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Tunneling nanotubes and actin cytoskeleton dynamics in glaucoma

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Neural Regeneration Research 2020年第11期15卷 2031-2032页

作者： kate e.Keller Department of Ophthalmology Department of Chemical Physiology and BiochemistryOregon Health&Science UniversityPortlandORUSA

Glaucoma and the actin cytoskeleton:Glaucoma is an optic neuropathy,with pathophysiological changes affecting anterior and posterior tissues of the *** trabecular meshwork(TM)in the anterior segment regulates intraocular pressure(IOP),while photoreceptors in the posterior retina convert light into signals that retinal ganglion cells(RGC)transmit to the *** TM is a small,fenestrated tissue located in the anterior chamber angle,between the iris and cornea(Figure 1A1).In humans,the majority of aqueous humor fluid drains through the TM into Schlemm’s *** the outflow channels become blocked,as in glaucoma,IOP starts to increase,pushing the lens and vitreous back onto the optic ***-induced damage to the optic nerve head causes a progressive loss of RGCs and their axons,which leads to irreversible *** or pharmacological management of IOP prevents RGC damage in glaucoma *** pharmacological therapies either reduce production of aqueous humor fluid,or increase aqueous drainage via the TM or the uveoscleral outflow ***,a new class of glaucoma therapies targeting the actin cytoskeleton were approved by the Food and Drug *** are known as the Rho kinase inhibitors,and they act on the Rho/Rho-associated protein kinase signaling pathway to disassemble actin stress fibers in TM and Schlemm’s canal cells(Rao et al.,2017;Lin et al.,2018).While the molecular details are only partially understood,perturbing the actomyosin system can alter cell shape,volume,contractility,and adhesion of cells to extracellular matrix(Tian et al.,2009),which in turn allows greater aqueous outflow and a reduction in *** addition to forming stress fibers,filamentous actin assembles into actin bundles,which are a major component of filopodia,long finger-like projections that emanate from the cell surface,as well as the related cellular protrusions known as tunneling nanotubes(TNTs).

关键词： glaucoma fibers Figure

Variability of cell proliferation in the proximal and distal colon of normal rats and rats with dimethylhydrazine induced carcinogenesis

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World Journal of Gastroenterology 2002年第5期8卷 847-852页

作者： kate e Williamson Brian J Rowlands Department of Surgery Institute of Clinical ScienceThe Queen's University of BelfastBelfastUK

AIM：To investigate the patterns of cell proliferation in proximal and distal colons in normal rats and rats with1,2-dimethylhydrazine(DMH)induced carcinogenesis using the thymidine analogue ***:Colonic crypt cell proliferation was immunohistochemically detected using the anti-bromodeoxyuridine Bu20a monoclonal ***:Marked regional differences were found in both *** labelling index(LI)and proliferative zone size in both normal(8.65±0.34vs7.2±0.45,27.74±1.07vs16.75±1.45)andDMH groups(13.13±0.46vs11.55±0.45,39.60±1.32vs35.52±1.58)were significantly higher in distal than in proximal colon(Pe number of cells per proxmal crypt was greater(31.45±0.20vs34.45±0.39,42.68±0.53vs49.09±0.65,Pength,total LT and proliferative zone size all increased in both proximal and distal regions of DMH rats compared to normal controls(Peated rat colon a shift of labelled cells to higher crypt cell positions was demonstrated distally whist a bi-directional shift was evident proximally(Pesults show that changes in cell proliferation patterns,as assessed by bromodeoxyuridine uptake,can act as a reliable intermediate marker of colonic cancer *** differences between proliferation patterns in distal and proximal colon may be associated with the higher incidence of tumors in t he distal colon.

关键词：溴脱氧尿嘧啶二甲肼细胞增殖致癌机制动物实验

Burn injury prevention in low-and middleincome countries:scoping systematic review

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Burns & Trauma 2021年第1期9卷 123-144页

作者： kate Price Kwang Chear lee Katherine e.Woolley Henry Falk Michael Peck Richard Lilford Naiem Moiemen College of Medical and Dental Sciences University of BirminghamEdgbastonBirminghamB152TTUK University Hospital Birmingham NHS Foundation Trust Queen Elizabeth Hospital BirminghamMindelsohn WayEdgbastonBirminghamB152WBUK Institute of Applied Health Research University of BirminghamEdgbastonBirminghamB152TTUK Adjunct Professor of environmental Health Emory UniversityRollins School of Public HealthAtlantaGA 30322US Clinical Professor of Surgery University of Arizona College of MedicinePhoenixAZ 85004US

Background:Burn injuries are a leading cause of morbidity and disability,with the burden of disease being disproportionately higher in low-and middle-income countries(LMIC).Burn prevention programmes have led to significant reductions in the incidence of burns in high-income ***,a previous systematic review published in 2015 highlighted that implementation and evaluation of similar programmes has been limited in *** objective of this scoping review and narrative synthesis was to summarise and understand the initiatives that have been carried out to reduce burn injuries in LMIC and their ***:We aimed to identify publications that described studies of effectiveness of burn prevention interventions applied to any population within a LMIC and measured burn incidence or burns-related *** publications were identified from three ***,data was extracted from manuscripts identified in the systematic review published by Rybarczyk et *** then performed a search for manuscripts on burn prevention interventions published between January 2015 and September ***,we extracted data from two systematic reviews where burn evidence was not the primary outcome,which were identified by senior authors.A quality assessment and narrative synthesis of included manuscripts were ***:In total,24 manuscripts were identified and categorized according to intervention *** majority of manuscripts(n=16)described education-based *** manuscripts focused on environmental modification interventions and four adopted a mixedmethods *** of the education-based initiatives demonstrated improvements in knowledge relating to burn safety or first aid,however few measured the impact of their intervention on burn *** manuscripts described population-based educational interventions and noted reductions in burn *** one of the four manuscripts describing environmental modification i

关键词： Burns Prevention Low-and-middle income countries Systematic review

*** Part Ⅰ:A Gridded Wet Bulb Temperature extremes Index Product for Climate Monitoring

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Advances in Atmospheric Sciences 2023年第11期40卷 1952-1967页

作者： kate M.WILLeTT Met Office Hadley Centre FitzRoy RoadExeterEX13PBU.K.

*** is an annually updated global gridded monthly monitoring product of wet and dry bulb temperature–based extremes indices,from January 1973 to December *** quality,including spatial and temporal stability,is a key *** hourly data are quality *** is assessed on monthly means and used to score each gridbox according to its homogeneity rather than to apply *** enables user-specific screening for temporal stability and avoids errors from inferring adjustments from monthly means for the daily maximum *** general use,a score(HQ Flag)of 0 to 6 is recommended.A range of indices are presented,aligning with existing standardised ***,provision of both wet and dry bulb indices allows exploration of heat event character—whether it is a“humid and hot”,“dry and hot”or“humid and warm”*** is designed for analysis of long-term trends in regional *** can be used to study local events,but given the greater vulnerability to errors of maximum compared to mean values,cross-validation with independent information is advised.

关键词： wet bulb temperature heat extremes climate monitoring

*** Part Ⅱ:exploring Humid Heat extremes Using Wet Bulb Temperature Indices

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Advances in Atmospheric Sciences 2023年第11期40卷 1968-1985页

作者： kate M.WILLeTT Met Office Hadley Centre FitzRoy RoadExeterEX13PBU.K.

Heat events may be humid or *** several indices incorporate humidity,such combined indices obscure identification and exploration of heat events by their different humidity *** new *** global gridded monitoring product uniquely provides a range of wet and dry bulb temperature extremes *** of this new data product demonstrates its value as a tool for quantifying exposure to humid verses dry heat *** also enables exploration into“stealth heat events”,where humidity is high,perhaps enough to affect productivity and health,while temperature remains *** events may not typically be identified as“heat events”by temperature-focused heat *** 1973-2022,the peak magnitude of humid extremes(maximum daily wet bulb temperature over a month;T_(w)X)for the global annual mean increased significantly at 0.13±0.04℃(10 yr)^(−1),which is slightly slower than the global annual mean T_(w) increase of 0.22±0.04℃(10 yr)^(−1).The frequency of moderate humid extreme events per year(90th per-centile daily maxima wet bulb temperature exceedance;T_(w)X90p)also increased significantly at 4.61±1.07 d yr^(−1)(10 yr)^(−1).These rates were slower than for temperature extremes,TX and TX90p,which respectively increased significantly at 0.27±0.04℃(10 yr)^(−1) and 5.53±0.72 d yr^(−1)(10 yr)^(−1).Similarly,for the UK/europe focus region,JJA-mean T_(w)X increased significantly,again at a slower rate than for TX and mean T_(w).*** shows some evidence of“stealth heat events”occurring where humidity is high but temperature remains more moderate.

关键词： wet bulb temperature heat extremes climate monitoring

Hwabyung experiences Among Korean Immigrant Women in the United States

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Fudan Journal of the Humanities and Social Sciences 2016年第2期9卷 325-349页

作者： Jonghyun lee Anna Martin-Jearld kate Robinson Susan Price School of Social Work Bridgewater State University 95 Burrill Avenue BridgewaterMA 02324 USA Taunton/Attleboro Community Counseling of Bristol County Taunton MA USA Boston Veterans Health Administration Pocasset MA USA

Hwabyung is an indigenous psychiatric illness commonly found among Korean women. Using hwabyung, this article describes the psychological ramifications of immigration experiences among Korean immigrant women in the United States. Data collected from an anonymous survey of adult Korean immigrant women （n = 143） were used for a statistical analysis. The findings highlight the significant effects of self-esteem, social support, financial hardship, and family cohesion on the changes in the hwabyung symptoms among Korean immigrant women. Based on the findings, the implications for practice and future study are discussed. Also discussed are the global significance of migrant women and their mental health issues.

关键词： Hwabyung Korean immigrant women Acculturation Stress Coping resources

What a difference a day makes! The contribution of intrinsic FGF9 signalling to germline masculinisation

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Asian Journal of Andrology 2011年第2期13卷 193-194页

作者： kate L Loveland Department of Biochemistry and Molecular Biology andDepartment of Anatomy and Developmental BiologyMonash University Wellington Road Clayton VIC3168 Austra a

Aithough the key discovery of sex-deter- mining region Y （SRY） 20 years ago as the essential sex-determining gene emerged from studies of sex-reversed humans, most of our knowledge of how male and female germ cells diverge after sex determination comes from studies of mice. This is demonstrated in a recent publication from Bowles and colleagues in Developmental Cell, which documents the functional importance of fibroblast growth factor 9 （FGFg） signalling in murine fetal germ cells.

关键词： Sex determination Cells Lymphocytes Gender Sex Sex diagnosis Gametes

Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?

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Neural Regeneration Research 2023年第3期18卷 543-544页

作者： kate Beecher Julie A.Wixey UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQLDAustralia

Fetal growth restriction(FGR)describes a fetus that has not grown to its expected biological potential in *** can result from maternal,fetal,or placental complications,though it is commonly caused by placental *** prolonged hypoxic environment the FGR fetus is exposed to has detrimental effects on the newborn,which extends to adverse long-term neurological outcomes in a significant proportion of FGR infants(Malhotra et al.,2019).Unfortunately,there are currently no therapies to reduce the adverse neurological outcomes in *** injury is evident in the FGR brain,and therefore understanding which neurons are lost and how they are lost will aid in the selection of treatment options for FGR.

关键词： fetal fetus insufficiency

A Trip to the Great Wall

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英语大王 2013年第Z2期 50-51页

作者： Kate.lee

Hi! I’m Kate.lee. I come from england. I’m ten years old. I love China very much. I think the Great Wall of China is the greatest building project in the world.* I want to visit it one day. I can’t imagine how the ... 详细信息

关键词： A Trip to the Great Wall