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Thermal properties of AlN polycrystals obtained by pulse plasma sintering method

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Journal of Advanced Ceramics 2013年第2期2卷 180-184页

作者： PawełJ.RUTKOWSKI Dariusz kata Department of Ceramics and Refractories Faculty of Materials Science and CeramicsAGH University of Science and Technologyal.Mickiewicza 3030-059 KrakowPoland

Aluminum nitride(AlN)polycrystals were prepared by pulse plasma sintering(PPS)*** starting AlN powder mixtures were composed with 3.0 wt%,5.0 wt%and 10 wt%of yttrium oxide(Y_(2)O_(3)),*** density of each polycrystal was measured by hydrostatic method and evaluated higher than 97%.X-ray diffraction(XRD)method was used for phase examination of the samples after heat *** examination supported by computer-aided analysis was performed by scanning electron microscopy(SEM)and energy dispersive spectrometry(EDS).The results were correlated with thermal conductivity of the samples carried out by laser pulse method(LFA).The influence of the rapid sintering technique and yttrium oxide additive content on the thermal conductivity and microstructure appearance of AlN polycrystals was clearly shown.

关键词： aluminum nitride(AlN) thermal conductivity microstructure thermal diffusivity specific heat

Dissociative Chemisorption of an H2（v,j） Molecule on Rigid Ni （100） Surface： Dependence on Surface Topologies and Initial Rovibrational States of the Molecules

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Chinese Physics Letters 2005年第2期22卷 420-423页

作者： MeryemEvecen MustafaBǒyǚkata MehmetCivi ZiyaB.Gǚvenc DepartmentofPhysics GaziUniversity06500AnkaraTurkey DepartmentofPhysics ErciyesUniversity66100YozgatTurkey DepartmentofElectronicandCommunicationEngineering CankayaUniversity06530AnkaraTurkey

The H2(v,j)+Ni(100) collision system has been studied to understand the effects of the surface sites and initial rovibrational states of the molecule on molecule-surface interactions, by a quasiclassical molecular dynamic simulation method. Dissociative adsorption of an H2 molecule on the rigid Ni(100) surface is investigated at topologically different three sites of the surface. Interaction between the molecule and Ni surface was described by a London–Eyring–Polani–Sato (LEPS) potential. Dissociative chemisorption probabilities of the H2(v,j) molecule on various sites of the surface are presented as a function of the translation energies between 0.001–1.0eV. The probabilities obtained at each collision site have unique behaviour. At lower collision energies, indirect processes enhance the reactivity, effects of the rotational excitations and impact sites on the reactivity are more pronounced. The results are compared with the available studies. The physical mechanisms underlying the results and quantum effects are discussed.

关键词：氢气分子游离化学吸收镍表面拓扑转振状态

Is the disease course predictable in inflammatory bowel diseases?

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World Journal of Gastroenterology 2010年第21期16卷 2591-2599页

作者： Peter Laszlo Lakatos Lajos S kiss 1st Department of Medicine Semmelweis UniversityH-1083 BudapestKoranyi S 2AHungary

During the course of the disease,most patients with Crohn's disease(CD) may eventually develop a stricturing or a perforating complication,and a significant number of patients with both CD and ulcerative colitis will undergo *** recent years,research has focused on the determination of factors important in the prediction of disease course in inflammatory bowel diseases to improve stratification of patients,identify individual patient profiles,including clinical,laboratory and molecular markers,which hopefully will allow physicians to choose the most appropriate management in terms of therapy and intensity of *** review summarizes the available evidence on clinical,endoscopic variables and biomarkers in the prediction of short and long-term outcome in patients with inflammatory bowel diseases.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Disease course Predictive markers Clinical Serology Genetics

Current status of thiopurine analogues in the treatment in Crohn's disease

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World Journal of Gastroenterology 2011年第39期17卷 4372-4381页

作者： Peter Laszlo Lakatos Lajos S kiss 1st Department of Medicine Semmelweis University

In the last decades,with the development of biological therapy,the treatment paradigms in patients with Crohn＇s disease have continuously *** studies focusing on the optimal use of both traditional immunosuppressants and biological therapy have been published,investigating conventional,accelerated stepup and top-down *** addition,much emphasis has been placed in recent years on the de-termination of important predictive factors that could enable early patient stratification,which would lead to a tailored management *** this review,the authors try to highlight new evidence on the optimal timing,benefits,and risks of immunosupressants alone,or in combination,in patients with Crohn＇s disease.

关键词： Crohn's disease Immunosuppressives Azathioprine Thiopurine methyltrans ferase Biologicals

Recent advances on the synthesis and application of tetrahydro-y-carbolines

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Chinese Chemical Letters 2023年第12期34卷 93-110页

作者： Haibo Mei Klara Aradi Lorand kiss Jianlin Han jiangsu Co-lnnovation Center of Eficient Processing and Utilization of Forest Resources Nanjing Forestry UniversityNanjing 210037China Institute of Organic Chemistry Research Centre for Natural SciencesStereochemistry Research GroupMagyar Tudsok krt.2117 BudapestHungary

Tetrahydro-y-carbolines(THyCs)constitute one of the most important subtypes of indole *** addition to being substructures of natural products,these structural motifs and moieties can often be found in pharmaceuticals due to their diverse bioactivities such as antiviral,antibacterial,antifungal,antiparasitic,antitumor,anti-inflammatory,and neuropharmacological *** the pharmacological and biological aspects of these scaffolds,they have considerable synthetic applications for the construction of further bioactive compounds,*** aim of this review is to summarize recent developments in the synthesis of this compound class.

关键词： Tetrahydro-y-carbolines Synthetic methods Bioactive molecuels Asymmetric synthesis Indole Polycyclic compounds

Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues

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Neural Regeneration Research 2015年第6期10卷 866-869页

作者： éva Korpos Ferenc Deák Ibolya kiss Institute of Physiological Chemistry and Pathobiochemistry University of Muenster Cells-in-Motion Cluster of Excellence University of Muenster Institute of Biochemistry Biological Research CentreHungarian Academy of Sciences Avidin Ltd.

The extracellular matrix （ECM） performs essential functions in the differentiation, maintenance and remodeling of tissues during development and regeneration, and it undergoes dynamic changes during remodeling concomitant to alterations in the cell-ECM interactions. Here we discuss recent data addressing the critical role of the widely expressed ECM protein, matrilin-2 （Matn2） in the timely onset of differentiation and regeneration processes in myogenic, neural and other tissues and in tumorigenesis. As a multiadhesion adaptor protein, it interacts with other ECM proteins and integrins. Matn2 promotes neurite outgrowth, Schwann cell migration, neuromuscular junction formation, skeletal muscle and liver regeneration and skin wound healing. Matn2 deposition by myoblasts is crucial for the timely induction of the global switch toward terminal myogenic differentiation during muscle regeneration by affecting transforming growth factor beta/bone morphogenetic protein 7/Smad and other signal transduction pathways. Depending on the type of tissue and the pathomechanism, Math2 can also promote or suppress tumor growth.

关键词： Schwann cells neurite outgrowth neuromuscular junction (NM]) multiple sclerosis TGF-β/BMP-7/Smad signaling myogenic differentiation Trf3 tumor suppression

Shunts, channels and lipoprotein endosomal traffic： a new model of cholesterol homeostasis in the hepatocyte

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The Journal of Biomedical Research 2017年第2期31卷 95-107页

作者： Robert Scott kiss Allan Sniderman Research Institute of the McGill University Health Centre Montreal Quebec H4A 3J1 Canada Department of Medicine McGill University Montreal Quebec H4A 3J1 Canada

The liver directs cholesterol metabolism in the organism. All the major fluxes of cholesterol within the body involve the liver： dietary cholesterol is directed to the liver; cholesterol from peripheral cells goes to the liver; the liver is a major site of cholesterol synthesis for the organism; cholesterol is secreted from the liver within the bile, within apoB lipoproteins and translocated to nascent HDL. The conventional model of cholesterol homeostasis posits that cholesterol from any source enters a common, rapidly exchangeable pool within the cell, which is in equilibrium with a regulatory pool. Increased influx of cholesterol leads rapidly to decreased synthesis of cholesterol. This model was developed based on in vitro studies in the fibroblast and validated only for LDL particles. The challenges the liver must meet in vivo to achieve cholesterol homeostasis are far more complex. Our model posits that the cholesterol derived from three different lipoproteins endosomes has three different fates： LDL-derived cholesterol is largely recycled within VLDL with most of the cholesterol shunted through the hepatocyte without entering the exchangeable pool of cholesterol; high density lipoprotein-derived CE is transcytosed into bile; and chylomicron remnant-derived cholesterol primarily enters the regulatory pool within the hepatocyte. These endosomal channels represent distinct physiological pathways and hepatic homeostasis represents the net result of the outcomes of these distinct channels. Our model takes into account the distinct physiological challenges the hepatocyte must meet, underlie the pathophysiology of many of the apoB dyslipoproteinemias and account for the sustained effectiveness of therapeutic agents such as statins.

关键词： ACAT2 cholesterol hepatocyte HMGCR LDLR

Classification of submucosal tumors in the gastrointestinal tract

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World Journal of Gastroenterology 2007年第24期13卷 3311-3315页

作者： Laura Graves Ponsaing katalin kiss Mark Berner Hansen Department ofSurgical Gastroenterology K Bispebjerg University Hospital ofCopenhagen Denmark Department of Pathology Herlev UniversityHospital Gentofte Denmark

This review is part two of three, which will present an update on the classification of gastrointestinal submucosal tumors. Part one treats of the diagnosis and part three of the therapeutic methods regarding gastrointestinal submucosal tumors. In the past there has been some confusion as to the classification of gastrointestinal submucosal tumors. Changes in classifications have emerged due to recent advances in mainly immunohistochemistry and electron microscopy. The aim of this paper is to update the reader on the current classification. Literature searches were performed to find information related to classification of gastrointestinal submucosal tumors. Based on these searches the twelve most frequent submucosal tumor types were chosen for description of their classification. The factors that indicate whether tumors are benign or malignant are mainly size and number of mitotic counts. Gastrointestinal stromal tumors are defined mainly by their CD117 positivity. In the future, there should be no more confusion between gastrointestinal stromal tumors and other types of submucosal tumors.

关键词： Submucosal tumor Immunohistochemistry Smooth muscle derived submucosal tumors Submucosal tumors of neurogenic origin Gastrointestinal stromal tumor Malignant Benign

Conceptual Design of the ITER Gas Injection System

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Plasma Science and Technology 2013年第3期15卷 287-290页

作者：杨愚 S.MARUYAMA G.kiss 李伟江涛李波 ITER Organization Route de Vinon sur Verdon Southwestern Institute of Physics

A conceptual design review of the ITER gas injection system （GIS） function, safety, operation, and maintenance has recently been successfully completed. The GIS design can now continue to the preliminary design stage. This paper gives an overall description of the requirements and implementation at the concept design level. The designs of the sub-systems according to its breakdown structure are discussed against the corresponding requirements.

关键词： ITER gas injection system system requirements concept design