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Bypassing major venous occlusion and duodenal lesions in rats, and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine

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World Journal of Gastroenterology 2018年第47期24卷 5366-5378页

作者： Fedor Amic Domagoj Drmic Zdenko Bilic Ivan Krezic Helena Zizek Marina Peklic Robert Klicek Alen Pajtak Enio Amic Tinka Vidovic Mislav Rakic Marija Milkovic Perisa katarina Horvat Pavlov Antonio Kokot Ante Tvrdeic Alenka Boban Blagaic Mario Zovak Sven Seiwerth Predrag Sikiric Department of Pharmacology Medical Faculty University of Zagreb Department of Pathology Medical Faculty University of Zagreb

AIM To investigate whether duodenal lesions induced by major venous occlusions can be attenuated by BPC 157 regardless nitric oxide(NO) system *** Male Wistar rats underwent superior anterior pancreaticoduodenal vein(SAPDV)-ligation and were treated with a bath at the ligated SAPDV site(BPC 157 10 μg, 10 ng/kg per 1 mL bath/rat; L-NAME 5 mg/kg per 1 m L bath/rat; L-arginine 100 mg/kg per 1 mL bath/rat, alone and/or together; or BPC 157 10 μg/kg instilled into the rat stomach, at 1 min ligation-time). We recorded the vessel presentation(filled/appearance or emptied/disappearance) between the 5 arcade vessels arising from the SAPDV on the ventral duodenum side, the inferior anterior pancreaticoduodenal vein(IAPDV) and superior mesenteric vein(SMV) as bypassing vascular pathway to document the duodenal lesions presentation; increased NO-and oxidative stress [malondialdehyde(MDA)]-levels in *** Unlike the severe course in the SAPDV-ligated controls, after BPC 157 application, the rats exhibited strong attenuation of the mucosal lesions and serosal congestion, improved vessel presentation, increased interconnections, increased branching by more than 60% from the initial value, the IAPDV and SMV were not congested. Interestingly, after 5 min and 30 min of L-NAME and L-arginine treatment alone, decreased mucosal and serosal duodenal lesions were observed; their effect was worsened at 24 h, and no effect on the collateral vessels and branching was seen. Together, L-NAME+L-arginine antagonized each other's response, and thus, there was an NO-related effect. With BPC 157, all SAPDV-ligated rats receiving L-NAME and/or L-arginine appeared similar to the rats treated with BPC 157 alone. Also, BPC 157 in SAPDV-ligated rats normalized levels of NO and MDA, two oxidative stress markers, in duodenal *** BPC 157, rapidly bypassing occlusion, rescued the original duodenal flow through IAPDV to SMV flow, aneffect related to the NO system and

关键词： Major venous occlusion Duodenal lesions BPC 157 L-NAME Bypassing L-arginine Reduction of free radical formation Rats

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这款雨衣很忧郁

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商业周刊（中文版） 2015年第6期 20-21页

作者： katarina Gustafsson 任文科

5年前，亚历山大·斯塔特海姆（Alexander Stutterheim）决定在他的斯德哥尔摩公寓出售雨衣，他想创设一个忧郁的场景。这位时年38岁的文案撰稿人随即将导演英格玛·伯格曼（Ingmar Bergman）的电影海报挂在墙上，并播放了一曲忧伤的瑞... 详细信息

5年前，亚历山大·斯塔特海姆（Alexander Stutterheim）决定在他的斯德哥尔摩公寓出售雨衣，他想创设一个忧郁的场景。这位时年38岁的文案撰稿人随即将导演英格玛·伯格曼（Ingmar Bergman）的电影海报挂在墙上，并播放了一曲忧伤的瑞典爵士乐。

关键词：忧郁雨衣斯德哥尔摩亚历山大电影海报撰稿人爵士乐忧伤

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小麦叶锈病抗性的诱发变异

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麦类作物学报 1982年第1期 24-26页

作者： katarina Borojevic ,宋孝三

为了鉴定叶锈菌（Puccinia reconditatritici）的抗性,作者以早期实验中按数量性状作为突变体,从San pastore中选出的突变品系M12、M13、M14为材料,以***为对照,进行了抗小麦叶锈菌的实验（菌种统一编号为8号小种和13号小种）。并在人... 详细信息

为了鉴定叶锈菌（Puccinia reconditatritici）的抗性,作者以早期实验中按数量性状作为突变体,从San pastore中选出的突变品系M12、M13、M14为材料,以***为对照,进行了抗小麦叶锈菌的实验（菌种统一编号为8号小种和13号小种）。并在人工接种发病的小区内测定其反应型及严重度。通过温室内一次鉴定和田间三次鉴定的结

关键词：突变品系小种加拿大反应型苗期北美洲抗叶锈基因抗性反应

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Natural Gas Power Plants in the System Security Role—The Situation and Solutions in Brazil

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Energy and Power Engineering 2024年第4期16卷 151-178页

作者： Ciro Galvão Hirdan katarina de Medeiros Costa Eduardo Guedes Pereira Edmilson Moutinho dos Santos Dorel Soares Ramos Polytechnic School (EP) University of S&#227o Paulo S&#227o Paulo Brazil Institute of Energy and Environment (IEE) University of S&#227o Paulo S&#227o Paulo Brazil

This study aims to apply a methodology to analyze the regulatory obstacles for the development of thermal power plants in a country. The study uses Brazil as an application case, although mostly of the findings can be useful to other countries. It also discusses other policies and actions by the government that may contribute to the growth of natural gas-fired power plants. Using deductive and comparative research methods, the first part of this method focuses on the stage of thermoelectric power generation in Brazil. The subsequent sections present the role of the integration of gas and electricity sectors, the main obstacles to the expansion of natural-gas power generation, how the country has deal with the expansion of natural-gas power generation, as well as how other obstacles has been faced. In raising the research question, when comparing the research results of selected countries, it should be noticed the impact that the experience and lessons elsewhere have had on policies formulation on Brazil. Our conclusions pointed out that adequate policies for the natural gas-electricity Brazilian market integration make advisable the unification of electricity and natural gas agencies. We recommended developing a mathematical model to support decision-making on natural gas and electricity integration.

关键词： Component Formatting Style Styling Insert

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时尚达人的呼声：改造我的宜家

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商业周刊（中文版） 2014年第6期 29-30页

作者： katarina Gustafsson 一毫

初创家具公司通过生产宜家家私附属产品获利“我们买宜家沙发的唯一原因”是它可以上特制沙发支脚在宜家家居（IKEA），你有9000多种商品可以选择，它们价位不一，可以满足不同消费档次的需求，将你的家打造成完美的北欧风格。但是，你... 详细信息

初创家具公司通过生产宜家家私附属产品获利“我们买宜家沙发的唯一原因”是它可以上特制沙发支脚在宜家家居（IKEA），你有9000多种商品可以选择，它们价位不一，可以满足不同消费档次的需求，将你的家打造成完美的北欧风格。但是，你却无法找到你的邻居不曾见过的东西。

关键词：宜家家居改造时尚家具公司消费档次沙发商品价位

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Pentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in ratsPentadecapeptide BPC 157 resolves suprahepatic occlusion of the inferior caval vein, Budd-Chiari syndrome model in rats

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World Journal of Gastrointestinal Pathophysiology 2020年第1期11卷 1-19页

作者： Slaven Gojkovic Ivan Krezic Borna Vrdoljak Dominik Malekinusic Ivan Barisic andreja Petrovic katarina Horvat Pavlov Marijan Kolovrat Antonija Duzel Mario Knezevic katarina Kasnik Kovac Domagoj Drmic Lovorka Batelja Vuletic Antonio Kokot Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric Departments of Pharmacology and Pathology Medical Faculty University of ZagrebZagreb 10000Croatia

BACKGROUND Recently,as a possible therapy resolving solution,pentadecapeptide BPC 157 therapy,has been used in alleviating various vascular occlusion *** 157 was previously reviewed as novel mediator of Robert cytoprotection and endothelium protection in the stomach,and gut-brain axis,beneficial therapy in gastrointestinal tract,with particular reference to vascular recruitment,ulcerative colitis and tumor cachexia,and other tissues *** we raised new hypothesis about BPC 157 therapy in the Budd-Chiari syndrome in rats,rapid bypassing of the suprahepatic inferior caval vein occlusion,and rats recovery with the active and effective pharmacotherapy *** To investigate Budd-Chiari syndrome model(inferior caval vein suprahepatic occlusion)resolution,since BPC 157 resolves various rat vascular *** We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt,counteracted caval/portal hypertension,aortal hypotension,venous/arterial thrombosis,electrocardiogram disturbances,liver and gastrointestinal lesions(i.e.,stomach and duodenum hemorrhages,in particular,congestion).Rats with suprahepatic occlusion of the inferior vena cava by ligation were medicated at 1 min,15 min,24 h,or 48 h *** consisted of 10μg/kg BPC 157,10 ng BPC 157 or 5 m L/kg saline,administered once as an abdominal bath or intragastric *** and microscopic observations were made,in addition to assessments of electrical activity of the heart(electrocardiogram),portal and caval hypertension,aortal hypotension,thrombosis,hepatomegaly,splenomegaly and ***,levels of nitric oxide,malondialdehyde in the liver and serum enzymes were *** BPC 157 counteracted increased P wave amplitude,tachycardia and ST-elevation,i.e.,right heart failure from acute thrombotic coronary *** bypassing pathway of the inferior vena cava-azygos(hemiazygos)vein-superior

关键词： BPC 157 Budd Chiari syndrome Portal/caval hypertension

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Brain Processing of Fearful Facial Expression in Mentally Disordered Offenders

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Journal of Behavioral and Brain Science 2011年第3期1卷 115-123页

作者： katarina Howner Hakan Fischer Thomas Dierks Andrea Federspiel Lars-Olof Wahlund Tomas Jonsson Maria Kristoffersen Wiberg Marianne Kristiansson Department of Clinical Neuroscience Karolinska InstituteStockholmSweden NVS-Department Karolinska InstituteStockholmSweden Department of Psychology Stockholm UniversityStockholmSweden Department of Psychiatric Neurophysiology University Hospital for PsychiatryBernSwitzerland Department of Clinical Science Intervention and TechnologyKarolinska InstituteStockholmSweden

Emotional facial expressions are important cues for interaction between people. The aim of the present study was to investigate brain function when processing fearful facial expressions in offenders with two psychiatric disorders which include impaired emotional facial perception;autism spectrum disorder (ASD) and psychopathy (PSY). Fourteen offenders undergoing forensic psychiatric assessment (7 with ASD, and 7 psychopathic offenders) and 12 healthy controls (HC) viewed fearful and neutral faces while undergoing functional magnetic resonance imaging (fMRI). Brain activity (fearful versus neutral faces) was compared both between HC and offenders and between the two offender groups (PSY and ASD). Functional co-activation was also investigated. The offenders had increased activity bilaterally in amygdala and medial cingulate cortex as well as the left hippocampus during processing fearful facial expressions compared to HC. The two subgroups of offenders differed in five regions compared with each other. Results from functional co-activation analysis suggested a strong correlation between the amygdala and anterior cingulate cortex (ACC) in the left hemisphere only in the PSY group. These findings suggest enhanced neural processing of fearful faces in the amygdala as well as in other facial processing brain areas in offenders compared to HC. Moreover, the co-activation between amygdala and ACC in the PSY but not the ASD group suggested qualitative differences in amygdala activity in the two groups. Since the sample size is small the study should be regarded as a pilot study.

关键词： Psychopathy Autism Spectrum Disorder Offenders fMRI Emotional Facial Processing

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海口市垃圾填埋场渗沥水处理技术探讨

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环境卫生工程 2001年第3期9卷 112-115页

作者： Par Elander katarina Starberg 郭祥信瑞典VAI VA-Projekt技术咨询公司北京100074 建设部城市建设研究院北京100029

渗沥水是城市生活垃圾填埋场的主要污染物 ,填埋场渗沥水处理的好坏是衡量垃圾填埋场设计、建设、运营是否成功的重要标志。我们结合海口市的实际情况探讨了垃圾填埋场渗沥水产生量的影响因素 ,根据统计资料 ,总结提出了渗沥水产生量的... 详细信息

渗沥水是城市生活垃圾填埋场的主要污染物 ,填埋场渗沥水处理的好坏是衡量垃圾填埋场设计、建设、运营是否成功的重要标志。我们结合海口市的实际情况探讨了垃圾填埋场渗沥水产生量的影响因素 ,根据统计资料 ,总结提出了渗沥水产生量的预测方法 ,得出了渗沥水产生量预测值 ,比较选择了垃圾渗沥水的处理工艺。

关键词：海口市垃圾填埋场填埋场渗沥水处理技术废水处理

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Correlation of methylprednisolone chemosensitivity in vitro with C3435T MDR1 polymorphism and clinical outcome in childhood acute lymphoblastic leukemia.

Correlation of methylprednisolone chemosensitivity in vitro ...

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第十五届国际药理学大会

作者： Mirossay Ladislav Oravkinova Irina Tokarcikova katarina Jamborova Erika Sarissky Marek Mojzis Jan Mirossay Andrej P.J.Safarik Univ. Fac. Med.Dept. Pharmacol.KosiceSlovak Republic. Pediatric Hospital Dept.Pediat.Oncol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic. P.J. Safarik Univ. Fac. Med.Dept.Pharmacol.KosiceSlovak Republic.

＜正＞ Objective: Cellular drug resistance measured at initial diagnosis is associated with an increased relapse risk and unfavorable clinical outcome in childhood ALL. In addition, the presence of adverse clinical prognostic factors such as age. and pro - B and T - lineage immunophenotype have been shown to be associated with cellular resistance to drugs in children with ALL. P - glycoprotein （Pgp）, the gene product of MDR1, confers multidrug resistance to a number of antineoplastic agents. A silent mutation in the exon 26 （C3435T） has been associated with altered expression and function of Pgp in tissues. Methods: MIT cytotoxicity assay, PCR alnalysis of C3435T polymorphism in MDR1 gene. Results: We compared the impact of C3435T polymorphism on in vitro chemosensitivity of leukemia cells to methylprednisolone. CC genotype carriers showed higher IC50 values in comparison with the carriers of CT or TT genotype. Statistical analysis Mann- Whitney U test showed P = 0.035. Conclusions: The group of patients with CC genotype seems to be more resistant to glucocorticoids, or at least methyprednisolone.

关键词： ALL MDR1 gene polymorphism glucocorticoid

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Stomach perforation-induced general occlusion/occlusion-like syndrome and stable gastric pentadecapeptide BPC 157 therapy effect

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World Journal of Gastroenterology 2023年第27期29卷 4289-4316页

作者： Luka Kalogjera Ivan Krezic Ivan Maria Smoday Hrvoje Vranes Helena Zizek Haidi Yago katarina Oroz Vlasta Vukovic Ivana Kavelj Luka Novosel Slavica Zubcic Ivan Barisic Lidija Beketic Oreskovic Sanja Strbe Marko Sever Ivica Sjekavica Anita Skrtic Alenka Boban Blagaic Sven Seiwerth Predrag Sikiric Department of Pharmacology School of MedicineZagreb 10000Croatia Division of Oncology and Radiotherapy University Hospital for TumorsSestre milosrdnice University Hospital CentreZagreb 10000Croatia Department of Pathology School of MedicineZagreb 10000Croatia

BACKGROUND Using rat stomach perforation as a prototypic direct lesion applied in cytoprotection research,we focused on the first demonstration of the severe occlusion/occlusion-like syndrome induced by stomach *** revealed stomachinduced occlusion/occlusion-like syndrome corresponds to the previously described occlusion/occlusion-like syndromes in rats suffering multicausal pathology and shared severe vascular and multiorgan *** general point was particularly *** in all the described occlusion/occlusion-like syndromes with permanent occlusion of major vessels,peripheral and central,and other similar noxious procedures that severely affect endothelium function,the stable gastric pentadecapeptide BPC 157 was resolving *** To reveal the stomach perforation-induced general occlusion/occlusion-like syndrome and BPC 157 therapy *** The procedure included deeply anesthetized rats,complete calvariectomy,laparotomy at 15 min thereafter,and stomach perforation to rapidly induce vascular and multiorgan failure occlusion/occlusion-like *** 5 min post-perforation time,rats received therapy[BPC 157(10μg or 10 ng/kg)or saline(5 mL/kg,1 mL/rat)(controls)]into the perforated defect in the stomach).Sacrifice was at 15 min or 60 min post-perforation ***(gross and microscopy;volume)included:Brain swelling,peripheral vessels(azygos vein,superior mesenteric vein,portal vein,inferior caval vein)and heart,other organs lesions(i.e.,stomach,defect closing or widening);superior sagittal sinus,and peripherally the portal vein,inferior caval vein,and abdominal aorta blood pressures and clots;electrocardiograms;and bleeding time from the perforation(s).RESULTS BPC 157 beneficial effects accord with those noted before in the healing of the perforated defect(raised vessel presentation;less bleeding,defect contraction)and occlusion/occlusion-like syndromes *** 157 therapy(into the perforated defect),induced immediate

关键词： Stomach perforation General occlusion/occlusion-like syndrome Stable gastric pentadecapeptide BPC 157 Cytoprotection Therapy Rats

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