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testicular fine-needle aspiration for the assessmen＇ of intratesticular hormone concentrations

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Asian Journal of Andrology 2016年第1期18卷 21-24页

作者： Ada P Lee Mara Y Roth Jean-Jacques Nya-Ngatchou kat.Lin thomas J Walsh Stephanie t Page Alvin M Matsumoto William J Bremner John K Amory Bradley D Anawalt Department of Medicine University of California San Francisco San Francisco CA USA Department of Medicine and Center for Research in Reproduction and Contraception University of Washington Seattle WA USA Department of Obstetrics and Gynecology University of Washington Seattle WA USA Department of Urology University of Washington Seattle WA USA Department of Medicine Geriatric Research Education and Clinical Center VA Puget Sound Health Care System Seattle WA USA.

Measurement of intratesticular sex steroid concentrations in men informs both the development of male hormonal contraceptives and the understanding of male infertility. Given the challenges of using invasive techniques to measure testicular hormone physiology, our group has used a minimally-invasive fine-needle aspiration technique to measure intratesticular hormones in normal healthy men. Herein, we present a post-hoc analysis of the safety and efficacy of testicular fine-needle aspiration （FNA） completed as part of six clinical trials. From 2001 through 2011, a total of 404 procedures were conducted among 163 research volunteers, 85.9% of which were successful in obtaining sufficient fluid for the measurement of intratesticular steroid concentrations. Pain was the most common side effect, with 36.8% of procedures associated with moderate procedural pain and 4.7% with severe procedural pain. Postprocedural pain was uncommon and abated within a few days. Mild local bruising occurred with 14.9% of procedures. two serious adverse events （0.5%） required surgical intervention. the risk of an adverse event was not associated with age, body mass index, testicular size, or the volume of fluid aspirated. testicular FNA to obtain fluid for measurement of intratesticular steroid concentrations frequently causes mild to moderate procedural pain, but serious adverse events occur rarely. testicular FNA has been instrumental for defining human intratesticular hormone physiology and is a minimally-invasive, safe, effective method for obtaining fluid for research on testicular physiology and pathology.

关键词： male contraception physiology reproductive and urinary testis

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《冰雪奇缘》续集大猜想

新高考(英语进阶) 2015年第11期 18-20页

作者： kat.Brown 阿柚

是的,《冰雪奇缘》要出续集了,但是先别高兴得太早,因为真正看到它还需要漫长的等待,目前,关于续集的剧情,我们只能作一些大胆的猜想。What a time to be alive!Well,unless you are the hapless parent of one of the millions of chil... 详细信息

是的,《冰雪奇缘》要出续集了,但是先别高兴得太早,因为真正看到它还需要漫长的等待,目前,关于续集的剧情,我们只能作一些大胆的猜想。What a time to be alive!Well,unless you are the hapless parent of one of the millions of children still obsessed with Anna,Elsa and everything *** March,Disney officially confirmed it:Frozen 2 is on the *** we can’t tell you

关键词：奇缘续集猜想

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t台魅影

房地产导刊 2006年第11期 89-89页

作者： kat

里斯本的Alcantara Dock水果市场每半年就有一个星期时间变成时尚嘉年华的梦想地带。由一个4000平米的市场改造的ModaLisboa,每年都会在此举办16位葡萄牙设计师的联合发布会。从2002年开始,设计师Miguel Vieira Baptista就一直担任这里... 详细信息

里斯本的Alcantara Dock水果市场每半年就有一个星期时间变成时尚嘉年华的梦想地带。由一个4000平米的市场改造的ModaLisboa,每年都会在此举办16位葡萄牙设计师的联合发布会。从2002年开始,设计师Miguel Vieira Baptista就一直担任这里的室内设计师,他可以在很小的预算内,创造出非常兼容的设计,塑造这个盛会的形象。这次,他利用发亮的黑色t型台和缝合的沙发作为主体。"潮流

关键词：沙发坐具设计师时尚潮流发布会

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命运之变

海外英语 2006年第4期 27-页

作者： kat.Voletto

　　When I got to where I am living now,I thought that I was going to just get a job and make ends meet. I didn't think that a person like me could get yet another chance of doing things right.……

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非St段抬高型急性冠状动脉综合征患者中促炎细胞因子与抗炎细胞因子比值和长期预后的关系

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世界核心医学期刊文摘（心脏病学分册） 2006年第12期2卷 39-40页

作者： Kilic t. Ural D. Ural E. 徐永城 Cardiology Department Kocaeli University Medical Faculty Cumhuriyet Mah Blok Kat: 1 Daire 4 Izmit/Kocaeli Kocaeli 41100 Turkey Dr.

Objective: to investigate the relation between serum high sensitivity(hs) C reactive protein(CRP), proinflammatory cytokine concentrations, proinflammatory to anti-inflammatory cytokine ratios and long-term prognosis in patients with non-St elevation acute coronary syndrome(NStEACS). Design: Prospective follow-up study for the first six months and then for the first year after admission to hospital. Setting: tertiary referral centre. Patients: 80 patients(60 men, 20 women, mean age 60(SD 10) years) with NStEACS and moderate to high tIMI(thrombolysis In Myocardial Infarction) risk scores. Interventions: Blood samples from patients with NStEACS were obtained at the time of admission. Serum concentrations of hs-CRP,(hs)-pro-inflammatory(interleukin(IL)-1β, IL-6, tumour necrosis factor α) and(hs) anti-inflammatory(IL-10) cytokines were analysed and proinflammatory to anti-inflammatory cytokine ratios were calculated by dividing proinflammatory cytokine concentrations by anti-inflammatory cytokine IL-10. Main outcome measure: the primary end point of the study was new coronary events(NCE) defined as the combination of cardiac death, non-fatal myocardial infarction and recurrent rest angina that required hospitalisation within 12 months of follow up. Results: During the one-year follow-up period, 23 patients(29%) met the NCE criteria. Concentrations of hs-CRP, IL-1βand IL-6 and ratios of IL-1β∶IL-10 and IL-6 ∶IL-10 were significantly higher in patients with NCE than in patients without NCE. In the logistic regression analysis, IL-6 ∶IL-10 ratio was the most important predictor for NCE(p=0.006) with an odds ratio of 2.24(95%CI 1.26 to 3.97). Conclusions: Cytokine concentrations and proinflammatory to anti-inflammatory cytokine ratios may be useful markers for predicting vascular risk in patients with NStEACS.

关键词：急性冠状动脉综合征长期预后炎细胞抗炎细胞因子患者 St

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帕金森病患者血浆和红细胞中的犬尿氨酸代谢

世界核心医学期刊文摘（神经病学分册） 2006年第3期2卷 22-22页

作者： Hartai Z. Klivenyi P. Janaky t. L. Vecsei 袁海峰 Department of Neurology University of Szeged 6 Semmelweis u. H6725 Szeged Hungary

Substantial evidence indicates that neuroactive kynurenine metabolites play a role in the normal physiology of the human brain, and are involved in the pathology of neurodegenerative disorders such as Parkinson’s disease (PD). A sidearm product of the pathway, kynurenic acid (KYNA), which is synthesized by the irreversible transamination of kynurenine (KYN) by kynurenine aminotransferases (kat.I and kat.II), is an excitatory amino acid receptor antagonist. In the present study we measured the level of KYNA and the activities of the biosynthetic enzyme isoforms kat.I and kat.II in the plasma and in the erythrocytes (RBC) of 19 PD patients and 17 age-matched controls. the kat.I and kat.II activities were significantly lower in the plasma of PD patients, followed by a tendency to a decrease in plasma KYNA. An elevated KYNA level correlated with a significant increase in kat.II activity in the RBC of PD patients. these data support the contribution of an altered KYNA metabolism in the RBC to the pathogenesis of PD. the increased activity of kat.II in correlation with the elevated KYNA level in the RBC may mediate a consecutive protective response against excitatory neurotoxic effects.

关键词：帕金森病犬尿氨酸神经退行性疾病正常生理过程犬尿酸转氨作用下经导抗人类大脑同工酶

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