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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1654-1664页

作者： Guillermo Valenzuela Mauricio Burotto katherine Marcelain Jaime Gonzalez-Montero Department of Basic and Clinical Oncology University of ChileSantiago 8380453Chile Department of Internal Medicine Hospital del SalvadorSantiago 7500922Chile Department of Oncology Bradford-Hill Clinical Research CenterSantiago 8420383Chile

Colorectal cancer(CRC) is a major cause of mortality worldwide, associated with a steadily growing prevalence. Notably, the identification of KRAS, NRAS, and BRAF mutations has markedly improved targeted CRC therapy by affording treatments directed against the epidermal growth factor receptor(EGFR) and other anti-angiogenic therapies. However, the survival benefit conferred by these therapies remains variable and difficult to predict, owing to the high level of molecular heterogeneity among patients with CRC. Although classification into consensus molecular subtypes could optimize response prediction to targeted therapies, the acquisition of resistance mutations to targeted therapy is, in part, responsible for the lack of response in some patients. However, the acquisition of such mutations can induce challenges in clinical practice. The utility of liquid biopsy to detect resistance mutations against anti-EGFR therapy has recently been described. This approach may constitute a new standard in the decision algorithm for targeted CRC therapy.

关键词： Colorectal neoplasms Precision medicine Liquid biopsy Cetuximab Panitumumab

Spectrum of Cytogenomic Abnormalities Revealed by Array Comparative Genomic Hybridization on Products of Conception Culture Failure and Normal Karyotype Samples

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Journal of Genetics and Genomics 2016年第3期43卷 121-131页

作者： Qinghua Zhou Shen-Yin Wu katherine Amato Autumn DiAdamo Peining Li The First Affiliated Hospital The Biomedical Translational Research Institute Jinan University Guangzhou 510632 China Department of Genetics Yale University School of Medicine New Haven CT 06520 USA

Approximately 30% of pregnancies after implantation end up in spontaneous abortions, and 50% of them are caused by chromosomal abnormalities. However, the spectrum of genomic copy number variants （CNVs） in products of conception （POC） and the underlying gene- dosage-sensitive mechanisms causing spontaneous abortions remain largely unknown. In this study, array comparative genornic hybridiza- tion （aCGH） analysis was performed as a salvage procedure for 128 POC culture failure （POC-CF） samples and as a supplemental procedure for 106 POC normal karyotype （POC-NK） samples. Chromosomal abnormalities were detected in 10% of POC-CF and pathogenic CNVs were detected in 3.9% of POC-CF and 5.7% of POC-NK samples. Compiled results from this study and relevant case series through a literature review demonstrated an abnormality detection rate （ADR） of 35% for chromosomal abnormalities in POC-CF samples, 3.7% for pathogenic CNVs in POC-CF samples, and 4.6% for pathogenic CNVs in POC-NK samples. Ingenuity Pathway Analysis （IPA） was performed on the genes from pathogenic CNVs found in POC samples. The denoted primary gene networks suggested that apoptosis and cell proliferation pathways are involved in miscarriage. In summary, a similar spectrum of cytogenomic abnormalities was observed in POC culture success and POC-CF samples. A threshold effect correlating the number of dosage-sensitive genes in a chromosome with the observed frequency of autosomai trisomy is proposed. A rationalized approach using firstly fluorescence in situ hybridization （FISH） testing with probes of chromosomes X/Y/ 18, 13/21, and 15/16/22 for common aneuploidies and polyploidies and secondly aCGH for other cytogenomic abnormalities is recommended for POC-CF samples.

关键词： Products of conception (POC) Culture failure Normal karyotype Array comparative genomic hybridization (aCGH) Chromosomal andgenomic abnormalities Apoptosis

Evaluation of thermodynamic equations of state across chemistry and structure in the materials project

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npj Computational Materials 2018年第1期4卷 323-329页

作者： katherine Latimer Shyam Dwaraknath Kiran Mathew Donald Winston Kristin A.Persson Department of Physics University of California BerkeleyBerkeleyCA 94720USA Energy Storage and Distributed Resources Division Lawrence Berkeley National LabBerkeleyCA 94720USA Department of Materials Science University of California BerkeleyBerkeleyCA 94720USA

Thermodynamic equations of state(EOS)for crystalline solids describe material behaviors under changes in pressure,volume,entropy and temperature,making them fundamental to scientific research in a wide range of fields including geophysics,energy storage and development of novel *** over a century of theoretical development and experimental testing of energy–volume(E–V)EOS for solids,there is still a lack of consensus with regard to which equation is indeed optimal,as well as to what metric is most appropriate for making this *** this study,several metrics were used to evaluate quality of fit for 8 different EOS across 87 elements and over 100 compounds which appear in the *** findings do not indicate a clear“best”EOS,but we identify three which consistently perform well relative to the rest of the ***,we find that for the aggregate data set,the RMSrD is not strongly correlated with the nature of the compound,e.g.,whether it is a metal,insulator,or semiconductor,nor the bulk modulus for any of the EOS,indicating that a single equation can be used across a broad range of classes of materials.

关键词： materials. solids state

Ovarian cancer recurrence:“is the definition of platinum resistance modified by PARP inhibitors and other intervening treatments?”

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Cancer Drug Resistance 2022年第2期5卷 451-458页

作者： Tanja Pejovic katherine Fitch Gordon Mills Knight Cancer Institute Oregon Health&Science UniversityPortlandOR 97239USA. Department of Obstetrics&Gynecology Oregon Health&Science UniversityPortlandOR 97239USA.

PolyADP ribose polymerase inhibitors(PARPi)have transformed the treatment of ovarian *** in high-grade serous ovarian cancer(HGSOC),a disease characterized by homologous recombination deficiency(HRD),PARPi have had a rapid and profound impact on the disease course,as well as biologic and biomarker definitions of HGSOC,thereby creating a paradigm shift in the approach to *** this review,we discuss the role of PARPi in the maintenance treatment of HGSOC,its effect on platinum sensitivity,and cross-resistance between platinum and PARP inhibitors.

关键词： PARP inhibitors olaparib niraparib ovarian cancer maintenance therapy

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Journal of Green Building 2009年第2期4卷 109-125页

作者： katherine Gregory Behdad Moghtaderi Adrian Page Priority Research Centre for Energy Chemical EngineeringSchool of EngineeringFaculty of Engineering&Built EnvironmentThe University of NewcastleCallaghanNSW 2308Australia

This paper summarises the results of a combined numerical,statistical and experimental study concerned with the use of dissimilar walling systems on the external parts of a given building *** rational behind this“hybrid wall”concept,as opposed to conventional approaches where identical walls are used in a building envelope,is to achieve a more effective distribution of thermal mass across the envelope and,hence,improve the overall thermal per-formance of the *** effectiveness of the“hybrid wall”concept was investigated using a series of hypothetical building modules of common Australian residential constructions,namely Light Weight(LW),Brick Veneer(BV),Reverse Brick Veneer(RBV)and Cavity Brick(CB).These designs were examined numerically using a commercial energy rating tool known as“AccuRate”,statistically using JMP software and experimentally using a novel bench-scale setup developed as part of this *** performance of each design was evaluated by its energy *** numerical predictions and experimental data highlighted that the east and west walls have the most impact on the energy consumption under Australian climatic *** was found that considerable reductions in the energy consumption could be achieved in cases where the hybrid wall concept was implemented through the use of high ther-mal mass insulated walls on the east and west sides of the building envelope.

关键词： thermal mass hybrid walling systems energy efﬁciency sustainable building

Ocular stem cells:a narrative review of current clinical trials

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International Journal of Ophthalmology(English edition) 2022年第9期15卷 1529-1537页

作者： Konstadinos Sotiropulos Dimitrios Kourkoutas Diamantis Almaliotis katherine Ploumidou Vasileios Karampatakis Department of Ophthalmology 417 Army Shared Fund HospitalAthens 11521Greece Department of Ophthalmology 401 Army General Hospital of AthensAthens 11525Greece Laboratory of Experimental Ophthalmology School of MedicineAristotle University of ThessalonikiThessaloniki 54124Greece Department of Otolaryngology Children’s Hospital“Aglaia Kyriakou”Athens 11527Greece

·Stem cells are undifferentiated cells showcasing a remarkable capacity of self-replenishing and differentiating into mature *** ability to proliferate connotes that a designated stem cell source is capable of generating an unrestricted number of mature *** ever-increasing comprehension of position,activity,and function of ocular stem cells has led to rapid progress and incessant improvement of possible procedures and therapies.A narrative review was conducted to summarize the current evidence on clinical trials and respective literature,regarding current evolution in the field of ocular regenerative *** tried to ascertain the safety of experimental and clinical procedures,their effectiveness,and the ethical repercussion of their use.

关键词： stem cells cell-based therapies limbal stem cells h ESC-derived retinal pigment epithelium human induced pluripotent stem cells olfactory mucosa mesenchymal stem cells

Different paths to sexual size dimorphism in two praying mantids, Pseudomantis albofimbriata and Hierodula majuscula

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Insect Science 2014年第2期21卷 227-233页

作者： Louise E. Allen katherine L. Barry Gregory I. Holwell Department of Biological Sciences Macquarie University North Ryde NSW 2109 Australia School of Biological Sciences The University of Auckland Auckland New Zealand

Sexual size dimorphism （SSD） is widespread among diverse animal taxa and has attracted the attention of evolutionary biologists for over a century. SSD is likely to be adaptive and the result of divergent selection on different size optima for males and females, given their different roles in reproduction. The developmental trajectory leading to SSD may help us to understand how selection acts on male and female size. Here, we describe the growth and development of two Australian praying mantids, Pseudomantis albofimbriata and Hierodula majuscula including the number of moults, time to adulthood, size at each moult, and the degree of SSD. While both species exhibit the common pattern of female-biased SSD, the number of moults required for individuals to reach adulthood differed between males and females and between species. Despite their larger adult size, P. albofimbriata females require fewer moults and less time than males to reach adulthood, but are significantly larger than males from the second instar onwards. In contrast, H. majuscula males reached adulthood in fewer moults, and less time than females, however males and females did not differ in size until females went through their final moult into adulthood. H. majuscula also required more time and more moults to reach adulthood than 17. albofimbriata. We discuss these different developmental pathways in light of the existing knowledge of reproductive biology for each species. We also suggest that these differences may relate to the different phenologies that occur in strongly seasonal temperate environments compared with those in the tropics. This study provides evidence that SSD can result from two different patterns of growth and development in closely related species.

关键词： developmental trajectories Mantodea sexual size dimorphism

Cyanobacterial bloom dynamics in Lake Taihu

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Journal of Environmental Sciences 2015年第6期27卷 249-251页

作者： katherine Z. Fu Birget Moe Xing-Fang Li X. Chris Le Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and Pathology University of Alberta

Lake Taihu is the third largest freshwater lake in China and serves as an important drinking water source for the local populace;however,decades of excessive nutrient loading fueled by anthropogenic activities have resulted in hypertrophic conditions,promoting the annual formation of nuisance phytoplankton blooms（Chen et al.,2003;Duan et al.,2009）

关键词： Cyanobacteria Blue-green algae Microcystin Natural toxins Water quality Nutrients Nitrogen and phosphorus Carbon dioxide

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Working girls

Working girls

Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders

作者： Mullin katherine.

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Translational Neurodegeneration 2014年第1期3卷 180-203,179页

作者： Kristi M Anderson katherine E Olson katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley Department of Pharmacology and Experimental Neuroscience Center for Neurodegenerative DisordersThe University of Nebraska Medical CenterOmahaNE 68198USA Prothena Biosciences Inc.650 Gateway BoulevardSouth San FranciscoCA 94080USA

Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s *** the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective *** temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent ***,immune responses that affect neurodegeneration may occur within or outside the *** of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal *** destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T ***,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the *** responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific *** final result is altered glial and neuronal behaviors that influence the disease ***,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression.

关键词： Neurodegeneration Neuroprotection Migration MPTP MCAM Regulatory T cell Effector T cell,Neuroinflammation