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Impact shock frequency components and attenuation in rearfoot and forefoot running

Journal of Sport and Health Science 2014年第2期3卷 113-121,153+157页

作者： Allison H.Gruber katherine A.Boyer Timothy R.Derrick Joseph Hamill Biomechanics Laboratory University of Massachusetts Amherst Biomechanics Laboratory Iowa State University

Background:The forefoot running footfall pattern has been suggested to reduce the risk of developing running related overuse injuries due to a reduction of impact related variables compared with the rearfoot running footfall ***,only time-domain impact variables have been compared between footfall *** frequency content of the impact shock and the degree to which it is attenuated may be of greater importance for injury risk and prevention than time-domain ***,the purpose of this study was to determine the differences in head and tibial acceleration signal power and shock attenuation between rearfoot and forefoot ***:Nineteen habitual rearfoot runners and 19 habitual forefoot runners ran on a treadmill at 3.5 m/s using their preferred footfall patterns while tibial and head acceleration data were *** magnitude of the first and second head acceleration peaks,and peak positive tibial acceleration were *** power spectral density of each signal was calculated to transform the head and tibial accelerations in the frequency *** attenuation was calculated by a transfer function of the head signal relative to the ***:Peak positive tibial acceleration and signal power in the lower and higher ranges were significantly greater during rearfoot than forefoot running(/> 0.05).Rearfoot running resulted in significantly greater shock attenuation for the lower and higher frequency ranges as a result of greater tibial acceleration(p mpact shock frequency content between footfall patterns suggests that the primary mechanisms for attenuation may *** relationship between shock attenuation mechanisms and injury is not clear but given the differences in impact frequency content,neither footfall pattern may be more benefi

关键词： Frequency domain Impact shock Running footfall patterns Shock attenuation Tibial acceleration

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跟骨的骨密度:参考值、可重复性及骨折史及体力活动的影响

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世界核心医学期刊文摘（儿科学分册） 2005年第5期1卷 18-19页

作者： chinn D. J. Fordham J. N. Kibirige m. S. 贺莉 James Co ok University Hospital Marton Road Middlesbrough TS4 3BW United KingdomDr.

Aims: To establish reference values for bone mineral density (BmD) measured at the os calcis (∝) in healthy UK Caucasian children. Secondary objectives were to assess the reproducibility of the measurement and the effects of fracture his tory and habitual physical activity. methods: A total of 403 children aged 5-18 were studied. main outcome measures were: BmD∝measured by peripheral DXA, tota l BmD measured by whole body axial scanner, age, anthropometry, pubertal status, selfreported fracture history, and physical activity (PA) expressed as a three point score. Results: Complete data were available on 171 girls and 123 boys fre e of a history of fracture. BmD∝was related positively to age, body size, and t otal BmD, and could be predicted using a proportional model based on height alon e (R2: 65%girls, 77%boys). mean BmD∝appears to plateau in girls at 15 years a nd attain a value that concurs with the mean peak value in adult women. The 95% limits of agreement in repeated measures were-0.029 to 0.029 g/cm2 (n = 53). Compared with sedentary children, those doing regular sports or PA for more than five hours a week had an increased BmD∝(by about 0.03 g/cm2 or about 7%of the overall mean). A history of fracture (n = 81) w as associated with a reduced BmD∝in boys but not in girls, though our study may have been underpowered for a subgroup analysis. Conclusions: BmD∝can be measur ed easily and quickly in children older than 5 years and provides an objective m easure of areal bone density for clinical and research studies using a reference range derived from its relation to height.

关键词：骨折史可重复性骨密度体力活动参考值骨矿物质密度重复测量全身扫描人体测量学亚群

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1974—2003年英国儿童超重和肥胖症的趋势:社会经济因素有何作用

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世界核心医学期刊文摘（儿科学分册） 2006年第A3期2卷 29-30页

作者： Stamatakis E. Primatesta P. chinn S. 贺莉 Department of Epidemiology and Public Health University College London 1-19 Torrington Place London WC1E 6BTUnited Kingdom

Aims: To examine the childhood overweight and obesity prevalence trends between 1974 and 2003 and to assess whether these trends relate to parental social class and household income. methods: A school based and a general population health survey: the National Study of Health and Growth in 1974, 1984, and 1994, and the Health Survey for England, yearly from 1996 to 2003. Participants were 14 587 white boys and 14 014 white girls aged 5-10 years. Overweight and obesity prevalence were calculated using UK specific as well as international body mass index (kg/m2) cut-offs. Socioeconomic status was measured using the Registrar General’ s social class; household income (1997 onwards only) was adjusted for household size. Results: The prevalence of obesity (UK specific definition) in boys increased from 1.2% in 1984 to 3.4% in 1996-97 and 6.0% in 2002-03. In girls, obesity increased from 1.8% in 1984 to 4.5% in 1996-97 and 6.6% in 2002-03. Obesity prevalence has been increasing at accelerating rates in the more recent years. Children from manual social classes had marginally higher odds (OR 1.14, 95% CI 0.98 to 1.33) and children from higher income households had lower odds (OR 0.74, 95% CI 0.61 to 0.89) to be obese than their peers from non-manual class, and lower income households, respectively. Conclusion: Childhood obesity is increasing rapidly into the 2000s in England and these increases are more marked among children from lower socioeconomic strata. There is an urgent need for action to prevent further increase in obesity among children.

关键词：儿童超重社会经济因素儿童肥胖症健康普查社会经济地位人群健康家庭收入肥胖率家庭成员高

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精通microsoft Word 2002中文版 1

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丛书名： Office XP专家之路系列丛书

2002年

作者：（美）mary millhollon （美）katherine murray 北京艾希亚（ASURE）公司译

本书详细介绍了Word 2002中文版的各项功能，既包括文档简单编辑、页面排版、图表制作、表格制作等内容。

ISBN: (纸本)7900641033

本书详细介绍了Word 2002中文版的各项功能，既包括文档简单编辑、页面排版、图表制作、表格制作等内容。

关键词：汉字处理软件系统基本知识

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Pilot Studies on the Novel Hypothesis that TSPO (Peripheral Benzodiazepine Receptor) Is Involved in Benzodiazepine/“Z-Drug” Physical Dependence and/or Withdrawal

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Pharmacology & Pharmacy 2023年第3期14卷 72-83页

作者： Cheyenne moffett katherine J. Kost Austen Thompson Joseph V. Pergolizzi Jr. Tally m. Largent-milnes Robert B. Raffa Todd Vanderah Department of Pharmacology and Comprehensive Pain and Addiction Center University of Arizona Tucson AZ USA NEmA Inc. Naples FL USA Neumentum Inc. Summit NJ USA Enalare Therapeutics Naples FL USA School of Pharmacy Temple University Philadelphia PA USA College of Pharmacy (Adjunct) University of Arizona Tucson AZ USA

Benzodiazepines and other benzodiazepine receptor agonists, such as the “Z” drugs, are widely prescribed medications mainly used for treating anxiety and seizures, and for inducing sedation. Unfortunately, despite their popularity, benzodiazepine prescribing often exceeds recommendations and the consequences can be severe. On September 23, 2020, the United States FDA announced a new requirement for a Boxed Warning for benzodiazepines prescribing. Along with this announcement, the FDA stated that relevant information regarding the initiation, continuation, and discontinuation of benzodiazepines is lacking. Here, we describe initial pilot studies intended to investigate the questions 1) can animal models be developed that demonstrate benzodiazepine physical dependence and/or withdrawal symptoms, and 2) determine whether translocator protein (TSPO) plays a role in benzodiazepine dependence and/or withdrawal processes. The former was demonstrated, methodological limitations prevented the latter.

关键词： Benzodiazepine TSPO Rats In Vivo Tests Western-Blot Analysis

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macrophage-specific inhibition of the histone demethylase JmJD3 decreases STING and pathologic inflammation in diabetic wound repair

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Cellular & molecular Immunology 2022年第11期19卷 1251-1262页

作者： Christopher O.Audu William J.melvin Amrita D.Joshi Sonya J.Wolf Jadie Y.moon Frank m.Davis Emily C.Barrett Kevin D.mangum Hongping Deng Xianying Xing Rachel Wasikowski Lam C.Tsoi Sriganesh B.Sharma Tyler m.Bauer James Shadiow matthew A.Corriere Andrea TObi Steven LKunkel Benjamin Levi Bethany Bmoore Johann EGudjonsson Andrew mSmith katherine A.Gallagher Department of Surgery Section of Vascular SurgeryUniversity of MichiganAnn ArborMIUSA Department of microbiology and Immunology University of MichiganAnn ArborMIUSA Department of medicinal Chemistry University of MichiganAnn ArborMIUSA Department of Surgery Section of General SurgeryUniversity of MichiganAnn ArborMIUSA Department of Bioengineering University of IllinoisUrbana-ChampaignChampaignILUSA Department of Dermatology University of MichiganAnn ArborMIUSA Department of Pathology University of MichiganAnn ArborMIUSA Department of Surgery University of Texas Southwestern Medical CenterDallasTXUSA

macrophage plasticity is critical for normal tissue repair following *** pathologic states such as diabetes,macrophage plasticity is impaired,and macrophages remain in a persistent proinflammatory state;however,the reasons for this are ***,using single-cell RNA sequencing of human diabetic wounds,we identified increased JmJD3 in diabetic wound macrophages,resulting in increased inflammatory gene ***,we report that in wound healing,JmJD3 directs early macrophage-mediated inflammation via JAK1,3/STAT3 ***,in the diabetic state,we found that IL-6,a cytokine increased in diabetic wound tissue at later time points post-injury,regulates JmJD3 expression in diabetic wound macrophages via the JAK1,3/STAT3 pathway and that this late increase in JmJD3 induces NFκB-mediated inflammatory gene transcription in wound macrophages via an H3K27me3 ***,RNA sequencing of wound macrophages isolated from mice with JmJD3-deficient myeloid cells(Jmjd3f/fLyz2Cre+)identified that the STING gene(Tmem173)is regulated by JmJD3 in wound *** limits inflammatory cytokine production by wound macrophages during ***,in diabetic mice,its role changes to limit wound repair and enhance *** finding is important since STING is associated with chronic inflammation,and we found STING to be elevated in human and murine diabetic wound macrophages at late time ***,we demonstrate that macrophage-specific,nanoparticle inhibition of JmJD3 in diabetic wounds significantly improves diabetic wound repair by decreasing inflammatory cytokines and *** together,this work highlights the central role of JmJD3 in tissue repair and identifies cell-specific targeting as a viable therapeutic strategy for nonhealing diabetic wounds.

关键词： wound healing epigenetics diabetes JmJD3 STING

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High affinity soluble ILT2 receptor:a potent inhibitor of CD8^(+)T cell activation

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Protein & Cell 2010年第12期1卷 1118-1127页

作者： Ruth K.moysey Yi Li Samantha J.Paston Emma E.Baston malkit S.Sami Brian J.Cameron Jessie Gavarret Penio Todorov Annelise Vuidepot Steven m.Dunn Nicholas J.Pumphrey katherine J.Adams Fang Yuan Rebecca E.Dennis Deborah H.Sutton Andy D.Johnson Joanna E.Brewer Rebecca Ashfield Nikolai m.Lissin Bent K.Jakobsen Immunocore Limited 57c Milton ParkAbingdonOxonOX144RXUK Current address:Oxford Nanopore Technologies UK Current address:Geneva merck Serono S.A. Switzerland Current address:Adaptimmune Limited UK

Using directed mutagenesis and phage display on a soluble fragment of the human immunoglobulin superfamily receptor ILT2(synonyms:LIR1,mIR7,CD85j),we have selected a range of mutants with binding affinities enhanced by up to 168,000-fold towards the conserved region of major histocompatibility complex(mHC)class I *** in a dimeric form,either by chemical cross-linking with bivalent polyethylene glycol(PEG)derivatives or as a genetic fusion with human IgG Fc-fragment,the mutants exhibited a further increase in ligand-binding strength due to the avidity effect,with resident half-times(t1/2)on the surface of mHC I-positive cells of many *** novel compounds antagonized the interaction of CD8 co-receptor with mHC I in vitro without affecting the peptide-specific binding of T-cell receptors(TCRs).In both cytokine-release assays and cell-killing experiments the engineered receptors inhibited the activation of CD8^(+)cytotoxic T lymphocytes(CTLs)in the presence of their target cells,with subnanomolar potency and in a dose-dependent *** a selective inhibitor of CD8^(+)CTL responses,the engineered high affinity ILT2 receptor presents a new tool for studying the activation mechanism of different subsets of CTLs and could have potential for the development of novel autoimmunity therapies.

关键词： CD8^(+)T cells cellular activation autoimmunity cell surface molecules binding affinity phage display

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Comparative transcriptomics of Central Asian Vitis vinifera accessions reveals distinct defense strategies against powdery mildew

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Horticulture Research 2015年第1期2卷 143-153页

作者： katherine C H Amrine Barbara Blanco-Ulate Summaira Riaz Dániel Pap Laura Jones Rosa Figueroa-Balderas m Andrew Walker Dario Cantu Department of Viticulture and Enology University of CaliforniaDavisDavis95616CAUSA Department of Genetics and Plant Breeding Corvinus University of BudapestVillányiút 29-341118BudapestHungary

Grape powdery mildew(Pm),caused by the biotrophic ascomycete Erysiphe necator,is a devastating fungal disease that affects most Vitis vinifera *** have previously identified a panel of *** accessions from Central Asia with partial resistance to Pm that possess a Ren1-like local *** this study,we show that in addition to the typical Ren1-associated late post-penetration resistance,these accessions display a range of different levels of disease development suggesting that alternative alleles or additional genes contribute to determining the outcome of the interaction with the *** identify potential Ren1-dependent transcriptional responses and functions associated with the different levels of resistance,we sequenced and analyzed the transcriptomes of these Central Asian accessions at two time points of Pm *** were compared to identify constitutive differences and Pm-inducible responses that may underlie their disease resistant *** to *** in all resistant accessions were characterized by an early up-regulation of 13 genes,most encoding putative defense functions,and a late down-regulation of 32 genes,enriched in transcriptional regulators and protein *** Ren1-dependent responses included a hotspot of co-regulated genes on chromosome *** also identified 81 genes whose expression levels and dynamics correlated with the phenotypic differences between the most resistant accessions‘Karadzhandahal’,DVIT3351.27,and O34-16 and the other *** study provides a first exploration of the functions associated with varying levels of partial resistance to Pm in *** accessions that can be exploited as sources of genetic resistance in grape breeding programs.

关键词： breeding mildew cultivar

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高一生活小贴士

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新东方英语（中学版） 2017年第10期 59-61页

作者： katherine Krane Jasmine 不详

我以前不是很清楚自己对开始高中生活到底抱有怎样的感受。既对交新朋友和学新东西感到兴奋，又对要在新环境中找到方向和努力试着离高年级学生远一点感到紧张不安。我已经知道高中的课程会很难，所以我很担心这个。不过我也知道高中会... 详细信息

我以前不是很清楚自己对开始高中生活到底抱有怎样的感受。既对交新朋友和学新东西感到兴奋，又对要在新环境中找到方向和努力试着离高年级学生远一点感到紧张不安。我已经知道高中的课程会很难，所以我很担心这个。不过我也知道高中会有太多的课外活动，而且我会过得很开心。所有这些感触加在一起变成了一种令人困惑的情绪。不过，了解了我现在所知道的这些之后，其实真的没有多少可担心的！所以所有在读这篇文章的高一新生们，我会通过这篇文章帮助你们度过你们的高一时光！

关键词：高一新生生活高年级学生课外活动高中文章课程

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Performance of Natural Antagonists and Commercial microbiocides towards <i>in Vitro</i>Suppression of Flower Bed Soil-Borne <i>Fusarium oxysporum</i>

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Advances in microbiology 2014年第3期4卷 151-159页

作者： David Nelson katherine Beattie Graham mcCollum Trevor martin Shekhar Sharma Juluri R. Rao Plant Health & Environmental Protection Sustainable Agri-Food Sciences Division Agri-Food & Biosciences Institute Belfast UK Plant Health & Environmental Protection Sustainable Agri-Food Sciences Division Agri-Food & Biosciences Institute Belfast UK Strathearn School Belfast UK

Fusarium oxysporum is the causal agent for wilt diseases of many major ornamental and horticultural crops. In this study, we plated a local cut flower grower’s soil, with a persistent history of Fusarium wilt of scented stock, matthiola incana but not the lettuce rotational crop. This yielded culture plates with characteristic pink to carmine red fungi, together with a mixed bacterial population, a percentage of which was visibly antagonistic to the Fusarium. Using molecular analyses via Polymerase Chain Reaction (PCR) assays, we identified that Fusarium oxysporum, Fusarium culmorum, Fusarium equiseti and Fusarium venenatum were prevalent in the soil. The co-habiting bacterial colonies that exhibited strong antagonistic activity (zone of clearance) towards the soil fungi corresponded to Bacillus subtilis, Bacillus amyloliquefaciens and Paenibacillus polymyxa species. Our results arising from an in vitro study involving Kirby-Bauer disc-diffusion agar assays, coupled with bio-imaging software techniques demonstrated that the three native soil bacteria were effective inhibitors of all Fusarium species tested, while Bacillus subtilis exhibited the highest antagonism towards the Fusarium oxysporum. Bioassay tests of micro-biocides Prestop (Gliocadium catenulatum), Serenade max (Bacillus subtilis QST713) and commercial seaweed extract, AlgiVyt suppressed in vitro growth of Fusarium oxysporum infecting the scented stock flower to a greater extent, whilst fresh aqueous extracts of garlic (Allium sativum) and meadowsweet (Filipendula ulmaria) flowers were ineffective towards soil pathogen suppression. This scoping study offers cut flower growers additional options of tapping into populations of antagonistic bacteria found in soil persistently infected with the opportunistic soil phytopathogen Fusarium oxysporum, affecting cut flower crops, such as m. incana.

关键词： Fusarium oxysporum Cut Flower Wilt Disease Natural Antagonistic Bacteria Bacillus subtilis Natural and Commercial Plant Extracts microbiocides

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