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Intermittent suckling with or without comingling of non-littermate piglets before weaning improves piglet performance in the immediate post-weaning period when compared with conventional weaning

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Journal of Animal Science and Biotechnology 2017年第3期8卷 721-732页

作者： Diana L.Turpin Pieter Langendijk kate Plush John R.Pluske School of Veterinary and Life Sciences Murdoch UniversityMurdochWA 6150Australia Trouw Nutrition Veerstraat 38Boxmeer 5831 iNThe Netherlands South Australian Research and Development Institute Roseworthy CampusJS Davis BuildingRoseworthySA 5371Australia Present address:SunPork Farms 563 Coleman RoadPinkerton PlainsSA 5400Australia

Background： In this experiment, intermittent suckling（IS） with or without the co-mingling（Co M） of piglets was studied as a method to stimulate solid feed intake and reduce post-weaning ***： Three weaning regimes using 30 multiparous sows were compared：（1） conventional weaning（CW）（n = 10 litters）, where piglets had continuous access to the sow until weaning（d 0, farrowing = d-25 relative to weaning）;（2） intermittent suckling（IS）（n = 10 litters）, where piglets were separated from the sow for 8 h/d starting at d-7（relative to weaning）; and（3） intermittent suckling with co-mingling（ISCo）（n = 10 litters） where IS started at d-7 and two litters were housed together during separation and then returned to their original sow. Ad libitum creep feed was available from d-17. At weaning pigs were housed in pens of 11 pigs, 27 pens in total. The ISCo treatment was divided in half to examine effects of different mixing strategies after weaning. Half of the ISCo litters were kept in familiar groups（ISCo F, familiar, n = 4） and the other half were mixed within treatment resulting in groups of unfamiliar pigs（ISCo NF, not familiar, n = 5）, the same as IS（n = 9） and CW（n = 9） ***： The ISCo piglets ate more creep feed in the week before weaning（P 〈 0.01）, but also showed more aggressive and manipulative behaviour on first day of Co M compared with CW piglets（P 〈 0.05）. IS with or without Co M increased exploratory and play behaviour on the first day of treatment intervention（P 〈 0.001） and increased sleeping behaviour on the last day of treatment intervention compared with CW（P 〈 0.001）. Mixing strategy at weaning had an effect on performance data with the highest growth and feed intake seen in ISCo F pigs 2 to 8 d after weaning（P 〈0.001）. IS and ISCo NF pigs also grew faster and ate more than CW pigs 2 to 8 d after weaning（P 〈 0.001）. Post-weaning injury scores suggested reduced aggression in ISCo as evidenced by reduced redness（skin irritation）（P 〈 0.05）, a

关键词： Behaviour Co-mingling Intermittent suckling Piglet Weaning

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Dendritic cells in hepatitis C virus infection:Key players in the IFNL3-genotype response

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World Journal of Gastroenterology 2014年第47期20卷 17830-17838页

作者： kate S O'Connor Jacob George David Booth Golo Ahlenstiel Institute for Immunology and Allergy Research Westmead Millennium InstituteUniversity of SydneySydneyNSW 2145Australia Storr Liver Unit Westmead Millennium Institute and Westmead HospitalUniversity of SydneySydneyNSW 2145Australia

Recently,single nucleotide polymorphisms,in the vicinity of the interferon lambda 3(IFNL3)gene have been identified as the strongest predictor of spontaneous and treatment induced clearance of hepatitis C virus(HCV)*** then,increasing evidence has implicated the innate immune response in mediating the IFNL3 genotype *** cells(DCs)are key to the host immune response in HCV infection and their vital role in the IFNL3 genotype effect is *** have identified subclasses of DCs,particularly myeloid DC2s and potentially plasmacytoid DCs as the major producers of IFNL3 in the setting of HCV *** the complexities of dendritic cell biology and the conflicting current available data,this review aims to summarize what is currently known regarding the role of dendritic cells in HCV infection and to placeit into context of what is know about lambda interferons and dendritic cells in general.

关键词： Hepatitis C virus Interferon lambda 3 Dendritic cells Plasmacytoid dendritic cells Myeloid dendritic cells Innate immunity

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Containment measures for emerging and re-emerging vector-borne and other infectious diseases of poverty in urban settings:a scoping review

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Infectious Diseases of Poverty 2018年第1期7卷 976-991页

作者： Laurence Campeau Stephanie Degroote Valery Ridde Mabel Carabali kate Zinszer University of Montreal Public Health Research Institute(IRSPUM) MontrealQuebecCanada French Institute For Research on sustainable Development(IRD) IRD-Paris Descartes University(CEPED)Paris Sorbonne Cites UniversityErl Inserm SagesudParisFrance McGill University MontrealQuebecCanada

Background:The emergence and re-emergence of vector-borne and other infectious diseases of poverty pose a threat to the health of populations living in urban and low-income settings.A detailed understanding of intervention strategies,including effectiveness of past outbreak containment,is necessary to improve future *** objective was to determine what is known about the effectiveness of containment measures for emerging and re-emerging vector-borne and other infectious diseases of poverty in urban settings and identify research gaps and implications for public health *** body:We conducted a scoping review and systematically searched peer-reviewed and grey literature published between 2000 and *** data extraction tools were used for data coding and extraction,and data on implementation process and transferability were extracted from all studies.A quality assessment was conducted for each included *** screened 205 full-text articles and reports for a total of 31 articles included in the *** quality of the studies was generally low to *** largest body of evidence concerned control activities for Ebola virus and dengue *** majority of interventions(87%)relied on multiple types of measures,which were grouped into four categories:1)healthcare provision;2)epidemiological investigation and/or surveillance;3)environmental or sanitary interventions;and 4)community-based *** quality of the majority of studies(90%)was poor or moderate,and one-third of the studies did not provide a clear description of the outcomes and of the procedures and/or tools used for the ***:Our results highlight the difficulty of establishing causation when assessing the effect of containment *** that extend beyond solely reporting on effectiveness and take into account the complexity of real-world settings are urgently *** recommend the allocation of research efforts to the evaluation of the

关键词： Vector-borne diseases Containment measures Interventions Urban health Scoping review

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Opening the black box of donor influence on Digital Earth in Africa

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International Journal of Digital Earth 2013年第S2期6卷 1-21页

作者： kate T.Lance Yola P.Georgiadou Arnold K.Bregt Faculty of Geo-Information Science and Earth Observation University of TwentePO Box 2177500 AEEnschedeThe Netherlands Centre for Geo-Information Wageningen University and Research CentrePO Box 476700 AAWageningenThe Netherlands

Africa’s participation in Digital Earth is *** is a tendency to ascribe this state to prevailing governance and cultural challenges in ***,foreign actors such as donors have an apparent role in shaping geospatial policies and *** far,the complex linkages between external aid and improved social and environmental monitoring and decision-making have been handled as a kind of‘black box’.To better understand the situation,we open the box and focus on the interaction between donors and *** use a heuristic from political science,as well as empirical evidence,to describe the policyinfluencing tools that donors employ based on four basic resources donors possess:organization,authority,treasure,and *** show an evolution of tool usage as donors shift from‘old aid’to‘new aid’*** new tools include:technical assistance for geospatial curriculum development,inscription of standards and data access requirements in contracts and grants,cross-agency project design,best-practice analysis,portfolio management,and the use of language to promote participation and *** these tools reflect donor intent to partner in the realization of Digital Earth,the tools stem from a persisting asymmetric power dynamic between donors and policy-makers.

关键词： foreign aid donors policy outcomes tools geospatial technologies

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Helicobacter pylori eradication in patients with chronic immune thrombocytopenic purpura

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World Journal of Gastroenterology 2014年第22期20卷 6918-6923页

作者： Ravinder Naik Noonavath Chandrasekharan Padma Lakshmi Tarun Kumar Dutta Vikram kate Department of Surgery Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India Department of Medical Gastroenterology Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India Department of Clinical Hematology Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India Department of General and Gastrointestinal Surgery Jawaharlal Institute of Postgraduate Medical Education and ResearchPondicherry 605006India

AIM: To assess the effect of Helicobacter pylori (H. pylori) eradication on platelet counts in patients with chronic immune thrombocytopenic purpura (cITP).

关键词： Helicobacter pylori Immune thrombocytopenic purpura Platelet counts

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Neonatal seizures and disruption to neurotransmitter systems

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Neural Regeneration Research 2017年第2期12卷 216-217页

作者： Stephanie M.Miller kate Goasdoue S.Tracey Bjorkman The University of Queensland UQ Centre for Clinical ResearchHerston QLD Australia

Seizure disorders and epilepsies are well documented to be associated with long-term neurological and cognitive deficits in the adult and pediatric patients,but what about seizures in the newborn？The neonatal brain i... 详细信息

关键词： AEDs Neonatal seizures and disruption to neurotransmitter systems GABAA Cl NmdA

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让事业起飞

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新理财（公司理财） 2019年第11期 73-74页

作者： kate Whitehead leslie Montgomery(摄影) 不详

为全球最繁忙的机场之一管理财务并非易事,香港机场管理局财务执行总监罗志聪分享他所参与的重要项目,以及如何发挥会计师的专业协助香港巩固国际航空交通枢纽地位。身为财务执行总监的罗志聪,从未想过他会坐在香港特别行政区立法会会... 详细信息

为全球最繁忙的机场之一管理财务并非易事,香港机场管理局财务执行总监罗志聪分享他所参与的重要项目,以及如何发挥会计师的专业协助香港巩固国际航空交通枢纽地位。身为财务执行总监的罗志聪,从未想过他会坐在香港特别行政区立法会会议席上,回答立法会议员的提问。然而,这就是公共机构管理层的分内事。

关键词：执行总监国际航空罗志香港特别行政区交通枢纽会计师香港机场管理局财务

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Immunobiology of congenital cytomegalovirus infection of the central nervous system--the murine cytomegalovirus model

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Cellular & Molecular Immunology 2015年第2期12卷 180-191页

作者： Irena Slavuljica Daria Kvestak Peter Csaba Huszthy kate Kosmac William J Britt Stipan Jonjic Department of Histology and Embryology School of Medicine University of Rijeka Rijeka Croatia Department of Infectious Diseases School of Medicine University of Rijeka Rijeka Croatia Department of Immunology Institute of Clinical Medicine University of Oslo Oslo Norway Department of Microbiology University of Alabama at Birmingham Birmingham AL USA

Congenital human cytomegalovirus infection is a leading infectious cause of long-term neurodevelopmental sequelae, including mental retardation and hearing defects. Strict species specificity of cytomegaloviruses has restricted the scope of studies of cytomegalovirus infection in animal models. To investigate the pathogenesis of congenital human cytomegalovirus infection, we developed a mouse cytomegalovirus model that recapitulates the major characteristics of central nervous system infection in human infants, including the route of neuroinvasion and neuropathological findings. Following intraperitoneal inoculation of newborn animals with mouse cytomegalovirus, the virus disseminates to the central nervous system during high-level viremia and replicates in the brain parenchyma, resulting in a focal but widespread, non-necrotizing encephalitis. Central nervous system infection is coupled with the recruitment of resident and peripheral immune cells as well as the expression of a large number of pro-inflammatory cytokines. Although infiltration of cellular constituents of the innate immune response characterizes the early immune response in the central nervous system, resolution of productive infection requires virus-specific CD8＋ T cells. Perinatal mouse cytomegalovirus infection results in profoundly altered postnatal development of the mouse central nervous system and long-term motor and sensory disabilities. Based on an enhanced understanding of the pathogenesis of this infection, prospects for novel intervention strategies aimed to improve the outcome of congenital human cytomegalovirus infection are proposed.

关键词： central nervous system congenital infection cytomegalovirus immune response

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Make it new

Make it new

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作者： (author.)kate Barry

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Combined VEGF/PDGF improves olfactory regeneration after unilateral bulbectomy in mice

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Neural Regeneration Research 2018年第10期13卷 1820-1826页

作者： kate Beecher Louise M.Hafner Jenny Ekberg James A.St.John Fatemeh Chehrehasa School of Biomedical Sciences Queensland University of Technology Clem Jones Centre for Neurobiology and Stem Cell Research Griffith Institute for Drug DiscoveryGriffith University Institute of Health and Biomedical Innovation Queensland University of Technology Menzies Health Institute Queensland Griffith University

The olfactory receptor neurons lining the nasal cavity have a remarkable capacity to regenerate throughout life. They are replenished continuously and their axons make new connections within the olfactory bulb. However, some factors such as head trauma and skull base surgery damage the olfactory nerve which lead to olfactory dysfunction. Losing the sense of smell has considerable effects on quality of life and life-expectancy. Therefore, there is a clear need to find a treatment for olfactory dysfunction. One such potential treatment is growth factor therapy which showed promising results in the spinal cord and brain injuries. The aim of the present study was to investigate whether combined delivery of two growth factors, vascular endothelial growth factor and platelet-derived growth factor treatment can improve the olfactory neurons regeneration in mice. The degeneration of the olfactory neurons was induced by unilateral bulbectomy. The treatment group received 1.5 μg of the combined growth factors intranasally, while the control injured group received saline. Growth factor treatment significantly increased the number of immature neurons at 5 and 7 days post injury and also the number of mature olfactory neurons at 10 and 14 days post bulbectomy. Regenerating axons extended over a larger volume in the operated cavity in the treatment group compared to control group at 14 days post bulbectomy. The growth factor treatment also significantly reduced astrocytic glia scar in the operated cavity. The results indicate that the combined delivery of the growth factors has the potential to improve olfactory dysfunction.

关键词： astrocytes olfactory bulb glial scar axon growth factors neuron

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