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Single nucleotide polymorphisms in candidate genes are significantly associated with resistance to Haemonchus contortus infection in goats

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Journal of Animal Science and Biotechnology 2019年第2期10卷 293-306页

作者： Mahmuda Bilkis Bintee Alam Abdullah Ibne Omar Md.Omar Faruque David Russell Notter kathiravan periasamy Md.Motahar Hussain Mondal Md.Jalal Uddin Sarder Md.Shamsuddin Jianhua Cao Xiaoyong Du Zhenyang Wu Shuhong Zhao Key Lab of Agricultural Animal Genetics Breeding and ReproductionMinistry of EducationCollege of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070People’s Republic of China National Engineering Laboratory for Animal Breeding Key Lab of Agricultural Animal GeneticsBreeding and ReproductionMinistry of AgricultureCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China Department of Animal and Poultry Sciences Virginia TechBlacksburgVA 24061USA Animal Production and Health Laboratory Join FAO/IAEA Division of Nuclear Techniques in Food and AgricultureInternational Atomic Energy AgencyViennaAustria Department of Parasitology Bangladesh Agricultural UniversityMymensingh 2202Bangladesh.7Department of Veterinary and Animal ScienceUniversity of RajshahiRajshahi 6205Bangladesh Agricultural Bioinformatics Key Laboratory of Hubei Province College of InformaticsHuazhong Agricultural UniversityWuhan 430070People’s Republic of China College of Agroforestry Engineering and Planning Tongren UnivesityTongrenGuizhou 554300People’s Republic of China.

Background: Haemonchosis is a major economic problem in goat production in humid, tropical and subtropical regions. The disease is caused by an abomasal nematode, Haemonchus contortus, which is highly pathogenic in small ruminants. The aim of this study was to identifying single-nucleotide polymorphisms(SNP) that were associated with fecal egg counts(FEC) and could be used as markers to identify resistance to H. contortus in goats.Results: Ten novel variants in the CI TA, ATP2 A3, HSPA8, STAT5 B, ESYT1, and SERPING1 genes were associated with FEC in goats with a nominal significance level of P G SNP locus in al goat breeds. Pairwise coefficients of linkage disequilibrium(D′, r2)revealed complete LD(r2= 1) between significant SNP polymorphisms in CI TA and SERPING1 and strong LD(r2= 0.93 and0.98) between polymorphisms in HSPA8 and ATP2 A3, respectively. Correlation coefficient(r) between FEC and body weight(BW) was significantly positive(r = 0.56***, P < 0.001) but that between FEC and packed cel volume(PCV) was negatively significant(r =-0.47**, P < 0.01) in the total population of goats. On the other hand, correlation coefficient(r)between BW and PCV was not significant in total population of goats. Association analysis revealed that haplotypes within ATP2 A3, HSPA8, and SERPING1 were significantly associated with FEC. Quantitative real-time PCR revealed that the relative expression of m RNA was higher(P < 0.001) for resistant, compared to susceptible, groups of goats for al candidate genes except CI TA.Conclusions: This study identified SNP markers that

关键词： Fecal egg count Goat Haemonchus contortus Parasite resistance SNP markers

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