者我要写书评

暂无评论

Open Journal of Medical Psychology 2024年第2期13卷 25-38页

作者： Kelly Frasier Vivian Li kathleen Click Christina Dudzik Michelle Sobotka Evadne Rodriguez Karina Stech Nuvance Health/Vassar Brothers Medical Center Poughkeepsie NY USA School of Osteopathic Medicine Kansas City University Kansas City MO USA Touro College of Osteopathic Medicine Middleton Campus Middletown NY USA Abrazo Health Network Goodyear AZ USA School of Medicine University of Missouri-Columbia Columbia MO USA Lewis Katz School of Medicine at Temple University Philadelphia PA USA

This comprehensive review investigates the significant psychological impact and profound psychological comorbidities found in individuals suffering from chronic pruritic dermatoses, including atopic dermatitis, chronic urticaria, and prurigo nodularis. Highlighting the complex, reciprocal relationship between pruritus and psychiatric conditions such as depression, anxiety, and sleep disturbances, this paper elucidates the comprehensive impact of dermatological disorders on the skin in addition to the far-reaching effects on an individual’s psychological well-being. By evaluating the efficacy of integrated psychodermatological interventions, including cognitive behavioral therapy, mindfulness practices, pharmacological treatments, and innovative telepsychiatry and digital health solutions, this review aims to lay the foundation for a more holistic approach to treatment of concurrent dermatological and psychiatric conditions. Future research endeavors should delve deeper into the mechanistic foundation of the pruritus-psychiatry interface, the refinement of tailored treatment strategies, and the evaluation of long-term patient outcomes. In doing so, this review seeks to contribute to the optimization of patient care and well-being, underscoring the pivotal role of addressing both dermatological and psychological needs in achieving comprehensive health outcomes.

关键词： Psychodermatology Chronic Pruritic Dermatoses Psychological Comorbidities Integrated Interventions Pruritus-Psychiatry Interface

The Impact of Psychosocial Influences on Chronic Wound Healing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Open Journal of Medical Psychology 2024年第3期13卷 39-57页

作者： Kelly Frasier Vivian Li Sara Christoforides kathleen Daly Alexandra Loperfito Karina Stech Milena Dragovic Nuvance Health/Vassar Brothers Medical Center Poughkeepsie NY USA Lake Erie College of Osteopathic Medicine New York NY USA Medical College of Georgia Augusta University Augusta GA USA Edward Via College of Osteopathic Medicine Blacksburg VA USA Lewis Katz School of Medicine Temple University Philadelphia PA USA College of Osteopathic Medicine California Health Sciences University Clovis CA USA

This comprehensive review explores the intricate dynamics between psychosocial factors and chronic wound healing processes, specifically focusing on prevalent conditions such as pressure ulcers, diabetic foot ulcers, and venous leg ulcers. By examining the roles of psychiatric conditions, including depression, anxiety, and post-traumatic stress disorder (PTSD), this paper illuminates how these factors intricately influence wound healing dynamics, including mechanisms of pain perception and inflammatory responses. Furthermore, we evaluate the effectiveness of integrated biopsychosocial interventions, which encompass a holistic approach to wound care, thereby enhancing healing outcomes for dermatology patients. Future studies should focus on investigating the specific psychosocial determinants that significantly influence wound healing, exploring novel therapeutic strategies, and implementing personalized interventions to meet the unique needs of each patient. Such endeavors hold promise in advancing the fields of psychodermatology and wound management, fostering a deeper understanding and application of psychosocial considerations in dermatological care.

关键词： Psychosocial Factors Chronic Wound Healing Biopsychosocial Interventions Psychiatric Conditions Dermatology Patients