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Effect of glycemic control on markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus:A review

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World Journal of Diabetes 2021年第11期12卷 1856-1874页

作者： Sofia Antoniou katerina k k naka Marios Papadakis Aris Bechlioulis Agathocles Tsatsoulis Lampros k Michalis Stelios Tigas Department of Endocrinology University of IoanninaIoannina 45110Greece 2^(nd)Department of Cardiology and Michaelidion Cardiac Center University of IoanninaIoannina 45110Greece Department of SurgeryⅡ University of Witten-HerdeckeWuppertal 42283Germany

Cardiovascular disease is the predominant cause of death in type 2 diabetes mellitus(T2DM).Evidence suggests a strong association between duration and degree of hyperglycemia and vascular ***,large trials failed to show cardiovascular benefit after intensive glycemic control,especially in patients with longer diabetes *** is a chronic and progressive disease,with a long asymptomatic *** atherosclerosis,which is impaired in T2DM,includes impaired vasodilation,increased coronary artery calcification(CAC),carotid intima media thickness,arterial stiffness,and reduced arterial *** of these alterations is represented by a marker of subclinical atherosclerosis,offering a cost-effective alternative compared to classic cardiac *** additional use on top of traditional risk assessment strengthens the predictive risk for developing coronary artery disease(CAD).We,herein,review the existing literature on the effect of glycemic control on each of these markers *** glycemic control,especially in earlier stages of the disease,attenuates progression of structural markers like intima-media thickness and *** markers are improved after use of newer antidiabetic agents,such as incretin-based treatments or sodium-glucose cotransporter-2 inhibitors,especially in T2DM patients with shorter disease *** prospective trials are needed to enhance causal inferences of glycemic control on clinical endpoints of CAD.

关键词： Glycemic control Atherosclerosis Type 2 diabetes mellitus Cardiovascular disease Carotid intima media thickness

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Exercise-mediated adaptations in vascular function and structure:Beneficial effects in coronary artery disease

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World Journal of Cardiology 2021年第9期13卷 399-415页

作者： Xenofon M Sakellariou Michail I Papafaklis Eleni M Domouzoglou Christos S katsouras Lampros k Michalis katerina k naka Michailideion Cardiac Centre University of IoanninaIoannina 45100EpirusGreece 2nd Department of Cardiology University Hospital of IoanninaIoannina 45100EpirusGreece Department of Pediatrics University Hospital of IoanninaIoannina 45100EpirusGreece

Exercise exerts direct effects on the vasculature via the impact of hemodynamic forces on the endothelium,thereby leading to functional and structural adaptations that lower cardiovascular *** patterns of blood flow and endothelial shear stress during exercise lead to atheroprotective hemodynamic stimuli on the endothelium and contribute to adaptations in vascular function and *** structural adaptations observed in arterial lumen dimensions after prolonged exercise supplant the need for acute functional vasodilatation in case of an increase in endothelial shear stress due to repeated exercise *** contrast,wall thickness is affected by rather systemic factors,such as transmural pressure modulated during exercise by generalized changes in blood *** mechanisms have been proposed to explain the exercise-induced benefits in patients with coronary artery disease(CAD).They include decreased progression of coronary plaques in CAD,recruitment of collaterals,enhanced blood rheological properties,improvement of vascular smooth muscle cell and endothelial function,and coronary blood *** review describes how exercise via alterations in hemodynamic factors influences vascular function and structure which contributes to cardiovascular risk reduction,and highlights which mechanisms are involved in the positive effects of exercise on CAD.

关键词： Exercise Endothelium Flow-mediated dilation Endothelial shear stress Coronary artery disease Hemodynamics

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Role of interleukin-6 in Barrett's esophagus pathogenesis

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World Journal of Gastroenterology 2013年第15期19卷 2307-2312页

作者： katerina Dvorak Bohuslav Dvorak Department of Cellular and Moleculart Medicine The University of ArizonaTucsonAZ 85724United States Department of Pediatrics and Steele Children's Research Center The University of ArizonaTucsonAZ 85724United States

Barrett's esophagus (BE) is a metaplastic lesion of the distal esophagus arising as a consequence of chronic gastroesophageal reflux disease. Multiple studies show that BE is associated with increased risk of esophageal adenocarcinoma (EAC). Epidemiological studies and animal models demonstrate that chronic inflammation triggered by repeated exposure to refluxate predisposes to the development of BE and EAC. The chronic inflammation is associated with cytokine alterations. Interleukin 6 (IL-6) is a cytokine that stimulates cell proliferation and apoptosis resistance is frequently increased in different cancers. Importantly, IL-6 and transcriptional factor signal transducer and activator of transcription 3 (STAT3) that is activated by IL-6 are also increased in BE and EAC. This review critically appraises the role of IL-6/STAT3 pathway in progression of BE to EAC from the published evidence currently available.

关键词： Barrett’s esophagus Interleukin 6 Bile acids Inflammation Apoptosis

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Evaluation of the Properties of Si3N4/Si3N4 Joint Brazed Using a Filler Alloy Containing Pd

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Journal of Materials Science & Technology 2003年第Z1期19卷 187-188页

作者： M. naka Jie ZHANG Yu ZHOU Joining and Welding Research Institute Osaka University Ibaraki Osaka 567-0047 Japan School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China School of Materials Science and Engineering Harbin Institute of Technology Harbin 150001 China

Si3N4 ceramic was jointed to itself using a filler alloy of Cu76.5Pd8.5Ti15, and the mechanical properties of the jointwere measured and analyzed. By using a filler alloy of Cu76.5Pd8.5Ti15, the SisN4/SisN4 joints were obtained bybrazing at 1373～1473 k for 0.9～5.4 ks under a pressure of 2×10-3 MPa. The effect of brazing parameters on theshear strength of the joint was investigated. When the brazing temperature and holding time is 1423 k and 5.4 ksrespectively, the maximum shear strength of the Si3N4/Si3N4 joint is obtained to be 198 MPa.

关键词： Si3N4 ceramic, Active brazing, Ci-Pd-Ti filler alloy, Shear strength

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Bright trions in direct-bandgap silicon nanocrystals revealed by low-temperature single-nanocrystal spectroscopy

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Light(Science & Applications) 2015年第1期4卷 179-186页

作者： katerina kusova Ivan Pelant Jan Valenta Institute of Physics of the ASCR v.v.i.Cukrovarnicka 1016200 Prague 6Czech Republic Faculty of Mathematics and Physics Charles UniversityKe Karlovu 512116 Prague 2Czech Republic

Strain-engineered silicon nanocrystals(SiNCs)have recently been shown to possess direct ***,we report the observation of a rich structure in the single-nanocrystal photoluminescence spectra of strain-engineered direct-bandgap SiNCs in the temperature range of 9–300 *** relationship between individual types of spectra is discussed,and the numerical modeling of spectral diffusion of the experimentally acquired spectra reveals a common origin for most *** intrinsic spectral shape is shown to be a structure that contains three peaks,approximately 150 meV apart,each of which possesses a Si phonon *** spectral lines,reaching ≤ meV at 20 k,are *** observed temperature dependence of the spectral structure can be assigned to the radiative recombination of positively charged trions,in contrast to several previous reports linking a very similar shape to phonons in the surface capping *** result serves as strong additional support for the direct-bandgap nature of the investigated SiNCs.

关键词： direct bandgap low-temperature single-nanocrystal spectroscopy silicon nanocrystals trions

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Reversing multiple age-related pathologies by controlling the senescence-associated secretory phenotype of stem cells

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Neural Regeneration Research 2016年第11期11卷 1746-1747页

作者： Daisuke Hisamatsu Hayato naka-kaneda Laboratory for Stem Cell Competency RIKEN Center for Integrative Medical Sciences(IMS) Department of Physiology Keio University School of Medicine

Regenerative medicine by cell transplantation is a novel therapy for treating end-stage organ failure and tissue damage. Cell-based therapy based on the transplantation of neural stem/progenitor cells （NSPCs） represents an attractive strategy for the treatment of neurodegenerative diseases, but obtaining large numbers of these cells is difficult and their differentiation potential is strictly restricted in a spatiotemporally-regulated manner during central nervous system （CNS） development. Therefore, embryonic stem cells and induced pluripotent stem cells represent an attractive alternative for cell-transplantation therapy in regenerative medicine.

关键词： cell stem Reversing multiple age-related pathologies by controlling the senescence-associated secretory phenotype of stem cells MSCs SASP

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Investigating the coagulation of non-proteinaceous algal organic matter: Optimizing coagulation performance and identification of removal mechanisms

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Journal of Environmental Sciences 2019年第5期31卷 25-34页

作者： Jana Naceradska katerina Novotna Lenka Cermakova Tomas Cajthaml Martin Pivokonsky Institute of Hydrodynamics of the Czech Academy of Sciences Institute of Microbiology of the Czech Academy of Sciences

The removal of algal organic matter(AOM) is a growing concern for the water treatment industry worldwide. The current study investigates coagulation of non-proteinaceous AOM(AOM after protein separation), which has been minimally explored compared with proteinaceous fractions. Jar tests with either aluminum sulphate(alum) or polyaluminium chloride(PACl) were performed at doses of 0.2–3.0 mg Al per 1 mg of dissolved organic carbon in the p H range 3.0–10.5. Additionally, non-proteinaceous matter was characterized in terms of charge, molecular weight and carbohydrate content to assess the treatability of its different fractions. Results showed that only up to 25% of non-proteinaceous AOM can be removed by coagulation under optimized conditions. The optimal coagulation p H(6.6–8.0 for alum and 7.5–9.0 for PACl) and low surface charge of the removed fraction indicated that the prevailing coagulation mechanism was adsorption of non-proteinaceous matter onto aluminum hydroxide precipitates. The lowest residual Al concentrations were achieved in very narrow p H ranges, especially in the case of PACl. High-molecular weight saccharidelike organics were amenable to coagulation compared to low-molecular weight(k Da)substances. Their high content in non-proteinaceous matter(about 67%) was the reason for its low removal. Comparison with our previous studies implies that proteinaceous and nonproteinaceous matter is coagulated under different conditions due to the employment of diverse coagulation mechanisms. The study suggests that further research should focus on the removal of low-molecular weight AOM, reluctant to coagulate, with other treatment processes to minimize its detrimental effect on water safety.

关键词： Algal organic matter Chlorella vulgaris Coagulation Flocculation Non-proteinaceous matter Water treatment

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Impact of water scarcity on spruce and beech forests

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Journal of Forestry Research 2019年第3期30卷 899-909页

作者： Lenka krupkova katerina Havrankova Jan krejza Pavel Sedlak Michal V.Marek Global Change Research Institute Czech Academy of SciencesBelidla 986/4a60300 BrnoCzech Republic Institute of Atmospheric Physics Czech Academy of SciencesBocni II 140114131 PragueCzech Republic

One of the greatest threats posed by ongoing climate change may be regarded the drought caused by changes in precipitation distribution. The aim of presented study was to characterize reactions to dry conditions and conditions without drought stress on gross primary production (GPP) and net ecosystem production (NEP) of spruce and beech forests, as these two species dominate within the European continent. Daily courses of GPP and NEP of these two species were evaluated in relation to an expected decrease in CO2 uptake during dry days. The occurrence of CO2 uptake hysteresis in daily production was also investigated. Our study was performed at Bily kriz(spruce) and Stitna(beech) mountain forest sites during 2010–2012 period. We applied eddy covariance technique for the estimation of carbon fluxes, vapor pressure deficit and precipitation characteristics together with the SoilClim model for the determination of drought conditions, and the inverse of the Penman–Monteith equation to compute canopy conductance. Significant differences were found in response to reduced water supply for both species. Spruce reacts by closing its stomata before noon and maintaining a reduced photosynthetic activity for the rest of the day, while beech keeps its stomata open as long as possible and slightly reduces photosynthetic activity evenly throughout the entire day. In the spruce forest, we found substantial hysteresis in the light response curve of GPP. In the beech forest, the shape of this curve was different: evening values exceeded morning values.

关键词： Picea abies Fagus sylvatica Drought stress Hysteresis Eddy covariance

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Multi-chromatic silicon nanocrystals

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Light(Science & Applications) 2017年第1期6卷 721-728页

作者： Benjamin Bruhn Benjamin JM Brenny Sidoeri Dekker Ilker Doğan Peter Schall katerina Dohnalová Van der Waals-Zeeman Institute University of AmsterdamScience Park 904Amsterdam 1098 XHThe Netherlands Center for Nanophotonics AMOLFScience Park 104Amsterdam 1098 XGThe Netherlands Department of Applied Physics Eindhoven University of TechnologyP.O.Box 512Eindhoven 5600 MBThe Netherlands Dutch Institute for Fundamental Energy Research(DIFFER) P.O.Box 6336Eindhoven 5600 HHThe Netherlands

Silicon nanocrystals(SiNCs)have great potential to become environmental friendly alternatives to heavy-metal containing nanocrystals for applications including medical imaging,lighting and *** exhibit excellent photostability,non-toxicity and abundant resources,but their often reported inefficient and spectrally limited light emission seriously impair their *** we demonstrate a new method that converts SiNCs into an efficient and robust multi-chromatic ***~15 keV electron-beam irradiation of oxide-capped SiNCs,we introduce several types of color centers into the nanocrystal’s oxide shell with efficient blue,green and red emission bands,together yielding warm-white photoluminescence,even for a single *** centers are not native to the original system and we relate them to known defects in *** in the silica host,however,here the centers are efficiently optically *** further optimization and up-scaling of this method,e-beam irradiated SiNCs can be of great interest as white phosphors for applications such as LEDs.

关键词： cathodoluminscence color center electron beam multi-chromaticity silicon nanocrystals

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SIRT1-dependent modulation of methylation and acetylation of histone H3 on lysine 9(H3k9)in the zygotic pronuclei improves porcine embryo development

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Journal of Animal Science and Biotechnology 2018年第2期9卷 339-350页

作者： katerina Adamkova Young-Joo Yi Jaroslav Petr Tereza Zalmanova kristyna Hoskova Pavla Jelinkova Jiri Moravec Milena kralickova Miriam Sutovsky Peter Sutovsky Jan Nevoral Department of Veterinary Sciences Faculty of AgricultureFood and Natural ResourcesCzech University of Life Sciences Prague6-SuchdolPragueCzech Republic Division of Biotechnology SafetyEnvironment and Life Science InstituteCollege of Environmental and Bioresource SciencesChonbuk National UniversityIksan 54596South Korea Institute of Animal Science 10-UhrinevesPragueCzech Republic Proteomic Laboratory Biomedical Center of Faculty of Medicine in PilsenCharles UniversityPilsenCzech Republic Laboratory of Reproductive Medicine of Biomedical Center Charles UniversityPilsenCzech Republic Department of Histology and Embryology Faculty of Medicine in PilsenCharles UniversityPilsenCzech Republic Division of Animal Science University of MissouriColumbiaMOUSA Departments of Obstetrics Gynecology and Women’s HealthUniversity of MissouriColumbiaMOUSA

Background: The histone code is an established epigenetic regulator of early embryonic development in *** lysine residue k9 of histone H3(H3 k9) is a prime target of SIRT1, a member of NAD+-dependent histone deacetylase family of enzymes targeting both histone and non-histone substrates. At present, little is known about SIRT1-modulation of H3 k9 in zygotic pronuclei and its association with the success of preimplantation embryo development. Therefore, we evaluated the effect of SIRT1 activity on H3 k9 methylation and acetylation in porcine zygotes and the significance of H3 k9 modifications for early embryonic ***: Our results show that SIRT1 activators resveratrol and BML-278 increased H3 k9 methylation and suppressed H3 k9 acetylation in both the paternal and maternal pronucleus. Inversely, SIRT1 inhibitors nicotinamide and sirtinol suppressed methylation and increased acetylation of pronuclear H3 k9. Evaluation of early embryonic development confirmed positive effect of selective SIRT1 activation on blastocyst formation rate(5.2 ± 2.9% versus 32.9 ± 8.1% in vehicle control and BML-278 group, respectively; P ≤ 0.05). Stimulation of SIRT1 activity coincided with fluorometric signal intensity of ooplasmic ubiquitin ligase MDM2, a known substrate of SIRT1 and known limiting factor of epigenome ***: We conclude that SIRT1 modulates zygotic histone code, obviously through direct deacetylation and via non-histone targets resulting in increased H3 k9 me3. These changes in zygotes lead to more successful pre-implantation embryonic development and, indeed, the specific SIRT1 activation due to BML-278 is beneficial for in vitro embryo production and blastocyst achievement.

关键词： Embryonic development Epigenetics H3k9 methylation SIRT1 Sirtuin

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