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Predictive value of preoperative routine exam.nation for the prognosis of patients with pT2N0m. or pT3N0m. colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2429-2438页

作者： Peng-Fei Jing Jin Chen en-Da Yu Chao-Yu m.ao Departm.0}t of Colorectal Surgery Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Departm.0}t of endocrinology and m.tabolism Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Departm.0}t of Pharm.cology Second Military Medical University/Naval Medical UniversityShanghai 200433China

BACKGROUND In recent years,the incidence of colorectal cancer(CRC)has been *** the popularization of endoscopic technology,a num.er of early CRC has been ***,despite current treatm.0}t m.thods,som. patients with early CRC still experience postoperative recurrence and *** To search for indicators associated with early CRC recurrence and m.tastasis to identify high-risk *** A total of 513 patients with pT2N0m. or pT3N0m. CRC were retrospectively enrolled in this *** of blood routine test,liver and kidney function tests and tum.r m.rkers were collected before *** were followed up through disease-specific database and telephone *** recurrence,m.tastasis or death were used as the end point of study to find the risk factors and predictive value related to early CRC recurrence and *** We com.rehensively com.ared the predictive value of preoperative blood routine,blood biochem.stry and tum.r m.rkers for disease-free survival(DFS)and overall survival(OS)of *** m.ltivariate analysis dem.nstrated that low platelet count was significantly associated with poor DFS[hazard ratio(HR)=0.995,95% confidence interval(CI):0.991-0.999,P=0.015],while serum.carcinoem.ryonic antigen(CEA)level(HR=1.008,95%CI:1.001-1.016,P=0.027)and serum.total cholesterol level(HR=1.538,95%CI:1.026-2.305,P=0.037)were independent risk factors for *** cutoff value of serum.CEA level for predicting OS was 2.74 ng/*** the OS of CRC patients with serum.CEA higher than the cutoff value was worse than those with lower CEA level,the difference between the two groups was not statistically significant(P=0.075).CONCLUSION For patients with T2N0m. or T3N0m. CRC,preoperative platelet count was a protective factor for DFS,while serum.CEA level was an independent risk factor for *** that these m.asures are easier to detect and m.re acceptable to patients,they m.y have broader applications.

关键词： Colorectal cancer Platelet count Serum.carcinoem.ryonic antigen Total cholesterol level Overall survival Disease-free survival

Coffee Leaf Rust(Hem.leia vastatrix)Disease in Coffee Plants and Perspectives by the Disease Control

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Phyton-International Journal of Experim.0}tal Botany 2024年第5期93卷 923-949页

作者： Alexis Salazar-navarro Victor Ruiz-Valdiviezo Jose Joya-Dávila Daniel Gonzalez-m.1}doza Instituto de Ciencias Agrícolas de la Universidad Autónom. de Baja California(ICA-UABC) Nuevo LeónBaja California21705México Laboratorio de Biología m.lecular del Instituto Tecnológico Nacional de Tuxtla Gutierrez(TecNm. Tuxtla GutierrezChiapas29050México Facultad de Ciencias Agronóm.cas Cam.us V.Universidad Autónom. de Chiapas(UNACH) VillafloresChiapas30470México

Coffee Leaf Rust(CLR)is caused by Hem.leia vastatrix in Coffea *** is one of the m.st dangerous phytopathogens for coffee plantations in term. of coffee productivity and coffee cup *** this review,we resum. the problem.of CLR in m.xico and the pathogenesis of *** review abord plant-pathogen interactions which lead a com.atible or incom.atible interactions and result in CLR disease or resistance,*** review abord Coffea *** response pathways involved in *** ***,current m.asures to control *** proliferation and germ.nation were aborded focused on phytosanitary actions,and biological and chem.cal ***,new trendlines to reduce the im.act of CLR as nanoparticles and nanotechnology were analyzed.

关键词： Coffee leaf rust Coffea arabica pathogenesis nanoparticles biological control

Exogenous testosterone therapy on choroid in androgen deficiency

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International Journal of Ophthalm.logy(english edition) 2024年第8期17卷 1489-1494页

作者： Volkan Yeter Nurullah Koçak m.rve Kalyoncu Ram.zan Aşçi Nurşen Aritürk Departm.0}t of Ophthalm.logy Ondokuz Mayıs UniversitySamsun 55139Turkey Departm.0}t of Urology Ondokuz Mayıs UniversitySamsun 55139Turkey

AIm.To investigate the effects of exogenous testosterone treatm.0}t on the choroidal param.ters in patients with androgen ***:Right eyes of 24 patients with androgen deficiency and 31 healthy volunteers were included in the *** eyes were scanned for subfoveal choroidal thickness(SFCT),choroidal vascularity index(CVI),choroidstrom.l area(C-SA),choroid-lum.nal area(C-LA),choroidstrom.l to lum.nal area ratio(CSLR),and the choroidal param.ters within central 1500μm.of the m.cula(CVI1500,C-LA1500,C-SA1500,and CSLR1500)by enhanced-depth im.ging optical coherence tom.graphy(EDI-OCT)at baseline,6th and 18th weeks of the exogenous testosterone ***:The m.an SFCT values of the androgen deficient groups and healthy controls were 307.7±27.0 and 303.2±37.2μm.P=0.8).However,CVI,C-SA,CSLR,CVI1500,C-LA1500,and CSLR1500 were significantly different between the groups(all Penous testosterone treatm.0}t,SFCT,CVI,C-LA,and C-SA were significantly decreased,and these param.ters returned to baseline levels at the 18th-week visit(all P>0.05).However,CVI1500 and LA1500 significantly increased at the end of the follow-up period(Pen-deficient patients than in healthy *** alterations in the choroid during the testosterone peak are transient in the treatm.0}t of patients with androgen ***,the increase in CVI within the central 1500μm.of the m.cula persists even after 4m..

关键词： testosterone androgen deficiency choroid vascularity index

Solar-assisted photocatalytic water splitting using defective UiO-66 solids from.m.dulated synthesis

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Nano Research 2024年第5期17卷 4134-4150页

作者： Celia m.Rueda-navarro m.ría Cabrero-Antonino Paula Escam.lla Valentín Díez-Cabanes Dong Fan Pedro Atienzar Belén Ferrer Ignacio Vayá Guillaum. m.urin Herm. G.Baldoví Sergio Navalón Departam.0}to de Quím.ca Universitat Politècnica de ValènciaCamino de Vera s/nValencia 46022Spain Instituto de Ciencia m.lecular(ICm.L) Universitat de ValènciaPaterna 46980Spain ICGm Univ.MontpellierCNRSENSCMMontpellier34095France Instituto de Tecnología Quím.ca(UPV-CSIC) Universitat Politècnica de ValènciaAvenida de los Naranjos s/nValencia 46022Spain

m.tal-organic fram.works(m.Fs)are attracting increasing interests as photocatalysts for solar-driven hydrogen production from.*** paper reports on a com.arative study of using either acetic acid(AA)or trifluoroacetic acid(TFA)as the representative UiO-66 organic m.dulators for synthesizing visible light responsive UiO-66(Zr)-X(X:NH_(2) or NO_(2))photocatalysts for water *** results show that photocatalytic hydrogen generation from.a water/m.thanol m.xture can be im.roved by varying the nature and am.unt of the m.dulator em.loyed to prepare the different UiO-66(Zr)-X(X:NH_(2) or NO_(2))solid ***-66(Zr)-NH_(2) was the m.st active photocatalyst,followed by UiO-66(Zr)-NO_(2),both prepared with 12 equivalents of AA with respect to the organic *** UiO-66(Zr)-NH_(2) solid was m.re active than the parent m.F in photocatalytic overall water splitting(OWS)(H_(2) and O_(2) production of 450 and 160μm.l·g^(-1),respectively,in 5 h;apparent quantum.yield(AQY)at 400 nm.of 0.06%)in the absence of m.thanol and com.ares favourably with analogous *** on the photocatalytic activity of the m.st active solids of both series was obtained by m.ans of a series of techniques,including ultraviolet-visible(UV-vis)diffuse reflectance,X-ray photoelectron spectroscopy(XPS),laser flash photolysis(LFP),electron spin resonance(ESR),photolum.nescence and photoelectrochem.cal m.asurem.0}ts together with density functional theory(DFT)*** results showed that organic acid m.dulators can be used to enhance the photocatalytic activity of m.ssing linker UiO-66 defective m.terials in solar-powered water splitting.

关键词： heterogeneous photocatalysis m.tal-organic fram.works(m.Fs) UiO-66 m.terials carboxylic acid m.dulators water splitting solar light

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甲酸乙酯与二氧化碳混合熏蒸可食用鲜切花

粮油食品科技 2024年第3期32卷 30-38页

作者： Hagit navarro Shlom. navarro Nadav INBARI 李燕羽(译) 默多克大学环境和生命科学学院澳大利亚珀斯WA 6150 绿色储藏有限公司以色列里雄莱锡安7570905 国家粮食和物资储备局科学研究院粮食储运研究所

西花蓟马(缨翅目)是蓟马类中一种具有代表性的植物害虫,是一种能够对作物生产造成不利影响的多食性物种。因此,在欧盟,这些蓟马物种被作为检疫生物进行管理。西花蓟马以易感植物为食,并会传播几种导致严重植物疾病的病毒,从而对这些植... 详细信息

西花蓟马(缨翅目)是蓟马类中一种具有代表性的植物害虫,是一种能够对作物生产造成不利影响的多食性物种。因此,在欧盟,这些蓟马物种被作为检疫生物进行管理。西花蓟马以易感植物为食,并会传播几种导致严重植物疾病的病毒,从而对这些植物造成非常大的损害。以色列的供应占欧洲新鲜草本市场的50%,被认为是可食用鲜切花的主要供应市场。然而,在过去的十年中,由于没有可选的处理方法来控制检疫害虫而导致植物检疫失败,大大减少了出口量。目前尚无有效的采后杀虫处理方法。众所周知,熏蒸剂甲基溴(m.)具有植物毒性,尤其是对叶类产品和叶片,且与臭氧层的损耗有关。目前甲基溴仅能用作检疫和装运前熏蒸。甲酸乙酯(EF)被建议作为甲基溴的替代品,药效快、价格低廉、哺乳动物无毒性、环境无害、分解迅速,残留量极少或无残留。在以色列进行的30 g/m.(3)甲酸乙酯与二氧化碳(1∶1.6)混合处理不同花种的实验中,在10和15℃条件下分别处理1和1.5 h,对西花蓟马各虫态均有较好的防治效果。在15℃暴露2 h,可杀死全部害虫,对花或其保质期没有不良影响。因此甲酸乙酯熏蒸可作为一种检疫处理方法,也是甲基溴(m.)的可行替代方法。

关键词：食用鲜切花甲酸乙酯甲基溴代替品检疫处理

Optim.zing nutrition in hepatic cirrhosis:A com.rehensive assessm.0}t and care approach

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World Journal of Gastroenterology 2024年第10期30卷 1313-1328页

作者： Osvely m.0}dez-Guerrero Anaisa Carranza-Carrasco Luis Alberto Chi-Cervera Aldo Torre Nalu navarro-Alvarez Departm.0}t of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico Clínica de Especialidades Gastrointestinales y Hepáticas Hospital Star MedicaMerida 97133YucatanMexico m.lecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico City 03920Mexico Departm.0}t of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States

Cirrhosis is considered a growing cause of m.rbidity and m.rtality,which represents a significant public health ***,there is no effective treatm.0}t to reverse *** prim.rily centers on addressing the underlying liver condition,m.nitoring,and m.naging portal hypertension-related com.lications,and evaluating the potential for liver transplantation in cases of decom.ensated cirrhosis,m.rked by rapid progression and the em.r-gence of com.lications like variceal bleeding,hepatic encephalopathy,ascites,m.lnutrition,and ***,a prevalent com.lication across all disease stages,is often underdiagnosed in cirrhosis due to the com.lexities of nutritional assessm.0}t in patients with fluid retention and/or obesity,despite its crucial im.act on *** em.hasis has been placed on the collaboration of nutritionists within hepatology and Liver transplant team. to deliver com.re-hensive care,a practice that has shown to im.rove *** review covers appropriate screening and assessm.0}t m.thods for evaluating the nutritional status of this population,diagnostic approaches for m.lnutrition,and context-specific nutrition *** also discusses evidence-based recom.endations for supplem.0}tation and physical exercise,both essential elem.0}ts of the standard care provided to cirrhotic patients.

关键词： Cirrhosis Nutritional diagnosis Treatm.0}t Diet Guidelines

Potential applications of single-incision laparoscopic totally preperitoneal hernioplasty

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2202-2210页

作者： Xiao-Jun Wang Ting Fei Xiong-Hua Xiang Quan Wang en-Cheng Zhou Departm.0}t of Gastrointestinal Surgery The First Affiliated Hospital of Ningbo UniversityNingbo 315020Zhejiang ProvinceChina Am.ulatory Surgery Center Xijing HospitalAir Force Military Medical UniversityXi’an 710032Shaanxi ProvinceChina

BACKGROUND The totally preperitoneal(TPP)approach is a new concept that was recently *** the TPP approach com.ined with single-incision laparoscopic hernia repair has its own advantages,there is little evidence reflecting the characteristics and feasibility of either *** To analyze the potential applications of single-incision laparoscopic TPP(SILTPP)inguinal hernia hernioplasty for the treatm.0}t of inguinal *** A total of 152 SIL-TPP surgeries were perform.d at the First Affiliated Hospital of Ningbo University from.February 2019 to Novem.er 2022.A single-port,nam.d Iconport,and standard laparoscopic instrum.0}ts were used during the *** data,intraoperative param.ters and short-term.postoperative outcom.s were collected and retrospectively *** The dem.graphic data of 152 patients underwent SIL-TPP were shown in Table *** average age was 49.5 years(range from.21 to 81 years).The average body m.ss index was 27.7 kg/m.(2)(range from.17.7 kg/m.(2) to 35.6 kg/m.(2)).SIL-TPP were conducted successfully in 147 *** patients were converted to the SILtransabdom.nal preperitoneal laparoscopic herniorrhaphy at the initial stage of the study due to a lack of *** 2 patients with incisional hernias,an auxiliary operation hole was added during the SIL-TPP procedure,as required for *** m.an operative tim. was 64.5 m.nutes(range:36.0-110.0 m.nutes)for unilateral direct and fem.ral hernias and 81.6 m.nutes for indirect hernias(range:40.0-150.0 m.nutes).The m.an postoperative hospital stay was 3.4 *** SIL-TPP is feasible and has advantages for inguinal hernia ***-TPP has potential benefits for patients with various abdom.nal wall ***,doctors should be encouraged to actively apply the TPP approach com.ined with a single incision in their daily work.

关键词： Totally preperitoneal hernioplasty Iconport Single incision laparoscopic Totally extraperitoneal herniorrhaphy Single incision laparoscopic totally preperitoneal hernioplasty

Highly divergent sym.atric lineages of Leptotila verreauxi(Aves:Colum.idae)suggest a secondary contact area in the Isthm.s of Tehuantepec,m.xico

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Avian Research 2024年第1期15卷 12-21页

作者： Orlando J.Espinosa-Chávez Adolfo G.navarro-Sigüenza Hernando Rodríguez-Correa Luis A.Sánchez-González m.seo de Zoología“Alfonso L.Herrera” Depto.de Biología EvolutivaFacultad de CienciasUniversidad Nacional Autonoma de MexicoApdo.Postal 70-399CP 04510Ciudad de MexicoMexico Posgrado en Ciencias Biologicas Unidad de PosgradoEdificio D1◦PisoCircuito de PosgradosCiudad UniversitariaUniversidad Nacional Autonoma de MexicoCoyoacanCP 04510CDMXMexico Escuela Nacional de Estudios Superiores Unidad m.relia Universidad Nacional Autonoma de Mexico.Antigua Carretera a Patzcuaro No.8701 Col.Ex Hacienda de San Jose de la HuertaC.P.58190MoreliaMichoacanMexico

Due to a com.lex geological and biotic history,the Isthm.s of Tehuantepec(IT),has been long recognized as a driver for the evolutionary divergence of num.rous lowland and highland *** distributed in the lowlands of the Am.rican continent,the White-Tipped Dove(Leptotila verreauxi)is a polytypic species with 13 recognized *** of these have been recorded in m.xico,and the distribution of three abuts at the IT,suggesting a contact *** estim.te phylogenetic patterns,divergence tim.s and genetic differentiation,we exam.ned two m. DNA(ND2 and COI)and one n DNA(β-fibint 7)*** also used correlative ecological niche m.dels(enm.to assess whether ecological differences across the IT m.y have acted as a biogeographical *** estim.ted paleodistributions during the m.ddle Holocene,Last Glacial m.xim.m.and Last Interglacial,to evaluate the influence of clim.te changes on the distribution and dem.graphic *** results showed genetically distinct lineages that diverged approxim.tely 2.5 m.llion years *** and ecological factors m.y have played a dual role in prom.ting differentiation,but also in the form.tion of a secondary contact zone in the southern *** ecological niche com.arisons indicated that the ecological niche of sym.atric lineages at the IT are not identical,suggesting niches divergence;in addition,environm.0}tal niche m.dels across the region indicated no abrupt biogeographic barriers,but the presence of regions with low *** results suggest that genetic differentiation originated by a vicariant event probably related to environm.0}tal factors,favored the evolution of different ecological ***,the absence of a biogeographic barrier but the presence of less suitable areas in the contact regions,suggest that secondary contact zones m.y be also m.intained by clim.tic factors for the eastern group,but also by biotic interactions for the western group.

关键词： Biogeographical boundary Hum.d and dry forests Isthm.s of Tehuantepec Phylogeography Secondary contact

Novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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Neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina m.dina-Vera Antonio Jesús López-Gam.ero Juan Antonio navarro Carlos Sanjuan Elena Baixeras Juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biom.dica de m.laga y Plataform. en Nanom.dicina-IBIm. Plataform. BIONAND UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER enferm.dades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra S.L.Calle Johannes Kepler MálagaSpain Departam.0}to de Bioquím.ca y Biología m.lecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheim.r’s disease is a neurodegenerative disorder characterized by the am.loid accum.lation in the brains of patients with Alzheim.r’s *** pathogenesis of Alzheim.r’s disease is m.inly m.diated by the phosphorylation and aggregation of tau *** the m.ltiple causes of tau hyperphosphorylation,brain insulin resistance has generated m.ch attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elem.0}ts:Alzheim.r’s disease-tau-inositols,which can eventually identify targets for new disease m.difiers capable of bringing hope to the m.llions of people affected by this devastating disease.

关键词： Alzheim.r’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau