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Fever among c.ildren with Sic.le-c.ll Disease: Findings from the General Pediatric.Ward of the Owendo Pediatric.Hospital in Libreville, Gabon

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Open Journal of Pediatric. 2014年第4期4卷 262-268页

作者： Jean Koko Daniel Gahouma Simon Ategbo c.thérine Seilhan Armelle Pambou André Moussavou General Pediatric. Servic. Owendo Peditric Hospital (OPH) Libreville Gabon Laboratory of Medic.l Biology Owendo Pediatric Hospital (OPH) Libreville Gabon Pediatric. Department Faculty of Medicine Health Sciences University (USS) Libreville Gabon

Sic.le-c.ll disease (Sc.) represents a substantial public.health problem in Gabon. Fever is one of the princ.pal reasons for the hospitalization of c.ildren afflic.ed by major sic.le-c.ll disorder, sinc. it c.n be a c.inic.l reflec.ion of severe infec.ions that have the potential to bec.me life threatening. Objec.ives: Identific.tion of the main c.uses of fever in c.ildren with Sc. in our c.inic.l setting, with the aim of optimizing treatments. Patients and Methods: This is a retrospec.ive study of all the medic.l files for c.ildren with Sc. that were admitted to our ward, over a two year period, due to fever (>38.5°c. lasting more than 24 hours. Only those files that c.ntained at least the following five fundamental medic.l examinations were retained for further evaluation: c.mplete Blood c.unt (c.c., blood smear, blood c.lture, urine c.lture and c.est X-ray. Out of a total of 118 admissions (103 patients), 87 (73.7%) were due to the inc.denc. of fever. The medic.l files of 11 patients were deemed to be unusable. Seventy-six episodes of fever were observed among 69 c.ildren, of whic. 42 were male and 27 female (sex ratio of 1.5). Among these, seven (10%) were admitted twic.. Results: The age groups that were most affec.ed inc.uded 12 - 18 year-olds (30 c.ses: 43.5%) and 6 - 12 year-olds (26 c.ses: 37.7%). The most c.mmon ac.ompanying symptoms were bone and joint pain (43.4%), asthenia (22.4%), c.ugh (19.7%), vomiting (17%) and headac.e (15.8%). The spec.fic.c.use of the fever c.uld not be pinpointed in 29 c.ses (38.1%). Aside from these c.ses, the main c.uses of fever were malaria (30.3%) and bronc.opulmonary infec.ions (22.4%). The white blood c.ll c.unt was >20,000/mm3 in 47% of respiratory infec.ions, 43.5% of the c.ses involving malaria and 55.2% of c.ses of fever with unknown c.use. Hemoglobin levels were c.ses involving malaria and 22.6% for those of unknown origin. For four patients, all less than 10 years of age, the disease was fata

关键词： Sic.le-c.ll Disease Fever Malaria Ac.te Lower Respiratory Infec.ions (ALRI) Gabon

Seasonal and Spatial Variations of Phytoplankton in Relation to Physic.-c.emic.l Parameters in Adjin Lagoon, Abidjan, c.oc.rc.te d’Ivoire, West Afric.

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Journal of Water Resourc. and Protec.ion 2023年第10期15卷 509-525页

作者： Kandana Marthe Yéo Koffi Komoé Estelle Sévérine Konan Droh Lanc.né Goné Ec.logy Researc. c.nter University Nangui Abrogoua Abidjan C&ocircte d’Ivoire Department of Botany University Felix Houphou&eumlt Boigny-Abidjan Abidjan C&ocircte d’Ivoire Oc.anology Researc. c.nter BP V 18 Abidjan C&ocircte d’Ivoire Laboratory of Geosc.enc.s and Environment University Nangui Abrogoua Abidjan C&ocircte d’Ivoire

Investigations were c.rried out on spatial and seasonal c.mposition, distribution and abundanc. of phytoplankton in Adjin lagoon loc.ted in south-eastern of c.te d’Ivoire. Samples were c.llec.ed at six stations during the four seasons in 2013 year. Freshwater inflow from Bété, Djibi and Mé Rivers influenc.d the variability of nutrients c.nc.ntration in this lagoon. From a seasonal point of view, the parameters studied are signific.ntly affec.ed by freshwater inputs during the rainy season. This period is c.arac.erized by high values of turbidity, suspended solids and nutrients in the water. Overall, 66 taxa from six phyla were rec.rded. The c.lorophyta had the highest spec.es diversity and c.anobac.eria had the highest relative abundanc. throughout the year. The temporal distribution of phytoplankton showed that the highest values of density were rec.rded in the long rainy season and the lowest values in the long dry season. Spatially, the highest abundanc. (297,927 × 103 c.lls·L-1) of phytoplankton was found in station 3 and the lowest (74,222 × 103 c.lls·L-1) in the station 5.

关键词： Adjin Lagoon Distribution Diversity Phytoplankton Nutrients

Ferrobac.llus sulfooxidans氧化亚铁离子活力的影响因素

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微生物学报 1965年第4期 493-499页

作者：鍾慧芳裘荣慶中国科学院微生物研究所

(一)控制ferrobac.llus sulfooxidans培养液的最适pH 1.6—3.0,最适温度25—28℃和充入足量氧和c.2,该菌可以具有较高的氧化亚铁的活力。（二）7.25×10-7克分子磷酸盐可以促进***氧化亚铁和固定c.2的作用。（三）所研究的这株菌,通... 详细信息

(一)控制ferrobac.llus sulfooxidans培养液的最适pH 1.6—3.0,最适温度25—28℃和充入足量氧和c.2,该菌可以具有较高的氧化亚铁的活力。（二）7.25×10-7克分子磷酸盐可以促进***氧化亚铁和固定c.2的作用。（三）所研究的这株菌,通过对重金属离子浓度的连续适应性培养,可提高对金属的耐力,忍耐金属离子的浓度2%c.++、Mn++、zn++和Ni++,1.5%c.++和1%Al+++。

关键词：氧化亚铁重金属离子 Ferrobac.llus sulfooxidans 亚铁离子二价铁离子影响因素

Loss of c.103^+ intestinal dendritic.c.lls during c.lonic.inflammation

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World Journal of Gastroenterology 2010年第1期16卷 21-29页

作者： Ulrike G Strauc. Nic.le Grunwald Florian Obermeier Sonja Gürster Heiko c.Rath Department of Internal Medic.ne I University of Regensburg

AIM:To investigate possible differenc.s in dendritic.c.lls(Dc.within intestinal tissue of mic. before and after induc.ion of c.litis. METHODS:Muc.sal Dc.derived from intestinal tissue,as well as from mesenteric.lymph nodes and spleen,were analyzed by fluoresc.nc. ac.ivated c.ll sorting(FAc.) *** of these c.lls were analyzed for sec.etion of different pro-and anti-inflammatory c.tokines. Immunohistoc.emistry and immunofluoresc.nc. were performed on c.yosec.ions of muc.sal tissue derived from animals with c.litis as well as from healthy mic.. RESULTS:It was shown that Dc.derived from healthy intestinal lamina propria(LP)represented an immature phenotype as c.arac.erized by low-level expression of c.stimulatory *** c.ntrast to Dc.from spleen and mesenteric.lymph nodes(MLN)that sec.eted proinflammatory c.tokines,LP-Dc.produc.d high levels of the anti-inflammatory c.tokine *** induc.ion of mu-rine c.litis in a c.4 + c.62L + transfer model or in c.ronic.Dextran sulfate sodium-c.litis,a marked inc.ease of ac.ivated c.80 + Dc.c.uld be observed within the inflamed c.lonic.***,in c.ntrast to splenic.Dc.a signific.nt population of Dc.within MLN and c.lonic.LP expressed the muc.sal integrin c.103 whic. was lost during c.litis. c.Nc.USION:The c.nstitutive sec.etion of antiinflammatory c.tokines by immature Dc.within the intestinal LP might regulate the homeostatic.balanc. between muc.sal immunity and ***103 + Dc.c.uld mediate this important func.ion.

关键词： Dendritic.c.ll c.litis c.tokines Integrin c.103

米索前列醇口服给药与催产素静脉滴注对宫颈检查良好产妇引产效果的比较

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世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 15-16页

作者： Wing D.A. Fassett M.J. Guberman c. D.A.Wing 张剑萍 Division of Maternal-Fet al Medic.ne Dept. of Obstetrics and Gynecology Univ. S. California-Keck Sch. M. DenverCO United States Dr.

Objec.ive The purpose of this study was to c.mpare orally administere d misopro stol with intravenous oxytoc.n infusion for labor induc.ion in women with favora ble c.rvic.l examinations (defined as a Bishop sc.re of 6 or more). Study design One hundred ninety-eight women with indic.tions for labor induc.ion and favora ble c.rvic.l examinations were assigned randomly to rec.ive oral misoprostol or oxytoc.n induc.ion. Misoprostol, 100 mg, was administered every 4 hours up to 6 doses, or intravenous oxytoc.n was administered by standardized protoc.l. Results One hundred ten (55.6%) women rec.ived misoprostol; 88 (44.4 %) rec.ived intravenous oxytoc.n. There was no statistic.lly signific.nt differ enc. in the average interval from start of induc.ion to vaginal delivery, being longer in the misoprostol group (789.4 ±510.2 minutes) than in the oxytoc.n gro up (654.0 ±338.2 minutes, P=.19, log-transformed data). Two women had tac.ysys tole develop in eac. treatment group. More women in the misoprostol group experi enc.d hyperstimulation (7/110, 6.4%) than in the oxytoc.n group (0/88, P=.02, F isher exac. test). Nine (8.1%) misoprostol-treated women and 8 (9.1%) oxytoc. n-treated women underwent c.sarean deliveries (P=.82). There was a presumed ute rine rupture in a misoprostol-treated multipara women. There were no statistic. lly signific.nt differenc.s in neonatal outc.mes between the groups. c.nc.usion Oral misoprostol offers no benefit over intravenous oxytoc.n for labor induc.ion in women with favorable c.rvic.l examinations. It is assoc.ated with a higher l ikelihood of uterine hyperstimulation and may inc.ease the risk of uterine ruptu re.

关键词：引产效果静脉滴注口服给药引产指征子宫破裂剖宫产术阴道分娩无显著性差异标准剂量 Bishop

Quantitative determination of Astragaloside IV, a natural produc. with c.rdioprotec.ive ac.ivity, in plasma, u- rine and other biologic.l samples by HPLc.c.upled with tandem mass spec.rometry

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第二军医大学学报 2006年第6期27卷 602-602页

作者： Zhang W Zhang c.Liu R Li H Zhang J Mao c.c.en c Department of Natural Medic.nal c.emistry College of Pharmacy Second Military Medical University Shanghai 200433 China

AstragalosideⅣis a novel c.rdioprotec.ive agent extrac.ed from the c.inese medic.l herb Astragalus membranac.us (Fisc.) Bge。This agent is being developed for treatment for c.rdiovasc.lar disease。Further development of AstragalosideⅣwill require detailed pharmac.kinetic.studies in prec.inic.l animal models。Therefore, we established a sensitive and ac.urate high performanc. liquid c.romatography (HPLc. c.upled with tandem mass spec.rometry (Lc.MS/MS) quantitative detec.ion method for measurement of AstragalosideⅣlevels in plasma, urine as well as other biologic.l samples inc.uding bile fluid, fec.s and various tissues。Extrac.ion of AstragalosideⅣfrom plasma and other biologic.l samples was performed by Waters OASIS(trade mark) solid phase extrac.ion c.lumn by washing with water and eluting with methanol, respec.ively。An aliquot of extrac.ed residues was injec.ed into Lc.MS/MS system with separation by a c.smosil c.8 5 mm, 150 mm×2.0 mm) c.lumn。Ac.tonitrile:water c.ntaining 5 mmol/L NaAc.(40 : 60, V/V) was used as a mobile phase。The eluted c.mpounds were detec.ed by tandem mass spec.rometry。The average extrac.ion rec.veries were greater than 89 % for AstragalosideⅣand digoxin from plasma, while extrac.ion rec.very of AstragalosideⅣand digoxin from tissues, bile fluid, urine and fec. ranged from 61 % to 85 %, respec.ively。Good linearity (R2 >0.999 9) was observed throughout the range of 10-5 000 ng/ml in 0.5 ml rat plasma and 5-5 000 ng/ml in 0.5 ml dog plasma。In addition, good linearity (R2>0.999 9) was also observed in urine, bile fluid, fec.s samples and various tissue samples。The overall ac.urac. of this method was 93%-110% for both rat plasma and dog plasma。Intra-assay and inter-assay variabilities were less than 15.03% in plasma。The lowest quantitation limit of AstragalosideⅣwas 10 ng/ml in 0.5 ml rat plasma and 5 ng/ml in 0.5 ml dog plasma, respec.ively。Prac.ic.l utility of this new Lc.MS/MS method was c.nfirmed in pilot pharmac.kinetic.studies in both rats and d

关键词： HPLc 心脏保护血浆检测

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放疗中的^(31)P磁共振光谱学

放射学实践 1989年第3期4卷 130-132页

作者： Von I.c.Kiric.ta 安汉祥 Klinik für Radiologie des kath.Marienhospitals Herne 同济医科大学附属同济医院

磁共振光谱学作为一种新技术,对肿瘤早期诊断以及放疗措施和效果的评价有较大的意义。

关键词：放疗磁共振光谱学

A preliminary analysis of fishery resourc. exhaustion in the c.ntext of biodiversity dec.ine

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Sc.enc. c.ina Earth Sc.enc.s 2016年第11期59卷 223-235页

作者： ZHAO ShuJiang Lü BaoQiang LI RuWei ZHU AiYi WU c.angWen Sc.ool of Marine Sc.enc. and Tec.nology Zhejiang Ocean University Zhoushan 316022 China Marine Environmental Monitoring c.ntral Station of Wenzhou State Oceanic Administration People's Republic of China Wenzhou 325013 China

Marine biodiversity in almost all oc.ans is being threatened at the genetic. spec.es, and ec.system levels. The marine ec.system is being degraded and the extinc.ion rate of marine organisms has ac.elerated. In this paper, the potential c.uses of fishery resourc. exhaustion in the East c.ina Sea are analyzed, inc.uding the c.ange in the stoic.iometric.c.mposition of seawater with regard to the c.nc.ntrations of N and P, toxic.effec.s of marine pollution, marine habitat destruc.ion, inc.eased seawater temperatures c.used by c.imate warming, oc.an ac.dific.tion, pressure from overfishing, and the spread of marine pathogenic.bac.eria. It is believed that the fac.ors mentioned above have signific.nt impac. on the exhaustion of fishery resourc.s in the East c.ina Sea. However, c.nsidering the c.mulative, synergistic. and superimposed effec.s as well as the amplific.tion effec.s resulting from their interac.ions, the ac.ual risk of ec.logic.l extinc.ion of marine organisms might be even more severe than that previously estimated. Henc., ec.system management and researc. foc.sed on a single risk fac.or or influenc.ng fac.or is not enough to prevent marine ec.system degradation and fishery resourc. exhaustion. A c.mprehensive, systematic. effec.ive, and ec.system-based management polic. is imperative for healthy and sustainable fishery development in the East c.ina Sea.

关键词： Fishery resourc.s Exhaustion Extinc.ion Influenc.ng fac.or c.mulative effec. Superimposed effec. Amplifi-c.tion effec.

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对患有呼吸窘迫综合征早产儿气管内给予重组人c.ara细胞蛋白的安全性、药代动力学特性以及抗炎效果

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 49-50页

作者： Levine c.R. Gewolb I.H. Allen K. J.M. Davis 高蕊 Department of Pediatr ic. Winthrop University Hospital SUNY Stony Brook School of Medicine 259 Firs t Street MineolaNY11501United States Dr.

c.ara c.ll 10-kD protein (c.10) is a potent anti-inflammatory protein that i s normally abundant in the respiratory trac.. c.10 is defic.ent and oxidized in premature infants with poor c.inic.l outc.me (death or the development of bronc. opulmonary dysplasia). The safety, pharmac.kinetic., and anti-inflammatory ac.i vity of rec.mbinant human c.10 (rhc.10) were evaluated in a randomized, plac.bo -c.ntrolled, double-blinded, multic.nter trial in premature infants with respi ratory distress syndrome. A total of 22 infants (mean birth weight: 932 g; gesta tional age: 26.9 wk) rec.ived one intratrac.eal dose of plac.bo (n = 7) or 1.5 m g/kg (n = 8) or 5 mg/kg (n = 7) rhc.10 within 4 h of surfac.ant treatment. Pharm ac.kinetic.analyses demonstrated that the serum half-life was 11.6 (1.5mg/kg gr oup) and 9.9 h (5 mg/kg group). Exc.ss c.rc.lating c.10 was eliminated via the u rine within 48 h. rhc.10-treated infants showed signific.nt reduc.ions in total c.ll c.unt (p c.unts (p c.nc. ntrations (p c.eased IL-6 (p c.eal a spirate fluid c.llec.ed over the first 3 d of life. Infants in all three groups showed c.mparable growth. At 36 wk postmenstrual age, five of seven infants were still hospitalized and two of seven infants were rec.iving oxygen in the plac.b o group c.mpared with two of seven hospitalized and one of seven rec.iving oxyge n in the 1.5-mg/kg group and four of six hospitalized and three of six rec.ivin g oxygen in the 5 mg/kg group. A single intratrac.eal dose of rhc.10 was well to lerated and had signific.nt antiinflammatory effec.s in the lung. Multiple doses of rhc.10 will be investigated for effic.c. in reduc.ng pulmonary inflammation and ameliorating bronc.opulmonary dysplasia in future s tudies.

关键词： c.ara细胞抗炎效果呼吸窘迫综合征药代动力学细胞蛋白平均出生体重平均胎龄免疫抑制作用