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Acta Pharmaceutica Sinica B 2023年第1期13卷 68-81页

作者： Lili Sun Jie Zhang Changshan Niu Cassandra E.Deering-Rice Ronald W.Hughen John G.Lamb katherine Rose Kevin m.Chase marysol Almestica-Roberts markel Walter Eric W.Schmidt Alan R.Light Baldomero m.Olivera Christopher A.Reilly Department of Pharmacology and Toxicology Center for Human ToxicologyUniversity of UtahSalt Lake CityUT84112USA Department of Anesthesiology School of MedicineUniversity of UtahSalt Lake CityUT 84112USA Department of medicinal Chemistry University of UtahSalt Lake CityUT 84112USA School of Biological Sciences University of UtahSalt Lake CityUT 84112USA

Pain is often debilitating,and current treatments are neither universally efficacious nor without *** receptor potential(TRP)ion channels offer alternative targets for pain relief,but little is known about the regulation or identities of endogenous TRP ligands that affect inflammation and ***,transcriptomic and targeted lipidomic analysis of damaged tissue from the mouse spinal nerve ligation(SNL)-induced chronic pain model revealed a time-dependent increase in Cyp1b1 mRNA and a concurrent accumulation of 8,9-epoxyeicosatrienoic acid(EET)and 19,20-EpDPA post *** of 8,9-EET and 19,20-EpDPA by human/mouse CYP1B1 was confirmed in vitro,and 8,9-EET and 19,20-EpDPA selectively and dose-dependently sensitized and activated TRPA1 in overexpressing HEK-293 cells and Trpa1-expressing/AITC-responsive cultured mouse peptidergic dorsal root ganglia(DRG)***1 activation by 8,9-EET and 19,20-EpDPA was attenuated by the antagonist A967079,and mouse TRPA1 was more responsive to 8,9-EET and 19,20-EpDPA than human *** latter effect mapped to residues Y933,G939,and S921 of ***-plantar injection of 19,20-EpDPA induced acute mechanical,but not thermal hypersensitivity in mice,which was also blocked by ***,Cyp1b1-knockout mice displayed a reduced chronic pain phenotype following SNL *** data suggest that manipulation of the CYP1B1-oxylipin-TRPA1 axis might have therapeutic benefit.

关键词： CYPIB1 Spinal nerve ligation Epoxides TRPA1 Calcium imaging Hyperalgesia Chronic pain Inflammation

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后桥钢板激光-mIG复合焊接优化研究

汽车技术 2008年第1期 54-57页

作者：姚远 m．Wouters J．powell K．Nilsson A．Kaplan 中国第一汽车集团公司技术中心瑞典Lulea工业大学英国Laser Expertise有限公司

研究了两种后桥桥壳用低合金钢板在激光-mIG复合焊接中,接头形状、接头间隙及mIG参数变化(大、中、小mIG参数)对焊缝形状及焊缝喉厚的影响。研究结果表明,mIG参数应设置成大、中mIG参数水平,以保证在一定的接头间隙下有充足的焊接材料... 详细信息

研究了两种后桥桥壳用低合金钢板在激光-mIG复合焊接中,接头形状、接头间隙及mIG参数变化(大、中、小mIG参数)对焊缝形状及焊缝喉厚的影响。研究结果表明,mIG参数应设置成大、中mIG参数水平,以保证在一定的接头间隙下有充足的焊接材料填入间隙而形成部分焊透的焊缝,使焊缝喉厚满足焊接强度要求;过高的mIG输入能量和过多的焊料(丝)填入将导致焊缝横截面积增大,但对焊缝喉厚的影响不是很明显;当mIG参数设置成小mIG参数水平时,0.5 mm的接头间隙或切角面为3 mm×2 mm时,对获得较大的焊缝喉厚有利。

关键词：激光焊 mIG焊复合焊接钢板

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师范小业书墨西哥的民众学校全1册

师范小业书墨西哥的民众学校全1册

Evaluation of mast Cells in Dermal versus Subcutaneous Hemangiomas and Hemangiosarcomas in Dogs

1934年

作者： mrs.katherine m.Cook 缪维章译

来源：汇雅图书（南通市图书馆... 评论

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Open Journal of Veterinary medicine 2012年第2期2卷 60-65页

作者： katherine A. Barber Kim m. Newkirk Ann Reed Robert L. Donnell College of Veterinary medicine University of Tennessee Knoxville USA Department of Biomedical and Diagnostic Sciences College of Veterinary Medicine University of Tennessee Knoxville USA Research Computing Support Office of Information Technology University of Tennessee Knoxville USA

This study investigated the role of mast cells in canine cutaneous vascular tumors, and is the first such study to distinguish between tumors arising in the dermis versus the subcutis. mast cell numbers in canine cutaneous hemangiomas (HA) and hemangiosarcomas (HSA) were evaluated to identify a relationship between mast cells, tumor type (HA, HSA), histologic location (dermis, subcutis) and tumor recurrence. One hundred and sixty-seven biopsies from 148 dogs were evaluated. Using only one biopsy from each dog, mast cell counts (mCC) for each tumor (n = 148) were obtained by averaging the number of mast cells counted in ten 400× fields. A significant difference in mean mCC was found only between tumor types, with HA having more mast cells than HSA (4.2 ± 4.2 vs. 2.2 ± 2.6;p mean mCC existed between tumors that recurred and those that did not. There was no difference in recurrence rate between tumor type or histologic location. Our results indicate that benign HA contain more mast cells than malignant endothelial cell tumors, regardless of histologic location;whether this is a cause or effect relationship remains to be determined.

关键词： Canine Dermis Hemangioma Hemangiosarcoma mast Cell Skin Subcutaneous

Tissue distribution of perfluoroalkyl acids and health status in wild mozambique tilapia(Oreochromis mossambicus) from Loskop Dam, mpumalanga, South Africa

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Journal of Environmental Sciences 2017年第11期29卷 59-67页

作者： Jacqueline T.Bangma Jessica L.Reiner Hannes Botha Theresa m.Cantu marco A.Gouws matthew P.Guillette Jeremy P.Koelmel Wilmien J.Luus-powell Jan myburgh Olivia Rynders Joseph R.Sara Willem J.Smit John A.Bowden medical University of South Carolina Department of Obstetrics and Gynecology Charleston SC 29412 United States National Institute of Standards and Technology Chemical Sciences Division Hollings Marine Laboratory Charleston SC 29412 United States Department of Biodiuersity University of Limpopo Souenga South Africa Scientific Services Mpumalanga Tourism and Parks Agency Nelspruit 1200 South Africa Department of Science School of Natural Resource Management Nelson Mandela Metropolitan University George 6529 South Africa Uniuersity of Florida Department of Chemistry Gainesville FL 32611 United States Department of ParaclinieaI Sciences Faculty of Veterinary Science University of Pretoria Onderstepoort South Africa

This study examined concentrations of 15 perfluoroalkyl acids（PFAAs） in tissues from male mozambique tilapia（Oreochromis mossambicus） collected at Loskop Dam, mpumalanga,South Africa in 2014 and 2016. Nine of the 15 PFAAs were detected frequently and were included in statistical analysis and included two of the most commonly known PFAAs,perfluorooctanesulfonic acid（PFOS）（median, 41.6 ng/g） and perfluorooctanoic acid（PFOA）（median, 0.0825 ng/g）. Of the tissues measured, plasma（2016 and 2014 median, 22.2 ng/g）contained the highest PFAA burden followed by（in descending order）： liver（median,11.6 ng/g）, kidney（median, 9.04 ng/g）, spleen（median, 5.92 ng/g）, adipose（median, 2.54 ng/g）, and muscle（median, 1.11 ng/g）. Loskop Dam tilapia have been affected by an inflammatory disease of the adipose tissue known as pansteatitis, so this study also aimed to investigate relationships between PFAA tissue concentrations and incidence of pansteatitis or fish health status. Results revealed that healthy tilapia exhibited an overall higher（p-value 〈 0.05） PFAA burden than pansteatitis-affected tilapia across all *** analysis showed that organs previously noted in the literature to contain the highest PFAA concentrations, such as kidney, liver, and plasma, were the organs driving the difference in PFAA burden between the two tilapia groups. Care must be taken in the interpretations we draw from not only the results of our study, but also other PFAA measurements made on populations（human and wildlife alike） under differing health status.

关键词： Perfluoroalkyl acids Liquid chromatography mass spectrometry Pansteatitis Perfluorooctanesulfonic acid Tissue distribution

Design Optimization of a micro-Combustor for Lean, Premixed Fuel-Air mixtures

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Journal of Power and Energy Engineering 2016年第6期4卷 13-26页

作者： Leigh T. powell Ralph C. Aldredge Department of mechanical and Aerospace Engineering University of California-Davis Davis CA USA

Present technology has been shifting towards miniaturization of devices for energy production for portable electronics. micro-combustors, when incorporated into a micro-power generation system, create the energy desired in the form of hot gases to power such technology. This creates the need for a design optimization of the micro-combustor in terms of geometry, fuel choice, and material selection. A total of five micro-combustor geometries, three fuels, and three materials were computationally simulated in different configurations in order to determine the optimal micro-combustor design for highest efficiency. Inlet velocity, equivalence ratio, and wall heat transfer coefficient were varied in order to test a comprehensive range of micro-combustor parameters. All simulations completed for the optimization study used ANSYS Fluent v16.1 and post-processing of the data was done in CFD Post v16.1. It was found that for lean, premixed fuel-air mixtures (φ= 0.6 - 0.9) ethane (C2H6) provided the highest flame temperatures when ignited within the micro-combustor geometries. An aluminum oxide converging micro-combustor burning ethane and air at an equivalence ratio of 0.9, an inlet velocity of 0.5 m/s, and heat transfer coefficient of 5 W/m2-K was found to produce the highest combustor efficiency, making it the optimal choice for a micro-combustor design. It is proposed that this geometry be experimentally and computationally investigated further in order to determine if additional optimization can be achieved.

关键词： micro-Combustor Combustion Computational Fluid Dynamics Ethane Efficiency

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长春新碱对激素依赖型肾病综合征的治疗

中国当代儿科杂志 2005年第6期7卷 495-498页

作者：殷蕾 Harley Robert powell 周纬上海第二医科大学附属新华医院上海儿童医学中心儿内科上海200127 澳大利亚墨尔本皇家儿童医院肾脏科

目的目前对于激素依赖型肾病综合征的治疗仍较困难,我们回顾性地评价了长春新碱对用过环磷酰胺治疗后而仍有复发的激素依赖型肾病综合征患儿的治疗效果.方法14例口服过一个疗程以上环磷酰胺而仍有复发的激素依赖型肾病综合征患儿接受了... 详细信息

目的目前对于激素依赖型肾病综合征的治疗仍较困难,我们回顾性地评价了长春新碱对用过环磷酰胺治疗后而仍有复发的激素依赖型肾病综合征患儿的治疗效果.方法14例口服过一个疗程以上环磷酰胺而仍有复发的激素依赖型肾病综合征患儿接受了长春新碱治疗.长春新碱的用法为每周静脉注射1次,连用4周,然后每月1次,连用4月,每次剂量为1～1.5 mg/m2.结果13例完成了长春新碱的整个疗程.正处于肾病复发期的8例患儿,6例(75%)完全缓解,蛋白尿在用长春新碱治疗2～3剂后消失.在疗程结束后对处于肾病缓解状态的12例患儿随访,发现4例(33.3%)未再复发,持续保持缓解9～40月(中位数为13.5月);半年内的肾病复发次数由治疗前的1.67次降至0.67次(P＜0.05);8例再复发者,7例再次注射长春新碱(1 mg/m2)1～2剂后蛋白尿均消失.除用1.5 mg/m2剂量时腹痛较显著外患儿未出现其他明显副作用.结论长春新碱能诱导激素依赖型肾病综合征复发患儿的完全缓解,还有可能降低复发频率.对于再复发患儿,少数几次长春新碱的使用可能优于口服一个疗程的泼尼松龙或环孢素.

关键词：长春新碱激素依赖型肾病综合征治疗儿童

Delayed referral for liver transplant evaluation worsens outcomes in chronic liver disease patients requiring inpatient transplant evaluation

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World Journal of Transplantation 2023年第4期13卷 169-182页

作者： katherine m Cooper Alessandro Colletta Nicholas J Hathaway Diana Liu Daniella Gonzalez Arslan Talat Curtis Barry Anita Krishnarao Savant mehta Babak movahedi Paulo N martins Deepika Devuni Department of medicine UMass Chan Medical SchoolWorcesterMA 01605United States Department of medicine Division of GastroenterologyUMass Chan Medical SchoolWorcesterMA 01605United States Department of Surgery Transplant DivisionUMass Chan Medical SchoolWorcesterMA 01605United States

BACKGROUND Indications to refer patients with cirrhosis for liver transplant evaluation(LTE)include hepatic decompensation or a model for end stage liver disease(mELDNa)score≥*** studies have evaluated how delaying referral beyond these criteria affects patient *** To evaluate clinical characteristics of patients undergoing inpatient LTE and to assess the effects of delayed LTE on patient outcomes(death,transplantation).mETHODS This is a single center retrospective cohort study assessing all patients undergoing inpatient LTE(n=159)at a large quaternary care and liver transplant center between 10/23/2017-7/31/*** referral was defined as having prior indication(decompensation,mELD-Na≥15)for LTE without *** referral was defined as referrals made within 3 mo of having an indication based on practice *** regression and Cox Hazard Regression were used to evaluate the relationship between delayed referral and patient *** many patients who require expedited inpatient LTE had delayed *** regarding transplant candidacy were a leading cause of delayed ***,delayed referrals negatively affected overall patient outcome and an independent predictor of both death and not receiving a *** referral was associated with a 2.5 hazard risk of *** Beyond initial access to an liver transplant(LT)center,delaying LTE increases risk of death and reduces risk of LT in patients with chronic liver *** is substantial opportunity to increase the percentage of patients undergoing LTE when first clinically *** is crucial for providers to remain informed about the latest guidelines on liver transplant candidacy and the transplant referral process.

关键词： Liver transplantation Liver transplant evaluation Liver transplant referral Patient access Equity Patient outcomes

Designing extra-curricular dance programs: UK physical education and dance teachers’ perspectives

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Open Journal of Preventive medicine 2013年第1期3卷 111-117页

作者： Simon J. Sebire Jade mcNeill Laura Pool Anne m. Haase Jane powell Russell Jago Centre for Exercise Nutrition & Health Sciences School for Policy Studies University of Bristol Bristol UK Faculty of Health & Life Sciences University of the West of England Bristol UK

many girls do not engage in sufficient physical activity (PA). Dance is a popular form of PA among UKsecondary school-aged girls and extracurricular dance programs delivered by dance specialists may provide an alternative way to increase PA amongst girls aged 11 - 12. The purpose of this study was to explore the views of physical education and dance teachers on the structure, content and delivery of an extra-curricular dance-based PA intervention for adolescent girls. methods: Semi-structured qualitative interviews were conducted with eleven physical education teachers and eleven dance teachers, and were analyzed using thematic analysis. Results: Themes identified addressed key logistical and content/delivery-based factors to be considered when designing a dance-based PA intervention. Logistical factors included optimizing participant recruitment and aligning external providers with school behavior management policies. Content/delivery factors focused on teacher-student rapport, facilitating dance competence, and balancing teacher and student-led time. Conclusions: This formative study highlighted that an extra-curricular dance-based PA intervention would be welcomed inUK schools. A number of considerations central to the design and delivery of such a program were identified from key user groups which can be used to inform the development of school-based dance (and non-dance) interventions aimed at increasing PA amongst adolescent girls.

关键词： Physical Activity Intervention Intervention Design Qualitative Research