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Effects of probiotic supplementation on abdominal pain severity in pediatric patients with irritable bowel syndrome:a systematic review and meta-analysis of randomized clinical trials

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World Journal of Pediatrics 2022年第5期18卷 320-332页

作者： Somayeh Fatahi Amirhossein Hosseini Mohammad Hassan Sohouli Aliakbar Sayyari katayoun khatami Zahra Fazeli Farsani Hamzeh Amiri Naghi Dara Ivan G.O.de Souza Heitor O.Santos Pediatric Gastroenterology Hepatologyand Nutrition Research Center.Research Institute for Children's HealthShahid Beheshti University of Medical SciencesTehranIran Student Research Committee Faculty of Public Health BranchIran University of Medical Sciences.Tehran.Iran Student Research Committee.Department of Clinical Nutrition and Dietetics Faculty of Nutrition and Food TechnologyShahid Beheshti University of Medical Sciences.TehranIran School of Health Sciences.Universidade Salvador(UNIFACS) SalvadorBahia.Brazil School of Medicine Federal University of Uberlandia(UFU)UberlandiaMinas GeraisBrazil

Background Probiotic supplementation has been used to alleviate abdominal pain in children and adolescents with irritable bowel syndrome(IBS),but the evidence is not ***,a systematic review and meta-analysis of randomized clinical trials(RCTs)were performed to investigate the effects of probiotic supplementation on abdominal pain in pediatric patients with *** PubMed/MEDLINE,Web of Science,Scopus,Cochrane Library,and Embase were the available databases searched to find relevant randomized clinical trials up to April *** effect size was expressed as weighted mean differenee(WMD)and 95% confidence interval(CI).Results Seven RCTs with 441 participants were included,from which the meta-analysis demonstrated that probiotic supplementation has a significant effect on reducing abdominal pain in pediatric patients with IBS(WMD=-2.36:95%CI-4.12 to-0.60;P=0.009).Although our study involved children and adolescents(≤18 years),the effects of probiotic supplementation seem to be more potent in patients under 10 years old(WMD=-2.55;95%CI-2.84 to -2.27)compared to patients aged 10-18 years(WMD=-1.70;95%CI-2.18 to -1.22).The length of supplementation longer than four weeks was more effective(WMD=-2.43;95%CI-2.76 to -2.09).Conclusion Probiotic supplementation can reduce abdominal pain in pediatric patients with IBS.

关键词： Abdominal pain Adolescents-Irritable bowel syndrome Meta-analysis Probiotic

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Nonlinear analysis of cable structures using the dynamic relaxation method

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Frontiers of Structural and Civil Engineering 2021年第1期15卷 253-274页

作者： Mohammad REZAIEE-PAJAND Mohammad MOHAMMADI-khatami Department of Civil Engineering Ferdowsi University of MashhadMashhad ***Iran

The analysis of cable structures is one of the most challenging problems for civil and mechanical *** they have highly nonlinear behavior,it is difficult to find solutions to these *** far,different assumptions and methods have been proposed to solve such *** dynamic relaxation method(DRM)is an explicit procedure for analyzing these types of *** utilize this scheme,investigators have suggested various stiffness matrices for a cable *** this study,the efficiency and suitability of six well-known proposed matrices are assessed using the *** achieve this goal,16 numerical examples and two criteria,namely,the number of iterations and the analysis time,are *** on a comprehensive comparison,the methods are ranked according to the two *** numerical findings clearly reveal the best ***,a variety of benchmark problems are suggested by the authors for future studies of cable structures.

关键词： nonlinear analysis cable structure stiffness matrix dynamic relaxation method

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A fast and accurate dynamic relaxation scheme

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Frontiers of Structural and Civil Engineering 2019年第1期13卷 176-189页

作者： Mohammad REZAIEE-PAJAND Mohammad MOHAMMADI-khatami Department of Civil Engineering Ferdowsi University of MashhadMashhadIran

Dynamic relaxation method (DRM)is one of the suitable numerical procedures for nonlinear structural *** the fictitious inertia and damping forces to the static equation,and turning it to the dynamic system,are the basis of this *** selection of the DRM artificial factors leads to the better convergence rate and efficient *** study aims to increase the numerical stability,and to decrease the analysis *** fulfil this objective,the reduction rate of analysis error for consecutive iterations is *** on this formulation,a new time step is found for the viscous dynamic *** combining this novel relationship with the other DRM factors,various geometrical nonlinear structures,such as trusses,frames,and shells,are *** obtained results verify the efficiency of authors'scheme.

关键词： viscous dynamic relaxation time step displacement error geometric nonlinear analysis

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Different effects of L-arginine on morphine tolerance in sham and ovariectomized female mice

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第12期12卷 1016-1023页

作者： Reza KARAMI Mahmoud HOSSEINI Fatimeh KHODABANDEHLOO Leila khatami Zahra TAIARANI Neuroscience Research Center and Department of Physiology School of MedicineMashhad University of Medical SciencesMashhadIran Pharmacological Research Center of Medicinal Plants Department of PhysiologySchool of MedicineMashhad University of Medical SciencesMashhadIran

Objective:The roles of gonadal hormones and nitric oxide(NO) on the analgesic effects of morphine,tolerance to morphine,and their interactions have been widely *** the present study,the effect of L-arginine(an NO precursor) on morphine tolerance in sham and ovariectomized(OVX) female mice was ***:Forty mice were divided into sham and OVX *** the first day,a hot plate test((55±0.2) °C;cut-off 30 s) was carried out as a base record 15 min before injection of morphine(10 mg/kg,subcutaneously(s.c.)) and was repeated every 15 min after *** sham group was then divided into two subgroups:sham-tolerance-L-arginine(Sham-Tol-LA) and sham-tolerance-saline(Sham-Tol-Sal) which received either L-arginine 50 mg/kg(intraperitoneally(i.p.)) or saline 10 ml/kg(i.p.),respectively,three times in a day for three consecutive *** tolerance was induced in animals by injecting 30 mg/kg morphine(s.c.) three times/day for three *** treatment was also used for OVX *** the fifth day,the hot plate test was *** analgesic effect of morphine was calculated as the maximal percent effect(MPE).The results were compared using repeated measure analysis of variance(ANOVA).Results:There was no significant difference in MPE between the OVX and sham *** MPEs in both the Sham-Tol-Sal and OVX-Tol-Sal groups were lower than those in both the sham and OVX groups(P<0.01).The MPE in the OVX-Tol-Sal group was greater than that in the Sham-Tol-Sal group(P<0.01).The MPE in the Sham-Tol-LA group was higher than that in the Sham-Tol-Sal group(P<0.01).However,there was no significant difference between the Sham-Tol-LA and sham groups or between the OVX-Tol-LA and OVX-Tol-Sal ***:The results of the present study showed that repeated administration of morphine causes tolerance to the analgesic effect of morphine.L-Arginine could prevent tolerance to morphine but its effect was different in the presence of ovarian hormones

关键词： L-Arginine Ovariectomized mice Morphine Tolerance

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Near-infrared spectroscopy(NIRS)as a useful tool to evaluate the treatment efficacy of positive airways pressure therapy in patients with obstructive sleep apnea syndrome(OSAS):A pilot study

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 143-152页

作者： Zhongxing Zhang Maja Schneider Ursula Fritschi Lsabela Lehner Ramin khatami Sleep Center Clinic BarmelweidSwitzerland Department of Neurology Uniuersity Hospital Zurich University of ZurichSuitzerland

In obstructive sleep apnea syndrome(OSA)the periodic reduction or cessation of breathing dueto narrowing or occlusion of the upper airway during slep leads to an impaired cerebral vascularautoregulation that is associated with an increased cardiovascular risk,including ***-tinuous positive airways pressure(CPAP)therapy at night is the most effective treatment forOSA and has been shown to reduce the cardiovascular risk in OSA ***,there is nosuitable bedside monitoring method evaluating the recovery of cerebral hemodynamics duringCPAP ***-infrared spectroscopy(NiRS)is idelly suited for non-invasive monitoringthe cerebral hemodynamics during sleep due to its properties of local measurement,totally sa feapplication and good tolerance to *** this pilot study,we monitored cerebral hemody-namics during standard CPAP therapy at night in thre patients with severe OSA using *** found periodic oscllations in HbO2,HHb,tisue oxygenation index(TO1)and blood volume(BV)associa ted with periodic apnea events without CPAP in all OSA *** osillationswere eliminated under the optimal CPAP pressures in all *** results sugg ested thatthe recovery of cerebral hemodynamics impaired by apnea events can be evaluated by bedsideNIRS measurements in real time during ll night CPAP *** is a usefi bedsidemonitoring tool to evaluate the treatment elicacy of CPAP therapy in patients with OSA.

关键词： Sleep cerebral hemodynamics hemodynamic oscillations bedside monitoring.

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Improved IChOA-Based Reinforcement Learning for Secrecy Rate Optimization in Smart Grid Communications

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Computers, Materials & Continua 2024年第11期81卷 2819-2843页

作者： Mehrdad Shoeibi Mohammad Mehdi Sharifi Nevisi Sarvenaz Sadat khatami Diego Martín Sepehr Soltani Sina Aghakhani The WPI Business School Worcester Polytechnic InstituteWorcesterMA 01609-2280USA Department of Computer Science Escuela de Ingeniería Informática de SegoviaUniversidad de ValladolidSegovia40005Spain Department of Data Science Engineering University of HoustonHoustonTX 77204USA Department of Industrial Engineering College of EngineeringUniversity of HoustonHoustonTX 77204USA Department of Industrial and Manufacturing Systems Engineering Iowa State UniversityAmesIA 50011USA

In the evolving landscape of the smart grid(SG),the integration of non-organic multiple access(NOMA)technology has emerged as a pivotal strategy for enhancing spectral efficiency and energy ***,the open nature of wireless channels in SG raises significant concerns regarding the confidentiality of critical control messages,especially when broadcasted from a neighborhood gateway(NG)to smart meters(SMs).This paper introduces a novel approach based on reinforcement learning(RL)to fortify the performance of *** by the need for efficient and effective training of the fully connected layers in the RL network,we employ an improved chimp optimization algorithm(IChOA)to update the parameters of the *** integrating the IChOA into the training process,the RL agent is expected to learn more robust policies faster and with better convergence properties compared to standard optimization *** can lead to improved performance in complex SG environments,where the agent must make decisions that enhance the security and efficiency of the *** compared the performance of our proposed method(IChOA-RL)with several state-of-the-art machine learning(ML)algorithms,including recurrent neural network(RNN),long short-term memory(LSTM),K-nearest neighbors(KNN),support vector machine(SVM),improved crow search algorithm(I-CSA),and grey wolf optimizer(GWO).Extensive simulations demonstrate the efficacy of our approach compared to the related works,showcasing significant improvements in secrecy capacity rates under various network *** proposed IChOA-RL exhibits superior performance compared to other algorithms in various aspects,including the scalability of the NOMA communication system,accuracy,coefficient of determination(R2),root mean square error(RMSE),and convergence *** our dataset,the IChOA-RL architecture achieved coefficient of determination of 95.77%and accuracy of 97.41%in validation *** was accompanied by the lowes

关键词： Smart grid communication secrecy rate optimization reinforcement learning improved chimp optimization algorithm

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Selective and mild oxidation of sulfides to sulfoxides by H_2O_2 using DBUH-Br_3 as catalyst

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Chinese Chemical Letters 2010年第6期21卷 651-655页

作者： Mehdi Bakavoli Alireza Motavalizadeh Kakhky Ali Shiri Mahdieh Ghabdian Abolghasem Davoodnia Hossein Eshghi Mola khatami Department of Chemistry School of SciencesIslamic Azad UniversityMashhad BranchMashhadIran Department of Chemistry School of SciencesIslamic Azad UniversityNeyshabur BranchNeyshaburIran Department of Chemistry School of SciencesFerdowsi University of Mashhad91775-1436 MashhadIran

DBUH-Br_3 catalyzed selective conversion of sulfides to sulfoxides in the presence of H_2O_2 as oxidizing agent is *** reaction was performed selectively at room temperature and relatively short reaction times.

关键词： Sulfide Sulfoxide Selective oxidation H2O2 DBUH-Br3

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Novel Point Mutations in 3'-Untranslated Region of GATA4 Gene Are Associated with Sporadic Non-syndromic Atrial and Ventricular Septal Defects

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Current Medical Science 2022年第1期42卷 129-143页

作者： Mehri khatami Sajedeh GHORBANI Mojgan Rezaii ADRIANI Sahar BAHALOO Mehri Azami NAEINI Mohammad Mehdi HEIDARI Mehdi HADADZADEH Department of Biology Faculty of ScienceYazd UniversityYazd ***Iran Department of Cardiac Surgery Afshar HospitalShahid Sadoughi University of Medical SciencesYazd ***Iran

Objective:Transcription factor GATA4 has significant roles in embryonic heart *** of GATA4 appear to be responsible for a wide variety of congenital heart defects(CHD).Despite the high prevalence of GATA4 mutations in CHD phenotypes,extensive studies have not been *** 3'-untranslated region(3'-UTR)of tho GATA4 gene comprises regulatory motifs and microRNA binding sites that are critical for the appropriate gene expression,nuclear transportation,and regulation of translation,and stability of *** study aimed to evaluate the association between mutations in the 3'-UTR of the GATA4 gene and CHD risk among Iranian patients.

关键词： congenital heart disease GATA4 S'-untranslated region mutation in-silico analysis

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The impact of central and obstructive respiratory events on cerebral oxygenation in adults with sleep disordered breathing

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Journal of Innovative Optical Health Sciences 2023年第6期16卷 43-52页

作者： Ramin khatami Dominik Gnaiger Gordana Hügli Ming Qi Zhongxing Zhang Center for Sleep Medicine Sleep Research and Epileptology Clinic Barmelweid AGBarmelweidSwitzerland Barmelweid Academy Clinic Barmelweid AGBarmelweidSwitzerland Department of Neurology Inselspital Bern University Hospital and University of BernBernSwitzerland

Obstructive sleep apnea(OSA)and central sleep apnea(CSA)are two main types of sleep disordered breathing(SDB).While the changes in cerebral hemodynamics triggered by OSA events have been well studied using near-infrared spectroscopy(NIRS),they are essentially unknown in CSA in ***,in this study,we compared the changes in cerebral oxygenation between OSA and CSA events in adult patients using *** tissue oxygen saturation(StO_(2))in 13 severe SDB patients who had both CSA and OSA events was measured using frequency-domain *** changes in cerebral StO_(2)desaturation and blood volume(BV)in the¯rst hour of natural sleep were compared between different types of respiratory events(i.e.,277 sleep hypopneas,161 OSAs and 113 CSAs)with linear mixed-effect models controlling for *** respiratory events occurred during non-rapid eye movement(NREM)*** found that apnea events induced greater cerebral desaturations and BV°uctuations compared to hypopneas,but there was no difference between OSA and *** results suggest that cerebral autoregulation in our patients are still capable to counteract the pathomechanisms of apneas,in particularly the negative intrathoracic pressure(ITP)caused by OSA *** larger BV°uctuations in OSA compared to CSA should be observed due to the negative ITP that reduces cardiac stroke volume and leads to lower systematic blood *** study suggests that OSA and CSA may have similar impact on cerebral oxygenation during NREM sleep in adult patients with SDB.

关键词： Near-infrared spectroscopy cerebral autoregulation sleep apnea

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Effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome

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World Journal of Gastroenterology 2006年第15期12卷 2427-2431页

作者： Mehri Najafi Sani Hamid Reza Kianifar Abdolrazagh Kianee Gholamreza khatami Division of pediatric Gastroenterology Department of Pediatrics Children's Medical Center Hospital of Tehran UniversityTehranIran Division of Pediatric Gastroenterology Department of Pediatrics Ghaem Medical Center of Mashhad University of Medical SciencesMashhadIran Division of Pediatric Cardiology Department of Pediatrics Children's Medical Center Hospital of Tehran UniversityTehranIran

AIM： To study the effect of oral garlic on arterial oxygen pressure in children with hepatopulmonary syndrome, METHODS： Garlic powder in a capsule form was given to 15 children with hepatopulmonary syndrome （confirmed by contrast echocardiography） at the dosage of 1 g/1.73 m^2 per day. Patients were evaluated clinically and by arterial blood gas every four weeks. RESULTS： The garlic capsule was administered to 15 patients with hepatopulmonary syndrome. There were 10 boys and 5 girls with a mean age of 9.4 ± 3.9 years. The underlying problems were biliary tract atresia （4 patients）, autoimmune hepatitis （4 patients）, cryptogenic cirrhosis （4 patients） and presinusoidal portal hypertension （3 patients）. Eight patients （53.3%） showed an increase of 10 mmHg in their mean arterial oxygen pressure. The baseline PaO2 was 65.6 ± 12.1 mmHg in the responder group and 47.1 ± 11.2 mmHg in nonresponder group. At the end of treatment the mean PaO2 in responders and non-responders was 92.2 ± 7.75 mmHg and 47.5 ± 11.87 mmHg, respectively （P 〈 0.01）. CONCLUSION： Garlic may increase oxygenation and improve dyspnea in children with hepatopulmonary syndrome.

关键词： Hepatopulmonary syndrome Garlic Arterial oxygen pressure Pediatric

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