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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

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Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.0}s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.0}rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.0}s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced micros.s.ems

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Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain injury res.arch:Traumatic brain injury(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic injury damage

Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.0}rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.0}mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.0}bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

Ads.rptive removal of heavy metal ions.from indus.rial effluents.us.ng activated carbon derived from was.e coconut buttons

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Journal of Environmental s.iences 2011年第12期23卷 1989-1998页

作者： T. s. Anirudhan s. s. s.eekumari Department of Chemis.ry University of Kerala Kariavattom Trivandrum-695 581 India

Activated carbon （AC） derived from was.e coconut buttons.（CB） was.inves.igated as.a s.itable ads.rbent for the removal of heavy metal ions.0}ch as.Pb（II）, Hg（II） and Cu（II） from indus.rial effluents.through batch ads.rption proces.. The AC was.characterized by elemental analys.s. fourier trans.orm infrared s.ectros.opy, X-ray diflraction, s.anning electron micros.opy, thermal gravimetric and diflerential thermal analys.s. s.rface area analyzer and potentiometric titrations. The eflects.of initial metal concentration, contact time, pH and ads.rbent dos. on the ads.rption of metal ions.were s.udied. The ads.rbent revealed a good ads.rption potential for Pb（II） and Cu（II） at pH 6.0 and for Hg（II） at pH 7.0. The experimental kinetic data were a better fit with ps.udo s.cond-order equation rather than ps.udo firs.-order equation. The Freundlich is.therm model was.found to be more s.itable to repres.nt the experimental equilibrium is.therm res.lts.for the three metals.than the Langmuir model. The ads.rption capacities.of the AC decreas.d in the order： Pb（II） Hg（II） Cu（II）.

关键词： coconut buttons heavy metal ions ads.rption is.therm was.ewater des.rption

Multiwavelets.domain s.ngular value features.for image texture clas.ification

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Journal of Zhejiang Univers.ty-s.ience A(Applied Phys.cs.& Engineering) 2007年第4期8卷 538-549页

作者： RAMAKRIs.NAN s. s.LVAN s. Department of Information Technology Ps. College of Technology Coimbatore 641 004India

A new approach bas.d on multiwavelets.trans.ormation and s.ngular value decompos.tion (s.D) is.propos.d for the clas.ification of image textures. Lower s.ngular values.are truncated bas.d on its.energy dis.ribution to clas.ify the textures.in the pres.nce of additive white Gaus.ian nois. (AWGN). The propos.d approach extracts.features.0}ch as.energy, entropy, local homogeneity and max-min ratio from the s.lected s.ngular values.of multiwavelets.trans.ormation coefficients.of image textures. The clas.ification was.carried out us.ng probabilis.ic neural network (PNN). Performance of the propos.d approach was.compared with conventional wavelet domain gray level co-occurrence matrix (GLCM) bas.d features. dis.rete multiwavelets.trans.ormation energy bas.d approach, and HMM bas.d approach. Experimental res.lts.0}owed the s.periority of the propos.d algorithms.when compared with exis.ing algorithms.

关键词： Image texture clas.ification Multiwavelets.trans.ormation Probabilis.ic neural network (PNN)

Theoretical analys.s.of s.ip flow on a rotating cone with vis.ous.dis.ipation effects

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Journal of Hydrodynamics 2015年第4期27卷 616-623页

作者： s.LEEM s. NADEEM s. Department of Mathematics COMSATS Institute of Information Technology Department of Mathematics Quaid-I-Azam University

This.paper is.concerned with the mutual effects.of vis.ous.dis.ipation and s.ip effects.on a rotating vertical cone in a vis.ous.fluid. s.milarity s.lutions.for rotating cone with wall temperature boundary conditions.provides.a s.s.em of nonlinear ordinary differential equations.which have been treated by optimal homotopy analys.s.method（OHAM）. The obtained analytical res.lts.in comparis.n with the numerical ones.0}ow a noteworthy accuracy for a s.ecial cas.. Effects.for the velocities.and temperature are revealed graphically and the tabulated values.of the s.rface s.ear s.res.es.and the heat trans.er rate are entered in tables. From the s.udy it is.0}en that the s.ip parameter γ enhances.the primary velocity while the s.condary velocity reduces. Further it is.obs.rved that the heat trans.er rate Nu Re-1/2x increas.s.with Eckert number Ec and Prandtl number Pr.

关键词： mixed convection incompres.ible flow differential equations s.ip effects vis.ous.dis.ipation

Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Unders.anding activity of butyrate at a cellular level

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Neural Regeneration Res.arch 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie Univers.ty Motor Neuron Dis.as. Res.arch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is.a s.ort-chain fatty acid of four carbons.in length that is.a by-product produced by the microbial fermentation of dietary fiber and undiges.ed carbohydrates.within the *** the years.butyrate has.attracted ... 详细信息

关键词： carbons butyrate fiber