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浮选动力学放大:实验室批次试验与试验厂生产对比

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国外金属矿选矿 1989年第2期26卷 35-40页

作者： M.bourassa 叶学龙

使用一台实验室的普通浮选机进行矿物浮选,提出了描述该过程动力学行为参数的校正方法。这种方法被用在Chessy(法国)的硫化铜-锌矿石的连续试验厂试验。测定了实验室和试验厂的参数,对其结果进行了比较。按比例放大因素为:平衡回收率、... 详细信息

使用一台实验室的普通浮选机进行矿物浮选,提出了描述该过程动力学行为参数的校正方法。这种方法被用在Chessy(法国)的硫化铜-锌矿石的连续试验厂试验。测定了实验室和试验厂的参数,对其结果进行了比较。按比例放大因素为:平衡回收率、疏水性矿物的一阶速率常数,在黄铜矿和闪锌矿浮选的粗选、扫选和精选作业中亲水性矿物的夹杂程度。按比例放大的主要参数是速率常数。容积的放大比值是30,速率常数减小为4.15。

关键词：铜锌硫化矿浮选动力学参数

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代谢综合征对冠心病患者长期死亡率的影响

世界核心医学期刊文摘（心脏病学分册） 2006年第4期2卷 12-14页

作者： Anil Nigam Martial G. bourassa Annik Fortier Marie-Claude Guertin Jean-Claude Tardif

代谢综合征包括了诸多冠心病(CHD)的危险因素,如肥胖、腹部脂肪沉积、糖代谢异常、脂质代谢异常和高血压.其中单个危险因素都可以增加心血管疾病的患病风险,代谢综合征本身可以增加无已知心血管疾病患者的心血管死亡率和全因死亡率.最... 详细信息

代谢综合征包括了诸多冠心病(CHD)的危险因素,如肥胖、腹部脂肪沉积、糖代谢异常、脂质代谢异常和高血压.其中单个危险因素都可以增加心血管疾病的患病风险,代谢综合征本身可以增加无已知心血管疾病患者的心血管死亡率和全因死亡率.最近公布的INTER-HEART研究结果显示,在传统的危险因素中,糖尿病、高血压和腹型肥胖共同导致了约50%的首次急性心肌梗死发病风险.但是,代谢综合征对已有CHD患者预后的影响尚未被充分研究.肥胖患者罹患急性心肌梗死时的年龄一般小于非肥胖患者,并且长期预后更差.另外,体重指数(BMI)升高已被证实是冠状动脉造影确诊CHD患者中急性冠状动脉综合征的危险因素.代谢综合征对稳定性CHD患者发生致死性和非致死性事件风险的影响尚不清楚.因此我们试图评估代谢综合征对可疑或已确诊CHD患者中、长期预后的影响,并确定代谢综合征中的某些异常因素是否对患者长期死亡风险具有比其他异常因素更明显的影响.

关键词：代谢综合征冠心病患者全因死亡率冠心病(CHD) 心血管疾病患者急性心肌梗死危险因素脂质代谢异常心血管死亡率腹型肥胖

An early proof-of-concept of cardiac resynchronization therapy

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World Journal of Cardiology 2011年第12期3卷 374-376页

作者： Martial G bourassa Paul Khairy Denis Roy Department of Medicine Montreal Heart Institute/Universitéde Montréal

Almost 50 years ago,we published detailed hemodynamic findings in a patient with heart failure and intermittent left bundle branch *** intraventricular conduction was consistently accompanied by an increased duration of left ventricular(LV)isometric contraction,a drop in systolic blood pressure,a rise in heart rate,and a drop in cardiac *** our knowledge,this observation provided the first ever evidence that delayed mechanical LV contraction was associated with deterioration,and return to a normal pre-ejection phase with improvement in LV function.

关键词： Intermittent left bundle branch bock Heart failure Left ventricular dyssynchrony Systolic blood pressure Cardiac output

代谢综合征及其各组成部分与冠心病患者远期死亡风险

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世界核心医学期刊文摘（心脏病学分册） 2006年第6期2卷 25-26页

作者： Nigam A. bourassa M.G. Fortier A. J.- C. Tardif 田雨灵 Montreal Heart Institute 5000 Belanger Street East Montreal Que. H1T 1C8 Canada Dr.

Background: The metabolic syndrome confers an increased risk of major cardiovascular events in individuals initially free from coronary heart disease(CHD). Presently, approximately 25% of the US population possesses the metabolic syndrome as defined using the National Cholesterol Education Program(NCEP) criteria. We sought to assess the impact of the metabolic syndrome and its individual components on intermediate- term and long- term outcomes in patients with CHD. Methods: The CASS registry represents a database of 24 958 patients with suspected or proven CHD who underwent cardiac catheterization between 1974 and 1979. Mean long- term follow- up was 12.6± 5.1 years. Metabolic syndrome was defined using modified definitions of the NCEP and World Health Organization(WHO) because high- density lipoprotein cholesterol measures were not available. Results: We identified 3279 and 1080 patients with metabolic syndrome using our modified NCEP and WHO definitions, respectively. Adjusted long- term all- cause death was higher in patients with metabolic syndrome(hazard ratio [HR] 1.21, 95% CI 1.14- 1.29; HR 1.56, 95% CI 1.43- 1.70 for NCEP and WHO criteria, respectively). Similarly, long- term adjusted risk of cardiovascular death and intermediate- term risk of morbidity and mortality were higher in patients with the metabolic syndrome. Fasting blood glucose ≥ 110 mg/dL was responsible for most of the increased risk associated with the metabolic syndrome(adjusted HR 1.47, 95% CI 1.39- 1.56). Conclusions: The metabolic syndrome confers a higher risk of long- term death in patients with preexisting CHD, and dysglycemia appears to be responsible for most of the associated risk.

关键词：冠心病患者代谢综合征死亡风险冠心病(CHD) 美国国家胆固醇教育计划组成高密度脂蛋白胆固醇心血管事件世界卫生组织 NCEP

疑似或已确诊为冠状动脉疾病的患者其静息心率的长期预后预测价值

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世界核心医学期刊文摘（心脏病学分册） 2005年第10期1卷 42-43页

作者： Diaz A. bourassa M. G. Guertin M.- C. Tardif J. - C. 滕增辉 Department of Medicine Research Center Montreal Heart Institute 5000 Belanger Street E Montreal Que. H1T 1C8 Canada

Heart rate reduction is the cornerstone of the treatment of angina. The purpose of this study was to explore the prognostic value of heart rate in patients with stable coronary artery disease(CAD). Methods and results: We assessed the relationship between resting heart rate at baseline and cardiovascular mortality/ morbidity, while adjusting for risk factors. A total of 24 913 patients with suspected or proven CAD from the Coronary Artery Surgery Study registry were studied for a median followup of 14.7 years. All-cause and cardiovascular mortality and cardiovascular rehospitalizations were increased with increasing heart rate(P< 0.0001). Patients with resting heart rate ≥ 83 bpm at baseline had a significantly higher risk for total mortality[hazard ratio(HR)=1.32, CI 1.19- 1.47, P< 0.0001]- and cardiovascular mortality(HR=1.31, CI 1.15- 1.48, P< 0.0001) after adjustment for multiple clinical variables when compared with the reference group. When comparing patients with heart rates between 77- 82 and ≥ 83 bpm with patients with a heart rate ≤ 62 bpm, the HR values for time to first cardiovascular rehospitalization were 1.11 and 1.14, respectively(P< 0.001 for both). Conclusion: Resting heart rate is a simple measurement with prognostic implications. High resting heart rate is a predictor for total and cardiovascular mortality independent of other risk factors in patients with CAD.

关键词：静息心率预后预测基线水平全因死亡率再住院率中位随访期总死亡率间隔时间