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高效的细菌——Linde公司的工艺利用高效细菌辅助工业废水的清洁处理

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流程工业 2006年第12期 53-55页

作者： katharina Becker

化工和石化工厂的工业废水在排放到河流以前需要彻底清洁。Linde公司正利用氧气帮助繁殖废水处理系统中的细菌，更有效地用于科隆附近德国壳牌石油公司的废水清洁处理。采用这一工艺，不但有利于环保，而且还节约了大量资金。

关键词： Linde公司工业废水清洁处理细菌工艺废水处理系统壳牌石油公司石化工厂

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利用现代化终端设备实现物流过程的可视化

现代制造 2020年第23期 64-66页

作者： katharina Ruhland 不详

爱马仕公司正在为自己高度现代化的物流中心寻找一种多功能、面向未来的货场管理解决方案。Advantech公司1500台性能强大的Linux操作系统UTC 318触控一体机和Inconso公司货场管理系统inconsoYmS可以确保长时间工作的性能优势。

关键词： Linux操作系统管理解决方案终端设备物流过程物流中心爱马仕可视化触控一体机

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machine Learning to Detect Alzheimer’s Disease from Circulating Non-coding RNAs

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Genomics, Proteomics & Bioinformatics 2019年第4期17卷 430-440页

作者： Nicole Ludwig Tobias Fehlmann Fabian Kern manfred Gogol Walter maetzler Stephanie Deutscher Simone Gurlit Claudia Schulte Anna-katharina von Thaler Christian Deuschle Florian metzger Daniela Berg Ulrike Suenkel Verena Keller Christina Backes Hans-Peter Lenhof Eckart meese Andreas Keller Department of Human Genetics Saarland University66421 Homburg/SaarGermany Chair for Clinical Bioinformatics Saarland University66123 Saarbru¨ckenGermany Institut fur Gerontologie Universitat Heidelberg69047 HeidelbergGermany Department of Neurology Christian-Albrechts-University of Kiel24118 KielGermany Center for Neurology and Hertie Institute for Clinical Brain Research Department of NeurodegenerationUniversity of Tuebingen72074 TuebingenGermany German Center for Neurodegenerative Diseases(DZNE) 72076 TuebingenGermany Department of Anesthesiology and Intensive Care St.Franziskus Hospital Muenster48145 MuensterGermany Department of Psychiatry and Psychotherapy University Hospital Tuebingen72016 TuebingenGermany Department of medicine II Saarland University Medical Center66421 Homburg/SaarGermany Center for Bioinformatics Saarland Informatics Campus66123 SaarbruckenGermany

Blood-borne small non-coding(snc RNAs)are among the prominent candidates for blood-based diagnostic ***,high-throughput approaches are applied to discover biomarker *** have to be validated in larger cohorts and evaluated by adequate statistical learning ***,we published high-throughput sequencing based microRNA(miRNA)signatures in Alzheimer’s disease(AD)patients in the United States(US)and ***,we determined abundance levels of 21 known circulating miRNAs in 465 individuals encompassing AD patients and controls by *** computed models to assess the relation between miRNA expression and phenotypes,gender,age,or disease severity(mini-mental State Examination;mmSE).Of the 21 miRNAs,expression levels of 20 miRNAs were consistently de-regulated in the US and German cohorts.18 miRNAs were significantly correlated with neurodegeneration(Benjamini-Hochberg adjusted PmiR-532-5 p(BenjaminiHochberg adjusted P=4.8×10^-30).machine learning models reached an area under the curve(AUC)value of 87.6%in differentiating AD patients from ***,ten miRNAs were significantly correlated with mmSE,in particular miR-26a/26b-5p(adjusted P=0.0002).Interestingly,the miRNAs with lower abundance in AD were enriched in monocytes and T-helper cells,while those up-regulated in AD were enriched in serum,exosomes,cytotoxic t-cells,and *** study represents the next important step in translational research for a miRNA-based AD test.

关键词： miRNAs Neurodegeneration Alzheimer’s disease Biomarker Non-coding RNAs Gene regulation

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mood assessment via animated characters: An instrument to access and evaluate emotions in young children

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Open Journal of Psychiatry 2013年第1期3卷 149-157页

作者： katharina manassis Sandra mendlowitz Annie Dupuis David Kreindler Charles Lumsden Suneeta monga Carly Guberman Department of Psychiatry University of Toronto Toronto Canada

Objective: mood Assessment via Animated Characters (mAAC) is a novel, computer-based instrument to improve assessment and communication about feelings in young children with internalizing distress. Well-validated assessment instruments are lacking for those under age eight years. method: Children ages 4 - 10 years with primary diagnosis of anxiety disorder (n = 74;33 boys, 41 girls) or no diagnosis (n = 83;40 boys, 43 girls) completed mAAC for 16 feelings. Those 8 - 10 years also completed standardized measures of internalizing symptoms. Results: mAAC’s emotions clustered into positive, negative, fearful, and calm/neutral factors. Clinical children rated themselves less positive (difference score -3.18;p = 0.002) and less calm/neutral (difference score -2.06;p = 0.04), and explored fewer emotions spontaneously (difference score = -2.37;p = 0.02) than nonanxious controls. Older children’s responses correlated with scores on several standardized measures. Conclusions: mAAC appears to be highly engaging, with clinical utility in the assessment of young anxious children. Applications in other populations are considered for future study.

关键词： Anxiety Children Perception of Emotion Computer Animation Assessment

Proteomics reveals differential adsorption of angiogenic platelet lysate proteins on calcium phosphate bone substitute materials

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Regenerative Biomaterials 2022年第1期9卷 636-649页

作者： Richard da Costa marques Johanna Simon Cyril d’Arros katharina Landfester Kerstin Jurk Volker mailänder Dermatology Clinic University Medical Center of the Johannes Gutenberg-University Mainz55131 MainzGermany max Planck Institute for Polymer Research 55128 MainzGermany INSERm UMR 1229Regenerative Medicine and SkeletonONIRISUniversitéde Nantes44042 NantesFrance Biomatlante—Advanced medical Solutions Group Plc 44360 Vigneux-de-BretagneFrance Center for Thrombosis and Hemostasis(CTH) University Medical Center of the Johannes Gutenberg-University Mainz55131 MainzGermany

Protein adsorption on biomaterials for bone substitution,such as calcium phosphates(CaP),evokes biological responses and shapes the interactions of biomaterials with the surrounding biological *** adsorb when CaP materials are combined with growth factor-rich hemoderivatives prior to implantation to achieve enhanced angiogenesis and stimulate new bone ***,the identification of the adsorbed proteins and their angiogenic effect on bone homeostasis remain incompletely *** this study,we analyzed the adsorbed complex protein composition on CaP surfaces when using the hemoderivatives plasma,platelet lysate in plasma(PL),and washed platelet lysate proteins(wPL).We detected highly abundant,non-regenerative proteins and anti-angiogenic proteins adsorbed on CaP surfaces after incubation with PL and wPL by liquid chromatography and mass spectrometry(LC–mS)***,we measured a decreased amount of adsorbed pro-angiogenic growth *** formation assays with human umbilical endothelial cells demonstrated that the CaP surfaces only stimulate an angiogenic response when kept in the hemoderivative medium but not after washing with *** results highlight the necessity to correlate biomaterial surfaces with complex adsorbed protein compositions to tailor the biomaterial surface toward an enrichment of pro-angiogenic factors.

关键词： protein adsorption calcium phosphates proteomics angiogenesis platelet lysate

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选择艰难之路

科学新闻 2019年第1期 61-62页

作者： katharina Henke 周彧伯尔尼大学心理学研究所伯尔尼大学认知、学习和记忆中心

上世纪80年代,当我选择攻读心理学学士学位时,是责任而不是喜欢支撑着我度过了前几个学期。我对学习人类行为很感兴趣,但感到沮丧的是,我似乎对其缺乏强有力的机理解释。我不知道自己是否选择了正确的道路。然后,一天早上,当我听到当地... 详细信息

上世纪80年代,当我选择攻读心理学学士学位时,是责任而不是喜欢支撑着我度过了前几个学期。我对学习人类行为很感兴趣,但感到沮丧的是,我似乎对其缺乏强有力的机理解释。我不知道自己是否选择了正确的道路。然后,一天早上,当我听到当地一所医学院的老师作关于大脑和行为的讲座时,我豁然开朗。我意识到

关键词：神经心理学跨学科研究

农村到城中村的空间结构转变:——以广州的一个城中村和两个农村为例

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住区 2011年第5期 71-75页

作者： katharina Wiethoff 张培德国亚琛工业大学

当前城市化进程对大都市广州的城市形态有着如何的影响?基于空间对比研究,本文将介绍三个参照地区(两个农村和一个城中村)空间结构是如何发展的。通过对三个地区初步的形态学调查研究,将过去的15年划分为三个阶段,对其结构变化过程作为... 详细信息

当前城市化进程对大都市广州的城市形态有着如何的影响?基于空间对比研究,本文将介绍三个参照地区(两个农村和一个城中村)空间结构是如何发展的。通过对三个地区初步的形态学调查研究,将过去的15年划分为三个阶段,对其结构变化过程作为可参照性范本进行阐述。关于空间结构和公共空间发展的不同变化过程是本文的焦点。

关键词：空间结构自然村城中村城市格局城市形态公共空间

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子宫内膜异位症的诊断和管理：NICE指南概要

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英国医学杂志中文版 2018年第3期21卷 161-164页

作者： Laura Kuznetsov katharina Dworzynski melanie Davies Caroline Overton 李卫华朱磊 National Guideline Alliance Royal College of Obstetricians and Gynaecologists London NW1 4RG UK University College London Hospitals London UK St michael's University Hospital Bristol UK 首都医科大学附属北京朝阳医院妇产科

子宫内膜异位症是最常见的妇科疾病之一。生育年龄（15～49岁）妇女的发病率约为10％。子宫内膜异位症是英国第二位最常见的妇科疾病，仅次于子宫肌瘤。子宫内膜异位症是激素依赖性疾病，与月经周期相关。确切的发病原因不清，但普遍认... 详细信息

子宫内膜异位症是最常见的妇科疾病之一。生育年龄（15～49岁）妇女的发病率约为10％。子宫内膜异位症是英国第二位最常见的妇科疾病，仅次于子宫肌瘤。子宫内膜异位症是激素依赖性疾病，与月经周期相关。确切的发病原因不清，但普遍认为与经血逆流，促使子宫内膜细胞生长并定植于盆腔有关。

关键词：内膜增生摘要管理诊断子宫

Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation

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World Journal of Gastroenterology 2017年第29期23卷 5295-5303页

作者： Philipp Ellinger Jan Stindt Carola Droge katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan mayatepek Dieter Haussinger Ralf Kubitz Lutz Schmitt In-stitute of Biochemistry Hein-rich-Hein-e-Un-iversity Düsseldorf medical Faculty Departmen-t of Gastroen-terology Hepatology an-d In-fectious Diseases Hein-rich-Hein-e-Un-iversity Düsseldorf Departmen-t of Gen-eral Pediatrics Neon-atology an-d Pediatric Cardiology Medical Faculty Hein-rich-Hein-e-Un-iversity Düsseldorf Departmen-t of Paediatrics Un-iversity Hospital Schleswig Holstein- Departmen-t of Paediatrics Helios Clin-ic Departmen-t of Gen-eral Surgery Hein-rich-Hein-e-Un-iversity

To investigate the relation of two different mutations to the outcome of partial external biliary diversion (PEBD) in severe bile salt export pump (BSEP) deficiency. mETHODSmutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney (HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatography-tandem mass spectrometry. Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays. RESULTSA girl (at 2 mo) presented with pruritus, jaundice and elevated serum bile salts (BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919del and the nonsense mutation p.R1235X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy (age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives (ma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecu

关键词： Familial intrahepatic cholestasis type 2 Partial external biliary diversion Bile salt export pump ATP binding cassette transporter Intrahepatic cholestasis