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Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats

World Journal of Gastroenterology 2006年第2期12卷 251-258页

作者： Annamaria Szabolcs Russel J Reiter Tamas Letoha Peter Hegyi Gabor Papai Ilona Varga katalin Jarmay Jozsef Kaszaki Reka Sari Zoltan Rakonczay Jr Janos Lonovics Tamas takacs st Department of Medicine University of SzegedHungary Department of Cellular and Structural Biology University of TexasHealth Science CentreSan AntonioTexasUnited States Institute of Chemistry University of SzegedHungary Biological Research Centre Hungarian Academy of SciencesSzegedHungary Biological Isotope Laboratory University of SzegedHungary Institute of Experimental Surgery University of SzegedHungary

AIM： To determine the effect of melatonin pre- and post-treatment on the severity of L-arginine （L-Arg） -induced experimental pancreatitis in rats. METHODS： Male Wistar rats （25） were divided into five groups. Those in group A received two injections of 3.2 g/kg body weight L-Arg i.p. at an interval of 1 h. In group MA, the rats were treated with 50 mg/kg body weight melatonin i.p. 30 min prior to L-Arg administration. In group AM, the rats received the same dose of melatonin 1 h after L-Arg was given. In group M, a single dose of melatonin was administered as described previously. In group C the control animals received physiological saline injections i.p. All rats were exsanguinated 24 h after the second L-Arg injection. RESULTS： L-Arg administration caused severe necrotizing pancreatitis confirmed by the significant elevations in the serum amylase level, the pancreatic weight/body weight ratio （pw/bw）, the pancreatic IL-6 content and the myeloperoxidase activity, relative to the control values. Elevation of the serum amylase level was significantly reduced in rats given melatonin following L-Arg compared to rats injected with L-Arg only. The activities of the pancreatic antioxidant enzymes （Cu/Zn-superoxide dismutase （CulZn-SOD） and catalase （CAT）） were significantly increased 24 h after pancreatitis induction. Melatonin given in advance of L-Arg significantly reduced the pancreatic CAT activity relative to that in the rats treated with L-Arg alone. In the liver, L-Arg significantly increased the lipid peroxidation level, and the glutathione peroxidase and Cu/Zn-SOD activities, whereas the Mn-SOD activity was reduced as compared to the control rats. Melatonin pre-treatment prevented these changes. CONCLUSION： Melatonin is an antioxidant that is able to counteract some of the L-Arg-induced changes during acute pancreatitis, and may therefore be helpful in the supportive therapy of patients with acute necrotizing pancreatitis.

关键词： Acute pancreatitis Melatonin Scavengers

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Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility

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World Journal of Gastroenterology 2014年第12期20卷 3208-3222页

作者： Lili Magyari Erzsebet Kovesdi Patricia Sarlos Andras Javorhazy katalin Sumegi Bela Melegh Department of Medical Genetics University of Pecs Szentagothai Research Centre 1~(st) Department of Internal Medicine University of Pecs Department of Urology University of Pecs

Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals. Genetic markers are associated with disease phenotype and long-term evolution, but their value in everyday clinical practice is limited at the moment. IBD has a clear immunological background and interleukins play key role in the process. Almost 130 original papers were revised including meta-analysis. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but text often do not available for the doctors use these in the clinical practice nowadays. We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD, performing an electronic search of PubMed Database from publications of the last 10 years, and used the following medical subject heading terms and/or text words: IBD, CD, UC, interleukins and polymorphisms.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Interleukin, Interleukin receptor, Polymorphisms

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ECG stress test induced atrial ischemia in a patient with old inferior myocardial infarction due to a distal coronary artery lesion

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Journal of Geriatric Cardiology 2017年第1期14卷 73-77页

作者： Andras Vereckei Gabor Katona Zsuzsanna Szelenyi Edit takacs Pal Maurovich-Horvat David Becker 3rd Department of Medicine Budapest Hungary MTA-SE Cardiovascular lmaging Research Group Heart and Vascular Center Budapest Hungary Center of Nuclear Medicine Semmelweis University Budapest Hungary

A 78-year-old man with a history of mitral valve prolapse underwent echocardiography during his cardiological check-up examination in 2011 in a symptom-free stage. Echocardiography revealed akinesis of the inferior septum and inferobasal free wall as a novel finding suggesting a distal right coronary artery （RCA） lesion （Figure 1）. The systolic left ventricular function was normal. Earlier echocardiographies did not show wall motion abnormalities.

关键词： Atrial infarction Atrial ischemia Electrocardiography

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The potential application of red mud and soil mixture as additive to the surface layer of a landfill cover system

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Journal of Environmental Sciences 2016年第6期28卷 189-196页

作者： Eva Ujaczki Viktória Feigl Mónika Molnár Emese Vaszita Nikolett Uzinger Attila Erdélyi katalin Gruiz Department of Applied Biotechnology and Food Science Faculty of Chemical Technology and Biotechnology Budapest University of Technology and Economics H-1111 Budapest Muegyetem rkp. 3 Hungar Institute for Soil Sciences and Agricultural Chemistry Centre for Agricultural Research Hungarian Academy of Sciences H-1022 Budapest Herman Otto Street 15 Hungary A.S.A. Hungary Ltd. H-2360 Gydl Karosi Street 53 Hungary

Red mud, the by-product of aluminum production, has been regarded as a problematic residue all over the world. Its storage involves risks as evidenced by the Ajka red mud spill,an accident in Hungary where the slurry broke free, flooding the surrounding areas. As an immediate remediation measure more than 5 cm thick red mud layer was removed from the flooded soil surface. The removed red mud and soil mixture（RMSM） was transferred into the reservoirs for storage. In this paper the application of RMSM is evaluated in a field study aiming at re-utilizing waste, decreasing cost of waste disposal and providing a value-added product. The purpose was to investigate the applicability of RMSM as surface layer component of landfill cover systems. The field study was carried out in two steps： in lysimeters and in field plots. The RMSM was mixed at ratios ranging between 0 and 50% w/w with low quality subsoil（LQS） originally used as surface layer of an interim landfill cover. The characteristics of the LQS ＋ RMSM mixtures compared to the subsoil（LQS） and the RMSM were determined by physical–chemical, biological and ecotoxicological methods. The addition of RMSM to the subsoil（LQS） at up to 20% did not result any ecotoxic effect, but it increased the water holding capacity. In addition, the microbial substrate utilization became about triple of subsoil（LQS） after 10 months. According to our results the RMSM mixed into subsoil（LQS） at20% w/w dose may be applied as surface layer of landfill cover systems.

关键词： Red mud Soil amelioration Environmental toxicology Landfill cover constituent Field-study Lysimeter

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The Challenges of the European Union＇s Migration and Integration Policy-The Road to a Common Immigration Policy

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Sociology Study 2011年第6期1卷 415-429页

作者： katalin Bandy Szechenyi Istvan University Hungary

This study is about the main problem of the European Union arising from the social status of migrant or migrant background population. It is trying to reveal the real causes, why migrants have difficulties in adapting to the conventions of the receiver countries. The study also focuses on three main questions： the social status of women, public education, and the anomalies of the labour market. It is also trying to find the possible way for the EU communities how to establish and develop a common immigration policy, which can solve the problem in an integrated package system and also fit into the characteristic features of the member-states. This paper is going to give an overview on issues affecting both migrant and migrant-originated communities and is going to analyse cause-reason connections. We also must find efficient responses adequate for applying as strategies for tackling challenges of this nature, which Hungary performs its EU Presidency in first term of the year 2011.

关键词： Migration integration common EU integration policy social challenge of immigrant communities

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Absorbability of Highly Porous Aluminum Oxide Ceramics

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材料科学与工程（中英文A版） 2017年第1期7卷 37-43页

作者： katalin Sinko Chemical Institute Eotvos University Budapest H-111 7 Hungary

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Effect of ageing on colonic mucosal regeneration

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World Journal of Gastroenterology 2011年第25期17卷 2981-2986页

作者： Ferenc Sipos katalin Leiszter Zsolt Tulassay 2nd Department of Internal Medicine Semmelweis University Molecular Medicine Research Unit Hungarian Academy of Sciences

The physiologic and pathologic cellular and molecular changes occurring with age in the human colon affect both the inflammatory process leading to mucosal injury and the regenerative capacity of the *** the one hand,age-related telomere shortening and inflamm-ageing may lead to the development of colonic inflammation,which results in epithelial *** the other hand,the altered migration and function of regenerative stem cells,the age-related methylation of mucosal healing-associated genes,together with the alterations of growth factor signaling with age,may be involved in delayed mucosal *** connections of these alterations to the process of ageing are not fully *** understanding and customtailored modification of these mechanisms are of great clinical importance with regard to disease prevention and modern therapeutic ***,we aim to summarize the age-related microscopic and molecular changes of the human colon,as well as their role in altered mucosal healing.

关键词： Colon Mucosal repair Ageing Colorectalcancer Telomere shortening DNA methylation

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Gradual refinement for application-specific MPSoC design from Simulink model to RTL implementation

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第2期10卷 151-164页

作者： Kai HUANG Xiao-lang YAN Sang-il HAN Soo-ik CHAE Ahmed A. JERRAYA katalin POPOVICI Xavier GUERIN Lisane BRISOLARA Luigi CARRO Institute of VLSI Design Zhejiang University Hangzhou 310027 China Svstem Design Group Seoul National University Seoul 151-744 Korea CEA-LETL Grenoble 38054 France SLS Group.TIMA Laboratory Grenoble 38031. France Informatics Institute Federal University of Rio Grande do Sul. Porto Alegre 15064 Brazil

The application-specific multiprocessor system-on-chip(MPSoC) architecture is becoming an attractive solution to deal with increasingly complex embedded applications,which require both high performance and flexible programmability. As an effective method for MPSoC development,we present a gradual refinement flow starting from a high-level Simulink model to a synthesizable and executable hardware and software specification. The proposed methodology consists of five different abstract levels:Simulink combined algorithm and architecture model(CAAM),virtual architecture(VA),transactional accurate architecture(TA),virtual prototype(VP) and field-programmable gate array(FPGA) emulation. Experimental results of Motion-JPEG and H.264 show that the proposed gradual refinement flow can generate various MPSoC architectures from an original Simulink model,allowing processor,communication and tasks design space exploration.

关键词： Multiprocessor system-on-chip (MPSoC) design Refinement Simulink SystemC Motion-JPEG H.264

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Severe infection with multidrug-resistant Salmonella choleraesuis in a young patient with primary sclerosing cholangitis

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World Journal of Gastroenterology 2017年第11期23卷 2086-2089页

作者： Philip G Ferstl Claudia Reinheimer katalin Jozsa Stefan Zeuzem Volkhard AJ Kempf Oliver Waidmann Georgios Grammatikos Department for Internal Medicine I/Gastroenterology and Hepatology University Hospital Frankfurt Institute for Medical Microbiology and Infection Control University Hospital Frankfurt University Center for Infectious Diseases(UCI) University Hospital Frankfurt

Massive global spread of multidrug-resistant(MDR) Salmonella spp. expressing extended-spectrum beta-lactamase(ESBL) and additional resistance to fluoroquinolones has often been attributed to high international mobility as well as excessive use of oral antibiotics in livestock farming. However, MDR Salmonella spp. have not been mentioned as a widespread pathogen in clinical settings so far. We demonstrate the case of a 25-year-old male with primary sclerosing cholangitis who tested positive for MDR Salmonella enterica serotype Choleraesuis expressing ESBL and fluoroquinolone resistance. The pathogen was supposedly acquired during a trip to Thailand, causing severe fever, cholangitis andpancreatitis. To our knowledge, this is the first report of Salmonella enterica serotype Choleraesuis in Europe expressing such a multidrug resistance pattern. ESBL resistance of Salmonella enterica spp. should be considered in patients with obstructive biliary tract pathology and travel history in endemic countries.

关键词： Biliary physiology Infectious disease Multidrug resistance Primary sclerosing cholangitis Salmonella choleraesuis

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2023年诺贝尔生理学或医学奖简介

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解剖学报 2024年第1期55卷 1-2页

作者： katalin Karik Drew Weissman 陈至鑫(编译) 曾武威(审校) 章静波(审校) 匈牙利塞格德(Szeged)大学美国宾夕法尼亚大学宾夕法尼亚RNA创新研究所北京大学国际医院中国医学科学院基础医学研究所

2023年诺贝尔生理学或医学奖授予两位科学家katalin Kariko和Drew Weissman,以表彰他们对于核苷碱基修饰的发现,从而使得开发针对新型冠状病毒肺炎(corona virus disease 2019,COVID-19)的有效mRNA疫苗成为可能。两位诺贝尔奖获得者的... 详细信息

2023年诺贝尔生理学或医学奖授予两位科学家katalin Kariko和Drew Weissman,以表彰他们对于核苷碱基修饰的发现,从而使得开发针对新型冠状病毒肺炎(corona virus disease 2019,COVID-19)的有效mRNA疫苗成为可能。两位诺贝尔奖获得者的发现对于开发针对在2020年初开始流行的COVID-19的有效mRNA疫苗起到了至关重要的作用。他们的突破性发现从根本上改变了我们对mRNA如何与机体免疫系统相互作用的理解,获奖者在现代人类健康面临最大威胁之一的关键性时刻,为疫苗开发做出了前所未有的杰出贡献。

关键词：机体免疫系统诺贝尔生理学或医学奖疫苗开发碱基修饰诺贝尔奖获得者

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