检索结果-南通市图书馆

Controversies in testosterone replacement therapy： testosterone and cardiovascular disease

Asian Journal of Andrology 2015年第2期17卷 187-191,I0006页

作者： kathleen hwang Martin Miner Department of Surgery (Urology) The Alpert Medical School of Brown University Providence Rhode Island USA Department of Family Medicine The Alpert Medical School of Brown University Providence Rhode Island USA.

The role of testosterone in the cardiovascular （CV） health of men is controversial. Data suggest that both the condition and treatment of clinical hypogonadism is associated with decreased CV mortality; however, two recent studies suggest that hypogonadal subjects treated with testosterone replacement therapy have a higher incidence of new CV events. There has been increased media attention concerning the risk of CV disease in men treated with testosterone. Until date, there are no long-term prospective studies to determine safety. Literature spanning over the past 30 years has suggested that not only is there a possible increased CV risk in men with low levels of testosterone, but the benefits from testosterone therapy may even lower this risk. We review here the recent studies that have garnered such intense scrutiny. This article is intended as a thorough review of testosterone levels and CV risk, providing the clinician with the facts needed to make informed clinical decisions in managing patients with clinical hypogonadism.

关键词： cardiovascular disease hypogonadism testosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In vitro production of functional sperm in mice

引用

Asian Journal of Andrology 2011年第6期13卷 791-792页

作者： kathleen hwang Dolores J Lamb Scott Department of Urology Baylor College of Medicine Houston TX 77030 USA Scott Department of Urology and Molecular and Cellular Biology Baylor College of Medicine Houston TX 77030 USA Laboratory for Male Reproductive Research and Testing Baylor College of Medicine Houston TX 77030 USA

Spermatogenesis refers to the process by which the production and development of the spermatozoa （the mature male gamete of most sexually reproducing species） occurs. It is a complex, stepwise process of sperm development, taking more than a month depending upon the species involving three specific functional phases： spermatogonial proliferation, meiosis and metamorphosis.1 Investigators have been successful in recreating this process in some species of fish; however, this whole process has never been reproduced in vitro in mammals.

关键词： Spermatogenesis refers production the spermatozoa

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sperm counts and sperm sex ratio in male infertility patients

引用

Asian Journal of Andrology 2012年第5期14卷 683-686页

作者： Michael L Eisenberg Lata Murthy kathleen hwang Dolores J Lamb Larry I Lipshultz Department of Urology Stanford University School of Medicine Stanford CA 94305 USA Scott Department of Urology Baylor College of Medicine Houston TX 77030 USA Department of Urology Brown University Providence RI 02912 USA

In recent years, investigators have noted a trend toward a declining proportion of male births in many industrialized nations. While men bear the sex-determining chromosome, the role of the female partner as it pertains to fertilization or miscarriage may also alter the gender ratio. We attempted to determine a man＇s secondary sex ratio （F1 generation） by directly examining the sex chromosomes of his sperm. We examined our male infertility clinic database for all men who had undergone a semen fluorescence in situ hybridization （FISH）. Patient demographic and semen parameters were recorded. Chi-squared analysis was used to compare gender ratios （Y chromosomes/total chromosomes）. Multivariable logistic regression was used to predict the odds of possessing a Y-bearing sperm after accounting for demographic and semen parameters. A total of 185 men underwent sperm FISH. For the entire cohort, the proportion of Y chromosome-bearing sperm was 51.5%. Men with less than five million motile sperm had a significantly lower proportion of Y chromosome-bearing sperm （50.8%） compared to men with higher sperm counts （51.6%; P= 0.02）. After multivariable adjustment, a higher sperm concentration, total motile sperm count and semen volume significantly increased the odds of having a Y chromosome-bearing sperm （P〈0.01）. As a man＇s sperm production declines, so does the proportion of Y chromosome-bearing sperm. Thus, a man＇s reproductive potential may predict his ability to sire male offspring.

关键词： infertility sex ratio spermatogenesis sperm chromosomes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of subcutaneous testosterone pellet therapy with developing secondary polycythemia

引用

Asian Journal of Andrology 2018年第2期20卷 195-199页

作者： Katherine Lang Rotker Michael Alavian Bethany Nelson Grayson L Baird Martin M Miner Mark Sigman kathleen hwang Division of Urology Brown University Providence RI 02903 USA Department of Biostatistics Lifespan Healthcare System Providence RI 02903 USA

A variety of methods for testosterone replacement therapy （TRT） exist, and the major potential risks of TRT have been well established. The risk of developing polycythemia secondary to exogenous testosterone （T） has been reported to range from 0.4% to 40%. Implantable T pellets have been used since 1972, and secondary polycythemia has been reported to be as low as 0.4% with this administration modality. However, our experience has suggested a higher rate. We conducted an institutional review board-approved, single-institution, retrospective chart review （2009-2013） to determine the rate of secondary polycythemia in 228 men treated with subcutaneously implanted testosterone pellets. Kaplan-Meyer failure curves were used to estimate time until the development of polycythemia （hematocrit 〉50%）. The mean number of pellets administered was 12 （range： 6-16）. The mean follow-up was 566 days. The median time to development of polycythemia whereby 50% of patients developed polycythemia was 50 months. The estimated rate of polycythemia at 6 months was 10.4%, 12 months was 17.3%, and 24 months was 30.2%. We concluded that the incidence of secondary polycythemia while on T pellet therapy may be higher than previously established.

关键词： hypogonadism pellet polycythemia testosterone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：