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Nutritiona. epigenetics educa.ion improves diet a.d a.titude of pa.ents of children with a.tism or a.tention deficit/hypera.tivity disorder

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World Journa. of Psychia.ry 2024年第1期14卷 159-178页

作者： Renee J Dufa.lt katherine m a.ler Da.id O Ca.penter Steven G Gilbert Ra.uel a.Crider College of Gra.ua.e Hea.th Studies A.T.Still UniversityKirksvilleMO 63501United States Depa.tment of Resea.ch Food Ingredient and Health Research InstituteNaalehuHI 96772United States Depa.tment of Hea.th Sciences University of New HavenWest HavenCT 06516United States Institute for Hea.th a.d the Environment School of Public HealthState University of New YorkAlbanyNY 12222United States Depa.tment of Resea.ch Institute of Neurotoxicology and Neurological DisordersSeattleWA 98105United States Depa.tment of Sta.istics Food Ingredient and Health Research InstituteNaalehuHI 96772United States

Ba.KGROUND Unhea.thy ma.erna. diet lea.s to hea.y meta. exposures from the consumption of ultra.processed foods tha. ma. impa.t gene beha.ior a.ross genera.ions,crea.ing conditions for the neurodevelopmenta. disorders known a. a.tism a.d a.tention deficit/hypera.tivity disorder(a.HD).Children with these disorders ha.e difficulty meta.olizing a.d excreting hea.y meta.s from their bloodstrea.,a.d the severity of their symptoms correla.es with the hea.y meta. levels mea.ured in their *** ma. pla. a.key role in helping pa.ents reduce their ultra.processed food a.d dieta.y hea.y meta. inta.e by providing a.cess to effective nutritiona. epigenetics *** To test the effica.y of nutritiona. epigenetics instruction in reducing pa.enta. ultra.processed food *** The study utilized a.semi-ra.domized test a.d control group pretest-posttest pilot study design with pa.ticipa.ts recruited from pa.ents ha.ing a.lea.ning-disa.led child with a.tism or ***-two pa.ents who met the inclusion criteria.were ra.domly selected to serve in the test(n=11)or control(n=11)*** test group pa.ticipa.ed in the six-week online nutritiona. epigenetics tutoria.,while the control group did *** effica.y of the nutritiona. epigenetics instruction wa. determined by mea.uring cha.ges in pa.ent diet a.d a.titude using da.a.derived from a. online diet survey a.ministered to the pa.ticipa.ts during the pre a.d post intervention *** inta.e scores were derived for both ultra.processed a.d whole/orga.ic *** sa.ple t-tests were conducted to determine a.y differences in mea. diet scores within ea.h *** There wa. a.significa.t difference in the diet scores of the test group between the pre-a.d post-intervention *** pa.ents in the test group significa.tly reduced their inta.e of ultra.processed foods with a.preintervention diet score of 70(mea.=5.385,SD=2.534)a.d a.post-intervention diet score of 113(mea.=8.692,SD=1.750)a.d the

关键词： Epigenomics Pa.entera. nutrition a.tism a.tention deficit/hypera.tivity disorder Ultra.processed foods Hea.y meta.s

Sa.copenic obesity in pa.ients a.a.ting liver tra.spla.t: Unique cha.lenges for nutritiona. recommenda.ions

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World Journa. of Tra.spla.ta.ion 2024年第2期14卷 40-47页

作者： Da.ya.m Herscovici katherine m Cooper a.essa.dro Colletta.michelle Rightmyer a.exa.dra.Shingina.La.ren D Feld Depa.tment of medicine UMass Chan Medical SchoolWorcesterMA 01655United States Division of Tra.spla.t Nutrition UMass Chan Medical SchoolWorcesterMA 01655United States Depa.tment of medicine Vanderbilt University Medical CenterNashvilleTN 37215United States Division of Ga.troenterology UMass Chan Medical SchoolWorcesterMA 01655United States

Sa.copenic obesity increa.es the risk of morta.ity in pa.ients with liver disea.e a.a.ting liver tra.spla.ta.ion a.d in the post-tra.spla.t *** recommenda.ions for individua.s with sa.copenia.differ from recommenda.ions for pa.ients with obesity or sa.copenic *** these nutrition guidelines ha.e been esta.lished in non-cirrhotic pa.ients,esta.lished guidelines for liver tra.spla.t ca.dida.es with sa.copenic obesity a.e *** this pa.er,we review existing litera.ure on sa.copenic obesity in pa.ients with chronic liver disea.e a.d a.dress opportunities to improve nutritiona. counseling in pa.ients a.a.ting liver tra.spla.ta.ion.

关键词： Nutrition Sa.copenia Sa.copenic obesity Liver tra.spla.t Cirrhosis Chronic liver disea.e Body composition myosta.in

COP28 ma.es It Officia.: Fossil Fuels Ca.se Clima.e Cha.ge

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Engineering 2024年第6期37卷 3-5页

作者： katherine Bourza. Senior Technology Writer

On November 30,2023,a.idst outra.e over its lea.ership’s ties to the oil a.d ga. industry[1],COP28—shortha.d for the 28th United Na.ions(UN)“Conference of the Pa.ties”Clima.e Cha.ge meeting—bega. in Duba.,United a.a. Emira.es(Ua.).However,by the end of the conference on December 12,its a.tendees ha. surprisingly rea.hed a.reement on a.ha.dful of steps to a.dress the cha.lenges posed by clima.e *** biggest surprise?Explicitly identifying fossil fuels a. the root ca.se of clima.e *** the first time in the summit’s 28-yea. history,delega.es representing nea.ly 200 countries a.knowledged the role of fossil fuels in driving clima.e *** a.reed to work on “tra.sitioning a.a. from fossil fuels in energy systems,in a.just,orderly,a.d equita.le ma.ner,a.celera.ing a.tion in this critica. deca.e,so a. to a.hieve net zero by 2050 in keeping with the science”[2].

关键词： representing driving steps

a.socia.ion of initia. a.sessment va.ia.les a.d morta.ity in severe pedia.ric tra.ma.ic bra.n injury

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World Journa. of Pedia.ric Surgery 2024年第2期7卷 125-133页

作者： katherine C Bergus Kelli N Pa.terson Lindsey a.ti Josh Bricker Ta.iku J Beyene La.ren N Schulz Da.a.m Schwa.tz Ra.a. K Tha.ka. Eric a.Sribnick Pedia.ric Surgery Nationwide Children's HospitalColumbusOhioUSA CenterforSurgica. Outcomes Resea.ch Nationwide Children's HospitalColumbusOhioUSA Neurologic Surgery The Ohio State UniversityColumbusOhioUSA Neurologic Surgery Nationwide Children's HospitalColumbusOhioUSA

Ba.kground Predictive sca.es ha.e been used to prognostica.e long-term outcomes of tra.ma.ic bra.n injury(TBI),but ga.s rema.n in predicting morta.ity using initia. tra.ma.resuscita.ion *** sought to eva.ua.e the a.socia.ion of clinica. va.ia.les collected during the initia. resuscita.ion of intuba.ed pedia.ric severe pa.ients with TBI with in-hospita. *** Intuba.ed pedia.ric tra.ma.pa.ientsa.s with severe TBI(Gla.gow coma.sca.e(GCS)score≤8)from Ja.ua.y 2011 to December 2020 were *** between initia. tra.ma.resuscita.ion va.ia.les(tempera.ure,pulse,mea. a.teria. blood pressure,GCS score,hemoglobin,interna.iona. norma.ized ra.io(INR),pla.elet count,oxygen sa.ura.ion,end tida. ca.bon dioxide,blood glucose a.d pupilla.y response)a.d morta.ity were eva.ua.ed with multiva.ia.le logistic *** a.ong 314 pa.ients,media. a.e wa. 5.5 yea.s(interqua.tile ra.ge(IQR):2.2-12.8),GCS score wa. 3(IQR:3-6),Hea. a.brevia.ed Injury Score(ha.S)wa. 4(IQR:3-5),a.d most ha. a.severe(25-49)Injury Severity Score(ISS)(48.7%,153/314).Overa.l morta.ity wa. 26.8%.GCS score,ha.S,ISS,INR,pla.elet count,a.d blood glucose were a.socia.ed with in-hospita. morta.ity(a.l pa. a.e a.d GCS score increa.ed,the odds of morta.ity *** 1-point increa.e in GCS score wa. a.socia.ed with a.35%decrea.e in odds of *** ha.S,INR,a.d blood glucose increa.ed,the odds of morta.ity *** ea.h 1.0 unit increa.e in INR,the odds of morta.ity increa.ed by 1427%.Conclusions Pedia.ric pa.ients with severe TBI a.e a. substa.tia. risk for in-hospita. *** a.e needed to exa.ine whether ea.lier interventions ta.geting specific pa.a.eters of INR a.d blood glucose impa.t morta.ity.

关键词： morta.ity pedia.ric tra.ma.ic

multiple myeloma.surviva. in New South Wa.es, a.stra.ia. by trea.ment era.to 2020

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Ca.cer Biology & medicine 2024年第8期21卷 703-711页

作者： Eleonora.Feletto Qingwei Luo a.na.Kelly ma.ia.ne Weber Da.id Goldsbury katherine Ba.ron Ka.en Ca.fell Xue Qin Yu The Da.fodil Centre The University of SydneyA Joint Venture with Cancer Council NSWSydney NSW 2006Australia

Objective: a.stra.ia.ha. rela.ively high multiple myeloma.mm) incidence a.d morta.ity ra.es. a.va.cements in mm trea.ment over recent deca.es ha.e driven improvements in mm surviva. in high-income countries;however, reporting in a.stra.ia.is limited. We investiga.ed tempora. trends in popula.ion-wide mm surviva. a.ross 3 periods of trea.ment a.va.cements in New South Wa.es(NSW), ***: Individua.s with a. mm dia.nosis in the NSW Ca.cer Registry between 1985 a.d 2015 with vita. follow-up to 2020, were ca.egorized into 3 previously defined trea.ment era. a.cording to their dia.nosis da.e(1985±1995, chemothera.y only;1996±2007, a.tologous stem cell tra.spla.ta.ion;a.d 2008±2015, novel a.ents including protea.ome inhibitors a.d immunomodula.ory drugs). Both rela.ive surviva. a.d ca.se-specific surviva. a.cording to Fine a.d Gra.'s competing risks cumula.ive incidence function were ca.cula.ed by trea.ment era.a.d a.e a. ***: Overa.l, 11,591 individua.s were included in the study, with a.media. a.e of 70 yea.s a. dia.nosis. Five-yea. rela.ive surviva. improved over the 36-yea.(1985±2020) study period(31.0% in 1985±1995;41.9% in 1996±2007;a.d 56.1% in 2008±2015). For individua.s dia.nosed before 70 yea.s of a.e, the 5-yea. rela.ive surviva. nea.ly doubled, from 36.5% in 1985±1995 to 68.5% in 2008±2015. Improvements for those > 70 yea.s of a.e were less pronounced between 1985±1995 a.d 1996±2007;however, significa.t improvements were observed for those dia.nosed in 2008±2015. Simila. overa.l a.d a.e-specific pa.terns were observed for ca.sespecific surviva.. a.ter a.justment for gender a.d a.e a. dia.nosis, trea.ment era.wa. strongly a.socia.ed with both rela.ive a.d ca.se-specific surviva.(P a. of individua.s with mm is improving in a.stra.ia.with trea.ment a.va.ces. However, older a.e groups continue to experience poor surviva. outcomes with only modest improvements over time. Given the increa.ing preva.ence of mm in

关键词： multiple myeloma ca.cer epidemiology surviva. a.a.ysis competing risk a.a.ysis a.stra.ia

Prima.y a.d Seconda.y micropla.tic a.d Na.opla.tic Regula.ions: Perspectives on Wa.er Industry Impa.ts

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Journa. of Environmenta. Protection 2024年第6期15卷 697-715页

作者： Shirin Esta.ba.a.i Giridha. Upa.hya.a.ma.tha.J. m. Wells katherine Y. Bell Brown a.d Ca.dwell New York NY USA Brown a.d Ca.dwell Irvine CA USA EnviroChem Services Cookeville TN USA Brown a.d Ca.dwell Nashville TN USA

Pla.tic pollution, both prima.y a.d seconda.y, is a. environmenta. cha.lenge, prompting regula.ory a.tions a. globa. a.d regiona. levels. With increa.ing resea.ch a.out the impa.ts of micro- a.d na.opla.tics on ecosystems a.d huma. hea.th, governments worldwide ha.e underta.en efforts to a.dress this issue. The globa. community ha. a.va.ced regula.ory efforts tha. ha.e led to the implementa.ion of na.iona. la.s or regula.ions in numerous countries. These mea.ures ba. or restrict the use of prima.y a.d seconda.y micropla.tics a.d na.opla.tics. a. overview of globa. a.d Europea. regula.ory fra.eworks is presented to provide context for the United Sta.es (US). In the endea.or to document pla.tics regula.ion development in the US, a.description of regula.ory a.encies a.d their roles in a.va.cing policy a.d rules a. well a. future direction a.d a.ea. for improvement in regula.ing pla.tics a.e introduced. a.discussion of wha. emerging regula.ions mea. to utilities a.d industries is a.so provided a.ong with a.compa.ison of regula.ory fra.eworks.

关键词： micropla.tic Regula.ion Environmenta. Governa.ce Pla.tic Pollution mitiga.ion Regula.ory Fra.ework

Weight ga.n a.ter 35 yea.s of a.e is a.socia.ed with increa.ed brea.t ca.cer risk: findings from a.la.ge prospective cohort study

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Ca.cer Biology & medicine 2024年第8期21卷 651-655页

作者： katherine De la.Torre Woo-Kyoung Shin Hwi-Won Lee Da. Hua.g Sukhong min a.sun Shin Wonshik Ha. Da.hee Ka.g Depa.tment of Preventive medicine Seoul National University College of MedicineSeoul 03080Republic of Korea Depa.tment of Biomedica. Sciences Seoul National University Graduate SchoolSeoul 03080Republic of Korea Division of Food a.d Pha.ma.eutica. Technology Mokwon UniversityDaejeon 35349Republic of Korea Integra.ed ma.or in Innova.ive medica. Science Seoul National University Graduate SchoolSeoul 03080Republic of Korea Ca.cer Resea.ch Institute Seoul National UniversitySeoul 03080Republic of Korea Depa.tment of Surgery Seoul National University College of MedicineSeoul 03080Republic of Korea Biomedica. Resea.ch Institute Seoul National University HospitalSeoul 03080Republicof Korea

a.iposity a.fects lifetime estrogen exposure,which is a.key fa.tor in brea.t ***,a.iposity effects,often a.sessed a. the body ma.s index(BmI),on pre-a.d post-menopa.sa. brea.t ca.cer risk a.e *** weight ga.n ma. reflect body fa. ma.s a.cumula.ion during a.ulthood better tha. the BmI,potentia.ly representing a.e-rela.ed meta.olic cha.ges.

关键词： brea.t ca.cer a.sessed

Cha.ging a.ea. with E-Buses: Benefits, Costs, a.d Tra.sition Roa.ma.

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Open Journa. of a.plied Sciences 2024年第9期14卷 2717-2748页

作者： a.ron Ya.g katherine Wa. a.gela.Fa.qi Jin Hora.e ma.n School Bronx NY USA

This pa.er rea.hes a.recommenda.ion for the 10-yea. e-bus tra.sition roa.ma. for New York City. The lifecycle model of emission reduction demonstra.es the ecologica. a.d fina.cia. impa.ts of a.complete tra.sition from the current diesel bus fleet to a. a.l-electric bus fleet in New York City by 2033. This study focuses on the NOx pollution, which is the highest a.ong a.l ma.or cities by Environmenta. Protection a.ency (EPa. a.d greenhouse ga.es (GHG) with a.nua. emissions of over five million tons. Our model predicts tha. switching to a. a.l-electric bus fleet will cut GHG emissions by over 390,000 tons a.d NOx emissions by over 1300 tons a.nua.ly, in a.dition to other polluta.ts such a. VOCs a.d Pm 2.5. yielding a. a.nua. economic benefit of over 75.94 million USD. This a.igns with the city ma.or office’s initia.ive of a.hieving tota. ca.bon neutra.ity. We further model a. optimized tra.sition roa.ma. tha. ba.a.ces ecologica. a.d long-term benefits a.a.nst the costs of the tra.sition, empha.izing fea.ibility a.d a.ignment with the na.ura. repla.ement cycle of existing buses, ensuring a.stea.y budgeting pa.tern to minimize interruptions a.d resista.ce. Fina.ly, we a.voca.e for colla.ora.ion between government a.encies, public tra.sporta.ion a.thorities, a.d priva.e sectors, including electric buses a.d cha.ging fa.ility ma.ufa.turers, which is essentia. for fostering innova.ion a.d reducing the costs a.socia.ed with the tra.sition to e-buses.

关键词： City Electric Bus Greenhouse Ga. Emission Reduction Economic a.a.ysis Optimiza.ion model Tota. Cost of Ownership

Crea.ion a.d va.ida.ion of a.novel low-cost dry la. for ea.ly resident tra.ning a.d a.sessment of robotic prosta.ectomy technica. proficiency

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Current Urology 2024年第2期18卷 133-138页

作者： Kevin Kunitsky a.hishek Venka.a.a.a.a.katherine E.Fero Jorge Ba.lon Ja.ob Komberg Robert Reiter Wa.ne Brisba.e Institute of Urologic Oncology Department of UrologyDavid Geffen School of MedicineUniversity of CaliforniaLos AngelesCAUSA Cha.les E.Schmidt College of medicine Florida Atlantic UniversityBoca RatonFLUSA

Purpose:To eva.ua.e the prelimina.y va.idity a.d a.cepta.ility of a.low-cost low-fidelity robotic surgery dry la. for tra.ning a.d a.sessing residents’technica. proficiency with key robotic ra.ica. prosta.ectomy *** a.d methods:Three sta.da.dized ina.ima.e ta.ks were crea.ed to simula.e the ra.ica. prosta.ectomy steps of posterior dissection,neurova.cula. bundle relea.e,a.d urethrovesica. *** tra.nees a.d fa.ulty a. a.single institution completed a.d eva.ua.ed ea.h dry la. *** va.idity wa. eva.ua.ed by compa.ing ta.k completion times a.d Globa. Eva.ua.ive a.sessment of Robotic Skills scores a.ross four pa.ticipa.t cohorts:medica. students(n=5),junior residents(n=5),senior residents(n=5),a.d a.tending surgeons(n=7).Content va.idity,fa.e va.idity,a.d a.cepta.ilitywere eva.ua.ed through a.postta.k survey using a.5-point Likert ***:There wa. a.significa.t difference in the individua. a.d composite ta.k completion times a.d Globa. Eva.ua.ive a.sessment of Robotic Skills scores a.ross a.l pa.ticipa.t cohorts(a.l pmodel wa. ra.ed fa.ora.ly in terms of its content va.idity a.d a.cepta.ility for use in residency ***,model rea.ism,compa.ed with huma. tissue,wa. poorly *** dry la. production cost wa. less tha. US$***:This low-cost procedure-specific dry la. demonstra.ed evidence of content va.idity,construct va.idity,a.d a.cepta.ility for simula.ing key robotic prosta.ectomy technica. steps a.d ca. be used to a.gment robot-a.sisted la.a.oscopic prosta.ectomy surgica. tra.ning.

关键词： Robotic surgery educa.ion Ra.ica. prosta.ectomy Simula.ion Dry la.ora.ory Va.ida.ion