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Evaluation of the Use of Ketamine for Acute Pain in the Emergency Department at a Tertiary Academic Medical Center

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Pharmacology & Pharmacy 2016年第1期7卷 19-24页

作者： Nahal Beik katelyn Sylvester Megan Rocchio Michael B. Stone Department of Pharmacy Brigham and Women’s Hospital Boston USA Department of Emergency Medicine Brigham and Women’s Hospital Boston USA

Introduction: At subdissociative doses of 0.1 - 0.5 mg/kg, ketamine provides effective analgesia when used alone or as an adjunct to opioid analgesics without causing cardiovascular or respiratory compromise. Ketamine is a beneficial analgesic agent in the emergency department (ED), particularly in patients with opioid-resistant pain or polytrauma patients who are hemodynamically unstable. Purpose: The purpose of this study was to evaluate current practice and describe clinical outcomes associated with the use of low-dose ketamine for acute pain in the ED. Methods: Adult patients receiving ketamine were retrospectively evaluated between March 1, 2012 and March 31, 2013. Patients were included if they were ordered for ketamine in the ED to treat acute pain. Outcomes included dose administered, cumulative doses, concurrent opioid administration, and any efficacy or adverse events documented after the administration of ketamine. Continuous variables are reported as mean (standard deviation [SD]) or median (interquartile range [IQR]). Results: A total of 46 patients were evaluated for inclusion. Of the 25 patients included, 38 doses of ketamine were documented. The mean age was 41 years old with 64% of the patients being female. The average initial ketamine dose was 0.12 ± 0.06 mg/kg and 8 (32%) patients received multiple doses of ketamine (1.5 ± 0.8 doses per patient). Ketamine was added to opioid therapy in 23 (92%) patients. Pain scores decreased post administration of ketamine from 10 (9 - 10) to 5 (4 - 7). Adequate pain relief was documented in 11 (44%) patients (felt comfortable going home);partial pain relief was noted in 5 (20%) patients;3 (12%) patients reported no pain relief;3 (12%) patients were able to have a procedure done, and efficacy was not documented in 3 (12%) patients. Anxiety and agitation were documented in 2 (8%) patients. No adverse outcomes were documented in 84% of patients. Conclusion: Administration of low-dose ketamine for acute pain in the

关键词： Ketamine Acute Pain Emergency Department

雷州英峰岭玄武岩中单斜辉石巨晶的地球化学和地幔交代作用

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岩石学报 2003年第4期19卷 637-649页

作者：于津海 O'reilly Y S 周新民南京大学地球科学系 National Key Center of GEMOC Department of Earth and Planetary SciencesMacquarie UniversityNorth Ryde NSW 2109 Australia

雷州半岛英峰岭火山岩中单斜辉石巨晶以低Mg#值(0.62～0.47)、贫重稀土(HREE)和富Al2O3、TiO2、Na2O和中稀土(MREE)为特征,并具有明显的成分变化.随着Mg#降低,单斜辉石的Al2O3(11.58～6.97%)、TiO2(2.28～1.06%)和HREE逐渐降低.这种变... 详细信息

雷州半岛英峰岭火山岩中单斜辉石巨晶以低Mg#值(0.62～0.47)、贫重稀土(HREE)和富Al2O3、TiO2、Na2O和中稀土(MREE)为特征,并具有明显的成分变化.随着Mg#降低,单斜辉石的Al2O3(11.58～6.97%)、TiO2(2.28～1.06%)和HREE逐渐降低.这种变化特征不同于世界上大多数辉石巨晶的变化规律.随着演化辉石巨晶的大多数不相容元素,如Nb、Sr、Zr、Hf和LREE-MREE逐渐增加.低的Mg#值和Ni、Co、Cr含量指示巨晶母岩浆是一种强烈演化的残余岩浆(Mg#=0.27～0.35).分离结晶模拟表明本研究最富镁的巨晶(Lz-54)的母岩浆很可能是由拉斑玄武质岩浆经70～80%以单斜辉石为主的结晶分异后形成.而本研究的其它辉石巨晶是该母岩浆在不同演化阶段(25～80%)分离结晶的产物.分离矿物中除了单斜辉石还包含了大量的石榴子石、斜长石和钛铁矿.温压计算表明英峰岭巨晶是高温岩浆在56～60km深的上地幔的结晶产物(T=1290℃～1130℃,P=1.73～1.83GPa),这一深度有利于石榴子石结晶.对比不同地区辉石巨晶的成分特征和形成条件,作者指出不同地区单斜辉石巨晶各种元素的不同变化规律主要受母岩浆成分和结晶条件控制.巨晶母岩浆在地幔结晶时对围岩橄榄岩进行了不同程度的交代作用.早期贫流体的岩浆对橄榄岩的交代作用较弱,只有Sr,La等强活动性元素被明显改变;晚期富流体(F,P,H2O)岩浆对橄榄岩的交代作用强烈,大多数元素被明显改变.因此,可以推断交代熔体中流体的含量是影响地幔橄榄岩交代作用的关键.

关键词：单斜辉石巨晶地球化学地慢交代作用雷州半岛

Trace element characteristics in the diopsides of peridotite xenoliths: a laser ablation-inductively coupled plasma-mass spectrometry study

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Chinese Science Bulletin 1998年第7期43卷 579-583页

作者： Shaohai Chen Xinghua Zhou S. Y. O’reilly W. L. Griffin Guohui Zhang M. Zhang Chinese Acad Sci Inst Geol Lab Lithosphere Tecton Evolut Beijing 100029 Peoples R China Macquarie Univ Sch Earth Sci GEMOC Sydney NSW 2109 Australia

Among the various xenoliths entrained by the Cenozoic Hannuoba basalts, peridotite is the most abundant one. The trace elements of the diopsides from the peridotite xenoliths were analysed by LA-ICP-MS. The overall depletion and some heterogeneity of the continental mantle beneath northern North China Craton were indicated by the characteristics of the trace elements. The ∑REE amount in diopside correlates with the Cr/(Cr+Al) ratio of diopside which is indicative of xenolith’s partial melting degree. As the peridotite hosts and pyroxenite veins show similar REE distribution patterns, the composite xenoliths are probably formed by mantle deformation, rather than by the late metasomatism of mantle fluids/melts.

关键词： LA-ICP-MS diopside trace elements.

华南晚古生代岩浆活动的新发现:岛弧还是陆内造山?

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科学通报 2012年第31期57卷 2964-2971页

作者：于津海刘潜胡修棉王勤 O'reilly Suzanne Y 南京大学地球科学与工程学院内生金属矿床成矿机制研究国家重点实验室南京210093 GEMOC ARC National Key Centre Department of Earth and Planetary SciencesMacquarie UniversitySydneyN.S.W.2109Australia

在福建省周宁县五凤楼村发现了一个形成于313±4Ma的片麻状花岗岩.该岩石具有高的K2O和Al2O3含量和低的SiO2和Na2O含量,其A/CNK比值高达1.22,指示其源区为经过化学风化的沉积岩,因此属于S型花岗岩.所含锆石为柱状自形形态,其U-Pb年龄变... 详细信息

在福建省周宁县五凤楼村发现了一个形成于313±4Ma的片麻状花岗岩.该岩石具有高的K2O和Al2O3含量和低的SiO2和Na2O含量,其A/CNK比值高达1.22,指示其源区为经过化学风化的沉积岩,因此属于S型花岗岩.所含锆石为柱状自形形态,其U-Pb年龄变化于326～301Ma(加权平均年龄为313±4Ma),具有负的?Hf(t)值(?8.35～?1.74)和1.43～1.84Ga的二阶段Hf模式年龄.这是首次在华南发现有确凿同位素年代学证据的晚石炭世S型花岗质岩浆活动.该S型花岗岩最可能形成于陆内造山阶段,源岩主要为古元古代晚期生长的地壳.结合前人对岩相古地理、古生代盆地性质、早二叠世火山作用以及晚古生代-早中生代沉积岩中碎屑锆石的U-Pb-Hf同位素资料,本文推断华夏东部可能曾经存在一个晚古生代造山带.从晚石炭世(340～310Ma)的挤压造山阶段演化到早二叠世(285～270Ma)的后造山或板内伸展阶段,华南东部经历了一个较为完整的晚古生代造山旋回,所形成的晚古生代岩浆岩是陆内造山作用的产物,而不是岛弧岩浆作用产物.

关键词： S型花岗岩锆石U-Pb年龄锆石Hf同位素晚古生代造山作用华南东部

Update of Meat Standards Australia and the cuts based grading scheme for beef and sheepmeat

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Journal of Integrative Agriculture 2018年第7期17卷 1641-1654页

作者： Sarah P.F.Bonny Rachel A.O'reilly David W.Pethick Graham E.Gardner Jean-Francois Hocquette Liselotte Pannier School of Veterinary and Life Sciences Murdoch UniversityMurdochWA 6150Australia Clermont Université INRAVetAgro SupUMR1213Recherches sur les HerbivoresSaint-Genes Champanelle F-63122France

Changing markets and evolving consumer demand present new challenges for the beef and sheep industries. In response, the industry has been investing in innovations to deliver new products and management systems to consumers. One such innovation is the Meat Standards Australia（MSA） system. This system is a Total Quality Management System, aimed at delivering an eating quality guarantee to consumers, and through this adding value to the entire supply chain. At present, it is well developed for beef and still evolving for sheepmeat. MSA has identified Critical Control Points（CCPs） in the production, pre-slaughter, processing and value-adding aspects of the supply chain that impact on consumer palatability through the large-scale taste testing of meat by untrained consumers. These CCPs are used as either（1） mandatory criteria determining eligibility for grading, and（2） inputs in a model predicting the palatability of individual combinations of muscle and different cooking methods. Through the prediction of palatability, MSA increases consumer satisfaction and is used to provide assurance for branded products and new marketing innovations in Australia and internationally. This has added significant value to the Australian beef industry, with several retail examples demonstrating consumer willingness to pay more for premium quality beef and sheepmeat products based on the MSA grading scores. This price differential at retail allows the value of the carcass to be calculated based on the eating quality as well as the volume produced, thereby delivering a financial reward for farmers producing high quality carcasses. The continuous quality scale of MSA allows producers to realise the financial gain of incremental improvements in quality, as well as the precise economic weights associated with traits such as marbling, ossification score, or breed. The use of MSA in this fashion has underpinned a new and innovative supply chain where the pricing is transparent and allows produ

关键词： eating quality consumer beef sheep Meat Standards Australia international cut

Writing a paper and getting it published Common mistakes and some practical tips

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Writing a paper and getting it published Common mistakes and...

The Language of Topology: A Turkish Case Study

2010中华医学会全国麻醉学术年会

作者： Charles reilly British Journal of Anaesthesia

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The Language of Topology: A Turkish Case Study

Ages, Trace Elements and Hf-Isotopic Compositions of Zircons from Claystones around the Permian-Triassic Boundary in the Zunyi Section, South China: Implications for Nature and Tectonic Setting of the Volcanism

2005国际一般拓扑学学术会议

作者： Ivan reilly Department of Mathematics The University of Auckland Private Bag 92019Auckland New Zealand

＜正＞ Topology has its own specialised language. Where did this come from? What are the differences in the language of topology when it is expressed in English, Spanish, Mandarin, Czech

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Journal of Earth Science 2015年第6期26卷 872-882页

作者： Qiuling Gao Zhong-Qiang Chen Ning Zhang William L.Griffin Wenchen Xia Guoqing Wang Tengfei Jiang Xuefei Xia Suzanne Y.O'reilly Exploration & Development Research Institute Zhongyuan Oilfield Company School of Earth Sciences China University of Geosciences Australian Research Council Centre of Excellence for Core to Crust Fluid Systems and GEMOC National Key Centre Department of Earth and Planetary Science Macquarie University State Key Laboratory of Biogeology and Environmental Geology China University of Geosciences Shandong Lunan Institute of Geo-Engineering Exploration Jianghan Oilfield Company

A growing body of evidence shows that volcanism near the Permian-Triassic boundary（PTB） may be crucial in triggering the Permian–Triassic（P–Tr） mass extinction. Thus, the ash beds near the PTB in South China may carry information on this event. Three volcanic ash layers, altered to clay, outcropped in the PTB beds in Zunyi Section, Guizhou Province, Southwest China. The U-Pb ages, trace elements, and Hf-isotope compositions of zircon grains from these three ash beds were analyzed using LA-ICPMS and LA-MC-ICPMS. The zircons are mainly magmatic in origin（241-279 Ma） except for two inherited/xenocrystic zircons（939 and 2 325 Ma）. The ages of these magmatic zircons indicate three episodes of magmatism which occurred around the MiddleLate Permian boundary（-261.5 Ma, MLPB）, the Wuchiapingian-Changhsingian boundary（-254.5 Ma, WCB）, and the PTB（-250.5 Ma）, respectively. The first two episodes of magmatism near the MLPB and WCB may be attributed to magmatic inheritance or re-deposition. All magmatic zircons share similar trace-element and Hf-isotope compositions. They have Y, Hf, Th and U contents and Nb/Ta ratios are typical of zircons from silicic calc-alkaline magmas. These zircons also exhibit enriched Hf-isotope compositions with _（εHf）（t） values of-11.4 to ＋0.2, which suggests that the three magmatic episodes involved melting of the continental crust. The more enriched Hf-isotope composition （_（εHf）（t）=-11.4--4.8） of Bed ZY13（-250.5 Ma） implies more input of ancient crustal material in the magma. Integration of the Hf-isotope and trace-element compositions of magmatic zircons suggest that these three episodes of magmatism may take place along the convergent continent margin in or near southwestern South China as a result of the closure of the Palaeo-Tethys Ocean.

关键词： Permian-Triassic boundary zircon trace elements Hf isotope silicic volcanism,convergent continental margin South China.

Grenvillian orogeny in the Southern Cathaysia Block:Constraints from U-Pb ages and Lu-Hf isotopes in zircon from metamorphic basement

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Chinese Science Bulletin 2008年第19期53卷 3037-3050页

作者： WANG LiJuan YU JinHai S.Y. O'reilly W.L. GRIFFIN SUN Tao WEI ZhenYang JIANG ShaoYong SHU LiangShu State Key Laboratory for Mineral Deposits Research Department of Earth Sciences Nanjing University Nanjing 210093 China GEMOC National Key Centre Department of Earth and Planetary Science Macquarie University Sydney NSW 2109 Australia

Metamorphic basement rocks in the Cathaysia Block are composed mainly of meta-sediments with different ages. New zircon U-Pb geochronological results from the meta-sedimentary rocks exposed in the Zengcheng and Hezi areas, southern Cathaysia Block, show that they consist dominantly of early Neoproterozoic (1.0―0.9 Ga) materials with minor Paleo- to Mesoproterozoic and late Neoproterozoic (0.8―0.6 Ga) components, suggesting that the detritus mostly come from a Grenvillian orogen. The youngest detrital zircon ages place a constraint on the deposition time of these sediments in Late Neoproterozoic. Zircon Hf isotopic compositions indicate that the Grenvillian zircons were derived from the reworking of Mesoproterozoic arc magmatic rocks and Paleoproterozoic continental crust, implying an arc-continent collisional setting. Single-peak age spectra and the presence of abundant euhedral Grenvillian zircons suggest that the sedimentary provenance is not far away from the sample location. Thus, the Grenvillian orogen probably preexisted along the southern margin of the Cathaysia Block, or very close to the south. Similarity in the ages of Grenvillian orogeny and the influence of the assembly of Gondwana in South China with India and East Antarctic are discussed, with suggestion that South China was more likely linked with the India-East Antarctica continents in Early Neoproterozoic rather than between western Laurentia and eastern Australia.

关键词：华夏古大陆格伦维尔期锆石同位素新元古代