检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

杜预相关的人和事

英语角 2024年第26期 8-9页

作者： kate 张霞(图) 欣巴达(图) 不详

历史上的杜预,既能领军作战,也能修订律法:他既是一个极具魄力的军事家,也是一个痴迷于典籍的学者。你对与他相关的历史事件了解多少?一起来看看吧。

关键词：杜预历史相关学者军事家

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人类应该吃什么?

环球科学 2024年第15期 22-29页

作者：凯特·王郭林(翻译) 《科学美国人》莫斯科大学生物系人类学教研室

一些社交平台上的“营养专家”建议我们应该像祖先那样只吃肉类。但实际上,我们的祖先并没有这样的饮食习惯。保罗·萨拉迪诺(Paul Saladino)正在锯一根牛的腿骨,他光着膀子,手臂上的肱二头肌随着动作鼓动。骨头终于锯开,围观者爆发出... 详细信息

一些社交平台上的“营养专家”建议我们应该像祖先那样只吃肉类。但实际上,我们的祖先并没有这样的饮食习惯。保罗·萨拉迪诺(Paul Saladino)正在锯一根牛的腿骨,他光着膀子,手臂上的肱二头肌随着动作鼓动。骨头终于锯开,围观者爆发出一阵欢呼。萨拉迪诺的脸上浮现出一抹笑意,再次确认自己还在镜头里。随即,他从腿骨中出一勺骨髓,倒进旁边一位迫不及待的年轻女士口中,好像牧师在分发圣餐一样。

关键词：饮食习惯圣餐腿骨社交平台营养专家肱二头肌围观者祖先

*** Part Ⅱ:Exploring Humid Heat Extremes Using Wet Bulb Temperature Indices

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2023年第11期40卷 1968-1985页

作者： kate M.WILLETT Met Office Hadley Centre FitzRoy RoadExeterEX13PBU.K.

Heat events may be humid or *** several indices incorporate humidity,such combined indices obscure identification and exploration of heat events by their different humidity *** new *** global gridded monitoring product uniquely provides a range of wet and dry bulb temperature extremes *** of this new data product demonstrates its value as a tool for quantifying exposure to humid verses dry heat *** also enables exploration into“stealth heat events”,where humidity is high,perhaps enough to affect productivity and health,while temperature remains *** events may not typically be identified as“heat events”by temperature-focused heat *** 1973-2022,the peak magnitude of humid extremes(maximum daily wet bulb temperature over a month;T_(w)X)for the global annual mean increased significantly at 0.13±0.04℃(10 yr)^(−1),which is slightly slower than the global annual mean T_(w) increase of 0.22±0.04℃(10 yr)^(−1).The frequency of moderate humid extreme events per year(90th per-centile daily maxima wet bulb temperature exceedance;T_(w)X90p)also increased significantly at 4.61±1.07 d yr^(−1)(10 yr)^(−1).These rates were slower than for temperature extremes,TX and TX90p,which respectively increased significantly at 0.27±0.04℃(10 yr)^(−1) and 5.53±0.72 d yr^(−1)(10 yr)^(−1).Similarly,for the UK/Europe focus region,JJA-mean T_(w)X increased significantly,again at a slower rate than for TX and mean T_(w).*** shows some evidence of“stealth heat events”occurring where humidity is high but temperature remains more moderate.

关键词： wet bulb temperature heat extremes climate monitoring

*** Part Ⅰ:A Gridded Wet Bulb Temperature Extremes Index Product for Climate Monitoring

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2023年第11期40卷 1952-1967页

作者： kate M.WILLETT Met Office Hadley Centre FitzRoy RoadExeterEX13PBU.K.

*** is an annually updated global gridded monthly monitoring product of wet and dry bulb temperature–based extremes indices,from January 1973 to December *** quality,including spatial and temporal stability,is a key *** hourly data are quality *** is assessed on monthly means and used to score each gridbox according to its homogeneity rather than to apply *** enables user-specific screening for temporal stability and avoids errors from inferring adjustments from monthly means for the daily maximum *** general use,a score(HQ Flag)of 0 to 6 is recommended.A range of indices are presented,aligning with existing standardised ***,provision of both wet and dry bulb indices allows exploration of heat event character—whether it is a“humid and hot”,“dry and hot”or“humid and warm”*** is designed for analysis of long-term trends in regional *** can be used to study local events,but given the greater vulnerability to errors of maximum compared to mean values,cross-validation with independent information is advised.

关键词： wet bulb temperature heat extremes climate monitoring

What a difference a day makes! The contribution of intrinsic FGF9 signalling to germline masculinisation

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2011年第2期13卷 193-194页

作者： kate L Loveland Department of Biochemistry and Molecular Biology andDepartment of Anatomy and Developmental BiologyMonash University Wellington Road Clayton VIC3168 Austra a

Aithough the key discovery of sex-deter- mining region Y （SRY） 20 years ago as the essential sex-determining gene emerged from studies of sex-reversed humans, most of our knowledge of how male and female germ cells diverge after sex determination comes from studies of mice. This is demonstrated in a recent publication from Bowles and colleagues in Developmental Cell, which documents the functional importance of fibroblast growth factor 9 （FGFg） signalling in murine fetal germ cells.

关键词： Neuroscience Animal behaviour

A One Health approach to fight antimicrobial resistance in Uganda: Implementation experience, results, and lessons learned

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biosafety and Health 2024年第2期6卷 125-132页

作者： Reuben Kiggundu J.P.Waswa Niranjan Konduri Hassan Kasuja Marion Murungi Patrick Vudriko Harriet Akello Eric Lugada Cecilia Muiva Esther Were Dinah Tjipura Henry Kajumbula kate Kikule Emmanuel Nfor Mohan P.Joshi USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthArlingtonVA 22203USA College of Veterinary Medicine Animal Resources and BiosecurityMakerere UniversityKampala 256Uganda Ministry of Health Uganda Kampala 256Uganda USAID Strengthening Supply Chain Systems Activity Management Sciences for HealthKampala 256Uganda USAID Medicines Technologiesand Pharmaceutical Services ProgramManagement Sciences for HealthNairobi 254Kenya Department of Microbiology College of Health SciencesMakerere UniversityKampala 256Uganda

Uganda has been implementing the Global Health Security Agenda(GHSA)since 2015 to build its capacity according to World Health Organization(WHO)Benchmarks on International Health Regulations *** country remains prone to outbreaks,with more than 20 disease outbreaks reported in the past five years,including Ebola virus disease,Crimean-Congo haemorrhagic fever,Marburg haemorrhagic fever,measles,yellow fever,coronavirus disease 2019(COVID-19),and *** resistance(AMR)is an ongoing *** scored capacity level 3 on infection prevention and control(IPC)and antimicrobial stewardship(AMS)in the 2017 Joint External Evaluation(JEE)*** gaps were being addressed after a self-assessment in *** paper describes the technical assistance approaches provided to Uganda by the Medicines,Technologies,and Pharmaceutical Services Program,funded by the United States(U.S.)Agency for International Development,and implemented by Management Sciences for *** program,through a One Health approach,supported systematic capacity strengthening based on the JEE's capacity advancement framework for global health security,specifically relating to *** program's interventions impacted 32 WHO benchmark actions(7 for AMR multisectoral coordination,16 for IPC,and 9 for AMS),contributing to Uganda's strengthened GHSA *** success built on the AMR platform,the program trained 745 health workers in IPC for the Ebola virus and provided support for simulation exercises by eight district IPC *** program also worked with the Ministry of Health to coordinate IPC for the COVID-19 response in five health regions,covering 45 districts and reaching 5,452 health workers at 858 health facilities.

关键词： One health Antimicrobial resistance Antibiotic resistance Jointexternal evaluation Global health security Uganda Africa WHO Benchmarks for International Health Regulations Capacities

Could serotonin play a role in abnormal brain outcomes in fetal growth restriction?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第3期18卷 543-544页

作者： kate Beecher Julie A.Wixey UQ Centre for Clinical Research Faculty of MedicineThe University of QueenslandHerstonQLDAustralia

Fetal growth restriction(FGR)describes a fetus that has not grown to its expected biological potential in *** can result from maternal,fetal,or placental complications,though it is commonly caused by placental *** prolonged hypoxic environment the FGR fetus is exposed to has detrimental effects on the newborn,which extends to adverse long-term neurological outcomes in a significant proportion of FGR infants(Malhotra et al.,2019).Unfortunately,there are currently no therapies to reduce the adverse neurological outcomes in *** injury is evident in the FGR brain,and therefore understanding which neurons are lost and how they are lost will aid in the selection of treatment options for FGR.

关键词： fetal fetus insufficiency

Tunneling nanotubes and actin cytoskeleton dynamics in glaucoma

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第11期15卷 2031-2032页

作者： kate E.Keller Department of Ophthalmology Department of Chemical Physiology and BiochemistryOregon Health&Science UniversityPortlandORUSA

Glaucoma and the actin cytoskeleton:Glaucoma is an optic neuropathy,with pathophysiological changes affecting anterior and posterior tissues of the *** trabecular meshwork(TM)in the anterior segment regulates intraocular pressure(IOP),while photoreceptors in the posterior retina convert light into signals that retinal ganglion cells(RGC)transmit to the *** TM is a small,fenestrated tissue located in the anterior chamber angle,between the iris and cornea(Figure 1A1).In humans,the majority of aqueous humor fluid drains through the TM into Schlemm’s *** the outflow channels become blocked,as in glaucoma,IOP starts to increase,pushing the lens and vitreous back onto the optic ***-induced damage to the optic nerve head causes a progressive loss of RGCs and their axons,which leads to irreversible *** or pharmacological management of IOP prevents RGC damage in glaucoma *** pharmacological therapies either reduce production of aqueous humor fluid,or increase aqueous drainage via the TM or the uveoscleral outflow ***,a new class of glaucoma therapies targeting the actin cytoskeleton were approved by the Food and Drug *** are known as the Rho kinase inhibitors,and they act on the Rho/Rho-associated protein kinase signaling pathway to disassemble actin stress fibers in TM and Schlemm’s canal cells(Rao et al.,2017;Lin et al.,2018).While the molecular details are only partially understood,perturbing the actomyosin system can alter cell shape,volume,contractility,and adhesion of cells to extracellular matrix(Tian et al.,2009),which in turn allows greater aqueous outflow and a reduction in *** addition to forming stress fibers,filamentous actin assembles into actin bundles,which are a major component of filopodia,long finger-like projections that emanate from the cell surface,as well as the related cellular protrusions known as tunneling nanotubes(TNTs).

关键词： glaucoma fibers Figure

The Triple Combination of Meropenem,Avibactam,and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

在线全文

学校读者我要写书评

暂无评论

Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair James Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker kate Cook Andrei Baran Charlotte Gray-Hammerton Claudia Orbegozo Rubio Edgars Suna Jordan Mathias Jürgen Brem Kirsty Sands Maria Nieto-Rosado Maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou Christopher Joseph Schofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimicrobial Research University of OxfordOxford OX13REUK Chemistry Research Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic Synthesis Riga LV-1006Latvia Department of Medical Microbiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Biocatalysis Research Center Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spectrum activity against carbapenemase-producing bacteria.A diverse panel comprising MBL-and SBL-producing strains was used for susceptibility testing of the triple combination using the agar dilution *** frequency of resistance(FoR)to MEM combined with InC58 was *** were sequenced and tested for cross resistance,fitness,and the stability of the resistance *** with the double combinations of MEM plus an SBL or MBL inhibitor,the triple combination extended the spectrum of activity to most of the isolates bearing SBLs(oxacillinase-48(OXA-48)and Klebsiella pneumoniae carbapenemase-2(KPC-2))and MBLs(New Delhi metallo-blactamases(NDMs)),although it was not effective against Verona integron-encoded metallo-blactamase(VIM)-carrying Pseudomonas aeruginosa(***)and OXA-23-carrying Acinetobacter baumannii(***).The FoR to MEM plus InC58 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistance correlated with mutations to ompC and comR,affecting porin C and copper permeability,*** mutants manifested a fitness cost,a decreased level of resistance during passage without antibiotic pressure,and cross resistance to another carbapenem(imipenem)and a b-lactamase inhibitor(taniborbactam).In conclusion,compared with the dual combinations,the triple combination of MEM with InC58 and AVI showed a much wider spectrum of activity against different carbapenemaseproducing bacteria,revealing a new strategy to combat b-lactamase-mediated antimicrobial resistance.

关键词： Carbapenemase Metallo/serine-b-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance